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Xue, Wen
first name: Wen
last name: Xue
full name: Wen Xue PhD
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Post Docs: We are looking for postdoc candidates with experience in cancer biology, mouse models and genome-engineering. Please email CV and 3 letters of recommendation to Wen.Xue@umassmed.edu.
Rotation Projects: Our lab uses CRISPR tools to speed up cancer gene discovery and disease gene repair. Rotation projects are available to explore experimental techniques such as molecular cloning of CRISPR plasmids, measuring genome-editing efficiency, dissecting mice, and processing of mouse tumor/tissue for histology.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866638

Sontheimer, Erik
first name: Erik
last name: Sontheimer
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Thompson, Paul
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full name: Paul R Thompson PhD
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Endowed Chair Honorary Title: Endowed Chair in Biochemistry and Molecular Biotechnology I
preferred title: Professor

Karlsson, Elinor
first name: Elinor
last name: Karlsson
full name: Elinor Kathryn Karlsson PhD
has faculty rank: Associate Professor
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Lab URL: http://karlssonlab.org
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Mello, Craig
first name: Craig
last name: Mello
full name: Craig Mello PhD
has faculty rank: Distinguished Professor
latitude: 42.27587600000000
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Person ID: 1009
person in primary position: Distinguished Professor
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Endowed Chair Honorary Title: Blais University Chair in Molecular Medicine
Rotation Projects: Potential Rotation Projects: There are numerous potential rotation project available in the Mello lab: Projects include: Investigation of RNAi and related mechanisms, including Piwi Argonaute pathways and their affects on fertility and epigenetic inheritance; Investigation of germline determination and cell-fate specification during embryogenesis; the exploration of CRISPR mediated genome editing tools for C. elegans and other organisms; and finally the use of CRISPR to generate C. elegans models for human genetic disease.
preferred title: Distinguished Professor
webpage: https://profiles.umassmed.edu/profile/28866500

Rando, Oliver
first name: Oliver
last name: Rando
full name: Oliver J Rando MD, PhD
has faculty rank: Professor
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Person ID: 1067
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Endowed Chair Honorary Title: Endowed Chair in Biochemistry and Molecular Biotechnology II
Post Docs: For more information about the Postdoctoral position in Dr. Rando’s lab please use the link provided. Post doc position
Rotation Projects: Rotation projects are available to study chromatin structure and function. Project 1. Measure histone dynamics in yeast. Histone dynamics play major roles in chromatin metabolism and in the inheritance of chromatin states. To measure histone replacement rates in yeast, we have created yeast strains carrying inducible epitope-tagged histones H3 and H2A. Using microarrays, we will measure histone replacement rates in a variety of mutant yeast to ascertain the role of various chromatin remodeling factors in histone exchange reactions. Project 2. Characterize mechanisms for epigenetic inheritance in yeast. We have identified a variety of genes whose expression state in yeast is epigenetically heritable. We will screen the yeast genome for genes that affect the inheritance of these expression patterns. Project 3. Measure histone dynamics in embryonic stem cells. Embryonic stem cells are pluripotent cells that can give rise to every type of cell in the adult animal. The role of chromatin structure in maintaining this pluripotent state is poorly understood, but it appears that stem cell chromatin is exceptionally labile relative to that in differentiated cells. We will create stem cell lines with inducible tagged histones to measure histone replacement rates across the mouse genome.
preferred title: Professor

Moore, Melissa
first name: Melissa
last name: Moore
full name: Melissa J Moore PhD
has faculty rank: Professor
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Person ID: 1083
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Rotation Projects: <p >Our laboratory combines biochemical, biophysical, molecular and cell biological approaches to investigate various aspects of pre-mRNA processing, mRNA metabolism and RNA quality control in eukaryotic cells. Potential rotation projects are available in all areas of the laboratory's interests (see Research section).
preferred title: Professor

Flotte, Terence
first name: Terence
last name: Flotte
full name: Terence R Flotte MD
has faculty rank: Professor
latitude: 42.27721310000000
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Person ID: 1094
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preferred title: Professor

Zhu, Lihua
first name: Lihua
last name: Zhu
full name: Lihua Zhu PhD
has faculty rank: Professor
latitude: 42.27587600000000
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Person ID: 1134
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preferred title: Professor

Kelliher, Michelle
first name: Michelle
last name: Kelliher
full name: Michelle A Kelliher PhD
has faculty rank: Professor
latitude: 42.27985300000000
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Person ID: 115
person in primary position: Professor
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Endowed Chair Honorary Title: Our Danny Cancer Fund Chair in Biomedical Research I
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Kelliher for additional details.
Rotation Projects: Please visit the Kelliher Lab website at: http://labs.umassmed.edu/kelliherlab/ to learn more about our current research areas. 1. Identify genes/pathways that mediate leukemia-initiating cell survival 2. Understand the molecular basis of glucocorticoid resistance in leukemia 3. Examine contribution of RIPK1 kinase in inflammatory and autoimmune disease mouse models. 4. Reveal tissue-specific roles for RIPK1 in cell death and inflammation. Use conditional Ripk1 allele to investigate effects of Ripk1 deletion in liver, pancreas and antigen presenting cells.
preferred title: Professor

Weng, Zhiping
first name: Zhiping
last name: Weng
full name: Zhiping Weng PhD
has faculty rank: Chair And Professor
latitude: 42.27985300000000
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Person ID: 1152
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Li Weibo Chair in Biomedical Research
Post Docs: The project aims to develop computational algorithms and software programs for analyzing high-throughput sequence data such as ChIP-Seq RNA-Seq small RNA sequencing data. PhD required. A strong background in computational biology especially experience with analyzing high-throughput sequencing data is highly desirable. Excellent communication and writing skills and the ability to work with experimental and computational collaborators are essential. To apply please forward CV cover letter and three references to: Zhiping.Weng@umassmed.edu
Rotation Projects: Please contact Dr. Weng for information on rotations that are available in her lab.
preferred title: Chair and Professor

Ambros, Victor
first name: Victor
last name: Ambros
full name: Victor R Ambros PhD
has faculty rank: Professor
latitude: 42.27913100000000
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Person ID: 1164
person in primary position: Professor
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Endowed Chair Honorary Title: Silverman Chair in Natural Sciences
Rotation Projects: Rotations <p >Project 1: Genetic screens for proteins that modify or regulate the activity of microRNAs in C. elegans.
preferred title: Professor

Gao, Guangping
first name: Guangping
last name: Gao
full name: Guangping Gao PhD
has faculty rank: Chair And Professor
latitude: 42.27714780000000
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Person ID: 1177
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Penelope Booth Rockwell Chair in Biomedical Research
Lab URL: https://www.umassmed.edu/gaolab/
Summary: Focus: Adeno-associated virus vector mediated gene transfer for gene therapy, gene therapy of inherited neurodegenerative Canavan Disease
preferred title: Chair and Professor

Mao, Junhao
first name: Junhao
last name: Mao
full name: Junhao Mao PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
Person ID: 1191
person in primary position: Professor
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Post Docs: Postdoctoral positions are available for this lab. Please contact Junhao Mao directly, 508-856-4149 or via email, Junhao.Mao@umassmed.edu
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866544

Landers, John
first name: John
last name: Landers
full name: John Landers PhD
has faculty rank: Professor
latitude: 42.27985300000000
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Person ID: 1222
person in primary position: Professor
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Rotation Projects: <p >Rotation Projects: Characterization of gene which influences survival in sporadic ALS patients. Characterization of 2 newly identified familial ALS genes. Development of a new mouse model for familial ALS. Positional cloning of novel genes which cause familial ALS.
Summary: Genetics of familial and sporadic ALS
preferred title: Professor

Brown, Robert
first name: Robert
last name: Brown
full name: Robert H Brown MD, DPhil
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
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Person ID: 1239
person in primary position: Professor
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Endowed Chair Honorary Title: Donna M. and Robert J. Manning Chair in Neurosciences
Lab URL: https://www.umassmed.edu/brownlab/
Summary: Dr. Brown’s laboratory has focused on the identification of gene defects that elucidate the molecular pathogenesis of selected neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis.
preferred title: Professor

Gao, Fen-Biao
first name: Fen-Biao
last name: Gao
full name: Fen-Biao Gao PhD
has faculty rank: Professor
latitude: 42.27694690000000
longitude: -71.76568470000000
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Person ID: 1368
person in primary position: Professor
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Endowed Chair Honorary Title: Governor Paul Cellucci Chair in Neuroscience Research
Lab URL: https://www.umassmed.edu/fen-biaogaolab
Rotation Projects: Project 1: Dervelop RNA-based therapies for frontotemporal dementia (FTD) and related disroders. Project 2: Study pathogenic mechanisms of FTD and related disorders in mouse models.
Summary: Our lab uses a combination of molecular, cellular, genetic, and behavioral approaches to further dissect the pathogenic mechanisms of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis with a focus on mutant CHMP2B, progranulin and C9ORF72. We will identify common underlying pathways as potential targets for therapeutic interventions.
preferred title: Professor

Fazzio, Thomas
first name: Thomas
last name: Fazzio
full name: Thomas G Fazzio PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 1385
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Please contact Dr. Fazzio for details.
Rotation Projects: Rotation Projects <p >Rotation projects are available on any of the main topics being studied in the lab. Our recent RNAi screen identifying chromatin regulators necessary for ES cell self-renewal has opened up several new potential projects aimed at identification of the important functions of these regulators in ES cells. Alternatively, projects focusing on the mechanisms of action and regulation of Tip60-p400 complex, or examining the functions of chromatin regulators in cancer stem cells are also possible, depending on the student’s interests. Rotation projects will usually involve some combination of mammalian cell culture, cell and molecular biology, biochemistry, and genomic approaches.
preferred title: Professor

Latz, Eicke
first name: Eicke
last name: Latz
full name: Eicke Latz MD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27985300000000
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Person ID: 153
person in primary position: Adjunct Professor
type: Agent
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preferred title: Adjunct Professor

Trivedi, Chinmay
first name: Chinmay
last name: Trivedi
Twitter: https://profiles.umassmed.edu/profile/28867131
full name: Chinmay M Trivedi MD, PhD
has faculty rank: Professor
latitude: 42.27834540000000
longitude: -71.76387620000000
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Person ID: 1655
person in primary position: Professor
type: Agent
type: Person
Lab URL: https://www.umassmed.edu/trivedilab/
Post Docs: A Postdoctoral position is available in the Trivedi lab to study roles of novel chromatin and epigenetic modifications during cardiovascular development and disease (for details of our research: The Journal of Clinical Investigation, Science Advances, Journal of Experimental Medicine, ATVB, Human Molecular Genetics, Journal of Biological Chemistry). Candidates with a PhD in Biochemistry, Molecular Biology, Stem Cell Biology or Developmental Biology are encouraged to apply. Previous experience with mice handling and biochemistry-molecular biology-epigenetics related techniques such as ChIP-seq is strongly desired. Candidate will be required to learn new techniques in the area of translational biology to advance their project.
Rotation Projects: Rotation Projects: Please contact Chinmay Trivedi (chinmay.trivedi@umassmed.edu) for information regarding potential rotation projects (for details - research performed by graduate students in the trivedi lab: The Journal of Clinical Investigation, Science Advances, Journal of Experimental Medicine, JCI Insight, ATVB, Human Molecular Genetics, Journal of Biological Chemistry). We will develop a specific rotation project based on student's interest, background, and goals of the rotation. Students can rotate either for a half- or full-semester.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866584

Fitzgerald, Katherine
first name: Katherine
last name: Fitzgerald
full name: Katherine A Fitzgerald PhD
has faculty rank: Professor
latitude: 42.27985300000000
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Person ID: 202
person in primary position: Professor
type: Agent
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Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair III
Rotation Projects: Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866427
webpage: https://profiles.umassmed.edu/profile/28866493

Shultz, Leonard
first name: Leonard
last name: Shultz
full name: Leonard Donald Shultz PhD
has faculty rank: Professor
latitude: 44.36637960000000
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Person ID: 2863
person in primary position: Professor
type: Agent
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preferred title: Professor

Davis, Roger
first name: Roger
last name: Davis
full name: Roger J Davis PhD, FRS
has faculty rank: Chair And Professor
latitude: 42.27913100000000
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Person ID: 3130
person in primary position: Chair and Professor
type: Agent
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Endowed Chair Honorary Title: H. Arthur Smith Chair in Cancer Research
Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866429

Zierath, Juleen
first name: Juleen
last name: Zierath
full name: Juleen R Zierath PhD
has faculty rank: ADJUNCT PROFESSOR
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Person ID: 3151
person in primary position: Adjunct Professor
type: Agent
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preferred title: Adjunct Professor

Rhind, Nicholas
first name: Nicholas
last name: Rhind
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Person ID: 318
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Potential Rotation Projects 1) Coordination of replication and recombination by the S-phase DNA damage checkpoint The replication checkpoint coordinates replication and recombinational repair to allow for the replication of damaged templates, however the mechanism by which the checkpoint regulates recombination is unknown. We have identified a number of potential checkpoint-kinase targets by phosphoproteomics. One possible rotation project would be to create site-directed mutations that would prevent kinase regulation of one or more of the targets. These mutations could be used to validate the role of the target in the checkpoint and to test the importance of checkpoint regulation in S-phase DNA repair. 2) Regulation of replication timing Heterochromatin regulates the timing of replication origin firing, however the mechanism by which it affects origin function is unknown. We have developed a model of how origin timing is regulated in non-heterochromatic chromatin; now we want to test how heterochromatin affects this mechanism. In particular, we want to manipulate the heterochromatic context at specific loci, measure the changes in origin timing and investigate the molecular mechanisms responsible for the change. One possible rotation project would be to establish heterochromatin at a well-characterized origin, measure origin timing, which we presume will be delayed, and then test at which step origin firing is delayed. <p >
preferred title: Professor

Garber, Manuel
first name: Manuel
last name: Garber
full name: Manuel Garber PhD
has faculty rank: Professor
latitude: 42.27767280000000
longitude: -71.76163720000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 3318
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: If you are interesting in applying computational methods to biological problems please contact me. Potential projects in my lab are Modeling of transcription factor gene expression control in innate immune cells Evolutionary analysis of gene transcription factor networks in mammals Epigenetics inheritance in mice: From male sperm to phenotypic effect in grandchildren Application of genome and exome sequencing to newborn screening Development of computational methods for analysis of RNA-protein interactions
preferred title: Professor

Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
has faculty rank: ADJUNCT PROFESSOR
latitude: 50.70274210000000
longitude: 7.10034010000000
Person ID: 3432
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Golenbock, Douglas
first name: Douglas
last name: Golenbock
full name: Douglas T Golenbock MD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 345
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Neil and Margery Blacklow Chair in Infectious Diseases and Immunology
preferred title: Professor

Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27636250000000
longitude: -71.76564740000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 36
person in primary position: Adjunct Professor
type: Agent
type: Person
Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Jerry, D Joseph
first name: D Joseph
last name: Jerry
full name: D Joseph Jerry BS, MS, PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3696
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Lian, Jane
first name: Jane
last name: Lian
full name: Jane B Lian PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27723620000000
longitude: -71.76070940000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 370
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Rotello, Vincent
first name: Vincent
last name: Rotello
full name: Vincent Rotello PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3741
person in primary position: Department Head
type: Agent
type: Person
preferred title: Department Head

Mager, Jesse
first name: Jesse
last name: Mager
full name: Jesse Mager PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3787
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Pederson, Thoru
first name: Thoru
last name: Pederson
full name: Thoru Pederson PhD
has faculty rank: Professor Emeritus
latitude: 42.28050130000000
longitude: -71.76534550000000
Person ID: 379
person in primary position: Professor Emeritus
type: Agent
type: Person
Endowed Chair Honorary Title: Vitold Arnett Professor of Cell Biology
Rotation Projects: Background for Student Rotation Projects <p >See Politz, Hogan and Pederson (2009) and Politz et al. (2005) in the above list. The novel microRNA work may be the most suitable for student rotations. Potential Rotation Projects <p >Are the nucleolar microRNAs pri-, pre- or mature? <p >Are they complexed with other nucleolar RNAs? <p >Do the cell cycle related proteins in the nucleolus exist as heterotypic complexes? <p >Does the nucleolus of human embryonic stem cells also share these features (which we have so far looked for, and found, only in transformed human cell lines)? <p >Can vanadium tagging be used to detect specific proteins by electron microscopy, perhaps exceeding the limitations of immuno-EM?
preferred title: Professor Emeritus

Xiao, Hang
first name: Hang
last name: Xiao
full name: Hang Xiao PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3795
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Rogaev, Evgeny
first name: Evgeny
last name: Rogaev
full name: Evgeny I Rogaev PhD
has faculty rank: Professor
latitude: 42.27380970000000
longitude: -71.76834340000000
Person ID: 39
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.
preferred title: Professor

Lawrence, Jeanne
first name: Jeanne
last name: Lawrence
Featured Videos: https://profiles.umassmed.edu/profile/28867178
full name: Jeanne B Lawrence PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 399
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Leo P. and Theresa M. LaChance Chair in Medical Research
Lab URL: https://www.umassmed.edu/lawrencelab
Summary: Lawrence lab research bridges fundamental questions of developmental epigenetics with translational research into the common problem of chromosome abnormalities, particularly Down syndrome.
preferred title: Professor

Zamore, Phillip
first name: Phillip
last name: Zamore
full name: Phillip D Zamore PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 418
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
webpage: https://profiles.umassmed.edu/profile/28866537
webpage: https://profiles.umassmed.edu/profile/28866541

Nickerson, Jeffrey
first name: Jeffrey
last name: Nickerson
full name: Jeffrey Alan Nickerson PhD
has faculty rank: Associate Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 454
person in primary position: Associate Professor
type: Agent
type: Person
Post Docs: POSTDOCTORAL POSITION A Postdoctoral Position is available immediately in the Department of Cell and Developmental Biology to study the regulation of RNA processing and export by signal transduction pathways. So far in this project we have found that the assembly of mRNA export complexes in live cells is regulated by the PI3 kinase/AKT signal transduction pathway and that, for a subset of mRNAs, nuclear export is AKT regulated. The experimental approach for this project integrates molecular techniques and microscopy, especially live cell microscopy. The postdoc in this position could also be involved in studies of the role of nuclear architecture in regulating gene expression and in studying the role of chromatin remodeling enzymes in breast cancer. Candidates with a strong background in cell biology, biochemistry, or molecular biology are especially desirable. Quaresma, A.J., Sievert, R. & Nickerson, J.A. Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway. Mol Biol Cell 24, 1208-1221 (2013). The University of Massachusetts Medical School is located in Worcester, at the western edge of the Boston Metropolitan Area. The Department of Cell and Developmental Biology has especially strong research programs in nuclear and chromatin structure, cytoskeletal function, and mitotic architecture. Interested candidates should contact: Jeffrey A. Nickerson, Ph.D. Department of Cell and Developmental Biology S7-214 University of Massachusetts Medical School 55 Lake Avenue North Worcester, MA 01655 (508) 856-2312 jeffrey.nickerson@umassmed.edu
Rotation Projects: Potential Rotation Projects Identify the AKT phosphorylation sites on mRNA export proteins. Determine the effect that point mutation of those sites has on mRNA export complex assembly and on the export of specific mRNAs. Investigate the role of chromatin remodeling in driving the important metabolic changes occurring during breast tumorigenesis.
preferred title: Associate Professor

Imbalzano, Anthony
first name: Anthony
last name: Imbalzano
full name: Anthony N Imbalzano PhD
has faculty rank: Professor
latitude: 42.27767280000000
longitude: -71.76163720000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 507
person in primary position: Professor
type: Agent
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Post Docs: Please contact Dr. Imbalzano to discuss the possibility of a postdoctoral training.See lab research interests and publications for recent topics of research. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
Rotation Projects: Please contact Dr. Imbalzano to discuss the possibility of a rotation project. Rotation projects are generally based on current work and tailored to the interests of the student. See lab research interests and publications for recent topics. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
preferred title: Professor

Richter, Joel
first name: Joel
last name: Richter
Featured Videos: https://profiles.umassmed.edu/profile/28867186
full name: Joel Richter PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 554
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Arthur F. Koskinas Chair in Neuroscience
Rotation Projects: Many rotation projects are available so please inquire.
preferred title: Professor

Wolfe, Scot
first name: Scot
last name: Wolfe
full name: Scot Wolfe PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 595
person in primary position: Professor
type: Agent
type: Person
Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
preferred title: Professor

Ip, Yicktung
first name: Yicktung
last name: Ip
full name: Yicktung T Ip PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
Person ID: 609
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Ip for additional details.
Rotation Projects: Rotation Projects Project #1: Mechanistic study of isolated mutants that show abnormal intestinal stem cell division phenotypes. Project #2:Perform transgenic RNAi-based genetic screen for genes required for intestinal stem cell response to tissue damage.
preferred title: Professor

Greiner, Dale
first name: Dale
last name: Greiner
full name: Dale L Greiner PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 612
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
preferred title: Professor

Peterson, Craig
first name: Craig
last name: Peterson
full name: Craig L Peterson PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
Person ID: 633
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Elisabeth Chair I
preferred title: Professor

Lawson, Nathan
first name: Nathan
last name: Lawson
full name: Nathan Lawson PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 755
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Rotation Projects Please contact Nathan Lawson (nathan.lawson@umassmed.edu) for information regarding potential rotation projects. For information concerning recent research in the lab, please see:lawsonlab.umassmed.edu/research.html
preferred title: Professor

Dekker, Job
first name: Job
last name: Dekker
full name: Job Dekker PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 759
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Joseph J. Byrne Chair in Biomedical Research
Rotation Projects: ? Rotation Projects Multiple rotation projects are available in several areas related to long-range gene regulation and higher order chromosome organization. Projects include thorough analyses of the biochemical mechanisms of long-range gene regulation of specific disease-related genes, as well as large-scale analyses of chromosome organization using high-throughput genomics technologies (5C and Hi-C). The lab employs a wide range of experimental approaches, including cell culture, protein biochemistry, microscopy, genomics as well computational approaches such as bioinformatics and modeling. Specific rotation projects are determined dependent on the interest of the student.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866525
webpage: https://profiles.umassmed.edu/profile/28866572

Mercurio, Arthur
first name: Arthur
last name: Mercurio
full name: Arthur M Mercurio PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 901
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
preferred title: Professor

Kaufman, Paul
first name: Paul
last name: Kaufman
full name: Paul D Kaufman PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 930
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866532

McManus, David
first name: David
last name: McManus
full name: David D McManus MD
has faculty rank: Chair And Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 994
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
preferred title: Chair and Professor

Brewster, Robert
first name: Robert
last name: Brewster
full name: Robert Charles Brewster PhD
has faculty rank: Associate Professor
latitude: 42.27721220000000
longitude: -71.76106070000000
Person ID: 4192
person in primary position: Associate Professor
type: Agent
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preferred title: Associate Professor

Professor
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ADJUNCT PROFESSOR
sort order: 46
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Pai, Athma
first name: Athma
last name: Pai
Twitter: https://profiles.umassmed.edu/profile/28867149
full name: Athma A Pai PhD
has faculty rank: Associate Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 5128
person in primary position: Associate Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Pai for additional details.
preferred title: Associate Professor
webpage: https://profiles.umassmed.edu/profile/28866467

Seddon, Johanna
first name: Johanna
last name: Seddon
full name: Johanna Margaret Seddon MD, ScM
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 5252
person in primary position: Professor
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Ophthalmology and Visual Sciences
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van Zundert, Brigitte
first name: Brigitte
last name: van Zundert
full name: Brigitte van Zundert PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: -33.48808120000000
longitude: -70.70879550000000
Person ID: 10246494
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Lim, Elaine
first name: Elaine
last name: Lim
Twitter: https://profiles.umassmed.edu/profile/28867074
email address: 6M2k75qfvDeLRovRxBUHc1S6kDMdZvk=
full name: Elaine Lim PhD
has faculty rank: Assistant Professor
latitude: 42.27664990000000
longitude: -71.76201680000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 10246664
person in primary position: Assistant Professor
type: Agent
type: Person
Post Docs: Post-doc positions are available, please contact me via email.
Rotation Projects: Rotation projects are designed to aim to train students in both computational genetics/genomics and experimental technologies such as brain organoids. Please contact me via email to discuss.
preferred title: Assistant Professor

Biochemistry and Molecular Biotechnology
type: Department
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Lin, Honghuang
first name: Honghuang
last name: Lin
full name: Honghuang Lin PhD
has faculty rank: Professor
latitude: 42.27525000000000
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photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
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Professor
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Adjunct Professor
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Mullen, Alan
first name: Alan
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Post Docs: The newly established Moore lab is looking for highly motivated post-doctoral fellows to be founding members of our team. We study gene regulation and its role in human disease by interpreting large scale multi-omic datasets using machine learning approaches. Ideal candidates will have extensive experience in multi-omic data processing and analysis (RNA-seq, ATAC-seq, ChIP-seq, etc.) and are interested in learning about the fundamental mechanisms governing gene regulation (regulating transcription, splicing, translation, etc.). Candidates from related fields, such as computer science or biomedical engineering, with machine learning experience are also highly encouraged to apply. To Apply: Interested candidates should email a cover letter, CV, and 3 references to: Jill Moore at Jill.Moore@umassmed.edu
Rotation Projects: Interested in rotating in the lab? Please contact Dr. Moore for more information.
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