Yang B, Li S, Wang H, Guo Y, Gessler DJ, Cao C, Su Q, Kramer J, Zhong L, Ahmed SS, Zhang H, He R, Desrosiers RC, Brown R, Xu Z, Gao G
Molecular therapy : the journal of the American Society of Gene Therapy
Yang B, Li S, Wang H, Guo Y, Gessler DJ, Cao C, Su Q, Kramer J, Zhong L, Ahmed SS, Zhang H, He R, Desrosiers RC, Brown R, Xu Z, Gao G. Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10. Mol Ther. 2014 Jul; 22(7):1299-1309.
Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10.
Morningside Graduate School of Biomedical Sciences
Elisabeth Chair for the Dean of Medicine
Penelope Booth Rockwell Chair in Biomedical Research
Focus: Adeno-associated virus vector mediated gene transfer for gene therapy, gene therapy of inherited neurodegenerative Canavan Disease
Dr. Esteves is a neuroscientist with interest in gene therapy to help treat neurodegenerative diseases.
Methods in molecular biology (Clifton, N.J.)
Gessler DJ, Gao G. Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders. Methods Mol Biol. 2016; 1382:429-65.
Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders.
Gessler DJ, Li D, Xu H, Su Q, Sanmiguel J, Tuncer S, Moore C, King J, Matalon R, Gao G
Gessler DJ, Li D, Xu H, Su Q, Sanmiguel J, Tuncer S, Moore C, King J, Matalon R, Gao G. Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease. JCI Insight. 2017 02 09; 2(3):e90807.
Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease.
University of Massachusetts Medical School
University of Massachusetts Medical School, Gene Therapy & Neurometabolism
Focus: Virology and vectorology of adeno-associated viruses
Wang D, Li S, Gessler DJ, Xie J, Zhong L, Li J, Tran K, Van Vliet K, Ren L, Su Q, He R, Goetzmann JE, Flotte TR, Agbandje-McKenna M, Gao G
Molecular therapy. Methods & clinical development
Wang D, Li S, Gessler DJ, Xie J, Zhong L, Li J, Tran K, Van Vliet K, Ren L, Su Q, He R, Goetzmann JE, Flotte TR, Agbandje-McKenna M, Gao G. A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates. Mol Ther Methods Clin Dev. 2018 Jun 15; 9:234-246.
A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates.
We are looking for motivated postdoctoral researchers. Send in your application and get in touch today!
- AAV gene therapy for genetic diseases - Therapeutic genome editing - RNA-based approaches to treating genetic diseases - Interactions between AAV vector and host cell - AAV vector capsid engineering
Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G
Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G. Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Nat Biotechnol. 2018 10; 36(9):839-842.
Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice.
Lu Y, Tai PWL, Ai J, Gessler DJ, Su Q, Yao X, Zheng Q, Zamore PD, Xu X, Gao G
Lu Y, Tai PWL, Ai J, Gessler DJ, Su Q, Yao X, Zheng Q, Zamore PD, Xu X, Gao G. Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs. Mol Ther Nucleic Acids. 2018 Mar 02; 10:349-360.
Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs.
Gessler DJ, Tai PWL, Li J, Gao G. Intravenous Infusion of AAV for Widespread Gene Delivery to the Nervous System. Methods Mol Biol. 2019; 1950:143-163.
Intravenous Infusion of AAV for Widespread Gene Delivery to the Nervous System.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Lee V, Gessler D, Cataltepe O. Case report: cranial angiosarcoma with multiple hemorrhagic brain metastasis in a child. Childs Nerv Syst. 2020 09; 36(9):2103-2107.
Case report: cranial angiosarcoma with multiple hemorrhagic brain metastasis in a child.
Hsu HL, Brown A, Loveland AB, Lotun A, Xu M, Luo L, Xu G, Li J, Ren L, Su Q, Gessler DJ, Wei Y, Tai PWL, Korostelev AA, Gao G
Hsu HL, Brown A, Loveland AB, Lotun A, Xu M, Luo L, Xu G, Li J, Ren L, Su Q, Gessler DJ, Wei Y, Tai PWL, Korostelev AA, Gao G. Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties. Nat Commun. 2020 06 30; 11(1):3279.
Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties.
Lotun A, Gessler DJ, Gao G. Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair. Front Cell Neurosci. 2021; 15:661928.
Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair.
Flotte TR, Gessler DJ. Gene Therapy for Rare Neurological Disorders. Clin Pharmacol Ther. 2022 04; 111(4):743-757.
Gene Therapy for Rare Neurological Disorders.
Ai J, Li J, Gessler DJ, Su Q, Wei Q, Li H, Gao G
Ai J, Li J, Gessler DJ, Su Q, Wei Q, Li H, Gao G. Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery. Sci Rep. 2017 01 09; 7:40336.
Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.
Gessler DJ, Neil EC, Shah R, Levine J, Shanks J, Wilke C, Reynolds M, Zhang S, ?z?temiz C, Gencturk M, Folkertsma M, Bell WR, Chen L, Ferreira C, Dusenbery K, Chen CC
Gessler DJ, Neil EC, Shah R, Levine J, Shanks J, Wilke C, Reynolds M, Zhang S, ?z?temiz C, Gencturk M, Folkertsma M, Bell WR, Chen L, Ferreira C, Dusenbery K, Chen CC. GammaTile? brachytherapy in the treatment of recurrent glioblastomas. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdab185.
GammaTile? brachytherapy in the treatment of recurrent glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Gessler DJ, Ferreira C, Dusenbery K, Chen CC. GammaTile?: Surgically targeted radiation therapy for glioblastomas. Future Oncol. 2020 Oct; 16(30):2445-2455.
GammaTile?: Surgically targeted radiation therapy for glioblastomas.
Fr?hlich D, Gessler DJ, Klugmann M. Editorial: Myelin Repair: At the Crossing-Lines of Myelin Biology and Gene Therapy. Front Cell Neurosci. 2022; 16:853742.
Editorial: Myelin Repair: At the Crossing-Lines of Myelin Biology and Gene Therapy.
Lu Y, Ai J, Gessler D, Su Q, Tran K, Zheng Q, Xu X, Gao G
Lu Y, Ai J, Gessler D, Su Q, Tran K, Zheng Q, Xu X, Gao G. Efficient Transduction of Corneal Stroma by Adeno-Associated Viral Serotype Vectors for Implications in Gene Therapy of Corneal Diseases. Hum Gene Ther. 2016 08; 27(8):598-608.
Efficient Transduction of Corneal Stroma by Adeno-Associated Viral Serotype Vectors for Implications in Gene Therapy of Corneal Diseases.
Gessler DJ, Parr AM. Editorial. Lost in translation: recognition of the "ceiling effect" as a potential barrier to the success of neuroprotective strategies in spinal cord injury. J Neurosurg Spine. 2023 03 01; 38(3):297-298.
Editorial. Lost in translation: recognition of the "ceiling effect" as a potential barrier to the success of neuroprotective strategies in spinal cord injury.
Lotun A, Li D, Xu H, Su Q, Tuncer S, Sanmiguel J, Mooney M, Baer CE, Ulbrich R, Eyles SJ, Strittmatter L, Hayward LJ, Gessler DJ, Gao G
Lotun A, Li D, Xu H, Su Q, Tuncer S, Sanmiguel J, Mooney M, Baer CE, Ulbrich R, Eyles SJ, Strittmatter L, Hayward LJ, Gessler DJ, Gao G. Renewal of oligodendrocyte lineage reverses dysmyelination and CNS neurodegeneration through corrected N-acetylaspartate metabolism. Prog Neurobiol. 2023 07; 226:102460.
Renewal of oligodendrocyte lineage reverses dysmyelination and CNS neurodegeneration through corrected N-acetylaspartate metabolism.
Corti M, Byrne BJ, Gessler DJ, Thompson G, Norman S, Lammers J, Coleman KE, Liberati C, Elder ME, Escolar ML, Tuna IS, Mesaros C, Kleiner GI, Barbouth DS, Gray-Edwards HL, Clement N, Cleaver BD, Gao G
Corti M, Byrne BJ, Gessler DJ, Thompson G, Norman S, Lammers J, Coleman KE, Liberati C, Elder ME, Escolar ML, Tuna IS, Mesaros C, Kleiner GI, Barbouth DS, Gray-Edwards HL, Clement N, Cleaver BD, Gao G. Adeno-associated virus-mediated gene therapy in a patient with Canavan disease using dual routes of administration and immune modulation. Mol Ther Methods Clin Dev. 2023 Sep 14; 30:303-314.
Adeno-associated virus-mediated gene therapy in a patient with Canavan disease using dual routes of administration and immune modulation.
Yekula A, Gessler DJ, Ferreira C, Shah R, Reynolds M, Dusenbery K, Chen CC
Yekula A, Gessler DJ, Ferreira C, Shah R, Reynolds M, Dusenbery K, Chen CC. GammaTile? (GT) as a brachytherapy platform for rapidly proliferating glioblastomas: from case series to clinical trials. J Neurooncol. 2024 Feb; 166(3):441-450.
GammaTile? (GT) as a brachytherapy platform for rapidly proliferating glioblastomas: from case series to clinical trials.
Liu H, Zhang Y, Yip M, Ren L, Liang J, Chen X, Liu N, Du A, Wang J, Chang H, Oh H, Zhou C, Xing R, Xu M, Guo P, Gessler D, Xie J, Tai PWL, Gao G, Wang D
Liu H, Zhang Y, Yip M, Ren L, Liang J, Chen X, Liu N, Du A, Wang J, Chang H, Oh H, Zhou C, Xing R, Xu M, Guo P, Gessler D, Xie J, Tai PWL, Gao G, Wang D. Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection. Mol Ther Methods Clin Dev. 2024 Jun 13; 32(2):101230.
Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection.
Wang JH, Gessler DJ, Zhan W, Gallagher TL, Gao G
Signal transduction and targeted therapy
Wang JH, Gessler DJ, Zhan W, Gallagher TL, Gao G. Adeno-associated virus as a delivery vector for gene therapy of human diseases. Signal Transduct Target Ther. 2024 04 03; 9(1):78.
Adeno-associated virus as a delivery vector for gene therapy of human diseases.
Wang JH, Cui M, Liu H, Guo P, McGowan J, Cheng SY, Gessler DJ, Xie J, Punzo C, Tai PWL, Gao G
Wang JH, Cui M, Liu H, Guo P, McGowan J, Cheng SY, Gessler DJ, Xie J, Punzo C, Tai PWL, Gao G. Cell-penetrating peptide-grafted AAV2 capsids for improved retinal delivery via intravitreal injection. Mol Ther Methods Clin Dev. 2025 Mar 13; 33(1):101426.
Cell-penetrating peptide-grafted AAV2 capsids for improved retinal delivery via intravitreal injection.
Byrne BJ, Flanigan KM, Matesanz SE, Finkel RS, Waldrop MA, D'Ambrosio ES, Johnson NE, Smith BK, B?nnemann C, Carrig S, Rossano JW, Greenberg B, Lalaguna L, Lara-Pezzi E, Subramony S, Corti M, Mercado-Rodriguez C, Leon-Astudillo C, Ahrens-Nicklas R, Bharucha-Goebel D, Gao G, Gessler DJ, Hwu WL, Chien YH, Lee NC, Boye SL, Boye SE, George LA
Byrne BJ, Flanigan KM, Matesanz SE, Finkel RS, Waldrop MA, D'Ambrosio ES, Johnson NE, Smith BK, B?nnemann C, Carrig S, Rossano JW, Greenberg B, Lalaguna L, Lara-Pezzi E, Subramony S, Corti M, Mercado-Rodriguez C, Leon-Astudillo C, Ahrens-Nicklas R, Bharucha-Goebel D, Gao G, Gessler DJ, Hwu WL, Chien YH, Lee NC, Boye SL, Boye SE, George LA. Current clinical applications of AAV-mediated gene therapy. Mol Ther. 2025 Jun 04; 33(6):2479-2516.
Current clinical applications of AAV-mediated gene therapy.