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Rotation Projects: Potential Rotation Projects Proteostasis regulators, HSF1, HSP70 and HSP90 in liver disease: Determine the expression and function in different cell types of the liver during acute and chronic liver injury using in vivo and in vitro models. Subsequently, we will test the relevance of the expression of these proteins in activation of intracellular signaling molecules involved in induction of fatty liver, inflammation and fibrosis. Role of chemokines in liver disease: CC-chemokines particularly CCL2/MCP-1, is significantly increased in serum as well as in the liver parenchyma in patients with alcoholic hepatitis. We test the role of MCP-1 in induction of fatty acid synthesis or metabolism and inflammation in the alcoholic liver. Our studies will also investigate the role of MCP-1 directed migration of immune cells in the liver contributing to injury.
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Rotation Projects: Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research …
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Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866429

Zierath, Juleen
first name: Juleen
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Lapane, Kate
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Puri, Ajit
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Person ID: 3253
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Henninger, Nils
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Person ID: 3265
person in primary position: Associate Professor
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Summary: Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
preferred title: Associate Professor

Heneka, Michael
first name: Michael
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latitude: 50.70274210000000
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Person ID: 3432
person in primary position: Adjunct Professor
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Szabo, Gyongyi
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Person ID: 36
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
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Hayman, Laura
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Chasan-Taber, Lisa
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Person ID: 3699
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Haran, John
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Person ID: 37
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Rotation Projects: Rotation projects are available related to microbiota-gut brain axis and antibiotic usage and the sequelae of antibiotic use in hospitalized patients which include Clostridium difficile and multi-drug resistant organism infection and colonization.
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Bertone-Johnson, Elizabeth
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McClements, David
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Xiao, Hang
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Spencer, Rebecca
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Debold, Edward
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Xia, Qiangfei
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Poudel, Krishna
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Person ID: 3832
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Crawford, Sybil
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Person ID: 465
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preferred title: Professor

Rosal, Milagros
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Person ID: 594
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Endowed Chair Honorary Title: Imoigele P. Aisiku, MD’97 Chair in Health Equity and Diversity
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webpage: https://profiles.umassmed.edu/profile/28866430

Wolfe, Scot
first name: Scot
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Person ID: 595
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Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
preferred title: Professor

Ruiz De Luzuriaga, Katherine
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last name: Ruiz De Luzuriaga
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latitude: 42.27913100000000
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Person ID: 651
person in primary position: Professor
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Endowed Chair Honorary Title: UMass Memorial Health Care Chair in Biomedical Research
Rotation Projects: Potential Rotation Projects: Contact Dr. Luzuriaga for project details.
preferred title: Professor

Lemon, Stephenie
first name: Stephenie
last name: Lemon
full name: Stephenie C Lemon PhD
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latitude: 42.27767280000000
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Person ID: 689
person in primary position: Professor
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Endowed Chair Honorary Title: Barbara Helen Smith Chair in Preventive & Behavioral Medicine
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webpage: https://profiles.umassmed.edu/profile/28866492

Lawson, Nathan
first name: Nathan
last name: Lawson
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latitude: 42.27587600000000
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Person ID: 755
person in primary position: Professor
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Rotation Projects: Rotation Projects Please contact Nathan Lawson (nathan.lawson@umassmed.edu) for information regarding potential rotation projects. For information concerning recent research in the lab, please see:lawsonlab.umassmed.edu/research.html
preferred title: Professor

Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
has faculty rank: Professor Emeritus
latitude: 42.27525000000000
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Person ID: 78
person in primary position: Professor Emeritus
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preferred title: Professor Emeritus

McManus, David
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latitude: 42.27525000000000
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Person ID: 994
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
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Research
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Friedmann, Peter
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last name: Friedmann
full name: Peter D Friedmann MD, MPH, DFASAM, FACP
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UMass Chan – Baystate Regional Campus
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Skiest, Daniel
first name: Daniel
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Person ID: 4595
person in primary position: Professor
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Singh, Sonal
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last name: Singh
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latitude: 42.27525000000000
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Person ID: 4649
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webpage: https://profiles.umassmed.edu/profile/28866602

Professor
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Associate Professor
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Fergus Clydesdale Endowed Chair
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Associate Professor
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Lindenauer, Peter
first name: Peter
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Person ID: 4845
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Wang, Bo
first name: Bo
last name: Wang
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latitude: 42.27834540000000
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Person ID: 4957
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Copeland, Laurel
first name: Laurel
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT PROFESSOR
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Seddon, Johanna
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Gurwitz, Jerry
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Endowed Chair Honorary Title: Dr. John Meyers Professor in Primary Care Medicine
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Usmani, Saad
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Ophthalmology and Visual Sciences
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Population and Quantitative Health Sciences
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Lin, Honghuang
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https://profiles.umassmed.edu/profile/28866427
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https://profiles.umassmed.edu/profile/28866429
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https://profiles.umassmed.edu/profile/28866430
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https://profiles.umassmed.edu/profile/28866556
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https://profiles.umassmed.edu/profile/28866602
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https://profiles.umassmed.edu/profile/28867032
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https://profiles.umassmed.edu/profile/28867068
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Professor
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Associate Professor
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Adjunct Professor
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Adjunct Assistant Professor
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Professor
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Adjunct Professor
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Chair and Professor
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Evans, Elizabeth
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Walkey, Allan
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Stain, Steven
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Medicine at UMass Chan - Lahey
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Surgery at UMass Chan - Lahey
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Radiology at UMass Chan - Lahey
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Health System Science
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Infectious Diseases
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Innate Immunity
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Neurointerventional Radiology
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Pulmonary Medicine
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Professor Emeritus
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Professor
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Professor
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Professor
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Stroke and Vascular Neurology
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Professor
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