Ling, Qinglan
first name: Qinglan
last name: Ling
full name: Qinglan Ling PhD
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Summary: My lab uses genetic approaches to understand and develop treatments for mitochondrial diseases. We develop the treatments in a translatable manner to directly benefit the patient population. The diseases that we are currently working on involve genes that are encoded in both the nuclear DNA and mitochondrial DNA, with neurological manifestations.
selected publications: Authorship 139882
selected publications: Authorship 123193
selected publications: Authorship 123194
selected publications: Authorship 123195
selected publications: Authorship 123196
selected publications: Authorship 123197
selected publications: Authorship 123198
awards and honors: K99 NIH Pathway to Independence Award
education and training: China Pharmaceutical University, Clinical Pharmacy
education and training: Chinese Academy of Sciences, Neuropharmacology
education and training: University of Houston, Pharmacology
research areas: Nervous System Diseases
research areas: Mitochondrial Diseases
research areas: Epoprostenol
research areas: Genetic Therapy
research areas: Neuroprotective Agents
mailing address: Worcester MA 01655
positions: Assistant Professor
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Kotin, Robert
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Flotte, Terence
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Endowed Chair Honorary Title: Elisabeth Chair for the Dean of Medicine
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Gao, Guangping
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Endowed Chair Honorary Title: Penelope Booth Rockwell Chair in Biomedical Research
Lab URL: https://www.umassmed.edu/gaolab/
Summary: Focus: Adeno-associated virus vector mediated gene transfer for gene therapy, gene therapy of inherited neurodegenerative Canavan Disease
preferred title: Chair and Professor

Sena-Esteves, Miguel
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Summary: Dr. Esteves is a neuroscientist with interest in gene therapy to help treat neurodegenerative diseases.
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Laforet, Genevieve
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Heneka, Michael
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Gruntman, Alisha
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China Pharmaceutical University, Clinical Pharmacy
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training location: Nanjing, , China
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Chinese Academy of Sciences, Neuropharmacology
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Gray-Edwards, Heather
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Wang, Dan
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Post Docs: We are looking for motivated postdoctoral researchers. Send in your application and get in touch today!
Rotation Projects: - AAV gene therapy for genetic diseases - Therapeutic genome editing - RNA-based approaches to treating genetic diseases - Interactions between AAV vector and host cell - AAV vector capsid engineering
preferred title: Assistant Professor
webpage: https://profiles.umassmed.edu/profile/28866581
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Worcester MA 01655
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address line 2: 55 Lake Avenue North
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Authorship 123193
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linked author: Ling, Qinglan
linked information resource: A "one size fits all" gene therapy for neurological disorders with mitochondrial dysfunction.

Authorship 123194
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author rank in publication: 1
linked author: Ling, Qinglan
linked information resource: AAV-based in vivo gene therapy for neurological disorders.

Authorship 123195
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linked author: Ling, Qinglan
linked information resource: Adeno-associated viral vector serotype 9-based gene replacement therapy for SURF1-related Leigh syndrome.

Authorship 123196
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linked author: Ling, Qinglan
linked information resource: The Protective Effects of Up-Regulating Prostacyclin Biosynthesis on Neuron Survival in Hippocampus.

Authorship 123197
type: Authorship
author rank in publication: 1
linked author: Ling, Qinglan
linked information resource: Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage.

Authorship 123198
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linked author: Ling, Qinglan
linked information resource: How can we address the controversies surrounding the use of NSAIDS in neurodegeneration?

K99 NIH Pathway to Independence Award
end date: 2024
start date: 2022
type: Award or Honor Receipt

A "one size fits all" gene therapy for neurological disorders with mitochondrial dysfunction.
PubMed Identifier: 38936369
author list: Ling Q
published in: Molecular therapy : the journal of the American Society of Gene Therapy
information resource reference: Ling Q. A "one size fits all" gene therapy for neurological disorders with mitochondrial dysfunction. Mol Ther. 2024 Jul 03; 32(7):2045-2046.
journal title abbreviation: Mol Ther
publication date: 2024-06-26T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

AAV-based in vivo gene therapy for neurological disorders.
PubMed Identifier: 37658167
author list: Ling Q, Herstine JA, Bradbury A, Gray SJ
published in: Nature reviews. Drug discovery
information resource reference: Ling Q, Herstine JA, Bradbury A, Gray SJ. AAV-based in vivo gene therapy for neurological disorders. Nat Rev Drug Discov. 2023 10; 22(10):789-806.
journal title abbreviation: Nat Rev Drug Discov
publication date: 2023-09-01T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Adeno-associated viral vector serotype 9-based gene replacement therapy for SURF1-related Leigh syndrome.
PubMed Identifier: 34703839
author list: Ling Q, Rioux M, Hu Y, Lee M, Gray SJ
published in: Molecular therapy. Methods & clinical development
information resource reference: Ling Q, Rioux M, Hu Y, Lee M, Gray SJ. Adeno-associated viral vector serotype 9-based gene replacement therapy for SURF1-related Leigh syndrome. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:158-168.
journal title abbreviation: Mol Ther Methods Clin Dev
publication date: 2021-09-07T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

How can we address the controversies surrounding the use of NSAIDS in neurodegeneration?
PubMed Identifier: 27357618
author list: Ling QL, Murdoch E, Ruan KH
published in: Future medicinal chemistry
information resource reference: Ling QL, Murdoch E, Ruan KH. How can we address the controversies surrounding the use of NSAIDS in neurodegeneration? Future Med Chem. 2016 07; 8(11):1153-5.
journal title abbreviation: Future Med Chem
publication date: 2016-06-30T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

The Protective Effects of Up-Regulating Prostacyclin Biosynthesis on Neuron Survival in Hippocampus.
PubMed Identifier: 31897976
author list: Ling QL, Akasaka H, Chen C, Haile CN, Winoske K, Ruan KH
published in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
information resource reference: Ling QL, Akasaka H, Chen C, Haile CN, Winoske K, Ruan KH. The Protective Effects of Up-Regulating Prostacyclin Biosynthesis on Neuron Survival in Hippocampus. J Neuroimmune Pharmacol. 2020 06; 15(2):292-308.
journal title abbreviation: J Neuroimmune Pharmacol
publication date: 2020-01-03T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage.
PubMed Identifier: 29374184
author list: Ling QL, Mohite AJ, Murdoch E, Akasaka H, Li QY, So SP, Ruan KH
published in: Scientific reports
information resource reference: Ling QL, Mohite AJ, Murdoch E, Akasaka H, Li QY, So SP, Ruan KH. Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage. Sci Rep. 2018 01 26; 8(1):1653.
journal title abbreviation: Sci Rep
publication date: 2018-01-26T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Microbiology
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Professor
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Assistant Professor
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Chair and Professor
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Assistant Professor
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Assistant Professor
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Authorship 139882
type: Authorship
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linked author: Ling, Qinglan
linked information resource: Improved AAV9-based gene therapy design for SURF1-related Leigh syndrome with minimal toxicity.

Improved AAV9-based gene therapy design for SURF1-related Leigh syndrome with minimal toxicity.
PubMed Identifier: 40893166
author list: Ling Q, Rioux M, Higgs H, Hu Y, Dwyer SE, Gray SJ
published in: Molecular therapy. Methods & clinical development
information resource reference: Ling Q, Rioux M, Higgs H, Hu Y, Dwyer SE, Gray SJ. Improved AAV9-based gene therapy design for SURF1-related Leigh syndrome with minimal toxicity. Mol Ther Methods Clin Dev. 2025 Sep 11; 33(3):101554.
journal title abbreviation: Mol Ther Methods Clin Dev
publication date: 2025-08-11T00:00:00
year: 2025
type: Academic Article
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type: Document
type: Information Resource

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position in organization: UMass Chan Medical School