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Thompson, Paul
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Molecular, Cell and Cancer Biology
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Orthopedics and Physical Rehabilitation
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Gazzinelli, Ricardo
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last name: Gazzinelli
full name: Ricardo T Gazzinelli DSc, DVM
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Post Docs: Fiocruz-Minas Caroline Junqueira, PhD - Staff Scientist Camila Brabosa, PhD student - Mapping of CD8 T cell-specifc Epitopes from Malaria Blood Stage Gregorio Almeida, DVM, PhD - Immunology of Asymptomatic Malaria Guilherme Maia, PhD - Innate Lymphocytes in Malaria Isabella Hirako, PhD - Monocyte-Derived Dendritic Cells in Malaria Júlia Castro, MSc student - Chagas Disease Vaccine Larissa Pereira, MSc student - Inflammatory Caspases in Malaria Kely Mateucci, PhD - Monocyte-Derived Dendritic Cells Metabolism in Malaria Milton Pereira, PhD - Caspases and inflammasomes in Malaria and Chagas Disease Natalia Satchiko Souza, PhD - CD8+ T cells in malaria UMASS Danielle Durso, PhD - IRAKs and Myddosomes in host resistance to T. gondii Patricia Assis, PhD - Host Clock genes and Malaria Ogooluwa Ojelabi, PhD - Glucose Metabolism and Malaria
preferred title: Adjunct Professor

Levitz, Stuart
first name: Stuart
last name: Levitz
full name: Stuart M Levitz MD
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Rando, Oliver
first name: Oliver
last name: Rando
full name: Oliver J Rando MD, PhD
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Person ID: 1067
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Endowed Chair Honorary Title: Endowed Chair in Biochemistry and Molecular Biotechnology II
Post Docs: For more information about the Postdoctoral position in Dr. Rando’s lab please use the link provided. Post doc position
Rotation Projects: Rotation projects are available to study chromatin structure and function. Project 1. Measure histone dynamics in yeast. Histone dynamics play major roles in chromatin metabolism and in the inheritance of chromatin states. To measure histone replacement rates in yeast, we have created yeast strains carrying inducible epitope-tagged histones H3 and H2A. Using microarrays, we will measure histone replacement rates in a variety of mutant yeast to ascertain the role of various chromatin remodeling factors in histone exchange reactions. Project 2. Characterize mechanisms for epigenetic inheritance in yeast. We have identified a variety of genes whose expression state in yeast is epigenetically heritable. We will screen the yeast genome for genes that affect the inheritance of these expression patterns. Project 3. Measure histone dynamics in embryonic stem cells. Embryonic stem cells are pluripotent cells that can give rise to every type of cell in the adult animal. The role of chromatin structure in maintaining this pluripotent state is poorly understood, but it appears that stem cell chromatin is exceptionally labile relative to that in differentiated cells. We will create stem cell lines with inducible tagged histones to measure histone replacement rates across the mouse genome.
preferred title: Professor

Flotte, Terence
first name: Terence
last name: Flotte
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Person ID: 1094
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Endowed Chair Honorary Title: Elisabeth Chair for the Dean of Medicine
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Kelliher, Michelle
first name: Michelle
last name: Kelliher
full name: Michelle A Kelliher PhD
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Endowed Chair Honorary Title: Our Danny Cancer Fund Chair in Biomedical Research I
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Kelliher for additional details.
Rotation Projects: Please visit the Kelliher Lab website at: http://labs.umassmed.edu/kelliherlab/ to learn more about our current research areas. 1. Identify genes/pathways that mediate leukemia-initiating cell survival 2. Understand the molecular basis of glucocorticoid resistance in leukemia 3. Examine contribution of RIPK1 kinase in inflammatory and autoimmune disease mouse models. 4. Reveal tissue-specific roles for RIPK1 in cell death and inflammation. Use conditional Ripk1 allele to investigate effects of Ripk1 deletion in liver, pancreas and antigen presenting cells.
preferred title: Professor

Kim, Jason
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Rotation Projects: Lab rotations are currently available in this lab. Please contact Dr. Kim.
Summary: My research for almost 30 years has focused on obesity, insulin resistance, and type 2 diabetes and explores the molecular link between inflammation and insulin resistance using transgenic mice with elegant in vivo metabolic experiments and molecular approaches. My research also investigates the role of inflammation and altered metabolism in diabetic heart disease.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866556

McCormick, Beth
first name: Beth
last name: McCormick
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Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair II
Lab URL: https://www.umassmed.edu/mccormicklab/
Summary: Focus: Mucosal inflammation, host: pathogen interactions, and cancer biology
preferred title: Chair and Professor

Rothstein, Ann
first name: Ann
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Post Docs: <p >Postdoctoral Research Associate Position available to work on topics related to the molecular mechanisms involved in theactivation and differentiation of both murine and human autoreactive Bcells. The lab is particularlyinterested in innate sensors of cell damage, including members of the Toll-likereceptor and Pyhin receptor gene families.
Rotation Projects: <p >Rotation position open to work on topics related to the molecular mechanisms involved in theactivation and differentiation of both murine and human autoreactive Bcells. The lab is particularlyinterested in innate sensors of cell damage, including members of the Toll-likereceptor and Pyhin receptor gene families.
preferred title: Professor

Swain, Susan
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last name: Swain
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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
preferred title: Professor

Latz, Eicke
first name: Eicke
last name: Latz
full name: Eicke Latz MD
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Person ID: 153
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Bergmann, Andreas
first name: Andreas
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Person ID: 1651
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Post Docs: Please contact the Human Resources at UMass for openings in Dr. Bergmann's lab.
preferred title: Professor

Luban, Jeremy
first name: Jeremy
last name: Luban
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latitude: 42.27587600000000
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Person ID: 1684
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Endowed Chair Honorary Title: David J. Freelander Memorial Professor in AIDS Research
Post Docs: PostDoc Position available
Rotation Projects: Lab rotation position is available
preferred title: Professor

Fitzgerald, Katherine
first name: Katherine
last name: Fitzgerald
full name: Katherine A Fitzgerald PhD
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latitude: 42.27985300000000
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Person ID: 202
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Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair III
Rotation Projects: Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866427
webpage: https://profiles.umassmed.edu/profile/28866493

Mandrekar, Pranoti
first name: Pranoti
last name: Mandrekar
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full name: Pranoti Mandrekar PhD
has faculty rank: Professor
latitude: 42.27985300000000
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media links: https://profiles.umassmed.edu/profile/60088917
media links: https://profiles.umassmed.edu/profile/60090046
Person ID: 212
person in primary position: Professor
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Rotation Projects: Potential Rotation Projects Proteostasis regulators, HSF1, HSP70 and HSP90 in liver disease: Determine the expression and function in different cell types of the liver during acute and chronic liver injury using in vivo and in vitro models. Subsequently, we will test the relevance of the expression of these proteins in activation of intracellular signaling molecules involved in induction of fatty liver, inflammation and fibrosis. Role of chemokines in liver disease: CC-chemokines particularly CCL2/MCP-1, is significantly increased in serum as well as in the liver parenchyma in patients with alcoholic hepatitis. We test the role of MCP-1 in induction of fatty acid synthesis or metabolism and inflammation in the alcoholic liver. Our studies will also investigate the role of MCP-1 directed migration of immune cells in the liver contributing to injury.
preferred title: Professor

Lien, Egil
first name: Egil
last name: Lien
full name: Egil Lien PhD
has faculty rank: Professor
latitude: 42.27985300000000
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preferred title: Professor

Serreze, David
first name: David
last name: Serreze
full name: David V Serreze PhD
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Person ID: 2838
person in primary position: Associate Professor
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preferred title: Associate Professor

Shultz, Leonard
first name: Leonard
last name: Shultz
full name: Leonard Donald Shultz PhD
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latitude: 44.36637960000000
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Person ID: 2863
person in primary position: Professor
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preferred title: Professor

Czech, Michael
first name: Michael
last name: Czech
full name: Michael Paul Czech PhD
has faculty rank: Professor Emeritus
latitude: 42.27913450000000
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Person ID: 289
person in primary position: Professor Emeritus
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type: Person
Endowed Chair Honorary Title: Isadore and Fannie Foxman Chair in Medical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Czech for additional details.
Rotation Projects: Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research …
preferred title: Professor Emeritus

Davis, Roger
first name: Roger
last name: Davis
full name: Roger J Davis PhD, FRS
has faculty rank: Chair And Professor
latitude: 42.27913100000000
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Person ID: 3130
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: H. Arthur Smith Chair in Cancer Research
Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866429

Zierath, Juleen
first name: Juleen
last name: Zierath
full name: Juleen R Zierath PhD
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Person ID: 3151
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preferred title: Adjunct Professor

Rock, Kenneth
first name: Kenneth
last name: Rock
full name: Kenneth L Rock MD
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latitude: 42.27525000000000
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Person ID: 332
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: UMass Chan Medical School Chair in Biomedical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rock for additional details.
Rotation Projects: Potential Rotation Projects <p >Rotations are available in Dr. Rock’s laboratory for graduate students in the GSBS program. The rotation projects will explore various aspects of how the immune system carries out surveillance to detect viral infections and cancers. Among the potential areas of research are: (1) The alarm signals that alert the immune system to potential danger; (2) The initial innate immune and inflammatory response to infection or other dangerous situations; (3) The biology of the sentinel cells (e.g. dendritic cells) that sense danger and report it the adaptive immune system; (4) The mechanisms by which sentinel cells (e.g. dendritic cells) acquire and display antigens to T cells; and, (5) The antigen presentation pathways by which virally infected or cancer cells display a sampling of their expressed gene products to the activated T cells. Specific rotation projects are chosen based on the student’s interests and state/availability of the various projects in the laboratory. The goals of rotations are for the student to gain knowledge in immunology, to learn how to approach experimental problems, to learn new techniques and methods, and to actually generate data that moves our knowledge forward. In addition, the rotation provides the student the opportunity to evaluate the laboratory as a possible place to conduct their thesis research in the future.
preferred title: Chair and Professor

Khvorova, Anastasia
first name: Anastasia
last name: Khvorova
full name: Anastasia Khvorova PhD
has faculty rank: Professor
latitude: 42.27767280000000
longitude: -71.76163720000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 3413
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Remondi Family Chair in Biomedical Research
Post Docs: POSTDOCTORAL POSITION: RNAI PRECLINICAL DEVELOPMENT Excellent training opportunity for a person considering industrial carrier in drug development Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several classes of oligonucleotides which can efficiently silence genes in various tissues with acceptable level of toxicity. There are also new chemistries being developed to further improve oligonucleotide tissue distribution and cellular uptake. The successful candidate will be a key part of an intra-disciplinary team working with biologists and chemists to develop novel types of therapeutics for treatment of neurological disease, liver disease and orphan indications. The work will include compounds identification, screening, characterization, in vivo efficacy and PK/PD studies, novel assays development etc. In addition exposure and training in nucleic acid pre-clinical development, project management etc will be provided. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular cell biology or pharmacology.
Post Docs: RNAI MEDICINAL CHEMISTRY/ RNA OLIGONUCLEOTIDE CHEMISTRY Develop and characterize novel RNA chemistries to promote efficient oligonucleotide internalization and tissue distribution. Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several chemistries and formulations developed by us and others that effectively support oligo internalization and favorable PK/PD. In most cases in vivo efficacy is limited by (1) poor PK (2) inefficient tissue distribution (3) compound entrapment in biologically inactive intracellular compartments. The objective of future studies will be development of novel chemistries, which promote receptor mediated cellular internalization and/ or endosomal escape. The successful candidate will be responsible for the design and synthesis of novel RNA precursors, optimization of RNA synthesis and conjugation protocols and interface with the biology part of the lab. In addition, exposure to pre-clinical development programs and oligonucleotide manufacturing will be available. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and have previous experience in nucleic acid / oligonucleotide chemistry.
Post Docs: SMALL RNA TRAFFICKING Discover, characterize and adapt mechanisms of small RNA extracellular and intracellular trafficking for development of novel classes of oligonucleotide drugs. A serious limitation in realizing the potential of oligonucleotide based therapies has been the exceedingly inefficient transit of oligonucleotides from outside cells to the intracellular compartments where the biologically relevant activity happens. On the other hand, there are multiple lines of evidence supporting the notion that nature has implemented evolutionarily conserved mechanisms and pathways for efficiently trafficking small RNAs across cellular boundaries. The objective of future studies will be the systematic evaluation of mechanisms of cellular uptake of different classes of oligonucleotides and their comparison to mechanisms of native RNA trafficking using a combination of experimental approaches, including advanced RNA chemistry and high temporal and spatial resolution microscopy in living cells, Mass spectrometry, cell biology and others. The successful candidate will work closely with Victor Ambros and Silvia Corvera labs and the UMASS imaging group and receive training in RNA chemistry, biochemistry, cell biology and pre-clinical development. QUALIFICATIONS:Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular and cell biology
Rotation Projects: Our laboratory uses a combination of nucleic acid and oligonucleotide chemistry, biochemistry, cell biology, and pharmacology and develops and evaluate novel technologies for development of oligonucleotide therapeutics. A rotation project is available to develop and identify chemically modified self-delivering RNAi compounds for treatment of Huntington and other diseases.
preferred title: Professor

Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
has faculty rank: ADJUNCT PROFESSOR
latitude: 50.70274210000000
longitude: 7.10034010000000
Person ID: 3432
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Behar, Samuel
first name: Samuel
last name: Behar
full name: Samuel M Behar MD, PhD
has faculty rank: Professor
latitude: 42.33730900000000
longitude: -71.10710510000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 3437
person in primary position: Professor
type: Agent
type: Person
Lab URL: https://www.umassmed.edu/maps/research-labs/behar/
Rotation Projects: LAB ROTATION PROJECTS AVAILABLE -- PLEASE CONTACT SAM BEHAR FOR MORE INFORMATION
Summary: Focus: We seek to understand how the causative agent of tuberculosis, namely the bacterium Mycobacterium tuberculosis evades host immunity, and how different components of the immune response work together to contain infection. Our ultimate goal is to inform vaccine development and the design of host directed therapy.
preferred title: Professor

Golenbock, Douglas
first name: Douglas
last name: Golenbock
full name: Douglas T Golenbock MD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 345
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Neil and Margery Blacklow Chair in Infectious Diseases and Immunology
preferred title: Professor

Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27636250000000
longitude: -71.76564740000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 36
person in primary position: Adjunct Professor
type: Agent
type: Person
Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Lian, Jane
first name: Jane
last name: Lian
full name: Jane B Lian PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27723620000000
longitude: -71.76070940000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 370
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Osborne, Barbara
first name: Barbara
last name: Osborne
full name: Barbara A Osborne PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3725
person in primary position: MCB Director
type: Agent
type: Person
preferred title: MCB Director

Rotello, Vincent
first name: Vincent
last name: Rotello
full name: Vincent Rotello PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3741
person in primary position: Department Head
type: Agent
type: Person
preferred title: Department Head

Xiao, Hang
first name: Hang
last name: Xiao
full name: Hang Xiao PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3795
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Brehm, Michael
first name: Michael
last name: Brehm
full name: Michael A Brehm PhD
has faculty rank: Professor
latitude: 42.27694690000000
longitude: -71.76568470000000
Person ID: 474
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Harvey A. Shultz Chair in Diabetes
preferred title: Professor

Harris, John
first name: John
last name: Harris
full name: John E Harris MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 53
person in primary position: Adjunct Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Lambi and Sarah Adams Chair in Genetic Research
Rotation Projects: Rotations: Targeting the IFN-?-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking real-time autoreactive T cell migration and interactions within the skin: We are usin…
Rotation Projects: Rotations: Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking autoreactive T cell interactions within the skin: We are using fluorescently tagged C…
Summary: Interests: Vitiligo, autoimmunity, immunology, translational research
preferred title: Adjunct Professor

Greiner, Dale
first name: Dale
last name: Greiner
full name: Dale L Greiner PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 612
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
preferred title: Professor

Pazour, Gregory
first name: Gregory
last name: Pazour
full name: Gregory J Pazour PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 621
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Potential Rotation Projects Rotation projects in my laboratory will involve questions of how cilia are assembled and the function these organelles play in mammals. Projects vary depending on ongoing work in the laboratory and interests of the rotation student. Rotations in my laboratory can give students exposure to a range of techniques from mouse breeding and histological analysis of mouse tissues to mammalian cell culture and other cell biological techniques.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/41661165

Silverman, Neal
first name: Neal
last name: Silverman
full name: Neal Silverman PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
media links: https://profiles.umassmed.edu/profile/36711668
Person ID: 657
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Kang, Joonsoo
first name: Joonsoo
last name: Kang
full name: Joonsoo Kang PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 680
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Kang for additional details.
Post Docs: <!-- [if gte mso 9]><xml> <o:DocumentProperties> <o:Template>Normal</o:Template> <o:Revision>0</o:Revision> <o:TotalTime>0</o:TotalTime> <o:Pages>1</o:Pages> <o:Words>109</o:Words> <o:Characters>624</o:Characters> <o:Company>UMass Medical School</o:Company> <o:Lines>5</o:Lines> <o:Paragraphs>1</o:Paragraphs> <o:CharactersWithSpaces>766</o:CharactersWithSpaces> <o:Version>11.1282</o:Version> </o:DocumentProperties> <o:OfficeDocumentSettings> <o:AllowPNG/> </o:OfficeDocumentSettings></xml><![endif]--><!-- [if gte mso 9]><xml> <w:WordDocument> <w:Zoom>0</w:Zoom> <w:DoNotShowRevisions/> <w:DoNotPrintRevisions/> <w:DisplayHorizontalDrawingGridEvery>0</w:DisplayHorizontalDrawingGridEvery> <w:DisplayVerticalDrawingGridEvery>0</w:DisplayVerticalDrawingGridEvery> <w:UseMarginsForDrawingGridOrigin/> </w:WordDocument></xml><![endif]--> <!-- [if gte mso 9]><xml> <o:DocumentProperties> <o:Template>Normal</o:Template> <o:Revision>0</o:Revision> <o:TotalTime>0</o:TotalTime> <o:Pages>1</o:Pages> <o:Words>130</o:Words> <o:Characters>743</o:Characters> <o:Company>UMass Medical School</o:Company> <o:Lines>6</o:Lines> <o:Paragraphs>1</o:Paragraphs> <o:CharactersWithSpaces>912</o:CharactersWithSpaces> <o:Version>11.1282</o:Version> </o:DocumentProperties> <o:OfficeDocumentSettings> <o:AllowPNG/> </o:OfficeDocumentSettings></xml><![endif]--><!-- [if gte mso 9]><xml> <w:WordDocument> <w:Zoom>0</w:Zoom> <w:DoNotShowRevisions/> <w:DoNotPrintRevisions/> <w:DisplayHorizontalDrawingGridEvery>0</w:DisplayHorizontalDrawingGridEvery> <w:DisplayVerticalDrawingGridEvery>0</w:DisplayVerticalDrawingGridEvery> <w:UseMarginsForDrawingGridOrigin/> </w:WordDocument></xml><![endif]--> Postdoctoral positionsstarting in March 2019 for studies of the gene regulatory networks underpinning the hematopoietic system (ImmGen.org), self- or tumor-reactive T cell trafficking to tissues in organ-specific autoimmunity and tumor surveillance, respectively. Applicants must have a record of accomplishment in immunology …
Rotation Projects: Potential Rotation Projects <p >1. SOX proteins in the maintenance of mucosal tissue integrity and innate immunity. There are ~20 Sox genes in mammals. Although the prototypic SOX-related proteins, SRY (Sex-determining gene on Y chromosome) and TCF/LEF are reasonably well characterized, very little is known about the relevance of SOX proteins in lymphocyte development and function. We have discovered that some SOX proteins can regulate the WNT/Wingless signaling cascade, a central morphogenetic pathways specifying cell fate in all organisms whose aberrant activity leads to tumourigenesis. Importantly, expression of specific combinations of Sox genes is lymphocyte subset-specific, temporally and spatially. Our results so far strongly indicate that Sox genes are important regulators of multiple lymphocyte subsets, in part by opposing WNT signaling. An impediment to advances in understanding Sox gene functions has been that they are critical for embryonic development and mutations lead to early lethality. We have therefore embarked on generating conditional KO mice of various Sox genes and their cofactors that we postulate are centrally involved in lymphocyte differentiation and function. A few rotation projects are available to analyze these newly derived mouse models, both at the level of cellular and molecular analysis of lymphocyte development and single-cell tracking of specific Sox gene expressing cells in vivo. These mice have defects in mucosal tissue barrier functions and often exhibit aberrant inflammatory responses in the skin that can model human skin diseases such as psoriasis and dermatitis. <p >a. analysis of Sox13 reporter mice <p >b. analysis of Sox4-deficient mice for innate lymphocyte developmental defects <p >c. analysis of spontaneous skin inflammation in mice lacking dermal innate IL-17 producers <p >d. analysis of global chromatin docking of HMG TFs in ex vivo T cells <p >e. comparative analysis of global gene regulation and gene networks across …
preferred title: Professor

Stern, Lawrence
first name: Lawrence
last name: Stern
full name: Lawrence Stern PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 730
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Potential Rotation Projects Several rotation projects are available in structural biology of immune receptors, antigen presentation pathways, T-cell activation, and development of novel T-cell detection reagents. Please see Prof. Stern for details.
preferred title: Professor

Kornfeld, Hardy
first name: Hardy
last name: Kornfeld
full name: Hardy Kornfeld MD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
Person ID: 739
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Dekker, Job
first name: Job
last name: Dekker
full name: Job Dekker PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 759
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Joseph J. Byrne Chair in Biomedical Research
Rotation Projects: ? Rotation Projects Multiple rotation projects are available in several areas related to long-range gene regulation and higher order chromosome organization. Projects include thorough analyses of the biochemical mechanisms of long-range gene regulation of specific disease-related genes, as well as large-scale analyses of chromosome organization using high-throughput genomics technologies (5C and Hi-C). The lab employs a wide range of experimental approaches, including cell culture, protein biochemistry, microscopy, genomics as well computational approaches such as bioinformatics and modeling. Specific rotation projects are determined dependent on the interest of the student.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866525
webpage: https://profiles.umassmed.edu/profile/28866572

Wang, Jennifer
first name: Jennifer
last name: Wang
full name: Jennifer Wang MD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
Person ID: 770
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
has faculty rank: Professor Emeritus
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 78
person in primary position: Professor Emeritus
type: Agent
type: Person
preferred title: Professor Emeritus

Sassetti, Christopher
first name: Christopher
last name: Sassetti
full name: Christopher M Sassetti PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 878
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Elisabeth Chair II
Lab URL: https://www.umassmed.edu/sassettilab/
Rotation Projects: Rotation Projects <p >We have identified a number of bacterial pathways that are required for bacterial viability or virulence. We are particularly interested in: Phosphosignaling systems that regulate cell wall synthesis Metabolic regulatory mechanisms that trigger the “dormancy” response observed during infection. <p >A variety of genetic, biochemical, and informatic methods will be used to define the functions of these genes and the role played by each during infection. <p >
Summary: Focus: Pathogenesis of tuberculosis
preferred title: Professor

Mercurio, Arthur
first name: Arthur
last name: Mercurio
full name: Arthur M Mercurio PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 901
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
preferred title: Professor

Kurt-Jones, Evelyn
first name: Evelyn
last name: Kurt-Jones
full name: Evelyn A Kurt-Jones PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
Person ID: 96
person in primary position: Professor
type: Agent
type: Person
Post Docs: We are seeking a post-doctoral fellow to study toll/interleukin 1 receptors and their role in inflammatory disease pathogenesis using human cells and mouse models. Candidates should have a Ph.D. or M.D. degree, or have completed degree requirements. Experience in immunology, molecular biology and/or biochemistry and publication of papers in the areas of cytokine biology, receptor biochemistry and/or cell signaling required.
Rotation Projects: Potential Rotation Projects Expression of Toll-like receptors: Patterns of TLR expression in normal cells. Control of TLR receptor expression by environmental factors and cytokines. TLR expression in diseased tissues. Role of TLRs in disease pathogenesis: Use of knockout and genetically defined animals to study the role of TLRs in the control of bacterial or viral diseases. Structure-function studies of TLR signaling: Assessing the signaling activity of wild type and mutant TLRs (altered by site-directed mutageneis) using transient transfection and luciferase reporter gene analysis.
preferred title: Professor

Ram, Sanjay
first name: Sanjay
last name: Ram
full name: Sanjay Ram MD
has faculty rank: Professor
latitude: 42.27636250000000
longitude: -71.76564740000000
Person ID: 993
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Reboldi, Andrea
first name: Andrea
last name: Reboldi
full name: Andrea Reboldi PhD
has faculty rank: Associate Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 4362
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor
webpage: https://profiles.umassmed.edu/profile/28866563

UMass Chan – Baystate Regional Campus
type: Organization

Dermatology
type: Department
type: Organization

Associate Professor
is primary position: true
position in department: College of Natural Sciences
position in division: Food Science
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: University of Massachusetts Amherst

MCB Director
is primary position: true
position in department: College of Natural Sciences
position in division: Vet & Animal Sciences
sort order: 1
type: Position
HR job title: MCB Director
position in organization: University of Massachusetts Amherst

Department Head
is primary position: true
position in department: College of Natural Sciences
position in division: Chemistry
sort order: 1
type: Position
HR job title: Department Head
position in organization: University of Massachusetts Amherst

Krieg, Arthur
first name: Arthur
last name: Krieg
full name: Arthur M Krieg MD
has faculty rank: Professor
latitude: 42.36278220000000
longitude: -71.08353750000000
Person ID: 4841
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

ADJUNCT PROFESSOR
sort order: 46
type: Faculty Rank

Agrawal, Sudhir
first name: Sudhir
last name: Agrawal
Featured Videos: https://profiles.umassmed.edu/profile/39662410
full name: Sudhir Agrawal MSc, DPhil
has faculty rank: Professor
latitude: 42.27491030000000
longitude: -71.76424060000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 5145
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Usmani, Saad
first name: Saad
last name: Usmani
full name: Saad Usmani MD
has faculty rank: Instructor
latitude: 42.07492460000000
longitude: -72.52221600000000
Person ID: 5394
person in primary position: Instructor
type: Agent
type: Person
preferred title: Instructor

Ophthalmology and Visual Sciences
type: Department
type: Organization

Population and Quantitative Health Sciences
type: Department
type: Organization

Bogunovic, Milena
first name: Milena
last name: Bogunovic
full name: Milena Bogunovic MD, PhD
has faculty rank: Associate Professor
latitude: 42.27834540000000
longitude: -71.76387620000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 5532
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor
webpage: https://profiles.umassmed.edu/profile/28866444
webpage: https://profiles.umassmed.edu/profile/28866491

Biochemistry and Molecular Biotechnology
type: Department
type: Organization

https://profiles.umassmed.edu/profile/28866427
type: URLLink
label: http://www.umassmed.edu/fitzgeraldlab
link anchor text: Fitzgerald Lab Page

https://profiles.umassmed.edu/profile/28866429
type: URLLink
label: https://www.umassmed.edu/davislab/
link anchor text: Roger Davis Lab

https://profiles.umassmed.edu/profile/28866444
type: URLLink
label: https://www.umassmed.edu/bogunoviclab/
link anchor text: Bogunovic Lab

https://profiles.umassmed.edu/profile/28866491
type: URLLink
label: https://www.umassmed.edu/bogunoviclab/
link anchor text: Bogunovic Lab

https://profiles.umassmed.edu/profile/28866493
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label: http://www.umassmed.edu/pii
link anchor text: Program in Innate Immunity

https://profiles.umassmed.edu/profile/28866525
type: URLLink
label: http://www.dekkerlab.org
link anchor text: Dekker lab

https://profiles.umassmed.edu/profile/28866556
type: URLLink
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Nundel, Kerstin
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