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Lab URL: https://www.umassmed.edu/maps/research-labs/behar/
Rotation Projects: LAB ROTATION PROJECTS AVAILABLE -- PLEASE CONTACT SAM BEHAR FOR MORE INFORMATION
Summary: Focus: We seek to understand how the causative agent of tuberculosis, namely the bacterium Mycobacterium tuberculosis evades host immunity, and how different components of the immune response work together to contain infection. Our ultimate goal is to inform vaccine development and the design of host directed therapy.
preferred title: Professor

Royer, William
first name: William
last name: Royer
full name: William E Royer PhD
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Rotation Projects: <Long Text /> Potential Rotation Projects Project #1: Probing the structural basis for cooperativity in a dimeric hemoglobin: Scapharca dimeric hemoglobin is an elegantly simple model system for exploring the structural basis for intersubunit communication. Our analysis to date has established a new paradigm for cooperativity in which tightly bound water molecules are used as sensors for ligand state. In this project, the student will first mutate the gene for the native hemoglobin at a residue that is suspected of playing a role in the intersubunit communication. The mutated protein will then be expressed in E. coli and purified and subjected to functional analysis of oxygen binding. Using conditions already established for the native protein, the mutant hemoglobin will then be crystallized and subjected to preliminary x-ray analysis. This project will provide the student with an introduction to two of the most powerful techniques for investigating the structure and function of proteins: site-directed mutagenesis and x-ray crystallography. Additionally, valuable experience in protein purification will be obtained. Project #2: Structural analysis of the polymerization of sickle-cell hemoglobin Sickle cell disease results from the pathological polymerization of deoxygenated hemoglobin S (ß6E->V) within erythrocytes. This polymerization depends upon a complicated interplay of multiple interactions between tetramers. Our high resolution crystal structure of this molecule has elucidated details of some of the important interactions. Several projects are available for rotation students. These include crystallization of sickle-cell hemoglobin in the presence of an inhibitor to identify its binding site, site-directed mutagenesis of hemoglobin S and crystallization of mutants that show altered polymerization characteristics.
preferred title: Professor Emeritus

Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Hayman, Laura
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Lian, Jane
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Arcaro, Kathleen
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Kaltashov, Igor
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Rotello, Vincent
first name: Vincent
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Pederson, Thoru
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Endowed Chair Honorary Title: Vitold Arnett Professor of Cell Biology
Rotation Projects: Background for Student Rotation Projects <p >See Politz, Hogan and Pederson (2009) and Politz et al. (2005) in the above list. The novel microRNA work may be the most suitable for student rotations. Potential Rotation Projects <p >Are the nucleolar microRNAs pri-, pre- or mature? <p >Are they complexed with other nucleolar RNAs? <p >Do the cell cycle related proteins in the nucleolus exist as heterotypic complexes? <p >Does the nucleolus of human embryonic stem cells also share these features (which we have so far looked for, and found, only in transformed human cell lines)? <p >Can vanadium tagging be used to detect specific proteins by electron microscopy, perhaps exceeding the limitations of immuno-EM?
preferred title: Professor Emeritus

Xiao, Hang
first name: Hang
last name: Xiao
full name: Hang Xiao PhD
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person in primary position: Associate Professor
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preferred title: Associate Professor

Wolf, Greg
first name: Greg
last name: Wolf
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Imbalzano, Anthony
first name: Anthony
last name: Imbalzano
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Post Docs: Please contact Dr. Imbalzano to discuss the possibility of a postdoctoral training.See lab research interests and publications for recent topics of research. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
Rotation Projects: Please contact Dr. Imbalzano to discuss the possibility of a rotation project. Rotation projects are generally based on current work and tailored to the interests of the student. See lab research interests and publications for recent topics. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
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Schiffer, Celia
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Endowed Chair Honorary Title: Arthur F. and Helen P. Koskinas Professor in Biochemistry and Molecular Biotechnology
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Lemon, Stephenie
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last name: Lemon
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Endowed Chair Honorary Title: Barbara Helen Smith Chair in Preventive & Behavioral Medicine
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Kornfeld, Hardy
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Cerny, Jan
first name: Jan
last name: Cerny
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Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
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Sassetti, Christopher
first name: Christopher
last name: Sassetti
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Person ID: 878
person in primary position: Professor
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Endowed Chair Honorary Title: Elisabeth Chair II
Lab URL: https://www.umassmed.edu/sassettilab/
Rotation Projects: Rotation Projects <p >We have identified a number of bacterial pathways that are required for bacterial viability or virulence. We are particularly interested in: Phosphosignaling systems that regulate cell wall synthesis Metabolic regulatory mechanisms that trigger the “dormancy” response observed during infection. <p >A variety of genetic, biochemical, and informatic methods will be used to define the functions of these genes and the role played by each during infection. <p >
Summary: Focus: Pathogenesis of tuberculosis
preferred title: Professor

Shaw, Leslie
first name: Leslie
last name: Shaw
full name: Leslie M Shaw PhD
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latitude: 42.27985300000000
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Person ID: 900
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Mercurio, Arthur
first name: Arthur
last name: Mercurio
full name: Arthur M Mercurio PhD
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Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
preferred title: Professor

McManus, David
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
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Szkwarko, Daria
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Pediatric Genetics
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Friedmann, Peter
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UMass Chan – Baystate Regional Campus
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Seddon, Johanna
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Usmani, Saad
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Ophthalmology and Visual Sciences
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Population and Quantitative Health Sciences
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Biochemistry and Molecular Biotechnology
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Lin, Honghuang
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Barbhuiya, Mustafa
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Summary: Dr. Mustafa Barbhuiya is currently the Medical Director of Clinical Chemistry and Point of Care Testing at the Department of Pathology, Baystate Medical Center, Springfield, MA. His basic and translational research interests include liver and biliary tract cancer biomarkers. He also conducts research on the role of essential diagnostics list in health care delivery and population health.
preferred title: Assistant Professor
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Weiss, Glen
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Medicine at UMass Chan - Lahey
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Wilcox, Susan
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Summary: Dr. Wilcox trained in EM at the Harvard Affiliated EM Residency, then completed an Anesthesia Critical Care fellowship. In addition to the ED, she has attended in Surgical, Medical, and Cardiac ICUs. She joined Lahey Hospital in 2022 as the Medical Director of the 5C Medical ICU. She is Vice Chair for Academic Affairs and a Professor of Medicine. She is the Associate CMO for Boston MedFlight.
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Genetic and Cellular Medicine
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https://profiles.umassmed.edu/profile/66923911
publication date: 2016
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https://profiles.umassmed.edu/profile/66924043
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Adjunct Professor
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Shin, Dong-Soo
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Adjunct Professor
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Professor
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position in organization: UMass Chan Medical School

Professor Emeritus
is primary position: true
position in department: Biochemistry and Molecular Biotechnology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Adjunct Professor
is primary position: true
position in department: Pediatrics
position in division: Pediatric Genetics
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Pediatrics
position in division: General Pediatrics
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School