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Rotation Projects: The Aroian Group is actively recruiting graduate students to: 1. use microbiology and genetics to develop new methods for delivery of protein therapies (anthelmintics) to the GI tract 2. discovery and mechanism of action studies of new anthelmintics to control soil-transmitted helminths 3. study how vertebrate hosts and their immune system interact with intestinal nematodes, with the particular goal of controlling autoimmune disease 4. study innate immune mechanisms that protect animals against pore-forming toxin attack
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Thompson, Paul
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Rotation Projects: Rotation Projects Rotation projects are available to address the following questions: How does the lack of structure in the C-terminal zinc finger of TTP affect the activity of the protein in the cell? In humans, there are three members in the TTP protein family: TTP, TIS11b and TIS11d. Structural studies performed by us and others have shown that while the TZF domain of TTP is partially unstructured in the free state and folds upon binding RNA, those of TIS11d and TIS11b are always folded. We have shown that the degree of structure of the TZF domain affects the activity of the protein in cells and indicates that the protein can modulate its activity through its dynamics. We want to determine whether structural disorder is directly linked to cellular stability or protein localization How do mutations in the RNA-binding domain of TIS11d cause cancer? Several point mutation in TTP and TIS11d have been linked to cancer. In particular, point mutations in the RNA-binding domain of TIS11d are found in leukemia patients. We are currently working on the characterization of the structure, dynamics and biological activity of these mutant proteins to understand their role in the pathogenesis of cancer. How does HuR regulate the stability of its target mRNA? HuR is another protein that, like TTP, binds to AU-rich elements (ARE) in mRNAs and regulate their stability. The detailed mechanisms that determine how HuR regulates transcripts stability are poorly understood. We are investigating how binding or HuR to the 3’UTR of an mRNA leads to its stabilization.
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Rotation Projects: Please contact Dr. Weng for information on rotations that are available in her lab.
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King, Oliver
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King, Michael
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Xiao, Hang
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Chien, Peter
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Zamore, Phillip
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
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Paydarfar, David
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Schiffer, Celia
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Wolfe, Scot
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Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
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Lambright, David
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Lambright for additional details.
Rotation Projects: Lab Rotations <p >Our lab takes an interdisciplinary approach to the study of fundamental problems in cell biology, signal transduction and membrane trafficking. Rotation projects are available in any of the areas of interest to the lab. Projects are tailored to the individual interests of the students and often involve a combination of molecular, biochemical, biophysical, structural and/or cell based analyses to investigate signaling and trafficking mechanisms. <p >
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Pazour, Gregory
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Rotation Projects: Potential Rotation Projects Rotation projects in my laboratory will involve questions of how cilia are assembled and the function these organelles play in mammals. Projects vary depending on ongoing work in the laboratory and interests of the rotation student. Rotations in my laboratory can give students exposure to a range of techniques from mouse breeding and histological analysis of mouse tissues to mammalian cell culture and other cell biological techniques.
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Gilmore, James Reid
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Rotation Projects: In yeast cells, protein translocation across the endoplasmic reticulum can occur by cotranslational or posttranslational pathways. The objective of this project is to develop a rapid method to inactivate the posttranslational pathway in vivo in yeast cells by appending the CMV-ribosome stalling sequence to the C-terminus of a typical posttranslational translocation substrate (carboxypeptidase Y). Complexes between the posttranslational translocation channel (SEC complex) and the stalled ribosomes will be purified for structural and functional analysis.
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Vedantham, Srinivasan
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Stern, Lawrence
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Rotation Projects: Potential Rotation Projects Several rotation projects are available in structural biology of immune receptors, antigen presentation pathways, T-cell activation, and development of novel T-cell detection reagents. Please see Prof. Stern for details.
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Dekker, Job
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Endowed Chair Honorary Title: Joseph J. Byrne Chair in Biomedical Research
Rotation Projects: ? Rotation Projects Multiple rotation projects are available in several areas related to long-range gene regulation and higher order chromosome organization. Projects include thorough analyses of the biochemical mechanisms of long-range gene regulation of specific disease-related genes, as well as large-scale analyses of chromosome organization using high-throughput genomics technologies (5C and Hi-C). The lab employs a wide range of experimental approaches, including cell culture, protein biochemistry, microscopy, genomics as well computational approaches such as bioinformatics and modeling. Specific rotation projects are determined dependent on the interest of the student.
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Sassetti, Christopher
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Rotation Projects: Rotation Projects <p >We have identified a number of bacterial pathways that are required for bacterial viability or virulence. We are particularly interested in: Phosphosignaling systems that regulate cell wall synthesis Metabolic regulatory mechanisms that trigger the “dormancy” response observed during infection. <p >A variety of genetic, biochemical, and informatic methods will be used to define the functions of these genes and the role played by each during infection. <p >
Summary: Focus: Pathogenesis of tuberculosis
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Bolon, Daniel
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Rotation Projects: Potential Rotation Projects <p >Our laboratory combines genetic and biochemical approaches to investigate the molecular underpinnings of adaptation. Potential rotation projects are available in two general (and partially overlapping) areas: exploring fitness landscapes through systematic approaches and investigating the molecular mechanism of the Hsp90 chaperone in signal transduction. Please contact the lab to discuss specific rotation projects in more detail.
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McManus, David
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Almeida, Sandra Cristina
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UMass Chan – Baystate Regional Campus
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Singh, Sonal
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Seddon, Johanna
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Gurwitz, Jerry
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Grigorieff, Nikolaus
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Robertson, David
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Ophthalmology and Visual Sciences
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Population and Quantitative Health Sciences
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Zhou, Chan
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Biochemistry and Molecular Biotechnology
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Lin, Honghuang
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Saranathan, Manojkumar
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HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/65681287
type: URLLink
label: https://www.umassmed.edu/research/cores/bioimage-dms-core/
link anchor text: BioImage DMS Core

https://profiles.umassmed.edu/profile/65681306
type: URLLink
label: https://wu-bimac.github.io/MicroMetaApp.github.io/
link anchor text: Micro-Meta App website

https://profiles.umassmed.edu/profile/65681334
type: URLLink
label: https://github.com/WU-BIMAC
link anchor text: Worcester BioImage DMS GitHub Page

https://profiles.umassmed.edu/profile/65681347
type: URLLink
label: https://doi.org/10.25504/FAIRsharing.87756d
link anchor text: 4DN-BINA-OME (NBO) Microscopy Metadata Specifications landing page

https://profiles.umassmed.edu/profile/65681384
type: URLLink
label: https://github.com/WU-BIMAC/MicroMetaApp-Electron/releases/tag/1.7.25-b1
link anchor text: Micro-Meta App software download

https://profiles.umassmed.edu/profile/65681456
type: URLLink
label: https://fish-omics-format.readthedocs.io/en/latest/
link anchor text: FISH Omics Format for Chromatin Tracing

https://profiles.umassmed.edu/profile/65681836
type: URLLink
label: https://github.com/OmegaProject
link anchor text: OMEGA Project GitHub Page

https://profiles.umassmed.edu/profile/65682288
ProfilesRNS Plugin Searchable Data: 2025 BINA Community Congress Presentation
ProfilesRNS Plugin Searchable Data: Presentation at BINA 2025 Community Congress
ProfilesRNS Plugin Searchable Data: Presentation at BINA 2024 Community Congress
ProfilesRNS Plugin Searchable Data: Presentation at BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress
ProfilesRNS Plugin Searchable Data: Presentation at the BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress
ProfilesRNS Plugin Searchable Data: Presentation at the BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress FocalPlane features... data managent webinar
ProfilesRNS Plugin Searchable Data: Presentation at the BINA 2024 Community Congress FocalPlane features... data managent webinar Presentation at the BINA 2023 Community Congress
ProfilesRNS Plugin Searchable Data: FocalPlane features... data managent webinar Presentation at the BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress
ProfilesRNS Plugin Searchable Data: FocalPlane features... data managent webinar Presentation at the BINA 2023 Community Congress Presentation at the BINA 2024 Community Congress
ProfilesRNS Plugin Searchable Data: FocalPlane features... data managent webinar Presentation at the BINA 2024 Community Congress
ProfilesRNS Plugin Searchable Data: FocalPlane features... data managent webinar Presentation at the BINA 2024 Community Congress FoundingGIDE: BioImage DMS for Everyone
ProfilesRNS Plugin Searchable Data: FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress
ProfilesRNS Plugin Searchable Data: FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress OME 2025 | Session 1 - Pre-publication BioImage DMS
ProfilesRNS Plugin Searchable Data: FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone OME 2025 | Session 1 - Pre-publication BioImage DMS Presentation at the BINA 2024 Community Congress
ProfilesRNS Plugin Searchable Data: FocalPlane features... data managent webinar OME 2025 | Session 1 - Pre-publication BioImage DMS FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress
ProfilesRNS Plugin Searchable Data: OME 2025 | Session 1 - Pre-publication BioImage DMS FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress
ProfilesRNS Plugin Searchable Data: OME 2025 | Pre-publication BioImage Data Management and Sharing FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress

Chair and Professor
is primary position: true
position in department: RNA Therapeutics Institute
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Distinguished Professor
is primary position: true
position in department: RNA Therapeutics Institute
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Distinguished Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: RNA Therapeutics Institute
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Genomics and Computational Biology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: RNA Therapeutics Institute
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Chair and Professor
is primary position: true
position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Associate Professor
is primary position: true
position in department: Biochemistry and Molecular Biotechnology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Biochemistry and Molecular Biotechnology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School