Perilipin-1
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research area of: Tran, Khanh-Van
research area of: Czech, Michael
research area of: Padilla-Benavides, Teresita
research area of: Imbalzano, Anthony
research area of: Corvera, Silvia
subject area for: Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473.
subject area for: Lipogenic Enzymes Complexes and Cytoplasmic Lipid Droplet Formation During Adipogenesis.
subject area for: The PPAR? locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner.
subject area for: Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean origin.
subject area for: Cidea is associated with lipid droplets and insulin sensitivity in humans.

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The PPAR? locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner.
PubMed Identifier: 24465921
author list: LeBlanc SE, Wu Q, Barutcu AR, Xiao H, Ohkawa Y, Imbalzano AN
published in: PloS one
information resource reference: LeBlanc SE, Wu Q, Barutcu AR, Xiao H, Ohkawa Y, Imbalzano AN. The PPAR? locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner. PLoS One. 2014; 9(1):e86140.
journal title abbreviation: PLoS One
publication date: 2014-01-20T00:00:00
year: 2014
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Medicine
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Program in Molecular Medicine
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Cardiovascular Medicine
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UMass Chan Medical School
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Corvera, Silvia
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Endowed Chair Honorary Title: Endowed Chair in Diabetes Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Corvera for additional details.
Rotation Projects: Rotation Projects Our rotation projects are in the area of diabetes and obesity, and we are interested in basic mechanisms of cell proliferation, differentiation and communication. Diabetes is highly correlated with obesity, but why obesity causes disease in some humans and not others is not understood. Amazingly, we still don’t understand how adipose tissue grows in human adults. A better understanding of this fascinating process can give us insight into basic mechanisms of cell growth, differentiation and communication, as well as mechanisms of disease, not only diabetes but also cancer and developmental defects. During your rotation, you will work on an important piece of a larger project, that has a well-defined outcome. Thus, your successful completion of the rotation project will allow you to be included at the time of publication of the work. Project 1: Adipose tissue is not only formed by adipocytes, but by other cells such as endothelial, mural and immune cells. Also, there are multiple kinds of adipocytes with different functions. We have recently developed conditions to develop adipose tissue from humans in-vitro (adipose tissue “organoids”). From this tissue we have been able to separated single cells, and find that they grow into different kinds of clones. We are now conducting RNAseq on >300 of those clones, to determine how many cell types exist in human adipose tissue, and what their roles are. In this rotation, you will be able to analyze RNAseq data to define what genes characterize these cells, and you will use virus transduction to create immortalized cells for further study. Project 2: Adipose tissue has many functions besides storing and releasing lipids. It also has to coordinate metabolism in the whole body. We have found that human “beige” adipose tissue, which is found in people who are metabolically healthy, expresses genes for secreted factors that communicate with the immune system and the brain. These include IL-33 and enkephalins. In t…
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Czech, Michael
first name: Michael
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full name: Michael Paul Czech PhD
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Endowed Chair Honorary Title: Isadore and Fannie Foxman Chair in Medical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Czech for additional details.
Rotation Projects: Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research …
preferred title: Professor Emeritus

Imbalzano, Anthony
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full name: Anthony N Imbalzano PhD
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Post Docs: Please contact Dr. Imbalzano to discuss the possibility of a postdoctoral training.See lab research interests and publications for recent topics of research. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
Rotation Projects: Please contact Dr. Imbalzano to discuss the possibility of a rotation project. Rotation projects are generally based on current work and tailored to the interests of the student. See lab research interests and publications for recent topics. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
preferred title: Professor

Padilla-Benavides, Teresita
first name: Teresita
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has faculty rank: ADJUNCT ASSISTANT PROFESSOR
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Post Docs: Claudia A. Vilchis Nestor. Visiting Scholar from CINVESTAV-IPN, MEXICO <img alt="" height="121" src="[binary]" width="93" />
preferred title: Adjunct Assistant Professor

Lipogenic Enzymes Complexes and Cytoplasmic Lipid Droplet Formation During Adipogenesis.
PubMed Identifier: 26928794
author list: Padilla-Benavides T, Velez-delValle C, Marsch-Moreno M, Castro-Mu?ozledo F, Kuri-Harcuch W
published in: Journal of cellular biochemistry
information resource reference: Padilla-Benavides T, Velez-delValle C, Marsch-Moreno M, Castro-Mu?ozledo F, Kuri-Harcuch W. Lipogenic Enzymes Complexes and Cytoplasmic Lipid Droplet Formation During Adipogenesis. J Cell Biochem. 2016 10; 117(10):2315-26.
journal title abbreviation: J Cell Biochem
publication date: 2016-03-14T00:00:00
year: 2016
type: Academic Article
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ADJUNCT ASSISTANT PROFESSOR
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Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473.
PubMed Identifier: 32440655
author list: Tran KV, Brown EL, DeSouza T, Jespersen NZ, Nandrup-Bus C, Yang Q, Yang Z, Desai A, Min SY, Rojas-Rodriguez R, Lundh M, Feizi A, Willenbrock H, Larsen TJ, Severinsen MCK, Malka K, Mozzicato AM, Deshmukh AS, Emanuelli B, Pedersen BK, Fitzgibbons T, Scheele C, Corvera S, Nielsen S
published in: Nature metabolism
information resource reference: Tran KV, Brown EL, DeSouza T, Jespersen NZ, Nandrup-Bus C, Yang Q, Yang Z, Desai A, Min SY, Rojas-Rodriguez R, Lundh M, Feizi A, Willenbrock H, Larsen TJ, Severinsen MCK, Malka K, Mozzicato AM, Deshmukh AS, Emanuelli B, Pedersen BK, Fitzgibbons T, Scheele C, Corvera S, Nielsen S. Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473. Nat Metab. 2020 05; 2(5):397-412.
journal title abbreviation: Nat Metab
publication date: 2020-05-21T00:00:00
year: 2020
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Tran, Khanh-Van
first name: Khanh-Van
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Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean origin.
PubMed Identifier: 18806092
author list: Smith CE, Tucker KL, Yiannakouris N, Garcia-Bailo B, Mattei J, Lai CQ, Parnell LD, Ordov?s JM
published in: The Journal of nutrition
information resource reference: Smith CE, Tucker KL, Yiannakouris N, Garcia-Bailo B, Mattei J, Lai CQ, Parnell LD, Ordov?s JM. Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean origin. J Nutr. 2008 Oct; 138(10):1852-8.
journal title abbreviation: J Nutr
publication date: 2008-10-01T00:00:00
year: 2008
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Cidea is associated with lipid droplets and insulin sensitivity in humans.
PubMed Identifier: 18509062
author list: Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7833-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2008-05-28T00:00:00
year: 2008
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