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Pagoto, Sherry
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Rando, Oliver
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Rotation Projects: Rotation projects are available to study chromatin structure and function. Project 1. Measure histone dynamics in yeast. Histone dynamics play major roles in chromatin metabolism and in the inheritance of chromatin states. To measure histone replacement rates in yeast, we have created yeast strains carrying inducible epitope-tagged histones H3 and H2A. Using microarrays, we will measure histone replacement rates in a variety of mutant yeast to ascertain the role of various chromatin remodeling factors in histone exchange reactions. Project 2. Characterize mechanisms for epigenetic inheritance in yeast. We have identified a variety of genes whose expression state in yeast is epigenetically heritable. We will screen the yeast genome for genes that affect the inheritance of these expression patterns. Project 3. Measure histone dynamics in embryonic stem cells. Embryonic stem cells are pluripotent cells that can give rise to every type of cell in the adult animal. The role of chromatin structure in maintaining this pluripotent state is poorly understood, but it appears that stem cell chromatin is exceptionally labile relative to that in differentiated cells. We will create stem cell lines with inducible tagged histones to measure histone replacement rates across the mouse genome.
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Moore Simas, Tiffany
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Brown, Robert
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Allison, Jeroan
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Kiefe, Catarina
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Boudreaux, Edwin
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Swain, Susan
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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
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Gao, Fen-Biao
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Summary: Our lab uses a combination of molecular, cellular, genetic, and behavioral approaches to further dissect the pathogenic mechanisms of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis with a focus on mutant CHMP2B, progranulin and C9ORF72. We will identify common underlying pathways as potential targets for therapeutic interventions.
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Latz, Eicke
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Fitzgerald, Katherine
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Lyons, Michael
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Shultz, Leonard
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Theurkauf, William
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Theurkauf for additional details.
Rotation Projects: Rotation Projects Proper control of cell division and accurate chromosome segregation are fundamental to cell function and normal development. Chromosome segregation errors lead to birth defects, and abnormal cell division control is associated with essentially all cancers. A major aim of research in the laboratory is to understand cell cycle control and chromosome segregation mechanisms. We use a combination of classical and molecular genetics, high-resolution in vivo imaging, and biochemical techniques to define pathways that control the cell cycle and chromosome segregation in response to environmental insult (DNA damaging agents) and developmental queues. Rotation projects focus on the role of cell cycle checkpoint and tumor suppressor pathways during the earliest stages of embryogenesis, and cell cycle control of actin and microtubule reorganization during mitosis. Through these projects, students gain exposure of the art in vivo imaging and genetic and molecular manipulations of gene function to define pathways controlling cell division and chromosome segregation. Embryonic Patterning Essentially all cells are asymmetric, with structurally distinct surfaces and polarized internal organization. This asymmetry is essential to the specialized functions cells serve within complex multi-cellular organisms . A second area of interest focuses on the mechanisms that establish cellular asymmetry. In Drosophila, the embryonic axes are specified during oogenesis through the asymmetric localization of key morphogenetic molecules within the developing oocyte. We use axis specification in the fly as a model for the processes that establish cellular asymmetry. An intact microtubule network is essential to axis specification in the fly oocyte and to polarization of somatic. We hope to define the molecular functions for microtubules in establishing cellular asymmetry. We are currently using in vivo imaging techniques to directly characterize the microtubule dependent mRNA tran…
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Davis, Roger
first name: Roger
last name: Davis
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has faculty rank: Chair And Professor
latitude: 42.27913100000000
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Person ID: 3130
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: H. Arthur Smith Chair in Cancer Research
Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866429

Zierath, Juleen
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Lapane, Kate
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Heneka, Michael
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Golenbock, Douglas
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Person ID: 345
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Endowed Chair Honorary Title: Neil and Margery Blacklow Chair in Infectious Diseases and Immunology
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Szabo, Gyongyi
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
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Chasan-Taber, Lisa
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Bertone-Johnson, Elizabeth
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Helfer, Karen
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Rotello, Vincent
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Meyer, Jerrold
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Kent-Braun, Jane
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Fissore, Rafael
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Visconti, Pablo
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Mager, Jesse
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Xiao, Hang
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Spencer, Rebecca
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Whitcomb, Brian
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Rogaev, Evgeny
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.
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Crawford, Sybil
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Richter, Joel
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Featured Videos: https://profiles.umassmed.edu/profile/28867186
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Person ID: 554
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Endowed Chair Honorary Title: Arthur F. Koskinas Chair in Neuroscience
Rotation Projects: Many rotation projects are available so please inquire.
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Rosal, Milagros
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Person ID: 594
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Endowed Chair Honorary Title: Imoigele P. Aisiku, MD’97 Chair in Health Equity and Diversity
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webpage: https://profiles.umassmed.edu/profile/28866430

Greiner, Dale
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Person ID: 612
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Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
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Goldberg, Robert
first name: Robert
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Ryder, Sean
first name: Sean
last name: Ryder
Twitter: https://profiles.umassmed.edu/profile/28867044
full name: Sean P Ryder PhD
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latitude: 42.27985300000000
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Person ID: 942
person in primary position: Professor
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Rotation Projects: Potential Rotation Projects A variety of rotation projects are available to study RNP assembly and post-transcriptional regulation during development using quantitative biochemical and modern molecular methods. Project 1: Characterization of the RNA-protein complexes that guide C. elegans early development. Several projects ranging in scope from biochemical characterization of RNA-binding protein complexes to genetic dissection of RNA binding protein function in development are currently available. Contact Sean for more details. Project 2: Post-transcriptional regulation of oligodendrocyte differentiation. Projects are available to monitor changes in gene expression as a function of differentiation with a focus on changes in alternative splicing and mRNA stability. Contact Sean for more details.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866432

McManus, David
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
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UMass Chan – Baystate Regional Campus
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Lindenauer, Peter
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ADJUNCT PROFESSOR
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Seddon, Johanna
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Gurwitz, Jerry
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Endowed Chair Honorary Title: Dr. John Meyers Professor in Primary Care Medicine
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Grigorieff, Nikolaus
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last name: Grigorieff
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Robertson, David
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Ophthalmology and Visual Sciences
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Population and Quantitative Health Sciences
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Schlaug, Gottfried
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Ruscetti, Marcus
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Yonkers, Kimberly
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Endowed Chair Honorary Title: Katz Family Chair in Psychiatry
Summary: cdro
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Biochemistry and Molecular Biotechnology
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Sacha, Caitlin
first name: Caitlin
last name: Sacha
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Lin, Honghuang
first name: Honghuang
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Family Medicine at UMass Chan - Baystate
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Neurology at UMass Chan - Baystate
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Pediatrics at UMass Chan - Baystate
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Wood, Emma
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Logan, Ryan
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Winder, Danny
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Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair I
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webpage: https://profiles.umassmed.edu/profile/108986324

Medicine at UMass Chan - Lahey
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Radiology at UMass Chan - Lahey
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Endocrinology & Diabetes
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Health System Science
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Infectious Diseases
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Reproductive
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