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Van Emmerik, Richard
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McClements, David
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Xiao, Hang
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Boyer, Katherine
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Zheng, Hua
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Crawford, Sybil
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Reed, George
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Rotation Projects: Additional information about lab rotations within the CPHR program can be found athttp://www.umassmed.edu/cphr/program/rotations.aspx
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Rosal, Milagros
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Wolfe, Scot
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Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
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Lemon, Stephenie
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Endowed Chair Honorary Title: Barbara Helen Smith Chair in Preventive & Behavioral Medicine
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Ayers, David
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Goldberg, Robert
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Shaw, Leslie
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McManus, David
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Research
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Friedmann, Peter
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UMass Chan – Baystate Regional Campus
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Singh, Sonal
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Professor
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Professor
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https://profiles.umassmed.edu/profile/16237425
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Fergus Clydesdale Endowed Chair
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Lindenauer, Peter
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Liu, Shao-Hsien
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Copeland, Laurel
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ADJUNCT PROFESSOR
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Wink, Alexandra
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Seddon, Johanna
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Gurwitz, Jerry
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Usmani, Saad
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Ophthalmology and Visual Sciences
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Population and Quantitative Health Sciences
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Schlaug, Gottfried
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DISTINGUISHED PROFESSOR AND CHAIR EMERITUS
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Lin, Honghuang
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https://profiles.umassmed.edu/profile/28866430
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https://profiles.umassmed.edu/profile/28866602
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Neurology at UMass Chan - Baystate
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Adjunct Professor
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Instructor
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Professor
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Adjunct Professor
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Assistant Professor
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Associate Professor
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Saranathan, Manojkumar
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Associate Professor
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Joint Replacement
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Driban, Jeffrey
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Professor
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Associate Professor
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Walkey, Allan
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Medicine at UMass Chan - Lahey
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https://profiles.umassmed.edu/profile/40402890
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Radiology at UMass Chan - Lahey
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Professor
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Distinguished Professor and Chair Emeritus
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Chair and Professor
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Professor
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Health System Science
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Infectious Diseases
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Neurointerventional Radiology
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Orthopedics Research
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Pulmonary Medicine
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Translational Anatomy
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Professor Emeritus
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Professor
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Professor
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Assistant Professor
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Professor
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Professor
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Professor
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Adjunct Professor
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Professor
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Professor
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Associate Professor
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Professor
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Stroke and Vascular Neurology
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Associate Professor
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Finlay, Andrea
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Professor
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Tan Chingfen Graduate School of Nursing
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https://profiles.umassmed.edu/profile/44403713
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McAlindon, Timothy
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