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Summary: Elucidating the factors involved in sporadic ALS and investigating protein misfunction associated with neurodegenerative disease.
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Rotation Projects: Rotation Projects for graduate students: Examining the role of cross-reactive CD8 memory T cells in mediating the EBV-induced infectious mononucleosis syndrome in humans. Examining the role of cross-reactive CD8 memory T cells and cytokines in murine models of viral infection. Examining the mechanisms used by these memory T cells to unrelated infections to modulate disease outcome either for the bad or the good.
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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rock for additional details.
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Rotation Projects: LAB ROTATION PROJECTS AVAILABLE -- PLEASE CONTACT SAM BEHAR FOR MORE INFORMATION
Summary: Focus: We seek to understand how the causative agent of tuberculosis, namely the bacterium Mycobacterium tuberculosis evades host immunity, and how different components of the immune response work together to contain infection. Our ultimate goal is to inform vaccine development and the design of host directed therapy.
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Green, Sharone
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last name: Green
full name: Sharone Green MD
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latitude: 42.27525000000000
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Person ID: 367
person in primary position: Associate Professor
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Rotation Projects: Sharone Green, M.D. Academic Role: Associate Professor Faculty Appointment(s) In: Medicine Other Affiliation(s): Center for Infectious Disease and Vaccine Research Potential Rotation Projects Flavivirus-specific T lymphocytes -characterization of T lymphocytes (human or murine) with novel specificities for epitopes ofdengue, yellow fever, Japanese encephalitis or West Nile viruses; functional characterization of T cell effector responses; quantitation of epitope-specific CD4 and/or CD8 T cells
preferred title: Associate Professor

Osborne, Barbara
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latitude: 42.39565560000000
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Person ID: 3725
person in primary position: MCB Director
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preferred title: MCB Director

Kaltashov, Igor
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last name: Kaltashov
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Person ID: 3736
person in primary position: Professor
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preferred title: Professor

Rotello, Vincent
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Sullivan, John
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person in primary position: Professor Emeritus
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Rotation Projects: Potential Rotation Projects Contact Dr. Sullivan for more project details.
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Xiao, Hang
first name: Hang
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Person ID: 3795
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Co, Marydawn
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Person ID: 414
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Brehm, Michael
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Endowed Chair Honorary Title: Harvey A. Shultz Chair in Diabetes
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Morrison, Trudy
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Person ID: 525
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Lab URL: https://www.umassmed.edu/maps/research-labs/morrison/
Summary: Focus: Paramyxovirus and Pneumovirius membrane fusion and virus assembly, virus vaccines
preferred title: Professor

Schiffer, Celia
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Endowed Chair Honorary Title: Arthur F. and Helen P. Koskinas Professor in Biochemistry and Molecular Biotechnology
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Greiner, Dale
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Person ID: 612
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Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
preferred title: Professor

Somasundaran, Mohan
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Ruiz De Luzuriaga, Katherine
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Endowed Chair Honorary Title: UMass Memorial Health Care Chair in Biomedical Research
Rotation Projects: Potential Rotation Projects: Contact Dr. Luzuriaga for project details.
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Ali, Akbar
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Stern, Lawrence
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Rotation Projects: Potential Rotation Projects Several rotation projects are available in structural biology of immune receptors, antigen presentation pathways, T-cell activation, and development of novel T-cell detection reagents. Please see Prof. Stern for details.
preferred title: Professor

Wang, Jennifer
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Cerny, Jan
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Person ID: 777
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Gottlinger, Heinrich
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Person ID: 886
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Gottlinger for additional details.
Rotation Projects: Potential Rotation Projects 1.The identification of novel binding partners for cellular proteins required for HIV-1 budding using a double tag immunoaffinity purification approach. 2.The characterization of mutant ESCRT-III components that block HIV-1 budding with regard to subcellular localization and their ability to interact with certain phosphoinositol lipids and with other proteins involved in late endosomal sorting. 3.The mapping of binding sites for cellular proteins that we have identified as specific components of HIV-1 using GST pulldown, yeast two-hybrid, and co-immunoprecipitation approaches. 4.The generation and functional characterization of mutant viral Gag proteins that fail to interact with specific cellular partners.
preferred title: Professor

Usami, Yoshiko
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Bogdanov, Alexei
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Person ID: 906
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Rice, Peter
first name: Peter
last name: Rice
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latitude: 42.27985300000000
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Person ID: 908
person in primary position: Professor Emeritus
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Kurt-Jones, Evelyn
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latitude: 42.27985300000000
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Person ID: 96
person in primary position: Professor
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Post Docs: We are seeking a post-doctoral fellow to study toll/interleukin 1 receptors and their role in inflammatory disease pathogenesis using human cells and mouse models. Candidates should have a Ph.D. or M.D. degree, or have completed degree requirements. Experience in immunology, molecular biology and/or biochemistry and publication of papers in the areas of cytokine biology, receptor biochemistry and/or cell signaling required.
Rotation Projects: Potential Rotation Projects Expression of Toll-like receptors: Patterns of TLR expression in normal cells. Control of TLR receptor expression by environmental factors and cytokines. TLR expression in diseased tissues. Role of TLRs in disease pathogenesis: Use of knockout and genetically defined animals to study the role of TLRs in the control of bacterial or viral diseases. Structure-function studies of TLR signaling: Assessing the signaling activity of wild type and mutant TLRs (altered by site-directed mutageneis) using transient transfection and luciferase reporter gene analysis.
preferred title: Professor

Ram, Sanjay
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latitude: 42.27636250000000
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Person ID: 993
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UMass Chan – Baystate Regional Campus
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MCB Director
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Krieg, Arthur
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Wang, Bo
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ADJUNCT PROFESSOR
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Engelman, Kathleen
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person in primary position: Assistant Professor
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preferred title: Assistant Professor

Agrawal, Sudhir
first name: Sudhir
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full name: Sudhir Agrawal MSc, DPhil
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Magnani, Diogo
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preferred title: Associate Professor
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Usmani, Saad
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Robertson, David
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Population and Quantitative Health Sciences
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Munro, James
first name: James
last name: Munro
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Person ID: 5541
person in primary position: Professor
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Summary: Focus: The Munro laboratory develops and applies quantitative biophysical approaches to visualize virus replication, and probe the functions of the proteins and RNAs involved.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866515

Durham, Natasha
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Person ID: 10246492
person in primary position: Instructor
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Summary: Focus: Viral entry, antibodies & vaccines, single molecule techniques
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webpage: https://profiles.umassmed.edu/profile/48427747
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Clayton, Kiera
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preferred title: Assistant Professor

Biochemistry and Molecular Biotechnology
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https://profiles.umassmed.edu/profile/28866505
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Medicine at UMass Chan - Baystate
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Pediatrics at UMass Chan - Baystate
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Assistant Professor
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Instructor
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Instructor
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Professor
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Professor
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Pfefferle, Susan
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Assistant Professor
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Lawrence, John
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