Gessler, Dominic
first name: Dominic
last name: Gessler
coauthor of: Gao, Guangping
coauthor of: Flotte, Terence
coauthor of: Wang, Dan
coauthor of: Tai, Phillip
coauthor of: Cataltepe, Oguz
full name: Dominic J Gessler MD, PhD
has faculty rank: Assistant Professor
has network: research areas
has network: coauthor of
has network: similar to
has network: selected publications
latitude: 42.27673450000000
longitude: -71.76198390000000
Person ID: 10247377
person in primary position: Assistant Professor
physical neighbor: Bai, Shi
physical neighbor: Kostova, Zlatina
physical neighbor: Lushina, Nadezhda
physical neighbor: Petersen, Christine
physical neighbor: Yankelev, Haya
similar to: Flotte, Terence
similar to: Gao, Guangping
similar to: Sena-Esteves, Miguel
similar to: Wang, Dan
similar to: Keeler-Klunk, Allison
type: Agent
type: Person
selected publications: Authorship 131967
selected publications: Authorship 132045
selected publications: Authorship 120217
selected publications: Authorship 120218
selected publications: Authorship 118300
selected publications: Authorship 114567
selected publications: Authorship 112575
selected publications: Authorship 109086
selected publications: Authorship 108330
selected publications: Authorship 108316
selected publications: Authorship 108314
selected publications: Authorship 108322
selected publications: Authorship 108339
selected publications: Authorship 108343
selected publications: Authorship 108340
selected publications: Authorship 108315
selected publications: Authorship 108329
selected publications: Authorship 108327
selected publications: Authorship 108337
selected publications: Authorship 108321
selected publications: Authorship 108319
selected publications: Authorship 108312
selected publications: Authorship 108313
selected publications: Authorship 108318
education and training: University of Heidelberg,
education and training: University of Massachusetts Medical School, Gene Therapy & Neurometabolism
research areas: Genetic Vectors
research areas: Dependovirus
research areas: Brachytherapy
research areas: Brain Neoplasms
research areas: Central Nervous System
mailing address: Worcester MA 01605
middle name or initial: J
positions: Assistant Professor
positions: https://profiles.umassmed.edu/profile/56960940
positions: https://profiles.umassmed.edu/profile/56960941
positions: https://profiles.umassmed.edu/profile/56960942
positions: https://profiles.umassmed.edu/profile/56960943
positions: https://profiles.umassmed.edu/profile/56960944
preferred title: Assistant Professor

coauthor of
tag name: prns:coAuthorOf
type: ObjectProperty

Faculty Rank
type: Class

full name
tag name: prns:fullName
type: DatatypeProperty

author list
tag name: prns:hasAuthorList
type: DatatypeProperty

has faculty rank
tag name: prns:hasFacultyRank
type: ObjectProperty

has network
tag name: prns:hasNetwork
type: ObjectProperty

published in
tag name: prns:hasPublicationVenue
type: DatatypeProperty

information resource reference
tag name: prns:informationResourceReference
type: DatatypeProperty

is primary position
tag name: prns:isPrimaryPosition
type: DatatypeProperty

latitude
tag name: prns:latitude
type: DatatypeProperty

longitude
tag name: prns:longitude
type: DatatypeProperty

photo
tag name: prns:mainImage
type: ObjectProperty

maximum weight
tag name: prns:maxWeight
type: DatatypeProperty

journal title abbreviation
tag name: prns:medlineTA
type: DatatypeProperty

MeSH DescriptorUI
tag name: prns:meshDescriptorUI
type: DatatypeProperty

MeSH semantic group name
tag name: prns:meshSemanticGroupName
type: DatatypeProperty

minimum weight
tag name: prns:minWeight
type: DatatypeProperty

number of authors
tag name: prns:numberOfAuthors
type: DatatypeProperty

number of connections
tag name: prns:numberOfConnections
type: DatatypeProperty

number of publications
tag name: prns:numberOfPublications
type: DatatypeProperty

Person ID
tag name: prns:personId
type: DatatypeProperty

person in primary position
tag name: prns:personInPrimaryPosition
type: ObjectProperty

physical neighbor
tag name: prns:physicalNeighborOf
type: ObjectProperty

position in department
tag name: prns:positionInDepartment
type: ObjectProperty

position in division
tag name: prns:positionInDivision
type: ObjectProperty

predicate node
tag name: prns:predicateNode
type: ObjectProperty

publication date
tag name: prns:publicationDate
type: DatatypeProperty

similar to
tag name: prns:similarTo
type: ObjectProperty

sort order
tag name: prns:sortOrder
type: DatatypeProperty

educational organization
tag name: prns:trainingAtOrganization
type: DatatypeProperty

training location
tag name: prns:trainingLocation
type: DatatypeProperty

uniqueness weight
tag name: prns:uniquenessWeight
type: DatatypeProperty

year
tag name: prns:year
type: DatatypeProperty

Endowed Chair Honorary Title
tag name: umass:honoraryTitle
type: DatatypeProperty

Lab URL
tag name: umass:LabUrl
type: DatatypeProperty

Post Docs
tag name: umass:PostDocs
type: DatatypeProperty

Rotation Projects
tag name: umass:Rotation
type: DatatypeProperty

Summary
tag name: umass:Summary
type: DatatypeProperty

Academic Article
type: Class

Article
type: Class

Document
type: Class

PubMed Identifier
tag name: bibo:pmid
type: DatatypeProperty

Address
type: Class

address line 1
tag name: vivo:address1
type: DatatypeProperty

address line 2
tag name: vivo:address2
type: DatatypeProperty

address line 3
tag name: vivo:address3
type: DatatypeProperty

selected publications
tag name: vivo:authorInAuthorship
type: ObjectProperty

author rank in publication
tag name: vivo:authorRank
type: DatatypeProperty
type: FunctionalProperty

Authorship
type: Class

degree earned
tag name: vivo:degreeEarned
type: ObjectProperty

Department
type: Class

Division
type: Class

education and training
tag name: vivo:educationalTraining
type: Class
type: ObjectProperty
label: Educational Training

research areas
tag name: vivo:hasResearchArea
type: ObjectProperty

HR job title
tag name: vivo:hrJobTitle
type: DatatypeProperty

Information Resource
type: Class

link anchor text
tag name: vivo:linkAnchorText
type: DatatypeProperty

linked author
tag name: vivo:linkedAuthor
type: ObjectProperty

linked information resource
tag name: vivo:linkedInformationResource
type: ObjectProperty

mailing address
tag name: vivo:mailingAddress
type: ObjectProperty

major field of degree
tag name: vivo:majorField
type: DatatypeProperty

middle name or initial
tag name: vivo:middleName
type: DatatypeProperty
type: FunctionalProperty

positions
tag name: vivo:personInPosition
type: ObjectProperty

Position
type: Class

position in organization
tag name: vivo:positionInOrganization
type: ObjectProperty

preferred title
tag name: vivo:preferredTitle
type: DatatypeProperty
type: FunctionalProperty

URLLink
type: Class

webpage
tag name: vivo:webpage
type: ObjectProperty

predicate
tag name: rdf:predicate
type: ObjectProperty

type
tag name: rdf:type
type: ObjectProperty

label
tag name: rdfs:label
type: DatatypeProperty

Concept
type: Class

Agent
type: Class

first name
tag name: foaf:firstName
type: DatatypeProperty
type: FunctionalProperty

last name
tag name: foaf:lastName
type: DatatypeProperty
type: FunctionalProperty

Organization
type: Class

Person
type: Class

Central Nervous System
MeSH DescriptorUI: D002490
MeSH semantic group name: Anatomy
number of authors: 98
number of publications: 197
uniqueness weight: 0.845967
type: Concept

Brain Neoplasms
MeSH DescriptorUI: D001932
MeSH semantic group name: Disorders
number of authors: 99
number of publications: 310
uniqueness weight: 0.775761
type: Concept

Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10.
PubMed Identifier: 24781136
author list: Yang B, Li S, Wang H, Guo Y, Gessler DJ, Cao C, Su Q, Kramer J, Zhong L, Ahmed SS, Zhang H, He R, Desrosiers RC, Brown R, Xu Z, Gao G
published in: Molecular therapy : the journal of the American Society of Gene Therapy
information resource reference: Yang B, Li S, Wang H, Guo Y, Gessler DJ, Cao C, Su Q, Kramer J, Zhong L, Ahmed SS, Zhang H, He R, Desrosiers RC, Brown R, Xu Z, Gao G. Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10. Mol Ther. 2014 Jul; 22(7):1299-1309.
journal title abbreviation: Mol Ther
publication date: 2014-04-30T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Dependovirus
MeSH DescriptorUI: D000229
MeSH semantic group name: Living Beings
number of authors: 94
number of publications: 709
uniqueness weight: 0.61784
type: Concept

Brachytherapy
MeSH DescriptorUI: D001918
MeSH semantic group name: Procedures
number of authors: 18
number of publications: 38
uniqueness weight: 0.97335
type: Concept

Genetic Vectors
MeSH DescriptorUI: D005822
MeSH semantic group name: Chemicals & Drugs
MeSH semantic group name: Living Beings
number of authors: 186
number of publications: 879
uniqueness weight: 0.631992
type: Concept

Interdisciplinary Graduate Program
type: Department
type: Organization

Neuroscience
type: Department
type: Organization

Pathology
type: Department
type: Organization

Pediatrics
type: Department
type: Organization

Radiology
type: Department
type: Organization

Translational Science
type: Department
type: Organization

Community Pediatrics
type: Division
type: Organization

Anatomic Pathology
type: Division
type: Organization

Morningside Graduate School of Biomedical Sciences
type: Organization

T.H. Chan School of Medicine
type: Organization

UMass Chan Medical School
type: Organization

Flotte, Terence
first name: Terence
last name: Flotte
full name: Terence R Flotte MD
has faculty rank: Professor
latitude: 42.27721310000000
longitude: -71.76076230000000
Person ID: 1094
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Elisabeth Chair for the Dean of Medicine
preferred title: Professor

Gao, Guangping
first name: Guangping
last name: Gao
full name: Guangping Gao PhD
has faculty rank: Chair And Professor
latitude: 42.27714780000000
longitude: -71.76564580000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 1177
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Penelope Booth Rockwell Chair in Biomedical Research
Lab URL: https://www.umassmed.edu/gaolab/
Summary: Focus: Adeno-associated virus vector mediated gene transfer for gene therapy, gene therapy of inherited neurodegenerative Canavan Disease
preferred title: Chair and Professor

Sena-Esteves, Miguel
first name: Miguel
last name: Sena-Esteves
full name: Miguel Sena-Esteves PhD
has faculty rank: Associate Professor
latitude: 42.27714780000000
longitude: -71.76564580000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 1276
person in primary position: Associate Professor
type: Agent
type: Person
Summary: Dr. Esteves is a neuroscientist with interest in gene therapy to help treat neurodegenerative diseases.
preferred title: Associate Professor

Yankelev, Haya
first name: Haya
last name: Yankelev
full name: Haya Yankelev MD
has faculty rank: Instructor
latitude: 42.27673450000000
longitude: -71.76198390000000
Person ID: 3041
person in primary position: Instructor
type: Agent
type: Person
preferred title: Instructor

Cataltepe, Oguz
first name: Oguz
last name: Cataltepe
full name: Oguz I Cataltepe MD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 985
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Musculoskeletal
type: Division
type: Organization

Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders.
PubMed Identifier: 26611604
author list: Gessler DJ, Gao G
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Gessler DJ, Gao G. Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders. Methods Mol Biol. 2016; 1382:429-65.
journal title abbreviation: Methods Mol Biol
publication date: 2016-01-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease.
PubMed Identifier: 28194442
author list: Gessler DJ, Li D, Xu H, Su Q, Sanmiguel J, Tuncer S, Moore C, King J, Matalon R, Gao G
published in: JCI insight
information resource reference: Gessler DJ, Li D, Xu H, Su Q, Sanmiguel J, Tuncer S, Moore C, King J, Matalon R, Gao G. Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease. JCI Insight. 2017 02 09; 2(3):e90807.
journal title abbreviation: JCI Insight
publication date: 2017-02-09T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

University of Heidelberg,
educational organization: University of Heidelberg
training location: Heidelberg, , Germany
type: EducationalTraining
degree earned: MD

University of Massachusetts Medical School, Gene Therapy & Neurometabolism
educational organization: University of Massachusetts Medical School
training location: Worcester, MA, United States
type: EducationalTraining
degree earned: PHD
major field of degree: Gene Therapy & Neurometabolism

Keeler-Klunk, Allison
first name: Allison
last name: Keeler-Klunk
full name: Allison May Keeler-Klunk PhD
has faculty rank: Assistant Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 4941
person in primary position: Assistant Professor
type: Agent
type: Person
Lab URL: https://www.umassmed.edu/keelerlab
preferred title: Assistant Professor

Tai, Phillip
first name: Phillip
last name: Tai
full name: Phillip Tai PhD
has faculty rank: Assistant Professor
latitude: 42.27834540000000
longitude: -71.76387620000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 5055
person in primary position: Assistant Professor
type: Agent
type: Person
Lab URL: https://www.umassmed.edu/tai/
Summary: Focus: Virology and vectorology of adeno-associated viruses
preferred title: Assistant Professor

NeuroNexus Institute
type: Department
type: Organization

A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates.
PubMed Identifier: 29766031
author list: Wang D, Li S, Gessler DJ, Xie J, Zhong L, Li J, Tran K, Van Vliet K, Ren L, Su Q, He R, Goetzmann JE, Flotte TR, Agbandje-McKenna M, Gao G
published in: Molecular therapy. Methods & clinical development
information resource reference: Wang D, Li S, Gessler DJ, Xie J, Zhong L, Li J, Tran K, Van Vliet K, Ren L, Su Q, He R, Goetzmann JE, Flotte TR, Agbandje-McKenna M, Gao G. A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates. Mol Ther Methods Clin Dev. 2018 Jun 15; 9:234-246.
journal title abbreviation: Mol Ther Methods Clin Dev
publication date: 2018-03-16T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Wang, Dan
first name: Dan
last name: Wang
full name: Dan Wang PhD
has faculty rank: Assistant Professor
latitude: 42.27834540000000
longitude: -71.76387620000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 5276
person in primary position: Assistant Professor
type: Agent
type: Person
Post Docs: We are looking for motivated postdoctoral researchers. Send in your application and get in touch today!
Rotation Projects: - AAV gene therapy for genetic diseases - Therapeutic genome editing - RNA-based approaches to treating genetic diseases - Interactions between AAV vector and host cell - AAV vector capsid engineering
preferred title: Assistant Professor
webpage: https://profiles.umassmed.edu/profile/28866581
webpage: https://profiles.umassmed.edu/profile/28866425
webpage: https://profiles.umassmed.edu/profile/28866590

Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice.
PubMed Identifier: 30102296
author list: Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G
published in: Nature biotechnology
information resource reference: Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G. Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Nat Biotechnol. 2018 10; 36(9):839-842.
journal title abbreviation: Nat Biotechnol
publication date: 2018-08-13T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs.
PubMed Identifier: 29499946
author list: Lu Y, Tai PWL, Ai J, Gessler DJ, Su Q, Yao X, Zheng Q, Zamore PD, Xu X, Gao G
published in: Molecular therapy. Nucleic acids
information resource reference: Lu Y, Tai PWL, Ai J, Gessler DJ, Su Q, Yao X, Zheng Q, Zamore PD, Xu X, Gao G. Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs. Mol Ther Nucleic Acids. 2018 Mar 02; 10:349-360.
journal title abbreviation: Mol Ther Nucleic Acids
publication date: 2017-12-30T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Neurological Surgery
type: Department
type: Organization

Intravenous Infusion of AAV for Widespread Gene Delivery to the Nervous System.
PubMed Identifier: 30783972
author list: Gessler DJ, Tai PWL, Li J, Gao G
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Gessler DJ, Tai PWL, Li J, Gao G. Intravenous Infusion of AAV for Widespread Gene Delivery to the Nervous System. Methods Mol Biol. 2019; 1950:143-163.
journal title abbreviation: Methods Mol Biol
publication date: 2019-01-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Case report: cranial angiosarcoma with multiple hemorrhagic brain metastasis in a child.
PubMed Identifier: 32157366
author list: Lee V, Gessler D, Cataltepe O
published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
information resource reference: Lee V, Gessler D, Cataltepe O. Case report: cranial angiosarcoma with multiple hemorrhagic brain metastasis in a child. Childs Nerv Syst. 2020 09; 36(9):2103-2107.
journal title abbreviation: Childs Nerv Syst
publication date: 2020-03-10T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties.
PubMed Identifier: 32606306
author list: Hsu HL, Brown A, Loveland AB, Lotun A, Xu M, Luo L, Xu G, Li J, Ren L, Su Q, Gessler DJ, Wei Y, Tai PWL, Korostelev AA, Gao G
published in: Nature communications
information resource reference: Hsu HL, Brown A, Loveland AB, Lotun A, Xu M, Luo L, Xu G, Li J, Ren L, Su Q, Gessler DJ, Wei Y, Tai PWL, Korostelev AA, Gao G. Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties. Nat Commun. 2020 06 30; 11(1):3279.
journal title abbreviation: Nat Commun
publication date: 2020-06-30T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Kostova, Zlatina
first name: Zlatina
last name: Kostova
full name: Zlatina Lyubomirova Kostova PhD
has faculty rank: Instructor
latitude: 42.27673450000000
longitude: -71.76198390000000
Person ID: 10246641
person in primary position: Instructor
type: Agent
type: Person
preferred title: Instructor

Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair.
PubMed Identifier: 33967698
author list: Lotun A, Gessler DJ, Gao G
published in: Frontiers in cellular neuroscience
information resource reference: Lotun A, Gessler DJ, Gao G. Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair. Front Cell Neurosci. 2021; 15:661928.
journal title abbreviation: Front Cell Neurosci
publication date: 2021-04-23T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

https://profiles.umassmed.edu/profile/28866425
type: URLLink
label: https://www.umassmed.edu/rti/
link anchor text: RNA Therapeutics Institute at UMMS

https://profiles.umassmed.edu/profile/28866581
type: URLLink
label: https://www.umassmed.edu/gtc/
link anchor text: Gene Therapy Center at UMMS

https://profiles.umassmed.edu/profile/28866590
type: URLLink
label: https://www.umassmed.edu/wanglab/
link anchor text: Laboratory website

Gene Therapy for Rare Neurological Disorders.
PubMed Identifier: 35102556
author list: Flotte TR, Gessler DJ
published in: Clinical pharmacology and therapeutics
information resource reference: Flotte TR, Gessler DJ. Gene Therapy for Rare Neurological Disorders. Clin Pharmacol Ther. 2022 04; 111(4):743-757.
journal title abbreviation: Clin Pharmacol Ther
publication date: 2022-02-25T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Instructor
is primary position: true
position in department: Pediatrics
position in division: Community Pediatrics
sort order: 1
type: Position
HR job title: Instructor
position in organization: UMass Chan Medical School

Worcester MA 01605
type: Address
address line 1: UMass Chan Medical School
address line 2: 368 Plantation Street
address line 3: Worcester MA 01605

research areas
maximum weight: 1.70054
minimum weight: 0.00683886
number of connections: 76
predicate node: https://profiles.umassmed.edu/profile/198
predicate: research areas
type: Network

coauthor of
maximum weight: 2.70888
minimum weight: 0.0275476
number of connections: 16
predicate node: https://profiles.umassmed.edu/profile/345
predicate: coauthor of
type: Network

similar to
maximum weight: 87.817
minimum weight: 2.49766
number of connections: 60
predicate node: https://profiles.umassmed.edu/profile/476
predicate: similar to
type: Network

selected publications
maximum weight: 1
minimum weight: 1
number of connections: 24
predicate node: https://profiles.umassmed.edu/profile/94
predicate: selected publications
type: Network

Authorship 108312
type: Authorship
author rank in publication: 3
linked author: Gessler, Dominic
linked information resource: Efficient Transduction of Corneal Stroma by Adeno-Associated Viral Serotype Vectors for Implications in Gene Therapy of Corneal Diseases.

Authorship 108313
type: Authorship
author rank in publication: 1
linked author: Gessler, Dominic
linked information resource: Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders.

Authorship 108314
type: Authorship
author rank in publication: 1
linked author: Gessler, Dominic
linked information resource: GammaTile? brachytherapy in the treatment of recurrent glioblastomas.

Authorship 108315
type: Authorship
author rank in publication: 1
linked author: Gessler, Dominic
linked information resource: Intravenous Infusion of AAV for Widespread Gene Delivery to the Nervous System.

Authorship 108316
type: Authorship
author rank in publication: 2
linked author: Gessler, Dominic
linked information resource: Editorial: Myelin Repair: At the Crossing-Lines of Myelin Biology and Gene Therapy.

Authorship 108318
type: Authorship
author rank in publication: 5
linked author: Gessler, Dominic
linked information resource: Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10.

Authorship 108319
type: Authorship
author rank in publication: 3
linked author: Gessler, Dominic
linked information resource: Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.

Authorship 108321
type: Authorship
author rank in publication: 1
linked author: Gessler, Dominic
linked information resource: Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease.

Authorship 108322
type: Authorship
author rank in publication: 2
linked author: Gessler, Dominic
linked information resource: Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair.

Authorship 108327
type: Authorship
author rank in publication: 3
linked author: Gessler, Dominic
linked information resource: A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates.

Authorship 108329
type: Authorship
author rank in publication: 12
linked author: Gessler, Dominic
linked information resource: Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice.

Authorship 108330
type: Authorship
author rank in publication: 2
linked author: Gessler, Dominic
linked information resource: Gene Therapy for Rare Neurological Disorders.

Authorship 108337
type: Authorship
author rank in publication: 4
linked author: Gessler, Dominic
linked information resource: Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs.

Authorship 108339
type: Authorship
author rank in publication: 1
linked author: Gessler, Dominic
linked information resource: GammaTile?: Surgically targeted radiation therapy for glioblastomas.

Authorship 108340
type: Authorship
author rank in publication: 2
linked author: Gessler, Dominic
linked information resource: Case report: cranial angiosarcoma with multiple hemorrhagic brain metastasis in a child.

Authorship 108343
type: Authorship
author rank in publication: 11
linked author: Gessler, Dominic
linked information resource: Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties.

Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.
PubMed Identifier: 28067312
author list: Ai J, Li J, Gessler DJ, Su Q, Wei Q, Li H, Gao G
published in: Scientific reports
information resource reference: Ai J, Li J, Gessler DJ, Su Q, Wei Q, Li H, Gao G. Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery. Sci Rep. 2017 01 09; 7:40336.
journal title abbreviation: Sci Rep
publication date: 2017-01-09T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

GammaTile? brachytherapy in the treatment of recurrent glioblastomas.
PubMed Identifier: 35088050
author list: Gessler DJ, Neil EC, Shah R, Levine J, Shanks J, Wilke C, Reynolds M, Zhang S, ?z?temiz C, Gencturk M, Folkertsma M, Bell WR, Chen L, Ferreira C, Dusenbery K, Chen CC
published in: Neuro-oncology advances
information resource reference: Gessler DJ, Neil EC, Shah R, Levine J, Shanks J, Wilke C, Reynolds M, Zhang S, ?z?temiz C, Gencturk M, Folkertsma M, Bell WR, Chen L, Ferreira C, Dusenbery K, Chen CC. GammaTile? brachytherapy in the treatment of recurrent glioblastomas. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdab185.
journal title abbreviation: Neurooncol Adv
publication date: 2021-12-27T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

GammaTile?: Surgically targeted radiation therapy for glioblastomas.
PubMed Identifier: 32618209
author list: Gessler DJ, Ferreira C, Dusenbery K, Chen CC
published in: Future oncology (London, England)
information resource reference: Gessler DJ, Ferreira C, Dusenbery K, Chen CC. GammaTile?: Surgically targeted radiation therapy for glioblastomas. Future Oncol. 2020 Oct; 16(30):2445-2455.
journal title abbreviation: Future Oncol
publication date: 2020-07-03T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Editorial: Myelin Repair: At the Crossing-Lines of Myelin Biology and Gene Therapy.
PubMed Identifier: 35221929
author list: Fr?hlich D, Gessler DJ, Klugmann M
published in: Frontiers in cellular neuroscience
information resource reference: Fr?hlich D, Gessler DJ, Klugmann M. Editorial: Myelin Repair: At the Crossing-Lines of Myelin Biology and Gene Therapy. Front Cell Neurosci. 2022; 16:853742.
journal title abbreviation: Front Cell Neurosci
publication date: 2022-02-11T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Efficient Transduction of Corneal Stroma by Adeno-Associated Viral Serotype Vectors for Implications in Gene Therapy of Corneal Diseases.
PubMed Identifier: 27001051
author list: Lu Y, Ai J, Gessler D, Su Q, Tran K, Zheng Q, Xu X, Gao G
published in: Human gene therapy
information resource reference: Lu Y, Ai J, Gessler D, Su Q, Tran K, Zheng Q, Xu X, Gao G. Efficient Transduction of Corneal Stroma by Adeno-Associated Viral Serotype Vectors for Implications in Gene Therapy of Corneal Diseases. Hum Gene Ther. 2016 08; 27(8):598-608.
journal title abbreviation: Hum Gene Ther
publication date: 2016-05-16T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 109086
type: Authorship
author rank in publication: 1
linked author: Gessler, Dominic
linked information resource: Editorial. Lost in translation: recognition of the "ceiling effect" as a potential barrier to the success of neuroprotective strategies in spinal cord injury.

Editorial. Lost in translation: recognition of the "ceiling effect" as a potential barrier to the success of neuroprotective strategies in spinal cord injury.
PubMed Identifier: 36401549
author list: Gessler DJ, Parr AM
published in: Journal of neurosurgery. Spine
information resource reference: Gessler DJ, Parr AM. Editorial. Lost in translation: recognition of the "ceiling effect" as a potential barrier to the success of neuroprotective strategies in spinal cord injury. J Neurosurg Spine. 2023 03 01; 38(3):297-298.
journal title abbreviation: J Neurosurg Spine
publication date: 2022-11-18T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Petersen, Christine
first name: Christine
last name: Petersen
full name: Christine L Petersen MD
has faculty rank: Assistant Professor
latitude: 42.27673450000000
longitude: -71.76198390000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 10247420
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Authorship 112575
type: Authorship
author rank in publication: 13
linked author: Gessler, Dominic
linked information resource: Renewal of oligodendrocyte lineage reverses dysmyelination and CNS neurodegeneration through corrected N-acetylaspartate metabolism.

Renewal of oligodendrocyte lineage reverses dysmyelination and CNS neurodegeneration through corrected N-acetylaspartate metabolism.
PubMed Identifier: 37149081
author list: Lotun A, Li D, Xu H, Su Q, Tuncer S, Sanmiguel J, Mooney M, Baer CE, Ulbrich R, Eyles SJ, Strittmatter L, Hayward LJ, Gessler DJ, Gao G
published in: Progress in neurobiology
information resource reference: Lotun A, Li D, Xu H, Su Q, Tuncer S, Sanmiguel J, Mooney M, Baer CE, Ulbrich R, Eyles SJ, Strittmatter L, Hayward LJ, Gessler DJ, Gao G. Renewal of oligodendrocyte lineage reverses dysmyelination and CNS neurodegeneration through corrected N-acetylaspartate metabolism. Prog Neurobiol. 2023 07; 226:102460.
journal title abbreviation: Prog Neurobiol
publication date: 2023-05-04T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Bai, Shi
first name: Shi
last name: Bai
full name: Shi Bai MD, PhD
has faculty rank: Assistant Professor
latitude: 42.27673450000000
longitude: -71.76198390000000
Person ID: 10247511
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Professor
is primary position: true
position in department: Neurological Surgery
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Authorship 114567
type: Authorship
author rank in publication: 3
linked author: Gessler, Dominic
linked information resource: Adeno-associated virus-mediated gene therapy in a patient with Canavan disease using dual routes of administration and immune modulation.

Adeno-associated virus-mediated gene therapy in a patient with Canavan disease using dual routes of administration and immune modulation.
PubMed Identifier: 37601414
author list: Corti M, Byrne BJ, Gessler DJ, Thompson G, Norman S, Lammers J, Coleman KE, Liberati C, Elder ME, Escolar ML, Tuna IS, Mesaros C, Kleiner GI, Barbouth DS, Gray-Edwards HL, Clement N, Cleaver BD, Gao G
published in: Molecular therapy. Methods & clinical development
information resource reference: Corti M, Byrne BJ, Gessler DJ, Thompson G, Norman S, Lammers J, Coleman KE, Liberati C, Elder ME, Escolar ML, Tuna IS, Mesaros C, Kleiner GI, Barbouth DS, Gray-Edwards HL, Clement N, Cleaver BD, Gao G. Adeno-associated virus-mediated gene therapy in a patient with Canavan disease using dual routes of administration and immune modulation. Mol Ther Methods Clin Dev. 2023 Sep 14; 30:303-314.
journal title abbreviation: Mol Ther Methods Clin Dev
publication date: 2023-06-19T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor
is primary position: true
position in department: Pathology
position in division: Anatomic Pathology
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Breast Imaging
type: Division
type: Organization

Assistant Professor
is primary position: true
position in department: Radiology
position in division: Breast Imaging
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Authorship 118300
type: Authorship
author rank in publication: 2
linked author: Gessler, Dominic
linked information resource: GammaTile? (GT) as a brachytherapy platform for rapidly proliferating glioblastomas: from case series to clinical trials.

GammaTile? (GT) as a brachytherapy platform for rapidly proliferating glioblastomas: from case series to clinical trials.
PubMed Identifier: 38281303
author list: Yekula A, Gessler DJ, Ferreira C, Shah R, Reynolds M, Dusenbery K, Chen CC
published in: Journal of neuro-oncology
information resource reference: Yekula A, Gessler DJ, Ferreira C, Shah R, Reynolds M, Dusenbery K, Chen CC. GammaTile? (GT) as a brachytherapy platform for rapidly proliferating glioblastomas: from case series to clinical trials. J Neurooncol. 2024 Feb; 166(3):441-450.
journal title abbreviation: J Neurooncol
publication date: 2024-01-28T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection.
PubMed Identifier: 38558570
author list: Liu H, Zhang Y, Yip M, Ren L, Liang J, Chen X, Liu N, Du A, Wang J, Chang H, Oh H, Zhou C, Xing R, Xu M, Guo P, Gessler D, Xie J, Tai PWL, Gao G, Wang D
published in: Molecular therapy. Methods & clinical development
information resource reference: Liu H, Zhang Y, Yip M, Ren L, Liang J, Chen X, Liu N, Du A, Wang J, Chang H, Oh H, Zhou C, Xing R, Xu M, Guo P, Gessler D, Xie J, Tai PWL, Gao G, Wang D. Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection. Mol Ther Methods Clin Dev. 2024 Jun 13; 32(2):101230.
journal title abbreviation: Mol Ther Methods Clin Dev
publication date: 2024-03-12T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 120217
type: Authorship
author rank in publication: 2
linked author: Gessler, Dominic
linked information resource: Adeno-associated virus as a delivery vector for gene therapy of human diseases.

Authorship 120218
type: Authorship
author rank in publication: 16
linked author: Gessler, Dominic
linked information resource: Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection.

Adeno-associated virus as a delivery vector for gene therapy of human diseases.
PubMed Identifier: 38565561
author list: Wang JH, Gessler DJ, Zhan W, Gallagher TL, Gao G
published in: Signal transduction and targeted therapy
information resource reference: Wang JH, Gessler DJ, Zhan W, Gallagher TL, Gao G. Adeno-associated virus as a delivery vector for gene therapy of human diseases. Signal Transduct Target Ther. 2024 04 03; 9(1):78.
journal title abbreviation: Signal Transduct Target Ther
publication date: 2024-04-03T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Lushina, Nadezhda
first name: Nadezhda
last name: Lushina
full name: Nadezhda Lushina MD
has faculty rank: Assistant Professor
latitude: 42.27673450000000
longitude: -71.76198390000000
Person ID: 10248152
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

https://profiles.umassmed.edu/profile/56960940
position in department: Neurological Surgery
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 2
type: Position
position in organization: T.H. Chan School of Medicine

https://profiles.umassmed.edu/profile/56960941
position in department: NeuroNexus Institute
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 3
type: Position
position in organization: T.H. Chan School of Medicine

https://profiles.umassmed.edu/profile/56960942
position in department: Interdisciplinary Graduate Program
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 4
type: Position
position in organization: Morningside Graduate School of Biomedical Sciences

https://profiles.umassmed.edu/profile/56960943
position in department: Neuroscience
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 5
type: Position
position in organization: Morningside Graduate School of Biomedical Sciences

https://profiles.umassmed.edu/profile/56960944
position in department: Translational Science
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 6
type: Position
position in organization: Morningside Graduate School of Biomedical Sciences

Assistant Professor
is primary position: true
position in department: Neurological Surgery
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Instructor
sort order: 17
type: Faculty Rank

Professor
sort order: 3
type: Faculty Rank

Assistant Professor
sort order: 13
type: Faculty Rank

Associate Professor
sort order: 10
type: Faculty Rank

Chair And Professor
sort order: 4
type: Faculty Rank

Psychiatry and Behavioral Sciences
type: Department
type: Organization

Instructor
is primary position: true
position in department: Psychiatry and Behavioral Sciences
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Instructor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Assistant Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Assistant Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Genetic and Cellular Medicine
type: Department
type: Organization

Assistant Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Cell-penetrating peptide-grafted AAV2 capsids for improved retinal delivery via intravitreal injection.
PubMed Identifier: 40027263
author list: Wang JH, Cui M, Liu H, Guo P, McGowan J, Cheng SY, Gessler DJ, Xie J, Punzo C, Tai PWL, Gao G
published in: Molecular therapy. Methods & clinical development
information resource reference: Wang JH, Cui M, Liu H, Guo P, McGowan J, Cheng SY, Gessler DJ, Xie J, Punzo C, Tai PWL, Gao G. Cell-penetrating peptide-grafted AAV2 capsids for improved retinal delivery via intravitreal injection. Mol Ther Methods Clin Dev. 2025 Mar 13; 33(1):101426.
journal title abbreviation: Mol Ther Methods Clin Dev
publication date: 2025-02-03T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 131967
type: Authorship
author rank in publication: 22
linked author: Gessler, Dominic
linked information resource: Current clinical applications of AAV-mediated gene therapy.

Authorship 132045
type: Authorship
author rank in publication: 7
linked author: Gessler, Dominic
linked information resource: Cell-penetrating peptide-grafted AAV2 capsids for improved retinal delivery via intravitreal injection.

Current clinical applications of AAV-mediated gene therapy.
PubMed Identifier: 40329530
author list: Byrne BJ, Flanigan KM, Matesanz SE, Finkel RS, Waldrop MA, D'Ambrosio ES, Johnson NE, Smith BK, B?nnemann C, Carrig S, Rossano JW, Greenberg B, Lalaguna L, Lara-Pezzi E, Subramony S, Corti M, Mercado-Rodriguez C, Leon-Astudillo C, Ahrens-Nicklas R, Bharucha-Goebel D, Gao G, Gessler DJ, Hwu WL, Chien YH, Lee NC, Boye SL, Boye SE, George LA
published in: Molecular therapy : the journal of the American Society of Gene Therapy
information resource reference: Byrne BJ, Flanigan KM, Matesanz SE, Finkel RS, Waldrop MA, D'Ambrosio ES, Johnson NE, Smith BK, B?nnemann C, Carrig S, Rossano JW, Greenberg B, Lalaguna L, Lara-Pezzi E, Subramony S, Corti M, Mercado-Rodriguez C, Leon-Astudillo C, Ahrens-Nicklas R, Bharucha-Goebel D, Gao G, Gessler DJ, Hwu WL, Chien YH, Lee NC, Boye SL, Boye SE, George LA. Current clinical applications of AAV-mediated gene therapy. Mol Ther. 2025 Jun 04; 33(6):2479-2516.
journal title abbreviation: Mol Ther
publication date: 2025-05-05T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor
is primary position: true
position in department: Radiology
position in division: Musculoskeletal
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Chair and Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Associate Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School