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Xiao, Hang
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Wolf, Greg
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Rotation Projects: Additional information about lab rotations within the CPHR program can be found athttp://www.umassmed.edu/cphr/program/rotations.aspx
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Harris, John
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Endowed Chair Honorary Title: Lambi and Sarah Adams Chair in Genetic Research
Rotation Projects: Rotations: Targeting the IFN-?-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking real-time autoreactive T cell migration and interactions within the skin: We are usin…
Rotation Projects: Rotations: Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking autoreactive T cell interactions within the skin: We are using fluorescently tagged C…
Summary: Interests: Vitiligo, autoimmunity, immunology, translational research
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Vedantham, Srinivasan
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Cerny, Jan
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Goldberg, Robert
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McManus, David
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Research
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UMass Chan – Baystate Regional Campus
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Goff, Sarah
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Dermatology
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Singh, Sonal
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Fergus Clydesdale Endowed Chair
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Lindenauer, Peter
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ADJUNCT ASSOCIATE PROFESSOR
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Seddon, Johanna
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Gurwitz, Jerry
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Endowed Chair Honorary Title: Dr. John Meyers Professor in Primary Care Medicine
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Usmani, Saad
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Ophthalmology and Visual Sciences
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Population and Quantitative Health Sciences
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Patel, Shyam
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Bokhour, Barbara
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Shipley, Rebecca
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Garg, Arvin
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Lin, Honghuang
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Adjunct Associate Professor
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Adjunct Professor
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Instructor
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Adjunct Professor
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Chief Information Officer
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Saranathan, Manojkumar
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Associate Professor
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Weiss, Glen
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Pezzuto, John
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Adjunct Professor
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Professor
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Adjunct Associate Professor
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Professor
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Associate Professor
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Assistant Professor
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Mehta, Geneva
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Associate Professor
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Walkey, Allan
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Genomics and Computational Biology
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Medicine at UMass Chan - Lahey
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Radiology at UMass Chan - Lahey
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Chair and Professor
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Professor
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Cardio Thoracic Radiology
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Health System Science
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Infectious Diseases
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Neurointerventional Radiology
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Pulmonary Medicine
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Professor Emeritus
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Professor
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Professor
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General Pediatrics
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Geissler, Kimberley
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Tan Chingfen Graduate School of Nursing
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position in organization: UMass Chan Medical School

Adjunct Professor
is primary position: true
position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Shin, Dong-Soo
first name: Dong-Soo
last name: Shin
full name: Dong-Soo Shin PhD, RN
has faculty rank: ADJUNCT PROFESSOR
Person ID: 10248397
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Associate Professor
is primary position: true
position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/88314388
publication date: 2025
type: URLLink
label: https://www.onclive.com/view/ihc-testing-may-enable-expedited-identification-of-tp53-mutant-mds-and-aml
link anchor text: OncLive with Dr. Patel and Dr. Gerber: p53 Immunohistochemistry

https://profiles.umassmed.edu/profile/89429665
publication date: 2025
type: URLLink
label: https://www.onclive.com/view/dr-patel-on-the-p53-ihc-positivity-as-potential-surrogate-for-multi-hit-tp53-mutations-in-mds-and-aml
link anchor text: Early Identification of TP53-Mutant MDS and AML Using p53 Immunostaining

https://profiles.umassmed.edu/profile/89429727
publication date: 2023
type: URLLink
label: https://journals.lww.com/oncology-times/blog/onlinefirst/pages/post.aspx
link anchor text: Point-of-Care p53 IHC Unveils TP53-Mutant MDS/AML

https://profiles.umassmed.edu/profile/89429786
publication date: 2025
type: URLLink
label: https://trial.medpath.com/news/61960d9f316e3daa/ihc-testing-enables-rapid-tp53-mutation-detection-in
link anchor text: IHC Enables Rapid Identification of TP53-Mutant MDS/AML

https://profiles.umassmed.edu/profile/95558627
publication date: 2025
type: URLLink
label: https://ashpublications.org/ashclinicalnews/news/8743/p53-IHC-Testing-May-Be-Reliable-Surrogate-for
link anchor text: ASH Clinical News: p53 Immunohistochemistry for TP53-Mutant MDS/AML

Professor
is primary position: true
position in department: Pediatrics
position in division: General Pediatrics
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Assistant Professor
is primary position: true
position in department: Pediatrics
position in division: General Pediatrics
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Adjunct Professor
is primary position: true
position in department: Dermatology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/99769701
publication date: 2025
type: URLLink
label: https://journals.lww.com/oncology-times/fulltext/2025/11000/immunostaining_offers_shortcut_to_detect_high_risk.20.aspx
link anchor text: p53 Immunostain in TP53-Mutant MDS and AML