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Gazzinelli, Ricardo
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Post Docs: Fiocruz-Minas Caroline Junqueira, PhD - Staff Scientist Camila Brabosa, PhD student - Mapping of CD8 T cell-specifc Epitopes from Malaria Blood Stage Gregorio Almeida, DVM, PhD - Immunology of Asymptomatic Malaria Guilherme Maia, PhD - Innate Lymphocytes in Malaria Isabella Hirako, PhD - Monocyte-Derived Dendritic Cells in Malaria Júlia Castro, MSc student - Chagas Disease Vaccine Larissa Pereira, MSc student - Inflammatory Caspases in Malaria Kely Mateucci, PhD - Monocyte-Derived Dendritic Cells Metabolism in Malaria Milton Pereira, PhD - Caspases and inflammasomes in Malaria and Chagas Disease Natalia Satchiko Souza, PhD - CD8+ T cells in malaria UMASS Danielle Durso, PhD - IRAKs and Myddosomes in host resistance to T. gondii Patricia Assis, PhD - Host Clock genes and Malaria Ogooluwa Ojelabi, PhD - Glucose Metabolism and Malaria
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Post Docs: A postdoctoral position is available to study in this laboratory. Clickhereto apply.
Rotation Projects: <p >Rotations <p >Potential rotations <p >1. To examine how TCR affinity and specificity for MHC + peptide influences the development and activation of CD4 T cells. <p >2. To assess the impact of self tolerance on the specificity, affinity and pathogenic potential of T cells reactive to proteins expressed in the central nervous system and b-islet cells of the pancreas.
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Lu, Shan
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Selin, Liisa
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Rotation Projects: Rotation Projects for graduate students: Examining the role of cross-reactive CD8 memory T cells in mediating the EBV-induced infectious mononucleosis syndrome in humans. Examining the role of cross-reactive CD8 memory T cells and cytokines in murine models of viral infection. Examining the mechanisms used by these memory T cells to unrelated infections to modulate disease outcome either for the bad or the good.
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Moormann, Ann
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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
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Ceol, Craig
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Swain, Susan
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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
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Clapham, Paul
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Rotation Projects: Rotation Projects Rotation projects are available in support of our research. See the research description section of this page.
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Rao, Lokinendi
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Abraham, George
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Fitzgerald, Katherine
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Serreze, David
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has faculty rank: Associate Professor
latitude: 44.36637960000000
longitude: -68.19692870000000
Person ID: 2838
person in primary position: Associate Professor
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type: Person
preferred title: Associate Professor

Lapane, Kate
first name: Kate
last name: Lapane
full name: Kate L Lapane PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
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Person ID: 3252
person in primary position: Professor
type: Agent
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preferred title: Professor

Puri, Ajit
first name: Ajit
last name: Puri
full name: Ajit Singh Puri MD, DM, DMRE
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latitude: 42.27525000000000
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Person ID: 3253
person in primary position: Professor
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preferred title: Professor

Garber, Manuel
first name: Manuel
last name: Garber
full name: Manuel Garber PhD
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latitude: 42.27767280000000
longitude: -71.76163720000000
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Person ID: 3318
person in primary position: Professor
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type: Person
Rotation Projects: If you are interesting in applying computational methods to biological problems please contact me. Potential projects in my lab are Modeling of transcription factor gene expression control in innate immune cells Evolutionary analysis of gene transcription factor networks in mammals Epigenetics inheritance in mice: From male sperm to phenotypic effect in grandchildren Application of genome and exome sequencing to newborn screening Development of computational methods for analysis of RNA-protein interactions
preferred title: Professor

Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
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latitude: 50.70274210000000
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Person ID: 3432
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27636250000000
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Person ID: 36
person in primary position: Adjunct Professor
type: Agent
type: Person
Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Haran, John
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last name: Haran
full name: John P Haran MD, PhD
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latitude: 42.27525000000000
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Person ID: 37
person in primary position: Professor
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Rotation Projects: Rotation projects are available related to microbiota-gut brain axis and antibiotic usage and the sequelae of antibiotic use in hospitalized patients which include Clostridium difficile and multi-drug resistant organism infection and colonization.
preferred title: Professor

Rotello, Vincent
first name: Vincent
last name: Rotello
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person in primary position: Department Head
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preferred title: Department Head

Minter, Lisa
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latitude: 42.39565560000000
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person in primary position: Professor
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preferred title: Professor

Poudel, Krishna
first name: Krishna
last name: Poudel
full name: Krishna Poudel PhD
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latitude: 42.39565560000000
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Person ID: 3832
person in primary position: Associate Professor
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preferred title: Associate Professor

Brehm, Michael
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latitude: 42.27694690000000
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Person ID: 474
person in primary position: Professor
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Endowed Chair Honorary Title: Harvey A. Shultz Chair in Diabetes
preferred title: Professor

Ellison, Richard
first name: Richard
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latitude: 42.27525000000000
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person in primary position: Professor
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preferred title: Professor

Harris, John
first name: John
last name: Harris
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latitude: 42.27525000000000
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Person ID: 53
person in primary position: Adjunct Professor
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Endowed Chair Honorary Title: Lambi and Sarah Adams Chair in Genetic Research
Rotation Projects: Rotations: Targeting the IFN-?-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking real-time autoreactive T cell migration and interactions within the skin: We are usin…
Rotation Projects: Rotations: Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking autoreactive T cell interactions within the skin: We are using fluorescently tagged C…
Summary: Interests: Vitiligo, autoimmunity, immunology, translational research
preferred title: Adjunct Professor

Schiffer, Celia
first name: Celia
last name: Schiffer
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full name: Celia A Schiffer PhD
has faculty rank: Chair And Professor
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Person ID: 558
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Arthur F. and Helen P. Koskinas Professor in Biochemistry and Molecular Biotechnology
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866505

Wiss, Karen
first name: Karen
last name: Wiss
full name: Karen Wiss MD
has faculty rank: Professor Emeritus
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Person ID: 599
person in primary position: Professor Emeritus
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Summary: Interests: Pediatric dermatology, epidermolysis bullosa, genodermatoses, midline developmental defects, childhood exanthems, medical education, pediatric laser
preferred title: Professor Emeritus

Wang, Jennifer
first name: Jennifer
last name: Wang
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latitude: 42.27985300000000
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person in primary position: Professor
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preferred title: Professor

Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
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latitude: 42.27525000000000
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Person ID: 78
person in primary position: Professor Emeritus
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Rice, Peter
first name: Peter
last name: Rice
full name: Peter A Rice MD
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latitude: 42.27985300000000
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Person ID: 908
person in primary position: Professor Emeritus
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Ram, Sanjay
first name: Sanjay
last name: Ram
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latitude: 42.27636250000000
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Person ID: 993
person in primary position: Professor
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preferred title: Professor

McManus, David
first name: David
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latitude: 42.27525000000000
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Person ID: 994
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
preferred title: Chair and Professor

Pediatric Genetics
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Research
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Stadinski, Brian
first name: Brian
last name: Stadinski
full name: Brian D Stadinski PhD
has faculty rank: Assistant Professor
latitude: 42.27525000000000
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Person ID: 4325
person in primary position: Assistant Professor
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preferred title: Assistant Professor

UMass Chan – Baystate Regional Campus
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Richmond, Jillian
first name: Jillian
last name: Richmond
full name: Jillian M Richmond PhD
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latitude: 42.27767280000000
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Person ID: 4448
person in primary position: Adjunct Assistant Professor
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Summary: Interests: Autoimmunity, Immunology, Fibrosis, Translational Research, Lupus
preferred title: Adjunct Assistant Professor

Steingrub, Jay
first name: Jay
last name: Steingrub
full name: Jay S Steingrub MD
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latitude: 42.12294230000000
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Person ID: 4472
person in primary position: Professor
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preferred title: Professor

Goff, Sarah
first name: Sarah
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latitude: 42.27525000000000
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Person ID: 4497
person in primary position: Adjunct Associate Professor
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preferred title: Adjunct Associate Professor

Dermatology
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position in organization: University of Massachusetts Amherst

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Associate Professor
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position in department: School of Public Health and Health Sciences
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position in organization: University of Massachusetts Amherst

Lindenauer, Peter
first name: Peter
last name: Lindenauer
full name: Peter K Lindenauer MD, MSc
has faculty rank: Chair And Professor
latitude: 42.12711190000000
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person in primary position: Chair and Professor
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT ASSOCIATE PROFESSOR
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ADJUNCT INSTRUCTOR
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ADJUNCT PROFESSOR
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Haessler, Sarah
first name: Sarah
last name: Haessler
full name: Sarah Haessler MD, MS
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latitude: 42.12294230000000
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Person ID: 5203
person in primary position: Chair and Professor
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preferred title: Chair and Professor

Magnani, Diogo
first name: Diogo
last name: Magnani
full name: Diogo Magnani PhD
has faculty rank: Associate Professor
latitude: 42.28485270000000
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Person ID: 5281
person in primary position: Associate Professor
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preferred title: Associate Professor
webpage: https://profiles.umassmed.edu/profile/28866462
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Usmani, Saad
first name: Saad
last name: Usmani
full name: Saad Usmani MD
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Person ID: 5394
person in primary position: Instructor
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Strauss, Kevin
first name: Kevin
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full name: Kevin Strauss MD
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latitude: 39.95747490000000
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Person ID: 5405
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Ophthalmology and Visual Sciences
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Population and Quantitative Health Sciences
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Antonelli, Lis
first name: Lis
last name: Antonelli
full name: Lis Antonelli PhD
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latitude: 42.27525000000000
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Person ID: 5497
person in primary position: Adjunct Assistant Professor
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Rashighi Firoozabadi, Mehdi
first name: Mehdi
last name: Rashighi Firoozabadi
full name: Mehdi Rashighi Firoozabadi MD
has faculty rank: Associate Professor
latitude: 42.27491030000000
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Person ID: 5521
person in primary position: Associate Professor
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Summary: Interests: Autoimmune connective tissues diseases (cutaneous lupus, dermatomyositis, morphea) inflammatory skin diseases, translational research
preferred title: Associate Professor

Garg, Arvin
first name: Arvin
last name: Garg
full name: Arvin Garg MD, MPH
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latitude: 42.27664990000000
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Biochemistry and Molecular Biotechnology
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https://profiles.umassmed.edu/profile/28866427
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https://profiles.umassmed.edu/profile/28866462
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link anchor text: Nonhuman Primate Reagent Resource

https://profiles.umassmed.edu/profile/28866493
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https://profiles.umassmed.edu/profile/28866505
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Instructor
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Professor
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Parker, Margaret
first name: Margaret
last name: Parker
full name: Margaret G.K. Parker MD, MPH
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Lee, Darren
first name: Darren
last name: Lee
full name: Darren James Lee PhD
has faculty rank: Associate Professor
latitude: 42.27525000000000
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Person ID: 10247152
person in primary position: Associate Professor
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preferred title: Associate Professor
webpage: https://profiles.umassmed.edu/profile/35298484

Vachha, Behroze
first name: Behroze
last name: Vachha
full name: Behroze Adi Vachha MD, PhD
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Professor
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Associate Professor
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Garza-Mayers, Anna
first name: Anna
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Adjunct Instructor
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Adjunct Associate Professor
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position in department: Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Pearson, Todd
first name: Todd
last name: Pearson
full name: Todd F Pearson PhD
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preferred title: Assistant Professor

Assistant Professor
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https://profiles.umassmed.edu/profile/35298484
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Abbas, Zainab
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latitude: 42.27525000000000
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https://profiles.umassmed.edu/profile/66923911
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https://profiles.umassmed.edu/profile/66923959
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https://profiles.umassmed.edu/profile/66924043
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Shin, Dong-Soo
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position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Radiology
position in division: Neuroradiology
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Adjunct Professor
is primary position: true
position in department: Pediatrics
position in division: Pediatric Genetics
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Pediatrics
position in division: General Pediatrics
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Pediatrics
position in division: Pediatric Neonatology
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Adjunct Professor
is primary position: true
position in department: Dermatology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School