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Weng, Zhiping
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Mao, Junhao
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Latz, Eicke
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Zierath, Juleen
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Post Docs: POSTDOCTORAL POSITION: RNAI PRECLINICAL DEVELOPMENT Excellent training opportunity for a person considering industrial carrier in drug development Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several classes of oligonucleotides which can efficiently silence genes in various tissues with acceptable level of toxicity. There are also new chemistries being developed to further improve oligonucleotide tissue distribution and cellular uptake. The successful candidate will be a key part of an intra-disciplinary team working with biologists and chemists to develop novel types of therapeutics for treatment of neurological disease, liver disease and orphan indications. The work will include compounds identification, screening, characterization, in vivo efficacy and PK/PD studies, novel assays development etc. In addition exposure and training in nucleic acid pre-clinical development, project management etc will be provided. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular cell biology or pharmacology.
Post Docs: RNAI MEDICINAL CHEMISTRY/ RNA OLIGONUCLEOTIDE CHEMISTRY Develop and characterize novel RNA chemistries to promote efficient oligonucleotide internalization and tissue distribution. Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several chemistries and formulations developed by us and others that effectively support oligo internalization and favorable PK/PD. In most cases in vivo efficacy is limited by (1) poor PK (2) inefficient tissue distribution (3) compound entrapment in biologically inactive intracellular compartments. The objective of future studies will be development of novel chemistries, which promote receptor mediated cellular internalization and/ or endosomal escape. The successful candidate will be responsible for the design and synthesis of novel RNA precursors, optimization of RNA synthesis and conjugation protocols and interface with the biology part of the lab. In addition, exposure to pre-clinical development programs and oligonucleotide manufacturing will be available. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and have previous experience in nucleic acid / oligonucleotide chemistry.
Post Docs: SMALL RNA TRAFFICKING Discover, characterize and adapt mechanisms of small RNA extracellular and intracellular trafficking for development of novel classes of oligonucleotide drugs. A serious limitation in realizing the potential of oligonucleotide based therapies has been the exceedingly inefficient transit of oligonucleotides from outside cells to the intracellular compartments where the biologically relevant activity happens. On the other hand, there are multiple lines of evidence supporting the notion that nature has implemented evolutionarily conserved mechanisms and pathways for efficiently trafficking small RNAs across cellular boundaries. The objective of future studies will be the systematic evaluation of mechanisms of cellular uptake of different classes of oligonucleotides and their comparison to mechanisms of native RNA trafficking using a combination of experimental approaches, including advanced RNA chemistry and high temporal and spatial resolution microscopy in living cells, Mass spectrometry, cell biology and others. The successful candidate will work closely with Victor Ambros and Silvia Corvera labs and the UMASS imaging group and receive training in RNA chemistry, biochemistry, cell biology and pre-clinical development. QUALIFICATIONS:Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular and cell biology
Rotation Projects: Our laboratory uses a combination of nucleic acid and oligonucleotide chemistry, biochemistry, cell biology, and pharmacology and develops and evaluate novel technologies for development of oligonucleotide therapeutics. A rotation project is available to develop and identify chemically modified self-delivering RNAi compounds for treatment of Huntington and other diseases.
preferred title: Professor

Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
has faculty rank: ADJUNCT PROFESSOR
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Epstein, Mara
first name: Mara
last name: Epstein
full name: Mara Meyer Epstein ScD, ScM
has faculty rank: Associate Professor
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person in primary position: Associate Professor
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Fisher, Marc
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full name: Marc Fisher MD
has faculty rank: Professor
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Person ID: 350
person in primary position: Professor
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preferred title: Professor

Szabo, Gyongyi
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last name: Szabo
full name: Gyongyi Szabo MD, PhD
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person in primary position: Adjunct Professor
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Jerry, D Joseph
first name: D Joseph
last name: Jerry
full name: D Joseph Jerry BS, MS, PhD
has faculty rank: Professor
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person in primary position: Professor
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Lian, Jane
first name: Jane
last name: Lian
full name: Jane B Lian PhD
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Bertone-Johnson, Elizabeth
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last name: Bertone-Johnson
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person in primary position: Associate Professor
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preferred title: Associate Professor

Arcaro, Kathleen
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person in primary position: Associate Professor
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preferred title: Associate Professor

Xiao, Hang
first name: Hang
last name: Xiao
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Person ID: 3795
person in primary position: Associate Professor
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preferred title: Associate Professor

Reeves, Katherine
first name: Katherine
last name: Reeves
full name: Katherine W Reeves PhD, MPH
has faculty rank: Assistant Professor
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Person ID: 3799
person in primary position: Assistant Professor
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preferred title: Assistant Professor

Rogaev, Evgeny
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last name: Rogaev
full name: Evgeny I Rogaev PhD
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Person ID: 39
person in primary position: Professor
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.
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Zamore, Phillip
first name: Phillip
last name: Zamore
full name: Phillip D Zamore PhD
has faculty rank: Chair And Professor
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Person ID: 418
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
webpage: https://profiles.umassmed.edu/profile/28866537
webpage: https://profiles.umassmed.edu/profile/28866541

Luckmann, Roger
first name: Roger
last name: Luckmann
full name: Roger S Luckmann MD, MPH
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latitude: 42.27525000000000
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Person ID: 431
person in primary position: Professor Emeritus
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preferred title: Professor Emeritus

Crawford, Sybil
first name: Sybil
last name: Crawford
full name: Sybil L Crawford PhD
has faculty rank: Professor
latitude: 42.27406470000000
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Person ID: 465
person in primary position: Professor
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preferred title: Professor

Aronin, Neil
first name: Neil
last name: Aronin
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latitude: 42.27587600000000
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Person ID: 490
person in primary position: Professor
type: Agent
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Endowed Chair Honorary Title: Higgins Family Professor in Neuroscience
Rotation Projects: Potential Rotation Projects Project #1: Molecular Mechanisms in the Pathogenesis of Neurodegenerative Disease. The student can select projects emphasizing either molecular mechanisms of huntingtin in trafficking in neurons or receptor stimulated effects on gene expression in neurons. Techniques include: Generation of fusion proteins, raising antisera Preparation of organelles Immunocytochemistry, light microscopy and electron microscopy Immunoprecipitation methods PCR Protein separation techniques, gel electrophoresis, immunoblotting Autoradiography
preferred title: Professor

Richter, Joel
first name: Joel
last name: Richter
Featured Videos: https://profiles.umassmed.edu/profile/28867186
full name: Joel Richter PhD
has faculty rank: Professor
latitude: 42.27913100000000
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Person ID: 554
person in primary position: Professor
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Endowed Chair Honorary Title: Arthur F. Koskinas Chair in Neuroscience
Rotation Projects: Many rotation projects are available so please inquire.
preferred title: Professor

Karellas, Andrew
first name: Andrew
last name: Karellas
full name: Andrew Karellas PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27767280000000
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Person ID: 665
person in primary position: Adjunct Professor
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Vedantham, Srinivasan
first name: Srinivasan
last name: Vedantham
full name: Srinivasan Vedantham PhD
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latitude: 42.27525000000000
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Person ID: 672
person in primary position: Adjunct Associate Professor
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Lemon, Stephenie
first name: Stephenie
last name: Lemon
full name: Stephenie C Lemon PhD
has faculty rank: Professor
latitude: 42.27767280000000
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Person ID: 689
person in primary position: Professor
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Endowed Chair Honorary Title: Barbara Helen Smith Chair in Preventive & Behavioral Medicine
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866492

Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
has faculty rank: Professor Emeritus
latitude: 42.27525000000000
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Person ID: 78
person in primary position: Professor Emeritus
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preferred title: Professor Emeritus

Vijayaraghavan, Gopal
first name: Gopal
last name: Vijayaraghavan
full name: Gopal R Vijayaraghavan MD, MPH
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 864
person in primary position: Professor
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preferred title: Professor

Shaw, Leslie
first name: Leslie
last name: Shaw
full name: Leslie M Shaw PhD
has faculty rank: Professor
latitude: 42.27985300000000
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Person ID: 900
person in primary position: Professor
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webpage: https://profiles.umassmed.edu/profile/28866558

Mercurio, Arthur
first name: Arthur
last name: Mercurio
full name: Arthur M Mercurio PhD
has faculty rank: Professor
latitude: 42.27985300000000
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Person ID: 901
person in primary position: Professor
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Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
preferred title: Professor

McManus, David
first name: David
last name: McManus
full name: David D McManus MD
has faculty rank: Chair And Professor
latitude: 42.27525000000000
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Person ID: 994
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
preferred title: Chair and Professor

Almeida, Sandra Cristina
first name: Sandra Cristina
last name: Almeida
full name: Sandra Cristina Vicente Almeida PhD
has faculty rank: Assistant Professor
latitude: 42.27658300000000
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Person ID: 4198
person in primary position: Assistant Professor
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Summary: Dr. Almeida focuses on uncovering the molecular mechanisms underlying frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD). Her research leverages patient-derived induced pluripotent stem cell (iPSC) lines to create neuronal models that closely mimic disease conditions.
preferred title: Assistant Professor

Friedmann, Peter
first name: Peter
last name: Friedmann
full name: Peter D Friedmann MD, MPH, DFASAM, FACP
has faculty rank: Professor
latitude: 42.10873680000000
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Person ID: 4333
person in primary position: Professor
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preferred title: Professor

UMass Chan – Baystate Regional Campus
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Haynes, Cole
first name: Cole
last name: Haynes
full name: Cole Michael Haynes PhD
has faculty rank: Professor
latitude: 42.27491030000000
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Person ID: 4422
person in primary position: Professor
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preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866621
webpage: https://profiles.umassmed.edu/profile/28866481

Crisi, Giovanna
first name: Giovanna
last name: Crisi
full name: Giovanna M Crisi MD, PhD
has faculty rank: Associate Professor
latitude: 42.12294230000000
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Person ID: 4597
person in primary position: Associate Professor
type: Agent
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preferred title: Associate Professor

Professor
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position in department: College of Natural Sciences
position in division: Veterinary & Animal Sciences; Pioneer Valley Life
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position in organization: University of Massachusetts Amherst

Associate Professor
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position in department: College of Natural Sciences
position in division: Food Science
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Assistant Professor
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Associate Professor
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Associate Professor
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Lindenauer, Peter
first name: Peter
last name: Lindenauer
full name: Peter K Lindenauer MD, MSc
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latitude: 42.12711190000000
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Person ID: 4845
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ADJUNCT ASSOCIATE PROFESSOR
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ADJUNCT PROFESSOR
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Usmani, Saad
first name: Saad
last name: Usmani
full name: Saad Usmani MD
has faculty rank: Instructor
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Population and Quantitative Health Sciences
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van Zundert, Brigitte
first name: Brigitte
last name: van Zundert
full name: Brigitte van Zundert PhD
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person in primary position: Adjunct Professor
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Casaubon, Jesse
first name: Jesse
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full name: Jesse Casaubon DO
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person in primary position: Assistant Professor
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Raza, Sughra
first name: Sughra
last name: Raza
full name: Sughra Raza MD
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Person ID: 10246810
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Summary: Editor in Chief - Journal of Global Radiology
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webpage: https://profiles.umassmed.edu/profile/33396583

Mehta, Tejas
first name: Tejas
last name: Mehta
full name: Tejas S Mehta MD, MPH
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https://profiles.umassmed.edu/profile/28866427
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https://profiles.umassmed.edu/profile/28866429
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https://profiles.umassmed.edu/profile/28866481
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https://profiles.umassmed.edu/profile/28866492
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https://profiles.umassmed.edu/profile/28866493
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https://profiles.umassmed.edu/profile/28866537
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https://profiles.umassmed.edu/profile/28866541
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Pathology at UMass Chan - Baystate
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Surgery at UMass Chan - Baystate
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Adjunct Professor
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Adjunct Professor
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Adjunct Associate Professor
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Adjunct Professor
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Instructor
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Associate Professor
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Professor
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Professor
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Professor Emeritus
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Assistant Professor
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Adjunct Professor
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Professor
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Professor
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https://profiles.umassmed.edu/profile/33396583
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Professor
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Professor
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Chair and Professor
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Beesen, Ayshe
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person in primary position: Adjunct Professor
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type: Person
preferred title: Adjunct Professor

Associate Professor
is primary position: true
position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School