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Aroian, Raffi
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Thompson, Paul
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Schafer, Dorothy
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Pukkila-Worley, Read
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Karlsson, Elinor
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Mello, Craig
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Francis, Michael
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr.Francis for additional details.
Rotation Projects: <p >Potential Rotation Projects <p >The Francis lab studies the regulation of post-synaptic neurotransmitter receptors and how alterations in synaptic transmission lead to changes in behavior. We combine patch-clamp electrophysiology with the powerful genetic techniques available in C. elegans. <p >A variety of potential rotation projects centered around the exploration of synaptic function, mechanisms for receptor localization and analysis of C. elegans movement are available. Students can expect to have access to training in a broad range of techniques including forward and reverse genetic strategies, molecular biology, fluorescent microscopy and electrophysiology. As projects are always evolving, I encourage students to contact the lab directly to discuss your specific interests.
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Rando, Oliver
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Rotation Projects: Rotation projects are available to study chromatin structure and function. Project 1. Measure histone dynamics in yeast. Histone dynamics play major roles in chromatin metabolism and in the inheritance of chromatin states. To measure histone replacement rates in yeast, we have created yeast strains carrying inducible epitope-tagged histones H3 and H2A. Using microarrays, we will measure histone replacement rates in a variety of mutant yeast to ascertain the role of various chromatin remodeling factors in histone exchange reactions. Project 2. Characterize mechanisms for epigenetic inheritance in yeast. We have identified a variety of genes whose expression state in yeast is epigenetically heritable. We will screen the yeast genome for genes that affect the inheritance of these expression patterns. Project 3. Measure histone dynamics in embryonic stem cells. Embryonic stem cells are pluripotent cells that can give rise to every type of cell in the adult animal. The role of chromatin structure in maintaining this pluripotent state is poorly understood, but it appears that stem cell chromatin is exceptionally labile relative to that in differentiated cells. We will create stem cell lines with inducible tagged histones to measure histone replacement rates across the mouse genome.
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Massi, Francesca
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last name: Massi
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Rotation Projects: Rotation Projects Rotation projects are available to address the following questions: How does the lack of structure in the C-terminal zinc finger of TTP affect the activity of the protein in the cell? In humans, there are three members in the TTP protein family: TTP, TIS11b and TIS11d. Structural studies performed by us and others have shown that while the TZF domain of TTP is partially unstructured in the free state and folds upon binding RNA, those of TIS11d and TIS11b are always folded. We have shown that the degree of structure of the TZF domain affects the activity of the protein in cells and indicates that the protein can modulate its activity through its dynamics. We want to determine whether structural disorder is directly linked to cellular stability or protein localization How do mutations in the RNA-binding domain of TIS11d cause cancer? Several point mutation in TTP and TIS11d have been linked to cancer. In particular, point mutations in the RNA-binding domain of TIS11d are found in leukemia patients. We are currently working on the characterization of the structure, dynamics and biological activity of these mutant proteins to understand their role in the pathogenesis of cancer. How does HuR regulate the stability of its target mRNA? HuR is another protein that, like TTP, binds to AU-rich elements (ARE) in mRNAs and regulate their stability. The detailed mechanisms that determine how HuR regulates transcripts stability are poorly understood. We are investigating how binding or HuR to the 3’UTR of an mRNA leads to its stabilization.
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Zhu, Lihua
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Baehrecke, Eric
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last name: Baehrecke
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Endowed Chair Honorary Title: Our Danny Cancer Fund Chair in Biomedical Research II
Post Docs: Postdoctoral positions are available for this lab. Please contact Eric Baehrecke directly, 508-856-6733 or via email, Eric.Baehrecke@umassmed.edu
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Weng, Zhiping
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last name: Weng
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Post Docs: The project aims to develop computational algorithms and software programs for analyzing high-throughput sequence data such as ChIP-Seq RNA-Seq small RNA sequencing data. PhD required. A strong background in computational biology especially experience with analyzing high-throughput sequencing data is highly desirable. Excellent communication and writing skills and the ability to work with experimental and computational collaborators are essential. To apply please forward CV cover letter and three references to: Zhiping.Weng@umassmed.edu
Rotation Projects: Please contact Dr. Weng for information on rotations that are available in her lab.
preferred title: Chair and Professor

Ambros, Victor
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Brown, Robert
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Endowed Chair Honorary Title: Donna M. and Robert J. Manning Chair in Neurosciences
Lab URL: https://www.umassmed.edu/brownlab/
Summary: Dr. Brown’s laboratory has focused on the identification of gene defects that elucidate the molecular pathogenesis of selected neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis.
preferred title: Professor

Kennedy, David
first name: David
last name: Kennedy
full name: David N Kennedy PhD
has faculty rank: Professor
latitude: 42.27635970000000
longitude: -71.76569530000000
Person ID: 1244
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Gao, Fen-Biao
first name: Fen-Biao
last name: Gao
full name: Fen-Biao Gao PhD
has faculty rank: Professor
latitude: 42.27694690000000
longitude: -71.76568470000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 1368
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Governor Paul Cellucci Chair in Neuroscience Research
Lab URL: https://www.umassmed.edu/fen-biaogaolab
Rotation Projects: Project 1: Dervelop RNA-based therapies for frontotemporal dementia (FTD) and related disroders. Project 2: Study pathogenic mechanisms of FTD and related disorders in mouse models.
Summary: Our lab uses a combination of molecular, cellular, genetic, and behavioral approaches to further dissect the pathogenic mechanisms of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis with a focus on mutant CHMP2B, progranulin and C9ORF72. We will identify common underlying pathways as potential targets for therapeutic interventions.
preferred title: Professor

Emery, Patrick
first name: Patrick
last name: Emery
Twitter: https://profiles.umassmed.edu/profile/34784926
full name: Patrick Emery PhD
has faculty rank: Professor
latitude: 42.27737440000000
longitude: -71.76346650000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 172
person in primary position: Professor
type: Agent
type: Person
Lab URL: https://www.umassmed.edu/emerylab
Post Docs: A postdoc position is available to study circadian rhythms in Drosophila. Contact Patrick Emery (patrick.emery@umassmed.edu).
Rotation Projects: Biological clocks play an essential role in the temporal organization of animal physiology and behavior. We combine the powerful genetics of Drosophila with molecular, cell culture and behavioral approaches to obtain a comprehensive view of the mechanisms regulating circadian clocks and one of their critical output: sleep. We also now study the mechanisms enabling marine organisms to anticipate tides. Indeed, we have developed a model organism to study circatidal rhythms: Parhyale hawaiensis. Rotation projects could for example focus on characterizing new candudate post-transcriptional regulators of circadian rhythms, the role of glial genes in the control of sleep, or studying the molecular mechanisms of circatidal clocks.
preferred title: Professor

Fitzgerald, Katherine
first name: Katherine
last name: Fitzgerald
full name: Katherine A Fitzgerald PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 202
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair III
Rotation Projects: Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866427
webpage: https://profiles.umassmed.edu/profile/28866493

Walker, Amy
first name: Amy
last name: Walker
full name: Amy K Walker PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 3101
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Determine links between SREBPs, SAMe levels and epigenetic regulation Methylation of histones or DNA affects gene expression at local as well as global levels. The major cellular methyl donor, s-adenosylmethionine (SAMe) is produced by the folate or 1-carbon (1C) cycle. 1CC function may be affected by dietary levels of folate, methionine, choline or betaine, genetic polymorphisms, or alcohol intake, linking potential for epigenetic modification in cancer progression to food intake and metabolism. Physiological limitation of 1CC function has multiple deleterious physiological effects from birth defects to the development of hepatosteatosis and has also been linked to hepatic and colon cancer. While many studies have shown that the availability of methyl donors may dramatically affect human disease, the mechanisms governing SAMe production and epigenetic modification are much less clear. We hypothesize that modulation of SBP-1 function affecting sams-1 expression will also alter methyl group levels and subsequently, histone modification, leading to changes in gene expression relevant to overall nutritional homeostasis. We will determine if modulation of SAMe levels through SBP-1 effects histone methylation at nutritionally important promoters and examine how diet quality and dietary supplementation affect SBP-1 activity by evaluating histone methylation, in addition to employing biological assays for epigenetic changes in gene expression. We will also use unbiased assays such as ChIP-Seq to identify genes whose expression levels are linked to epigenetic changes after sbp-1 RNAi, selecting those with roles in metabolism for further study. These studies will provide a basis for understanding how lipid homeostasis and other dietary influences affect SAMe production and how those are linked to increased lipid accumulation in C. elegans. Future studies will extend these models to mammalian systems to investigate how these changes predispose hepatosteatosis, a component of …
Rotation Projects: Determine mechanisms for differential regulation of SREBP-1 and SREBP-2 by PC-based feedback In recent studies, we have found that inactive precursors for SREBP-1 are cleaved, accumulate in the nucleus and activate lipogenic transcription programs when membrane changes linked to low PC levels alter localization of SREBP-activating proteases (see Research Interests). We also found that SREBP-2 was resistant to this regulation (Figure 1), and note that while mouse models of PC depletion are associated with hepatic steatosis, cholesterol levels are not necessarily affected (Jacobs, et al. 2008, JBC). We will determine the mechanisms of this differential regulation which will be important for understanding how lipid or cholesterol synthesis may be inappropriately stimulated in metabolic disease. Figure 1: Depletion of PC biosynthesis enzymes in HepG2 human hepatoma cells causes nuclear localization of SREBP-1, but not SREBP-2. Yellow line shows cell boundary
Rotation Projects: Identify cellular responses to decreased SAMe production Our studies in C. elegans showed that SREBP transcriptional activators could control expression 1CC genes. These studies are important because they demonstrate that levels of these critical enzymes mRNAa are not controlled as a “housekeeping function” but are instead are coordinated with other cellular processes. We have developed two models for 1CC dysfunction in C. elegans, a genetic model based on loss of function (lof) of sams-1, a SBP-1/SREBP responsive gene encoding the enzyme for producing the methyl donor SAMe and a dietary model in which C. elegans are fed bacteria unable to synthesize folate. In both of these models, transcription of lipogenic genes are highly increased and sams-1(lof) worms accumulate large lipid droplets, mimicking aspects of fatty liver disease in mammals. These models will allow use genetic screens as a tool for identifying 1) other regulatory pathways affecting SAMe production or utilization and 2) cellular responses that limit lipogenesis when methyl donor levels are low.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866527

Davis, Roger
first name: Roger
last name: Davis
full name: Roger J Davis PhD, FRS
has faculty rank: Chair And Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 3130
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: H. Arthur Smith Chair in Cancer Research
Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866429

Henninger, Nils
first name: Nils
last name: Henninger
email address: w8ip9dqS9xWMQqXDzAY0dVS+h24VZ+hbL+eK
full name: Nils Henninger MD, PhD
has faculty rank: Associate Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 3265
person in primary position: Associate Professor
type: Agent
type: Person
Summary: Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
preferred title: Associate Professor

Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
has faculty rank: ADJUNCT PROFESSOR
latitude: 50.70274210000000
longitude: 7.10034010000000
Person ID: 3432
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

King, Michael
first name: Michael
last name: King
full name: Michael A King PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 349
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866610
webpage: https://profiles.umassmed.edu/profile/28866628
webpage: https://profiles.umassmed.edu/profile/28866539
webpage: https://profiles.umassmed.edu/profile/28866499
webpage: https://www.umassmed.edu/globalassets/radiology/documents/King-Graduate Student-Training-UpTo-2020.pdf

Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27636250000000
longitude: -71.76564740000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 36
person in primary position: Adjunct Professor
type: Agent
type: Person
Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Blaustein, Jeffrey
first name: Jeffrey
last name: Blaustein
full name: Jeffrey D Blaustein BS, PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3698
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Lian, Jane
first name: Jane
last name: Lian
full name: Jane B Lian PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27723620000000
longitude: -71.76070940000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 370
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Siegelmann, Hava
first name: Hava
last name: Siegelmann
full name: Hava Siegelmann PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3712
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Zoeller, R.
first name: R.
last name: Zoeller
full name: R. Thomas Zoeller Ph.D.
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3739
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Meyer, Jerrold
first name: Jerrold
last name: Meyer
full name: Jerrold S Meyer BS, MS, PhD
has faculty rank: Research Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3743
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

McClements, David
first name: David
last name: McClements
full name: David J McClements B.S., Ph.D.
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3760
person in primary position: Fergus Clydesdale Endowed Chair
type: Agent
type: Person
preferred title: Fergus Clydesdale Endowed Chair

Park, Yeonhwa
first name: Yeonhwa
last name: Park
full name: Yeonhwa Park BS, MS, PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3772
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Downes, Gerald
first name: Gerald
last name: Downes
full name: Gerald Downes B.S., Ph.D.
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3776
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Mager, Jesse
first name: Jesse
last name: Mager
full name: Jesse Mager PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3787
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Pederson, Thoru
first name: Thoru
last name: Pederson
full name: Thoru Pederson PhD
has faculty rank: Professor Emeritus
latitude: 42.28050130000000
longitude: -71.76534550000000
Person ID: 379
person in primary position: Professor Emeritus
type: Agent
type: Person
Endowed Chair Honorary Title: Vitold Arnett Professor of Cell Biology
Rotation Projects: Background for Student Rotation Projects <p >See Politz, Hogan and Pederson (2009) and Politz et al. (2005) in the above list. The novel microRNA work may be the most suitable for student rotations. Potential Rotation Projects <p >Are the nucleolar microRNAs pri-, pre- or mature? <p >Are they complexed with other nucleolar RNAs? <p >Do the cell cycle related proteins in the nucleolus exist as heterotypic complexes? <p >Does the nucleolus of human embryonic stem cells also share these features (which we have so far looked for, and found, only in transformed human cell lines)? <p >Can vanadium tagging be used to detect specific proteins by electron microscopy, perhaps exceeding the limitations of immuno-EM?
preferred title: Professor Emeritus

Xiao, Hang
first name: Hang
last name: Xiao
full name: Hang Xiao PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3795
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Sluder, Greenfield
first name: Greenfield
last name: Sluder
full name: Greenfield Sluder PhD
has faculty rank: Professor Emeritus
latitude: 42.28050130000000
longitude: -71.76534550000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 385
person in primary position: Professor Emeritus
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Sluder for additional details.
Rotation Projects: Potential Rotation Projects We favor having students work independently on defined projects that have promise of completion during the study period. Project #1: Use a frog egg extract that supports multiple rounds of centrosome duplication in vitro to investigate the role of various high interest kinases in the control of centrosome duplication. Also, we can use these extracts to further investigate how various other proteins interact with the centrosome to influence its duplication. Hinchcliffe, E.H., C. Li, E.A. Thompson, J.L. Maller and G. Sluder. 1999. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extract. Science 283:851-854. Project #2: Use microsurgery and immunofluorescence on BSC-1 cells to further investigate how centrioles influence the interphase progression of the cell cycle. Hinchcliffe, E.H., F.J. Miller, M. Cham, A. Khodjakov and G. Sluder. 2001. Requirement of a centrosomal activity for cell cycle progression through G1 into S phase. Science 291: 1547-1550.
preferred title: Professor Emeritus
webpage: https://profiles.umassmed.edu/profile/28866635

Rogaev, Evgeny
first name: Evgeny
last name: Rogaev
full name: Evgeny I Rogaev PhD
has faculty rank: Professor
latitude: 42.27380970000000
longitude: -71.76834340000000
Person ID: 39
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.
preferred title: Professor

Conte, Darryl
first name: Darryl
last name: Conte
full name: Darryl Conte PhD
has faculty rank: Associate Professor
latitude: 42.27932700000000
longitude: -71.76549170000000
Person ID: 4
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Aronin, Neil
first name: Neil
last name: Aronin
full name: Neil Aronin MD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 490
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Higgins Family Professor in Neuroscience
Rotation Projects: Potential Rotation Projects Project #1: Molecular Mechanisms in the Pathogenesis of Neurodegenerative Disease. The student can select projects emphasizing either molecular mechanisms of huntingtin in trafficking in neurons or receptor stimulated effects on gene expression in neurons. Techniques include: Generation of fusion proteins, raising antisera Preparation of organelles Immunocytochemistry, light microscopy and electron microscopy Immunoprecipitation methods PCR Protein separation techniques, gel electrophoresis, immunoblotting Autoradiography
preferred title: Professor

Imbalzano, Anthony
first name: Anthony
last name: Imbalzano
full name: Anthony N Imbalzano PhD
has faculty rank: Professor
latitude: 42.27767280000000
longitude: -71.76163720000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 507
person in primary position: Professor
type: Agent
type: Person
Post Docs: Please contact Dr. Imbalzano to discuss the possibility of a postdoctoral training.See lab research interests and publications for recent topics of research. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
Rotation Projects: Please contact Dr. Imbalzano to discuss the possibility of a rotation project. Rotation projects are generally based on current work and tailored to the interests of the student. See lab research interests and publications for recent topics. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
preferred title: Professor

Richter, Joel
first name: Joel
last name: Richter
Featured Videos: https://profiles.umassmed.edu/profile/28867186
full name: Joel Richter PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 554
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Arthur F. Koskinas Chair in Neuroscience
Rotation Projects: Many rotation projects are available so please inquire.
preferred title: Professor

Budnik, Vivian
first name: Vivian
last name: Budnik
full name: Vivian Budnik PhD
has faculty rank: Professor And Chair Emeritus
latitude: 42.27737440000000
longitude: -71.76346650000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 610
person in primary position: Professor and Chair Emeritus
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Budnik for additional details.
preferred title: Professor and Chair Emeritus

Reppert, Steven
first name: Steven
last name: Reppert
full name: Steven Reppert MD
has faculty rank: DISTINGUISHED PROFESSOR EMERITUS
latitude: 42.27737440000000
longitude: -71.76346650000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 622
person in primary position: Distinguished Professor Emeritus
type: Agent
type: Person
preferred title: Distinguished Professor Emeritus

Tissenbaum, Heidi
first name: Heidi
last name: Tissenbaum
full name: Heidi A Tissenbaum PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 658
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Graduate students are encouraged to contact Heidi Tissenbaum to discuss projects available for rotations. Each student has a project tailored for both their abilities and class time commitments.
preferred title: Professor

Walhout, Marian
first name: Marian
last name: Walhout
full name: Marian Walhout PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 758
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Maroun Semaan Chair in Biomedical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Please contact Dr. Walhout for additional details.
preferred title: Chair and Professor

Shirayama, Masaki
first name: Masaki
last name: Shirayama
full name: Masaki Shirayama PhD
has faculty rank: Assistant Professor
latitude: 42.27932700000000
longitude: -71.76549170000000
Person ID: 765
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Alkema, Mark
first name: Mark
last name: Alkema
Featured Videos: https://profiles.umassmed.edu/profile/28867180
full name: Mark Alkema PhD
has faculty rank: Professor
latitude: 42.27737440000000
longitude: -71.76346650000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 915
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Mark Alkema for additional details. Contact Information: Mark Alkema, Ph.D. University of Massachusetts Medical School Department of Neurobiology, LRB 717 364 Plantation Street Worcester, MA 01605 USA phone: 508-856-6158 (office) phone: 508-856-8541 (lab) e-mail: mark.alkema@umassmed.edu
Rotation Projects: Rotation Projects 1) Molecular and neuronal characterization of C. elegans escape behavior Defining sensorimotor circuits requires detailed knowledge of the neural connectivity of the nervous system, and the ability to manipulate the functions of the component neurons and to define and quantify the behavioral outputs. The simplicity and completely defined synaptic connectivity of C. elegans nervous system provides unique opportunity to dissect how neural networks control behavior. 2) Identify genes involved in the processing, expression and subunit composition of voltage-gated calcium channels The release of neurotransmitter from synaptic vesicles is critical for the propagation of signals that generate behavioral outputs. Voltage-gated calcium channels provide the calcium influx essential for synaptic vesicle exocytosis. We are characterizing mutants to identify new genes involved in the proper assembly, expression and trafficking of functional calcium channels. 3) Investigate the evolutionary origins of escape behavior Nematophagous fungi employ a variety of strategies to capture worms. In predator-prey experiments, we have been able to show that the suppression of head movements allows the animal to escape from constricting traps. Further investigation of the neurobiology behind the escape from predation may provide insight into how this behavior evolves. Contact Information: Mark Alkema, Ph.D. University of Massachusetts Medical School Department of Neurobiology, LRB 717 364 Plantation Street Worcester, MA 01605 USA phone: 508-856-6158 (office) phone: 508-856-8541 (lab) e-mail: mark.alkema@umassmed.edu
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866428

Ryder, Sean
first name: Sean
last name: Ryder
Twitter: https://profiles.umassmed.edu/profile/28867044
full name: Sean P Ryder PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 942
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Potential Rotation Projects A variety of rotation projects are available to study RNP assembly and post-transcriptional regulation during development using quantitative biochemical and modern molecular methods. Project 1: Characterization of the RNA-protein complexes that guide C. elegans early development. Several projects ranging in scope from biochemical characterization of RNA-binding protein complexes to genetic dissection of RNA binding protein function in development are currently available. Contact Sean for more details. Project 2: Post-transcriptional regulation of oligodendrocyte differentiation. Projects are available to monitor changes in gene expression as a function of differentiation with a focus on changes in alternative splicing and mRNA stability. Contact Sean for more details.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866432

Almeida, Sandra Cristina
first name: Sandra Cristina
last name: Almeida
full name: Sandra Cristina Vicente Almeida PhD
has faculty rank: Assistant Professor
latitude: 42.27658300000000
longitude: -71.76559620000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 4198
person in primary position: Assistant Professor
type: Agent
type: Person
Summary: Dr. Almeida focuses on uncovering the molecular mechanisms underlying frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD). Her research leverages patient-derived induced pluripotent stem cell (iPSC) lines to create neuronal models that closely mimic disease conditions.
preferred title: Assistant Professor

UMass Chan – Baystate Regional Campus
type: Organization

Irazoqui, Javier
first name: Javier
last name: Irazoqui
Featured Videos: https://profiles.umassmed.edu/profile/28867206
full name: Javier Elbio Irazoqui PhD
has faculty rank: Professor
latitude: 42.27834540000000
longitude: -71.76387620000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 4412
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Marcellette G. Williams Scholar
Lab URL: https://www.umassmed.edu/lci/
Post Docs: Swarupa Mallick, PhD
Rotation Projects: Pathogen genetics of the host immune response
Rotation Projects: How the cholinergic nervous system communicates peroxisomal stress to the whole organism during bacteria infection
Rotation Projects: Role and regulation of novel innate immune effectors that are conserved across animalia
Summary: Focus: Microbiota-gut-brain axis in C. elegans; mucosal innate immunity; staphylococcus aureus; transcriptional regulation of host defense; autophagy; lysosomes; peroxisomes
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/37757225

Haynes, Cole
first name: Cole
last name: Haynes
full name: Cole Michael Haynes PhD
has faculty rank: Professor
latitude: 42.27491030000000
longitude: -71.76424060000000
Person ID: 4422
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866621
webpage: https://profiles.umassmed.edu/profile/28866481

DISTINGUISHED PROFESSOR EMERITUS
sort order: 42
type: Faculty Rank

Professor
is primary position: true
position in department: Psychology Department and Center for Neuroendocrin
position in division: Psychology Department And Center for Neuroendocrin
sort order: 1
type: Position
HR job title: Professor
position in organization: University of Massachusetts Amherst

Professor
is primary position: true
position in department: College of Natural Sciences
position in division: Computer Science
sort order: 1
type: Position
HR job title: Professor
position in organization: University of Massachusetts Amherst

Associate Professor
is primary position: true
position in department: College of Natural Sciences
position in division: Food Science
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: University of Massachusetts Amherst

Professor
is primary position: true
position in department: College of Natural Sciences
position in division: Biology
sort order: 1
type: Position
HR job title: Professor
position in organization: University of Massachusetts Amherst

Professor
is primary position: true
position in department: College of Natural Sciences
position in division: Department of Psychology; Neuroscience And Behavio
sort order: 1
type: Position
HR job title: Professor
position in organization: University of Massachusetts Amherst

Fergus Clydesdale Endowed Chair
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https://profiles.umassmed.edu/profile/34784926
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Winder, Danny
first name: Danny
last name: Winder
full name: Danny G Winder PhD
has faculty rank: Chair And Professor
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Person ID: 10247531
person in primary position: Chair and Professor
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type: Person
Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair I
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/108986324

https://profiles.umassmed.edu/profile/37757225
type: URLLink
label: https://www.umassmed.edu/lci
link anchor text: Laboratory of Comparative Immunology

Genomics and Computational Biology
type: Department
type: Organization

Wani, Khursheed
first name: Khursheed
last name: Wani
full name: Khursheed A. Wani PhD
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Person ID: 10247693
person in primary position: Instructor
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Lab URL: https://www.umassmed.edu/pukkila-worleylab/
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Radiology at UMass Chan - Lahey
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Endocrinology & Diabetes
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Infectious Diseases
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Innate Immunity
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Orthopedics Research
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Professor
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Adjunct Professor
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HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Instructor
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position in division: Infectious Diseases
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HR job title: Instructor
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Adjunct Professor
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position in division: Infectious Diseases
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HR job title: Adjunct Professor
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Associate Professor
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Neuromuscular
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Stroke and Vascular Neurology
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Chair and Professor
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position in department: Neurobiology
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sort order: 1
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HR job title: Chair and Professor
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Professor
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Keil, Boris
first name: Boris
last name: Keil
full name: Boris Keil PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27525000000000
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Person ID: 10247826
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Adjunct Professor
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position in department: Radiology
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HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
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position in division: Infectious Diseases
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HR job title: Professor
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Assistant Professor
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sort order: 1
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HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Biochemistry and Molecular Biotechnology
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sort order: 1
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HR job title: Professor
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Professor
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position in department: Biochemistry and Molecular Biotechnology
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sort order: 1
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HR job title: Professor
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Chair and Professor
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sort order: 1
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HR job title: Chair and Professor
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https://profiles.umassmed.edu/profile/44403713
type: URLLink
label: https://www.umassmed.edu/lanai/
link anchor text: LANAI website

Microbiology
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Professor
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position in department: Program in Molecular Medicine
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Krings, Timo
first name: Timo
last name: Krings
full name: Timo Krings MD, PhD, FRCP
has faculty rank: Professor
latitude: 42.48526100000000
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Person ID: 10247952
person in primary position: Professor
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Professor
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position in department: Microbiology
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sort order: 1
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HR job title: Professor
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Assistant Professor
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position in department: Neurology
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sort order: 1
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HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Genomics and Computational Biology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
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HR job title: Associate Professor
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Professor
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position in department: Biochemistry and Molecular Biotechnology
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sort order: 1
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Assistant Professor
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position in department: Neurobiology
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sort order: 1
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HR job title: Assistant Professor
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Professor
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position in department: Radiology
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Instructor
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Professor
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Professor Emeritus
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Research Professor
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Professor And Chair Emeritus
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Assistant Professor
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Associate Professor
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Chair And Professor
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Distinguished Professor
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Psychiatry and Behavioral Sciences
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Professor
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Professor
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Neurology
position in division: Stroke and Vascular Neurology
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Neurology
position in division: Neuromuscular
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HR job title: Professor
position in organization: UMass Chan Medical School

Chair and Professor
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position in department: Systems Biology
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sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Medicine
position in division: Endocrinology & Diabetes
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HR job title: Professor
position in organization: UMass Chan Medical School

Distinguished Professor
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position in department: RNA Therapeutics Institute
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sort order: 1
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HR job title: Distinguished Professor
position in organization: UMass Chan Medical School

Professor
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position in department: RNA Therapeutics Institute
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Molecular, Cell and Cancer Biology
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sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: RNA Therapeutics Institute
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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sort order: 1
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HR job title: Professor
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Professor Emeritus
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HR job title: Professor Emeritus
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Professor
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position in department: Program in Molecular Medicine
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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sort order: 1
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HR job title: Professor
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Professor and Chair Emeritus
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position in department: Neurobiology
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HR job title: Professor and Chair Emeritus
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