We are looking for postdoc candidates with experience in cancer biology, mouse models and genome-engineering. Please email CV and 3 letters of recommendation to Wen.Xue@umassmed.edu.
Our lab uses CRISPR tools to speed up cancer gene discovery and disease gene repair. Rotation projects are available to explore experimental techniques such as molecular cloning of CRISPR plasmids, measuring genome-editing efficiency, dissecting mice, and processing of mouse tumor/tissue for histology.
Molly McGovern Chair in Biomedical Research
There are a variety of rotation projects that use a variety of imaging and biochemical techniques to assess microglial function in the CNS. The main projects are highlighted below. 1. Dissecting novel molecular mechanisms underlying microglial function at synapses. 2. Exploring new roles for microglia in the spread of neuroinflammation in neurological disease. 3. Identifying novel ways microglia regulate other glial cell populations (astrocytes and oligodendrocytes) in the CNS.
School of Public Health and Health Sciences
Department of Psychology; Neuroscience And Behavio
Biostatistics And Health Services Research
Postdoctoral positions are available in the Tapper laboratory. For more information, please contact Dr. Tapper (andrew.tapper@umassmed.edu).
Elisabeth Chair for the Dean of Medicine
The project aims to develop computational algorithms and software programs for analyzing high-throughput sequence data such as ChIP-Seq RNA-Seq small RNA sequencing data. PhD required. A strong background in computational biology especially experience with analyzing high-throughput sequencing data is highly desirable. Excellent communication and writing skills and the ability to work with experimental and computational collaborators are essential. To apply please forward CV cover letter and three references to: Zhiping.Weng@umassmed.edu
Please contact Dr. Weng for information on rotations that are available in her lab.
Penelope Booth Rockwell Chair in Biomedical Research
Focus: Adeno-associated virus vector mediated gene transfer for gene therapy, gene therapy of inherited neurodegenerative Canavan Disease
<p >Rotation Projects: Characterization of gene which influences survival in sporadic ALS patients. Characterization of 2 newly identified familial ALS genes. Development of a new mouse model for familial ALS. Positional cloning of novel genes which cause familial ALS.
Robert M. and Shirley S. Siff Chair in Autism
Governor Paul Cellucci Chair in Neuroscience Research
Project 1: Dervelop RNA-based therapies for frontotemporal dementia (FTD) and related disroders. Project 2: Study pathogenic mechanisms of FTD and related disorders in mouse models.
Our lab uses a combination of molecular, cellular, genetic, and behavioral approaches to further dissect the pathogenic mechanisms of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis with a focus on mutant CHMP2B, progranulin and C9ORF72. We will identify common underlying pathways as potential targets for therapeutic interventions.
Worcester Foundation for Biomedical Research Chair III
Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
Potential Rotation Projects Proteostasis regulators, HSF1, HSP70 and HSP90 in liver disease: Determine the expression and function in different cell types of the liver during acute and chronic liver injury using in vivo and in vitro models. Subsequently, we will test the relevance of the expression of these proteins in activation of intracellular signaling molecules involved in induction of fatty liver, inflammation and fibrosis. Role of chemokines in liver disease: CC-chemokines particularly CCL2/MCP-1, is significantly increased in serum as well as in the liver parenchyma in patients with alcoholic hepatitis. We test the role of MCP-1 in induction of fatty acid synthesis or metabolism and inflammation in the alcoholic liver. Our studies will also investigate the role of MCP-1 directed migration of immune cells in the liver contributing to injury.
H. Arthur Smith Chair in Cancer Research
Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
LAB ROTATION PROJECTS AVAILABLE -- PLEASE CONTACT SAM BEHAR FOR MORE INFORMATION
Focus: We seek to understand how the causative agent of tuberculosis, namely the bacterium Mycobacterium tuberculosis evades host immunity, and how different components of the immune response work together to contain infection. Our ultimate goal is to inform vaccine development and the design of host directed therapy.
Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
Rotation projects are available related to microbiota-gut brain axis and antibiotic usage and the sequelae of antibiotic use in hospitalized patients which include Clostridium difficile and multi-drug resistant organism infection and colonization.
A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.
Gretchen Stone Cook Chair in Biomedical Sciences
A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
Dr. Benjamin is a double-boarded neuropsychiatrist who focuses on the diagnosis and treatment of brain-behavior disorders, teaching neuropsychiatry, and working to increase the neurologic education of psychiatrists.
Herman G. Berkman Chair in Diabetes Care Innovation
A rotation project focusing on neuronal processing in alcohol-naive and binge alcohol drinking mice is available
Focus: Director of the Sanderson Center for Optics Experimentation (SCOPE)
Population and Quantitative Health Sciences
Wet-lab and Bioinformatic postdoctoral fellow positions are available for candidates with recent Ph.D. or M.D./Ph.D. degrees in Molecular Biology, Neuroscience, Genetics, Genomics, Cell Biology, or related fields. They should be highly motivated, have a strong desire to learn, and excellent communication skills. Applicants should send their CV, summary of previous research and the name of three references to Dr. Michael Lodato.
Rotations will revolve around studying somatic mutations in the normal brain, in the diseased brain, and outside of the brain using single-cell genomics. Please contact Dr. Lodato for details.
Emergency Medicine at UMass Chan - Baystate
Dr. Edmiston's research focuses on bottom-up sensory perception in people with or at risk for mood and anxiety disorders. He uses neuroimagingand neuromodulation techniques to assess the function of the ventral visual stream during emotion and novelty perception in children, adolescents, and young adults. Dr. Edmiston has secondary interests in transgender health education and healthcare access.
Worcester Foundation for Biomedical Research Chair I
On Mentorship and Memory (2013) Brain Can Vodcast (On Growing Up without Frontal Lobes)
On Mentorship and Memory (2013) Brain Can Vodcast (on frontal lobes and behavior)
On Mentorship and Memory (2013) Brain Can Vodcast (on frontal lobes and behavior) Growing Up Without Frontal Lobes
On Mentorship and Memory (2013) Brain Can Vodcast (on frontal lobes and behavior) Growing Up Without Frontal Lobes 6 Landmark Neuropsychiatry Cases (Astana, Kazakhstan)
On Mentorship and Memory (2013) Brain Can Vodcast (on frontal lobes and behavior) Growing Up Without Frontal Lobes 6 Landmark Neuropsychiatry Cases ( presented in Astana, Kazakhstan with Russian interpretation
On Mentorship and Memory (2013) Brain Can Vodcast (on frontal lobes and behavior) Growing Up Without Frontal Lobes 6 Landmark Neuropsychiatry Cases ( presented in Astana, Kazakhstan with Russian interpretation)
On Mentorship and Memory (2013) Brain Can Vodcast (on frontal lobes and behavior) Growing Up Without Frontal Lobes 6 Landmark Neuropsychiatry Cases ( presented in Astana, Kazakhstan with Russian interpretation) Molecular Mimicry and the Mind (The Sulllivan Lecture)
On Mentorship and Memory (2013) Brain Can Vodcast (on frontal lobes and behavior) 6 Landmark Neuropsychiatry Cases ( presented in Astana, Kazakhstan with Russian interpretation) Growing Up Without Frontal Lobes Molecular Mimicry and the Mind (The Sulllivan Lecture)
On Mentorship and Memory (2013) 6 Landmark Neuropsychiatry Cases ( presented in Astana, Kazakhstan with Russian interpretation) Brain Can Vodcast (on frontal lobes and behavior) Growing Up Without Frontal Lobes Molecular Mimicry and the Mind (The Sulllivan Lecture)
On Mentorship and Memory (2013) 6 Landmark Neuropsychiatry Cases ( presented in Astana, Kazakhstan with Russian interpretation) Growing Up Without Frontal Lobes Brain Can Vodcast (on frontal lobes and behavior) Molecular Mimicry and the Mind (The Sulllivan Lecture)
Advisory links alcohol consumption to cancers: Here's how Worcester feels about the report