Lai, Rocky
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research areas: Mycobacterium tuberculosis
research areas: Tuberculosis, Pulmonary
research areas: Lung
research areas: Macrophages, Alveolar
research areas: Tuberculosis Vaccines
mailing address: Worcester MA 01655
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Macrophages, Alveolar
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number of authors: 27
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Swain, Susan
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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
preferred title: Professor

Behar, Samuel
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Rotation Projects: LAB ROTATION PROJECTS AVAILABLE -- PLEASE CONTACT SAM BEHAR FOR MORE INFORMATION
Summary: Focus: We seek to understand how the causative agent of tuberculosis, namely the bacterium Mycobacterium tuberculosis evades host immunity, and how different components of the immune response work together to contain infection. Our ultimate goal is to inform vaccine development and the design of host directed therapy.
preferred title: Professor

Baker, Richard
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Sassetti, Christopher
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Person ID: 878
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Endowed Chair Honorary Title: Elisabeth Chair II
Lab URL: https://www.umassmed.edu/sassettilab/
Rotation Projects: Rotation Projects <p >We have identified a number of bacterial pathways that are required for bacterial viability or virulence. We are particularly interested in: Phosphosignaling systems that regulate cell wall synthesis Metabolic regulatory mechanisms that trigger the “dormancy” response observed during infection. <p >A variety of genetic, biochemical, and informatic methods will be used to define the functions of these genes and the role played by each during infection. <p >
Summary: Focus: Pathogenesis of tuberculosis
preferred title: Professor

Irazoqui, Javier
first name: Javier
last name: Irazoqui
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full name: Javier Elbio Irazoqui PhD
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Endowed Chair Honorary Title: Marcellette G. Williams Scholar
Lab URL: https://www.umassmed.edu/lci/
Post Docs: Swarupa Mallick, PhD
Rotation Projects: Pathogen genetics of the host immune response
Rotation Projects: How the cholinergic nervous system communicates peroxisomal stress to the whole organism during bacteria infection
Rotation Projects: Role and regulation of novel innate immune effectors that are conserved across animalia
Summary: Focus: Microbiota-gut-brain axis in C. elegans; mucosal innate immunity; staphylococcus aureus; transcriptional regulation of host defense; autophagy; lysosomes; peroxisomes
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/37757225

Bucci, Vanni
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Summary: Focus: Host-microbiome interaction, computational biology, synthetic biology
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Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice.
PubMed Identifier: 31636345
author list: Patankar YR, Sutiwisesak R, Boyce S, Lai R, Lindestam Arlehamn CS, Sette A, Behar SM
published in: Mucosal immunology
information resource reference: Patankar YR, Sutiwisesak R, Boyce S, Lai R, Lindestam Arlehamn CS, Sette A, Behar SM. Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice. Mucosal Immunol. 2020 01; 13(1):140-148.
journal title abbreviation: Mucosal Immunol
publication date: 2019-10-21T00:00:00
year: 2019
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Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice.
PubMed Identifier: 31772048
author list: Smith CM, Proulx MK, Lai R, Kiritsy MC, Bell TA, Hock P, Pardo-Manuel de Villena F, Ferris MT, Baker RE, Behar SM, Sassetti CM
published in: mBio
information resource reference: Smith CM, Proulx MK, Lai R, Kiritsy MC, Bell TA, Hock P, Pardo-Manuel de Villena F, Ferris MT, Baker RE, Behar SM, Sassetti CM. Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice. mBio. 2019 11 26; 10(6).
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Lu, Ping
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Summary: Focus: Study the physiology and pathophysiology of smooth muscle with state-of-art technology ranging from molecular biology, gene editing, calcium imaging, organ culture, and transgenic animal model.
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Mortzfeld, Benedikt
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Diaz Salinas, Marco Aurelio
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Host genetic background is a barrier to broadly effective vaccine-mediated protection against tuberculosis.
PubMed Identifier: 37200108
author list: Lai R, Gong DN, Williams T, Ogunsola AF, Cavallo K, Lindestam Arlehamn CS, Acolatse S, Beamer GL, Ferris MT, Sassetti CM, Lauffenburger DA, Behar SM
published in: The Journal of clinical investigation
information resource reference: Lai R, Gong DN, Williams T, Ogunsola AF, Cavallo K, Lindestam Arlehamn CS, Acolatse S, Beamer GL, Ferris MT, Sassetti CM, Lauffenburger DA, Behar SM. Host genetic background is a barrier to broadly effective vaccine-mediated protection against tuberculosis. J Clin Invest. 2023 07 03; 133(13).
journal title abbreviation: J Clin Invest
publication date: 2023-07-03T00:00:00
year: 2023
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Worcester MA 01655
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linked information resource: Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine.

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linked author: Lai, Rocky
linked information resource: Role of B Cells in Mucosal Vaccine-Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis.

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linked author: Lai, Rocky
linked information resource: Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice.

Authorship 112693
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linked author: Lai, Rocky
linked information resource: Age at Mycobacterium bovis BCG Priming Has Limited Impact on Anti-Tuberculosis Immunity Boosted by Respiratory Mucosal AdHu5Ag85A Immunization in a Murine Model.

Authorship 112694
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linked information resource: CD11b+ Dendritic Cell-Mediated Anti-Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103+ Dendritic Cells via IL-10.

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linked author: Lai, Rocky
linked information resource: Mucosal immunity and novel tuberculosis vaccine strategies: route of immunisation-determined T-cell homing to restricted lung mucosal compartments.

Authorship 112696
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linked author: Lai, Rocky
linked information resource: Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice.

Authorship 112697
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linked author: Lai, Rocky
linked information resource: Single-Dose Mucosal Immunotherapy With Chimpanzee Adenovirus-Based Vaccine Accelerates Tuberculosis Disease Control and Limits Its Rebound After Antibiotic Cessation.

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linked information resource: Airway Macrophages Mediate Mucosal Vaccine-Induced Trained Innate Immunity against Mycobacterium tuberculosis in Early Stages of Infection.

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linked information resource: Host genetic background is a barrier to broadly effective vaccine-mediated protection against tuberculosis.

Authorship 112700
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linked author: Lai, Rocky
linked information resource: CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine-Induced T Cells to Both the Lung Parenchyma and Airway.

Airway Macrophages Mediate Mucosal Vaccine-Induced Trained Innate Immunity against Mycobacterium tuberculosis in Early Stages of Infection.
PubMed Identifier: 32998983
author list: D'Agostino MR, Lai R, Afkhami S, Khera A, Yao Y, Vaseghi-Shanjani M, Zganiacz A, Jeyanathan M, Xing Z
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: D'Agostino MR, Lai R, Afkhami S, Khera A, Yao Y, Vaseghi-Shanjani M, Zganiacz A, Jeyanathan M, Xing Z. Airway Macrophages Mediate Mucosal Vaccine-Induced Trained Innate Immunity against Mycobacterium tuberculosis in Early Stages of Infection. J Immunol. 2020 11 15; 205(10):2750-2762.
journal title abbreviation: J Immunol
publication date: 2020-09-30T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine-Induced T Cells to Both the Lung Parenchyma and Airway.
PubMed Identifier: 28827285
author list: Jeyanathan M, Afkhami S, Khera A, Mandur T, Damjanovic D, Yao Y, Lai R, Haddadi S, Dvorkin-Gheva A, Jordana M, Kunkel SL, Xing Z
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Jeyanathan M, Afkhami S, Khera A, Mandur T, Damjanovic D, Yao Y, Lai R, Haddadi S, Dvorkin-Gheva A, Jordana M, Kunkel SL, Xing Z. CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine-Induced T Cells to Both the Lung Parenchyma and Airway. J Immunol. 2017 10 01; 199(7):2555-2569.
journal title abbreviation: J Immunol
publication date: 2017-08-21T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Age at Mycobacterium bovis BCG Priming Has Limited Impact on Anti-Tuberculosis Immunity Boosted by Respiratory Mucosal AdHu5Ag85A Immunization in a Murine Model.
PubMed Identifier: 26098423
author list: Damjanovic D, Khera A, Afkhami S, Lai R, Zganiacz A, Jeyanathan M, Xing Z
published in: PloS one
information resource reference: Damjanovic D, Khera A, Afkhami S, Lai R, Zganiacz A, Jeyanathan M, Xing Z. Age at Mycobacterium bovis BCG Priming Has Limited Impact on Anti-Tuberculosis Immunity Boosted by Respiratory Mucosal AdHu5Ag85A Immunization in a Murine Model. PLoS One. 2015; 10(6):e0131175.
journal title abbreviation: PLoS One
publication date: 2015-06-22T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of B Cells in Mucosal Vaccine-Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis.
PubMed Identifier: 26268652
author list: Khera AK, Afkhami S, Lai R, Jeyanathan M, Zganiacz A, Mandur T, Hammill J, Damjanovic D, Xing Z
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Khera AK, Afkhami S, Lai R, Jeyanathan M, Zganiacz A, Mandur T, Hammill J, Damjanovic D, Xing Z. Role of B Cells in Mucosal Vaccine-Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis. J Immunol. 2015 Sep 15; 195(6):2900-7.
journal title abbreviation: J Immunol
publication date: 2015-08-12T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Mucosal immunity and novel tuberculosis vaccine strategies: route of immunisation-determined T-cell homing to restricted lung mucosal compartments.
PubMed Identifier: 26028646
author list: Lai R, Afkhami S, Haddadi S, Jeyanathan M, Xing Z
published in: European respiratory review : an official journal of the European Respiratory Society
information resource reference: Lai R, Afkhami S, Haddadi S, Jeyanathan M, Xing Z. Mucosal immunity and novel tuberculosis vaccine strategies: route of immunisation-determined T-cell homing to restricted lung mucosal compartments. Eur Respir Rev. 2015 Jun; 24(136):356-60.
journal title abbreviation: Eur Respir Rev
publication date: 2015-06-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine.
PubMed Identifier: 28531291
author list: Yao Y, Lai R, Afkhami S, Haddadi S, Zganiacz A, Vahedi F, Ashkar AA, Kaushic C, Jeyanathan M, Xing Z
published in: The Journal of infectious diseases
information resource reference: Yao Y, Lai R, Afkhami S, Haddadi S, Zganiacz A, Vahedi F, Ashkar AA, Kaushic C, Jeyanathan M, Xing Z. Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine. J Infect Dis. 2017 07 01; 216(1):135-145.
journal title abbreviation: J Infect Dis
publication date: 2017-07-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Single-Dose Mucosal Immunotherapy With Chimpanzee Adenovirus-Based Vaccine Accelerates Tuberculosis Disease Control and Limits Its Rebound After Antibiotic Cessation.
PubMed Identifier: 31198944
author list: Afkhami S, Lai R, D'agostino MR, Vaseghi-Shanjani M, Zganiacz A, Yao Y, Jeyanathan M, Xing Z
published in: The Journal of infectious diseases
information resource reference: Afkhami S, Lai R, D'agostino MR, Vaseghi-Shanjani M, Zganiacz A, Yao Y, Jeyanathan M, Xing Z. Single-Dose Mucosal Immunotherapy With Chimpanzee Adenovirus-Based Vaccine Accelerates Tuberculosis Disease Control and Limits Its Rebound After Antibiotic Cessation. J Infect Dis. 2019 09 13; 220(8):1355-1366.
journal title abbreviation: J Infect Dis
publication date: 2019-09-13T00:00:00
year: 2019
type: Academic Article
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CD11b+ Dendritic Cell-Mediated Anti-Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103+ Dendritic Cells via IL-10.
PubMed Identifier: 29374077
author list: Lai R, Jeyanathan M, Afkhami S, Zganiacz A, Hammill JA, Yao Y, Kaushic C, Xing Z
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Lai R, Jeyanathan M, Afkhami S, Zganiacz A, Hammill JA, Yao Y, Kaushic C, Xing Z. CD11b+ Dendritic Cell-Mediated Anti-Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103+ Dendritic Cells via IL-10. J Immunol. 2018 03 01; 200(5):1746-1760.
journal title abbreviation: J Immunol
publication date: 2018-01-26T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

https://profiles.umassmed.edu/profile/37757225
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label: https://www.umassmed.edu/lci
link anchor text: Laboratory of Comparative Immunology

Authorship 115602
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author rank in publication: 1
linked author: Lai, Rocky
linked information resource: Key advances in vaccine development for tuberculosis-success and challenges.

Authorship 115637
type: Authorship
author rank in publication: 6
linked author: Lai, Rocky
linked information resource: Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice.

Key advances in vaccine development for tuberculosis-success and challenges.
PubMed Identifier: 37828070
author list: Lai R, Ogunsola AF, Rakib T, Behar SM
published in: NPJ vaccines
information resource reference: Lai R, Ogunsola AF, Rakib T, Behar SM. Key advances in vaccine development for tuberculosis-success and challenges. NPJ Vaccines. 2023 Oct 13; 8(1):158.
journal title abbreviation: NPJ Vaccines
publication date: 2023-10-13T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice.
PubMed Identifier: 36823425
author list: Afkhami S, D'Agostino MR, Vaseghi-Shanjani M, Lepard M, Yang JX, Lai R, Choi MWY, Chacon A, Zganiacz A, Franken KLMC, Ertl HC, Ottenhoff THM, Jeyanathan M, Gillgrass A, Xing Z
published in: NPJ vaccines
information resource reference: Afkhami S, D'Agostino MR, Vaseghi-Shanjani M, Lepard M, Yang JX, Lai R, Choi MWY, Chacon A, Zganiacz A, Franken KLMC, Ertl HC, Ottenhoff THM, Jeyanathan M, Gillgrass A, Xing Z. Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice. NPJ Vaccines. 2023 Feb 23; 8(1):25.
journal title abbreviation: NPJ Vaccines
publication date: 2023-02-23T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 117431
type: Authorship
author rank in publication: 1
linked author: Lai, Rocky
linked information resource: Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is determined by T cells.

Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is determined by T cells.
PubMed Identifier: 38076803
author list: Lai R, Williams T, Rakib T, Lee J, Behar SM
published in: bioRxiv : the preprint server for biology
information resource reference: Lai R, Williams T, Rakib T, Lee J, Behar SM. Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is determined by T cells. bioRxiv. 2023 Dec 01.
journal title abbreviation: bioRxiv
publication date: 2023-12-01T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Basic Pathology
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Pulmonary Medicine
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Professor
is primary position: true
position in department: Medicine
position in division: Pulmonary Medicine
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Pathology
position in division: Basic Pathology
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Martinez, Fernando
first name: Fernando
last name: Martinez
full name: Fernando J Martinez MD, MS
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 10247895
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
preferred title: Professor

Professor
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position in department: Medicine
position in division: Pulmonary Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Authorship 122698
type: Authorship
author rank in publication: 3
linked author: Lai, Rocky
linked information resource: Understanding delayed T-cell priming, lung recruitment, and airway luminal T-cell responses in host defense against pulmonary tuberculosis.

Authorship 122699
type: Authorship
author rank in publication: 7
linked author: Lai, Rocky
linked information resource: Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.

Authorship 122749
type: Authorship
author rank in publication: 1
linked author: Lai, Rocky
linked information resource: Restoration of innate immune activation accelerates Th1-cell priming and protection following pulmonary mycobacterial infection.

Authorship 122762
type: Authorship
author rank in publication: 1
linked author: Lai, Rocky
linked information resource: Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is modulated by T cells.

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.
PubMed Identifier: 30433869
author list: Yao Y, Jeyanathan M, Haddadi S, Barra NG, Vaseghi-Shanjani M, Damjanovic D, Lai R, Afkhami S, Chen Y, Dvorkin-Gheva A, Robbins CS, Schertzer JD, Xing Z
published in: Cell
information resource reference: Yao Y, Jeyanathan M, Haddadi S, Barra NG, Vaseghi-Shanjani M, Damjanovic D, Lai R, Afkhami S, Chen Y, Dvorkin-Gheva A, Robbins CS, Schertzer JD, Xing Z. Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity. Cell. 2018 11 29; 175(6):1634-1650.e17.
journal title abbreviation: Cell
publication date: 2018-10-25T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is modulated by T cells.
PubMed Identifier: 38977711
author list: Lai R, Williams T, Rakib T, Lee J, Behar SM
published in: Nature communications
information resource reference: Lai R, Williams T, Rakib T, Lee J, Behar SM. Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is modulated by T cells. Nat Commun. 2024 Jul 08; 15(1):5710.
journal title abbreviation: Nat Commun
publication date: 2024-07-08T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Understanding delayed T-cell priming, lung recruitment, and airway luminal T-cell responses in host defense against pulmonary tuberculosis.
PubMed Identifier: 22545059
author list: Shaler CR, Horvath C, Lai R, Xing Z
published in: Clinical & developmental immunology
information resource reference: Shaler CR, Horvath C, Lai R, Xing Z. Understanding delayed T-cell priming, lung recruitment, and airway luminal T-cell responses in host defense against pulmonary tuberculosis. Clin Dev Immunol. 2012; 2012:628293.
journal title abbreviation: Clin Dev Immunol
publication date: 2012-04-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Restoration of innate immune activation accelerates Th1-cell priming and protection following pulmonary mycobacterial infection.
PubMed Identifier: 24519467
author list: Lai R, Jeyanathan M, Shaler CR, Damjanovic D, Khera A, Horvath C, Ashkar AA, Xing Z
published in: European journal of immunology
information resource reference: Lai R, Jeyanathan M, Shaler CR, Damjanovic D, Khera A, Horvath C, Ashkar AA, Xing Z. Restoration of innate immune activation accelerates Th1-cell priming and protection following pulmonary mycobacterial infection. Eur J Immunol. 2014 May; 44(5):1375-86.
journal title abbreviation: Eur J Immunol
publication date: 2014-04-04T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Microbiology
type: Department
type: Organization

Associate Professor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Instructor
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position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Instructor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/50600503
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 2
type: Position
position in organization: T.H. Chan School of Medicine

Instructor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Instructor
position in organization: UMass Chan Medical School

Instructor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Instructor
position in organization: UMass Chan Medical School

Instructor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Instructor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Instructor
sort order: 17
type: Faculty Rank

Professor
sort order: 3
type: Faculty Rank

Associate Professor
sort order: 10
type: Faculty Rank

Authorship 130693
type: Authorship
author rank in publication: 5
linked author: Lai, Rocky
linked information resource: CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages.

CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages.
PubMed Identifier: 39896604
author list: Shinkawa T, Chang E, Rakib T, Cavallo K, Lai R, Behar SM
published in: bioRxiv : the preprint server for biology
information resource reference: Shinkawa T, Chang E, Rakib T, Cavallo K, Lai R, Behar SM. CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages. bioRxiv. 2025 Jan 24.
journal title abbreviation: bioRxiv
publication date: 2025-01-24T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 137643
type: Authorship
author rank in publication: 5
linked author: Lai, Rocky
linked information resource: CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages.

CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages.
PubMed Identifier: 40886314
author list: Shinkawa T, Chang E, Rakib T, Cavallo K, Lai R, Behar SM
published in: Cell reports
information resource reference: Shinkawa T, Chang E, Rakib T, Cavallo K, Lai R, Behar SM. CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages. Cell Rep. 2025 Sep 23; 44(9):116184.
journal title abbreviation: Cell Rep
publication date: 2025-08-30T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource