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Peyton, Shelly
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Brehm, Michael
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Endowed Chair Honorary Title: Harvey A. Shultz Chair in Diabetes
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Litwin, Demetrius
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Wolfe, Scot
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Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
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Greiner, Dale
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Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
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Han, Gang
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Post Docs: Positions for postdoctoral fellows are available in the laboratory of Dr. Gang Han at the Department of Biochemistry and Molecular Pharmacology of The University of Massachusetts- Medical School. Research will focus on developing novel small molecule/ nanoparticle approaches for translational biomedical sciences and molecular imaging. Qualifications: Candidates have a Ph.D degree in (1)Organic Chemistry/polymer synthesis , (2) Molecular cell biology , (3) Biophysics or (4) Biochemistry. A solid training and substantial organic synthesis, animal experiments, spectroscopy and microscopy are desired. Candidates need to have strong work ethic, creativity, and enthusiasm with proven ability to work independently and collaboratively. To apply: Applicants should submit their CV including a full publication list and sources of three reference letters by email to gang.han@umassmed.edu
Rotation Projects: Rotation projects <p >(1) Specific cell membrane component labeling using bioconjugated nanoparticles <p >(2) To develop tools for targeted and traceable siRNA delivery <p >(3) To synthesize functional nanomaterials for detecting biomarkers in biological fluids
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Cerny, Jan
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Goldberg, Robert
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Shaw, Leslie
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Mercurio, Arthur
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Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
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Bogdanov, Alexei
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Gounis, Matthew
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Moriarty, Kevin
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Seymour, Neal
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Politi, Letterio
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UMass Chan – Baystate Regional Campus
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Arenas, Richard
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Johnson, Mark
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Tirabassi, Michael
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Lindenauer, Peter
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Schneider, Sallie
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Gardiner, Paula
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ADJUNCT ASSISTANT PROFESSOR
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Usmani, Saad
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Population and Quantitative Health Sciences
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Neurological Surgery
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Patel, Shyam
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Bankier, Alexander
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Gardner, Heather
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Ruscetti, Marcus
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Cachia, David
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Wong, Kaitlyn
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publication date: 2024
type: URLLink
label: https://journals.lww.com/oncology-times/fulltext/2024/01000/tp53_in_mds___aml__prognostication___treatment.19.aspx
link anchor text: TP53 in MDS & AML Prognostication & Treatment Strategies

https://profiles.umassmed.edu/profile/68653317
publication date: 2022
type: URLLink
label: https://journals.lww.com/oncology-times/fulltext/2022/05201/exploring_the_biological_basis_of_tp53_aberrant.2.aspx
link anchor text: Exploring the Biological Basis of TP53-Aberrant MDS & AML

https://profiles.umassmed.edu/profile/68653327
publication date: 2022
type: URLLink
label: https://journals.lww.com/oncology-times/fulltext/2022/02200/improving_outcomes_in_blast_phase_chronic_myeloid.3.aspx
link anchor text: Improving Outcomes in Blast Phase Chronic Myeloid Leukemia

https://profiles.umassmed.edu/profile/71480860
publication date: 2025
type: URLLink
label: https://ashpublications.org/ashclinicalnews/news/8551/Practical-Solutions-to-Promoting-Scholarly-Out
link anchor text: ASH Clinical News - Practical Solutions Amid Cuts to Federally Funded Research

Adjunct Professor
is primary position: true
position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
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type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Shin, Dong-Soo
first name: Dong-Soo
last name: Shin
full name: Dong-Soo Shin PhD, RN
has faculty rank: ADJUNCT PROFESSOR
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person in primary position: Adjunct Professor
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type: Person
preferred title: Adjunct Professor

Professor
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position in department: Program in Molecular Medicine
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position in organization: UMass Chan Medical School

Professor Emeritus
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position in department: Radiology
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type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
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HR job title: Associate Professor
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Professor
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position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/88314388
publication date: 2025
type: URLLink
label: https://www.onclive.com/view/ihc-testing-may-enable-expedited-identification-of-tp53-mutant-mds-and-aml
link anchor text: OncLive with Dr. Patel and Dr. Gerber: p53 Immunohistochemistry

https://profiles.umassmed.edu/profile/89429665
publication date: 2025
type: URLLink
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link anchor text: Early Identification of TP53-Mutant MDS and AML Using p53 Immunostaining

https://profiles.umassmed.edu/profile/89429727
publication date: 2023
type: URLLink
label: https://journals.lww.com/oncology-times/blog/onlinefirst/pages/post.aspx
link anchor text: Point-of-Care p53 IHC Unveils TP53-Mutant MDS/AML

https://profiles.umassmed.edu/profile/89429786
publication date: 2025
type: URLLink
label: https://trial.medpath.com/news/61960d9f316e3daa/ihc-testing-enables-rapid-tp53-mutation-detection-in
link anchor text: IHC Enables Rapid Identification of TP53-Mutant MDS/AML

https://profiles.umassmed.edu/profile/95558627
publication date: 2025
type: URLLink
label: https://ashpublications.org/ashclinicalnews/news/8743/p53-IHC-Testing-May-Be-Reliable-Surrogate-for
link anchor text: ASH Clinical News: p53 Immunohistochemistry for TP53-Mutant MDS/AML

Adjunct Assistant Professor
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position in department: Pediatrics
position in division: Pediatric Research
sort order: 1
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HR job title: Adjunct Assistant Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/99769701
publication date: 2025
type: URLLink
label: https://journals.lww.com/oncology-times/fulltext/2025/11000/immunostaining_offers_shortcut_to_detect_high_risk.20.aspx
link anchor text: p53 Immunostain in TP53-Mutant MDS and AML