Proposals for Next Classification Schema of Myeloid Neoplasms
Biostatistics And Health Services Research
Elisabeth Chair for the Dean of Medicine
The lab is currently looking for motivated postdoctoral scholars with backgrounds in genomics and computational biology. Please email the PI.
Rotation projects are available related to malaria and Burkitt lymphoma. Our projects range from genetic epidemiology to directed genomics studying human, parasite and tumor.
William and Doris Krupp Professor in Medicine
Lambi and Sarah Adams Chair in Genetic Research
Rotations: Targeting the IFN-?-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking real-time autoreactive T cell migration and interactions within the skin: We are using fluorescently/bioluminescently tagged CD8 T cells to track their movements and interactions within the skin in live mice, using real-time confocal microscopy and bioluminescent imaging. Initial studies will focus on the role of cytokines and chemokines in T cell migration within the skin. Clinical trial to test a novel treatment for vitiligo: We are in the early stages of developing a clinical trial based on insights developed from our animal data to test a novel drug for its ability to treat vitiligo.
Rotations: Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking autoreactive T cell interactions within the skin: We are using fluorescently tagged CD8 T cells to track their cellular interactions within the skin using confocal microscopy. Future studies will adapt this model to investigate real-time migration and other movements of these cells within compartments of the skin. Clinical trial to test a novel treatment for vitiligo: We recently completed a clinical trial based on insights developed from our animal data to test a novel drug for its ability to treat vitiligo.
Interests: Vitiligo, autoimmunity, immunology, translational research
Herman G. Berkman Chair in Diabetes Care Innovation
Interests: Psoriasis, atopic dermatitis, acne vulgaris, perioral dermatitis, fungal infections, cutaneous malignancies, infectious diseases, medical education
Potential Rotation Projects Several rotation projects are available in structural biology of immune receptors, antigen presentation pathways, T-cell activation, and development of novel T-cell detection reagents. Please see Prof. Stern for details.
Population and Quantitative Health Sciences
Our team welcomes applications from individuals interested in advancing clinical care, science, and education through multidisciplinary innovation and research in restorative, regenerative, and global surgery. Positions are available for national and international undergraduate, graduate (including residents), and post-graduate students with a broad range of diverse expertise and backgrounds. Please submit your request along your CV to: giorgio.giatsidis@umassmed.edu Main areas of interest * Biological Sciences (wound healing & burns, tissue engineering, scaffolds, tissue mechanobiology, angiogenesis, lymphangiogenesis, tissue regeneration [skeletal muscle, adipose tissue, skin], scarring and fibrosis, aging, tissue allotransplantation) * Clinical Sciences (trials in plastic surgery [breast reconstruction, post-bariatric surgery, burns, chronic wounds, fat grafting], microsurgery, extremity trauma and replantation, aesthetic surgery/medicine) * Global Surgery & Advocacy * Surgical Education (design and evaluation of skill courses, simulation-based training, cadaver-based training, use of Augmented Reality and Virtual Reality in surgical education) * Biomedical Engineering (design and development of devices or technologies for wound care, tissue preservation, trauma care, surgical robotics, tissue imaging, and tissue diagnostics) * Software Engineering (mHealth applications in surgery, tele-surgery) * Art sciences (Medical illustrations)
Our team is committed to provide opportunities to UMMS students to both advance their education and produce scholarly work. Committment and goals are individually discussed and tailored based on the student's interests, goals, needs, and availability. Projects are commonly designed to be led by the student under guidance, and to result in a scientific publication authored by the student. For applications please contact: giorgio.giatsidis@umassmed.edu. Areas of specific interest include (but are not limited to): - Surgical Education - Global Surgery
Biochemistry and Molecular Biotechnology
Restorative & Regenerative Surgery Innovation Center
Healthcare Delivery and Population Sciences at UMass Chan - Baystate
Dr Ningcheng (Peter) Li is an Assistant Professor in the Division of Interventional Radiology with a clinical and research focus on venous thromboembolism. He is also the associate program director for the Interventional Radiology Integrated/Independent Residency Program.
Susan D Moffatt-Bruce MD, PhD, FRCSC, MBOE, MBA,FACS
Jack M. Wilson Chair in Biomedical Research
Joseph D. Early Chair in Biomedical Research
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Dr Patel on the Impact of Donor-Engrafted Clonal Hematopoiesis on Outcomes With Auto-/Allo-HSCT
Effects of donor-engrafted clonal hematopoiesis in stem cell transplantation
High-Risk Myelodysplastic Syndrome Findings in the SELECT-MDS-1 Study
Stem Cell Transplantation: How Clonal Hematopoiesis Shapes Patient Outcomes
Olutasidenib as a Breakthrough for R/R mIDH1 AML Patients
The Impact of Mutations in Clonal Hematopoiesis
TP53 in MDS & AML Prognostication & Treatment Strategies
Exploring the Biological Basis of TP53-Aberrant MDS & AML
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ASH Clinical News - Practical Solutions Amid Cuts to Federally Funded Research
OncLive with Dr. Patel and Dr. Gerber: p53 Immunohistochemistry
Early Identification of TP53-Mutant MDS and AML Using p53 Immunostaining
Point-of-Care p53 IHC Unveils TP53-Mutant MDS/AML
IHC Enables Rapid Identification of TP53-Mutant MDS/AML
ASH Clinical News: p53 Immunohistochemistry for TP53-Mutant MDS/AML
p53 Immunostain in TP53-Mutant MDS and AML