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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
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Mazor, Kathleen
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full name: Kathleen Mazor EdD
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Zierath, Juleen
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Lapane, Kate
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Heneka, Michael
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Verma, Ashish
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Szabo, Gyongyi
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Person ID: 36
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Haran, John
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full name: John P Haran MD, PhD
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Person ID: 37
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Rotation Projects: Rotation projects are available related to microbiota-gut brain axis and antibiotic usage and the sequelae of antibiotic use in hospitalized patients which include Clostridium difficile and multi-drug resistant organism infection and colonization.
preferred title: Professor

Pederson, Thoru
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Person ID: 379
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Endowed Chair Honorary Title: Vitold Arnett Professor of Cell Biology
Rotation Projects: Background for Student Rotation Projects <p >See Politz, Hogan and Pederson (2009) and Politz et al. (2005) in the above list. The novel microRNA work may be the most suitable for student rotations. Potential Rotation Projects <p >Are the nucleolar microRNAs pri-, pre- or mature? <p >Are they complexed with other nucleolar RNAs? <p >Do the cell cycle related proteins in the nucleolus exist as heterotypic complexes? <p >Does the nucleolus of human embryonic stem cells also share these features (which we have so far looked for, and found, only in transformed human cell lines)? <p >Can vanadium tagging be used to detect specific proteins by electron microscopy, perhaps exceeding the limitations of immuno-EM?
preferred title: Professor Emeritus

Xiao, Hang
first name: Hang
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Crawford, Sybil
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Schiffer, Celia
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full name: Celia A Schiffer PhD
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Endowed Chair Honorary Title: Arthur F. and Helen P. Koskinas Professor in Biochemistry and Molecular Biotechnology
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Lemon, Stephenie
first name: Stephenie
last name: Lemon
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Person ID: 689
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Endowed Chair Honorary Title: Barbara Helen Smith Chair in Preventive & Behavioral Medicine
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webpage: https://profiles.umassmed.edu/profile/28866492

Wang, Jennifer
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Cerny, Jan
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Person ID: 777
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Goldberg, Robert
first name: Robert
last name: Goldberg
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Person ID: 78
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Bolon, Daniel
first name: Daniel
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Person ID: 948
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Rotation Projects: Potential Rotation Projects <p >Our laboratory combines genetic and biochemical approaches to investigate the molecular underpinnings of adaptation. Potential rotation projects are available in two general (and partially overlapping) areas: exploring fitness landscapes through systematic approaches and investigating the molecular mechanism of the Hsp90 chaperone in signal transduction. Please contact the lab to discuss specific rotation projects in more detail.
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McManus, David
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
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Research
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Friedmann, Peter
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Politi, Letterio
first name: Letterio
last name: Politi
full name: Letterio Salvatore Politi MD
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Person ID: 4360
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UMass Chan – Baystate Regional Campus
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Koupenova, Milka
first name: Milka
last name: Koupenova
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Person ID: 4386
person in primary position: Assistant Professor
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Lab URL: https://www.umassmed.edu/koupenovalab
Summary: Research in Dr. Koupenova's lab focuses on the contribution of platelets to the immune response during viral infection and the consequent implications of that response to cardiovascular disease. For additional information about projects or joining the lab, contact Dr. Koupenova @ milka.koupenova@umassmed.edu
preferred title: Assistant Professor

Steingrub, Jay
first name: Jay
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Catanzano, Tara
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Engelman, Daniel
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Lagu, Tara
first name: Tara
last name: Lagu
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Lindenauer, Peter
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT ASSOCIATE PROFESSOR
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ADJUNCT PROFESSOR
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Gurwitz, Jerry
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Endowed Chair Honorary Title: Dr. John Meyers Professor in Primary Care Medicine
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Gerber, Jonathan
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Usmani, Saad
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Robertson, David
first name: David
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Population and Quantitative Health Sciences
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Munro, James
first name: James
last name: Munro
full name: James B Munro PhD
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Person ID: 5541
person in primary position: Professor
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Summary: Focus: The Munro laboratory develops and applies quantitative biophysical approaches to visualize virus replication, and probe the functions of the proteins and RNAs involved.
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webpage: https://profiles.umassmed.edu/profile/28866515

Shipley, Rebecca
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Garg, Arvin
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Soni, Apurv
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Biochemistry and Molecular Biotechnology
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ProfilesRNS Plugin Searchable Data: Tweets by @DrSherryPagoto
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Pediatrics at UMass Chan - Baystate
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Surgery at UMass Chan - Baystate
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Adjunct Professor
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position in organization: UMass Chan Medical School

Pfefferle, Susan
first name: Susan
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Wilcox, Susan
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https://profiles.umassmed.edu/profile/66923911
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https://profiles.umassmed.edu/profile/66923959
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https://profiles.umassmed.edu/profile/66924043
publication date: 2018
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Vyas, Jatin
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