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Tjia, Jennifer
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Muehlschlegel, Susanne
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Rotation Projects: Clinical research opportunities are available for medical and PhD students, residents and junior faculty upon request. We are currently not hiring paid research staff. We cannot accept basic scientists. Please read up on our research first before applying.
Summary: Dr. Muehlschlegel is a neurointensivist devoted to improving the care of patients with catastrophic neurological injuries. Her research interests concentrate on outcome prognostication in neurocritical care, particularly in moderate-severe traumatic brain injury. She is the principal investigator for several research studies at the UMASS Neuro-Intensive care unit (NeuroICU).
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McCormick, Beth
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Brown, Robert
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Kennedy, David
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Gao, Fen-Biao
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Summary: Our lab uses a combination of molecular, cellular, genetic, and behavioral approaches to further dissect the pathogenic mechanisms of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis with a focus on mutant CHMP2B, progranulin and C9ORF72. We will identify common underlying pathways as potential targets for therapeutic interventions.
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Latz, Eicke
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Bova, Carol
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Puri, Ajit
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Henninger, Nils
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Summary: Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
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Khvorova, Anastasia
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Endowed Chair Honorary Title: Remondi Family Chair in Biomedical Research
Post Docs: POSTDOCTORAL POSITION: RNAI PRECLINICAL DEVELOPMENT Excellent training opportunity for a person considering industrial carrier in drug development Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several classes of oligonucleotides which can efficiently silence genes in various tissues with acceptable level of toxicity. There are also new chemistries being developed to further improve oligonucleotide tissue distribution and cellular uptake. The successful candidate will be a key part of an intra-disciplinary team working with biologists and chemists to develop novel types of therapeutics for treatment of neurological disease, liver disease and orphan indications. The work will include compounds identification, screening, characterization, in vivo efficacy and PK/PD studies, novel assays development etc. In addition exposure and training in nucleic acid pre-clinical development, project management etc will be provided. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular cell biology or pharmacology.
Post Docs: RNAI MEDICINAL CHEMISTRY/ RNA OLIGONUCLEOTIDE CHEMISTRY Develop and characterize novel RNA chemistries to promote efficient oligonucleotide internalization and tissue distribution. Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several chemistries and formulations developed by us and others that effectively support oligo internalization and favorable PK/PD. In most cases in vivo efficacy is limited by (1) poor PK (2) inefficient tissue distribution (3) compound entrapment in biologically inactive intracellular compartments. The objective of future studies will be development of novel chemistries, which promote receptor mediated cellular internalization and/ or endosomal escape. The successful candidate will be responsible for the design and synthesis of novel RNA precursors, optimization of RNA synthesis and conjugation protocols and interface with the biology part of the lab. In addition, exposure to pre-clinical development programs and oligonucleotide manufacturing will be available. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and have previous experience in nucleic acid / oligonucleotide chemistry.
Post Docs: SMALL RNA TRAFFICKING Discover, characterize and adapt mechanisms of small RNA extracellular and intracellular trafficking for development of novel classes of oligonucleotide drugs. A serious limitation in realizing the potential of oligonucleotide based therapies has been the exceedingly inefficient transit of oligonucleotides from outside cells to the intracellular compartments where the biologically relevant activity happens. On the other hand, there are multiple lines of evidence supporting the notion that nature has implemented evolutionarily conserved mechanisms and pathways for efficiently trafficking small RNAs across cellular boundaries. The objective of future studies will be the systematic evaluation of mechanisms of cellular uptake of different classes of oligonucleotides and their comparison to mechanisms of native RNA trafficking using a combination of experimental approaches, including advanced RNA chemistry and high temporal and spatial resolution microscopy in living cells, Mass spectrometry, cell biology and others. The successful candidate will work closely with Victor Ambros and Silvia Corvera labs and the UMASS imaging group and receive training in RNA chemistry, biochemistry, cell biology and pre-clinical development. QUALIFICATIONS:Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular and cell biology
Rotation Projects: Our laboratory uses a combination of nucleic acid and oligonucleotide chemistry, biochemistry, cell biology, and pharmacology and develops and evaluate novel technologies for development of oligonucleotide therapeutics. A rotation project is available to develop and identify chemically modified self-delivering RNAi compounds for treatment of Huntington and other diseases.
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Heneka, Michael
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Golenbock, Douglas
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Endowed Chair Honorary Title: Neil and Margery Blacklow Chair in Infectious Diseases and Immunology
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Szabo, Gyongyi
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
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Haran, John
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Person ID: 37
person in primary position: Professor
type: Agent
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Rotation Projects: Rotation projects are available related to microbiota-gut brain axis and antibiotic usage and the sequelae of antibiotic use in hospitalized patients which include Clostridium difficile and multi-drug resistant organism infection and colonization.
preferred title: Professor

Zoeller, R.
first name: R.
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Clifton, Charles
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Staub, Adrian
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latitude: 42.39565560000000
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Person ID: 3769
person in primary position: Assistant Professor
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type: Person
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Rogaev, Evgeny
first name: Evgeny
last name: Rogaev
full name: Evgeny I Rogaev PhD
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Person ID: 39
person in primary position: Professor
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.
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Crawford, Sybil
first name: Sybil
last name: Crawford
full name: Sybil L Crawford PhD
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Person ID: 465
person in primary position: Professor
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type: Person
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Harris, John
first name: John
last name: Harris
full name: John E Harris MD, PhD
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latitude: 42.27525000000000
longitude: -71.76233800000000
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Person ID: 53
person in primary position: Adjunct Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Lambi and Sarah Adams Chair in Genetic Research
Rotation Projects: Rotations: Targeting the IFN-?-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking real-time autoreactive T cell migration and interactions within the skin: We are usin…
Rotation Projects: Rotations: Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking autoreactive T cell interactions within the skin: We are using fluorescently tagged C…
Summary: Interests: Vitiligo, autoimmunity, immunology, translational research
preferred title: Adjunct Professor

Lemon, Stephenie
first name: Stephenie
last name: Lemon
full name: Stephenie C Lemon PhD
has faculty rank: Professor
latitude: 42.27767280000000
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Person ID: 689
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Endowed Chair Honorary Title: Barbara Helen Smith Chair in Preventive & Behavioral Medicine
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866492

Goldberg, Robert
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last name: Goldberg
full name: Robert Joel Goldberg PhD
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Shaw, Leslie
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Person ID: 900
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McManus, David
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latitude: 42.27525000000000
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Person ID: 994
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
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Almeida, Sandra Cristina
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last name: Almeida
full name: Sandra Cristina Vicente Almeida PhD
has faculty rank: Assistant Professor
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Person ID: 4198
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Summary: Dr. Almeida focuses on uncovering the molecular mechanisms underlying frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD). Her research leverages patient-derived induced pluripotent stem cell (iPSC) lines to create neuronal models that closely mimic disease conditions.
preferred title: Assistant Professor

Research
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Friedmann, Peter
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UMass Chan – Baystate Regional Campus
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Dermatology
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Schoenfeld, Elizabeth
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Singh, Sonal
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Person ID: 4649
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webpage: https://profiles.umassmed.edu/profile/28866602

Lagu, Tara
first name: Tara
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Person ID: 4718
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preferred title: Adjunct Professor

Ashendorf, Lee
first name: Lee
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full name: Lee Ashendorf PhD
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Person ID: 4793
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preferred title: Assistant Professor

Professor
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Research Professor
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Lindenauer, Peter
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has faculty rank: Chair And Professor
latitude: 42.12711190000000
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Person ID: 4845
person in primary position: Chair and Professor
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DeGrush, Elizabeth
first name: Elizabeth
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full name: Elizabeth R DeGrush DO
has faculty rank: Assistant Professor
latitude: 42.27525000000000
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Person ID: 4975
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ADJUNCT ASSOCIATE PROFESSOR
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ADJUNCT PROFESSOR
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Alcusky, Matthew
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Person ID: 5243
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Gurwitz, Jerry
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Person ID: 5308
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Endowed Chair Honorary Title: Dr. John Meyers Professor in Primary Care Medicine
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Usmani, Saad
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full name: Saad Usmani MD
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Population and Quantitative Health Sciences
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Schlaug, Gottfried
first name: Gottfried
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Person ID: 5779
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type: Agent
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van Zundert, Brigitte
first name: Brigitte
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has faculty rank: ADJUNCT PROFESSOR
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Person ID: 10246494
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Bokhour, Barbara
first name: Barbara
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latitude: 42.27525000000000
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Person ID: 10246595
person in primary position: Professor
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preferred title: Professor

Lim, Elaine
first name: Elaine
last name: Lim
Twitter: https://profiles.umassmed.edu/profile/28867074
email address: 6M2k75qfvDeLRovRxBUHc1S6kDMdZvk=
full name: Elaine Lim PhD
has faculty rank: Assistant Professor
latitude: 42.27664990000000
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Person ID: 10246664
person in primary position: Assistant Professor
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Post Docs: Post-doc positions are available, please contact me via email.
Rotation Projects: Rotation projects are designed to aim to train students in both computational genetics/genomics and experimental technologies such as brain organoids. Please contact me via email to discuss.
preferred title: Assistant Professor

Lin, Honghuang
first name: Honghuang
last name: Lin
full name: Honghuang Lin PhD
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 10247010
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https://profiles.umassmed.edu/profile/28866492
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https://profiles.umassmed.edu/profile/28866543
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link anchor text: Muehlschlegel Lab Website

https://profiles.umassmed.edu/profile/28866558
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https://profiles.umassmed.edu/profile/28866602
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https://profiles.umassmed.edu/profile/28867074
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Emergency Medicine at UMass Chan - Baystate
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Neurology at UMass Chan - Baystate
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Professor
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Adjunct Professor
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Assistant Professor
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position in department: Pediatrics
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Saranathan, Manojkumar
first name: Manojkumar
last name: Saranathan
full name: Manojkumar Saranathan PhD
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webpage: https://profiles.umassmed.edu/profile/44403713

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Adjunct Professor
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Driban, Jeffrey
first name: Jeffrey
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Featured Videos: https://profiles.umassmed.edu/profile/40402890
full name: Jeffrey B Driban PhD, AT Ret, CSCS
has faculty rank: Professor
latitude: 42.27834540000000
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Professor
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Associate Professor
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Walkey, Allan
first name: Allan
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full name: Allan Jay Walkey MD, MSc
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Person ID: 10247602
person in primary position: Professor
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webpage: https://profiles.umassmed.edu/profile/104051488

Sperling, Scott
first name: Scott
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latitude: 42.48526100000000
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Medicine at UMass Chan - Lahey
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Assistant Professor
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https://profiles.umassmed.edu/profile/40402890
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury
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Qian, Jing
first name: Jing
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full name: Jing Qian PhD
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Person ID: 10247681
person in primary position: Adjunct Associate Professor
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Radiology at UMass Chan - Lahey
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Health System Science
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Infectious Diseases
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Innate Immunity
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Neurointerventional Radiology
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Pulmonary Medicine
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Professor Emeritus
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Adjunct Professor
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Professor
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Professor
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Adjunct Professor
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Neurocritical Care
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Neuromuscular
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Stroke and Vascular Neurology
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Neurology at UMass Chan - Lahey
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Tan Chingfen Graduate School of Nursing
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Professor Emeritus
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https://profiles.umassmed.edu/profile/44403713
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Martinez, Fernando
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Professor
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Microbiology
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Professor
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Professor
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Krings, Timo
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Assistant Professor
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Yerstein, Oleg
first name: Oleg
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latitude: 42.48526100000000
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Person ID: 10247991
person in primary position: Assistant Professor
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position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/98085746
number of subject areas: 18
type: Connection Details