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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
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m3C32 tRNA modification controls serine codon-biased mRNA translation, cell cycle, and DNA-damage response.
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METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
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linked information resource: The Lin28/let-7 axis regulates glucose metabolism.

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linked information resource: Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.

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linked information resource: Click chemistry enables preclinical evaluation of targeted epigenetic therapies.

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linked information resource: Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects.

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linked information resource: A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression.

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linked information resource: MicroRNA biogenesis pathways in cancer.

Authorship 139962
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linked information resource: Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016.

Authorship 139963
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linked information resource: A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression.

Authorship 139964
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linked information resource: TSC2 regulates microRNA biogenesis via mTORC1 and GSK3?.

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linked information resource: Identification of small molecule inhibitors of Zcchc11 TUTase activity.

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linked information resource: Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias.

Authorship 139967
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linked information resource: The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.

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linked information resource: TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs.

Authorship 139969
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linked information resource: Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs.

Authorship 139970
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linked information resource: Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia.

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linked information resource: LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of?pluripotency.

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linked information resource: Linking miRNA regulation to BCR-ABL expression: the next dimension.

Authorship 139973
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linked information resource: Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.

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linked information resource: Genetic drivers of m6A methylation in human brain, lung, heart and muscle.

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linked information resource: Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.

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linked information resource: mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.

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linked author: Gregory, Richard
linked information resource: Reconstitution of human RNA interference in budding yeast.

Authorship 139982
type: Authorship
author rank in publication: 8
linked author: Gregory, Richard
linked information resource: Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.

Authorship 139983
type: Authorship
author rank in publication: 6
linked author: Gregory, Richard
linked information resource: m3C32 tRNA modification controls serine codon-biased mRNA translation, cell cycle, and DNA-damage response.

Authorship 139984
type: Authorship
author rank in publication: 4
linked author: Gregory, Richard
linked information resource: Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).

Authorship 139985
type: Authorship
author rank in publication: 21
linked author: Gregory, Richard
linked information resource: METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.

Authorship 139986
type: Authorship
author rank in publication: 16
linked author: Gregory, Richard
linked information resource: The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function.

Authorship 139987
type: Authorship
author rank in publication: 2
linked author: Gregory, Richard
linked information resource: Autoregulatory mechanisms controlling the Microprocessor.

Authorship 139988
type: Authorship
author rank in publication: 6
linked author: Gregory, Richard
linked information resource: Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation.

Authorship 139989
type: Authorship
author rank in publication: 5
linked author: Gregory, Richard
linked information resource: Impact of caffeine on metabolic activity and biofilm formation of Candida albicans on acrylic denture resin in the presence of nicotine.

Authorship 139991
type: Authorship
author rank in publication: 2
linked author: Gregory, Richard
linked information resource: How does Lin28 let-7 control development and disease?

Authorship 139992
type: Authorship
author rank in publication: 3
linked author: Gregory, Richard
linked information resource: Molecular basis for interaction of let-7 microRNAs with Lin28.

Authorship 139993
type: Authorship
author rank in publication: 8
linked author: Gregory, Richard
linked information resource: Lin28a regulates germ cell pool size and fertility.

Authorship 139994
type: Authorship
author rank in publication: 2
linked author: Gregory, Richard
linked information resource: MicroRNA regulation of stem cell fate.

Authorship 139995
type: Authorship
author rank in publication: 3
linked author: Gregory, Richard
linked information resource: Selective blockade of microRNA processing by Lin28.

Authorship 139996
type: Authorship
author rank in publication: 8
linked author: Gregory, Richard
linked information resource: m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation.

Authorship 139997
type: Authorship
author rank in publication: 2
linked author: Gregory, Richard
linked information resource: Argonaute2 expression is post-transcriptionally coupled to microRNA abundance.

Authorship 139999
type: Authorship
author rank in publication: 4
linked author: Gregory, Richard
linked information resource: A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway.

Authorship 140000
type: Authorship
author rank in publication: 7
linked author: Gregory, Richard
linked information resource: The tRNA Editing Complex ADAT2/3 Promotes Cancer Cell Growth and Codon-biased mRNA Translation.

Authorship 140001
type: Authorship
author rank in publication: 2
linked author: Gregory, Richard
linked information resource: Methyltransferases modulate RNA stability in embryonic stem cells.

Authorship 140002
type: Authorship
author rank in publication: 7
linked author: Gregory, Richard
linked information resource: Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.

Authorship 140003
type: Authorship
author rank in publication: 2
linked author: Gregory, Richard
linked information resource: MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity.

Authorship 140005
type: Authorship
author rank in publication: 10
linked author: Gregory, Richard
linked information resource: METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing.

Authorship 140006
type: Authorship
author rank in publication: 12
linked author: Gregory, Richard
linked information resource: The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.

Authorship 140007
type: Authorship
author rank in publication: 9
linked author: Gregory, Richard
linked information resource: Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).

Authorship 140008
type: Authorship
author rank in publication: 3
linked author: Gregory, Richard
linked information resource: Antibacterial TAP-mimic electrospun polymer scaffold: effects on P. gingivalis-infected dentin biofilm.

Authorship 140009
type: Authorship
author rank in publication: 16
linked author: Gregory, Richard
linked information resource: BET inhibitor resistance emerges from leukaemia stem cells.

Authorship 140010
type: Authorship
author rank in publication: 15
linked author: Gregory, Richard
linked information resource: miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction.

The Lin28/let-7 axis regulates glucose metabolism.
PubMed Identifier: 21962509
author list: Zhu H, Shyh-Chang N, Segr? AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI, Altshuler D, Daley GQ
published in: Cell
information resource reference: Zhu H, Shyh-Chang N, Segr? AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI, Altshuler D, Daley GQ. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011 Sep 30; 147(1):81-94.
journal title abbreviation: Cell
publication date: 2011-09-30T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

TSC2 regulates microRNA biogenesis via mTORC1 and GSK3?.
PubMed Identifier: 29509898
author list: Og?rek B, Lam HC, Khabibullin D, Liu HJ, Nijmeh J, Triboulet R, Kwiatkowski DJ, Gregory RI, Henske EP
published in: Human molecular genetics
information resource reference: Og?rek B, Lam HC, Khabibullin D, Liu HJ, Nijmeh J, Triboulet R, Kwiatkowski DJ, Gregory RI, Henske EP. TSC2 regulates microRNA biogenesis via mTORC1 and GSK3?. Hum Mol Genet. 2018 05 01; 27(9):1654-1663.
journal title abbreviation: Hum Mol Genet
publication date: 2018-05-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular basis for interaction of let-7 microRNAs with Lin28.
PubMed Identifier: 22078496
author list: Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P
published in: Cell
information resource reference: Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91.
journal title abbreviation: Cell
publication date: 2011-11-10T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity.
PubMed Identifier: 20621047
author list: Martinez NJ, Gregory RI
published in: Cell stem cell
information resource reference: Martinez NJ, Gregory RI. MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell. 2010 Jul 02; 7(1):31-5.
journal title abbreviation: Cell Stem Cell
publication date: 2010-07-02T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).
PubMed Identifier: 25223788
author list: Thornton JE, Du P, Jing L, Sjekloca L, Lin S, Grossi E, Sliz P, Zon LI, Gregory RI
published in: Nucleic acids research
information resource reference: Thornton JE, Du P, Jing L, Sjekloca L, Lin S, Grossi E, Sliz P, Zon LI, Gregory RI. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91.
journal title abbreviation: Nucleic Acids Res
publication date: 2014-09-15T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation.
PubMed Identifier: 39322760
author list: Kahraman S, De Jesus DF, Wei J, Brown NK, Zou Z, Hu J, Pirouz M, Gregory RI, He C, Kulkarni RN
published in: The EMBO journal
information resource reference: Kahraman S, De Jesus DF, Wei J, Brown NK, Zou Z, Hu J, Pirouz M, Gregory RI, He C, Kulkarni RN. m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation. EMBO J. 2024 Nov; 43(22):5445-5468.
journal title abbreviation: EMBO J
publication date: 2024-09-25T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs.
PubMed Identifier: 32816599
author list: Foster DJ, Chang HM, Haswell JR, Gregory RI, Slack FJ
published in: Cell cycle (Georgetown, Tex.)
information resource reference: Foster DJ, Chang HM, Haswell JR, Gregory RI, Slack FJ. TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs. Cell Cycle. 2020 09; 19(18):2314-2326.
journal title abbreviation: Cell Cycle
publication date: 2020-08-20T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells.
PubMed Identifier: 19713958
author list: Hagan JP, Piskounova E, Gregory RI
published in: Nature structural & molecular biology
information resource reference: Hagan JP, Piskounova E, Gregory RI. Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol. 2009 Oct; 16(10):1021-5.
journal title abbreviation: Nat Struct Mol Biol
publication date: 2009-08-27T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.
PubMed Identifier: 22118463
author list: Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, Hagan JP, Iliopoulos D, Gregory RI
published in: Cell
information resource reference: Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, Hagan JP, Iliopoulos D, Gregory RI. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell. 2011 Nov 23; 147(5):1066-79.
journal title abbreviation: Cell
publication date: 2011-11-23T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs.
PubMed Identifier: 27498873
author list: Pirouz M, Du P, Munaf? M, Gregory RI
published in: Cell reports
information resource reference: Pirouz M, Du P, Munaf? M, Gregory RI. Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs. Cell Rep. 2016 08 16; 16(7):1861-73.
journal title abbreviation: Cell Rep
publication date: 2016-08-04T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Linking miRNA regulation to BCR-ABL expression: the next dimension.
PubMed Identifier: 18538729
author list: Faber J, Gregory RI, Armstrong SA
published in: Cancer cell
information resource reference: Faber J, Gregory RI, Armstrong SA. Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell. 2008 Jun; 13(6):467-9.
journal title abbreviation: Cancer Cell
publication date: 2008-06-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
PubMed Identifier: 30232453
author list: Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI
published in: Nature
information resource reference: Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560.
journal title abbreviation: Nature
publication date: 2018-09-19T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.
PubMed Identifier: 18550544
author list: Piskounova E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, Sliz P, Gregory RI
published in: The Journal of biological chemistry
information resource reference: Piskounova E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, Sliz P, Gregory RI. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008 Aug 01; 283(31):21310-4.
journal title abbreviation: J Biol Chem
publication date: 2008-06-12T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

How does Lin28 let-7 control development and disease?
PubMed Identifier: 22784697
author list: Thornton JE, Gregory RI
published in: Trends in cell biology
information resource reference: Thornton JE, Gregory RI. How does Lin28 let-7 control development and disease? Trends Cell Biol. 2012 Sep; 22(9):474-82.
journal title abbreviation: Trends Cell Biol
publication date: 2012-07-09T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia.
PubMed Identifier: 33087503
author list: Taylor AM, Macari ER, Chan IT, Blair MC, Doulatov S, Vo LT, Raiser DM, Siva K, Basak A, Pirouz M, Shah AN, McGrath K, Humphries JM, Stillman E, Alter BP, Calo E, Gregory RI, Sankaran VG, Flygare J, Ebert BL, Zhou Y, Daley GQ, Zon LI
published in: Science translational medicine
information resource reference: Taylor AM, Macari ER, Chan IT, Blair MC, Doulatov S, Vo LT, Raiser DM, Siva K, Basak A, Pirouz M, Shah AN, McGrath K, Humphries JM, Stillman E, Alter BP, Calo E, Gregory RI, Sankaran VG, Flygare J, Ebert BL, Zhou Y, Daley GQ, Zon LI. Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 10 21; 12(566).
journal title abbreviation: Sci Transl Med
publication date: 2020-10-21T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation.
PubMed Identifier: 39892392
author list: Ali RH, Orellana EA, Lee SH, Chae YC, Chen Y, Clauwaert J, Kennedy AL, Gutierrez AE, Papke DJ, Valenzuela M, Silverman B, Falzetta A, Ficarro SB, Marto JA, Fletcher CDM, Perez-Atayde A, Alcindor T, Shimamura A, Prensner JR, Gregory RI, Gutierrez A
published in: Molecular cell
information resource reference: Ali RH, Orellana EA, Lee SH, Chae YC, Chen Y, Clauwaert J, Kennedy AL, Gutierrez AE, Papke DJ, Valenzuela M, Silverman B, Falzetta A, Ficarro SB, Marto JA, Fletcher CDM, Perez-Atayde A, Alcindor T, Shimamura A, Prensner JR, Gregory RI, Gutierrez A. A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation. Mol Cell. 2025 Mar 06; 85(5):948-961.e11.
journal title abbreviation: Mol Cell
publication date: 2025-01-31T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function.
PubMed Identifier: 33156926
author list: Mapperley C, van de Lagemaat LN, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J, Sarapuu A, Choe J, Ivanova I, Krause DS, von Kriegsheim A, Much C, Morgan M, Gregory RI, Mead AJ, O'Carroll D, Kranc KR
published in: The Journal of experimental medicine
information resource reference: Mapperley C, van de Lagemaat LN, Lawson H, Tavosanis A, Paris J, Campos J, Wotherspoon D, Durko J, Sarapuu A, Choe J, Ivanova I, Krause DS, von Kriegsheim A, Much C, Morgan M, Gregory RI, Mead AJ, O'Carroll D, Kranc KR. The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. J Exp Med. 2021 03 01; 218(3).
journal title abbreviation: J Exp Med
publication date: 2021-03-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias.
PubMed Identifier: 30991026
author list: Hinze L, Pfirrmann M, Karim S, Degar J, McGuckin C, Vinjamur D, Sacher J, Stevenson KE, Neuberg DS, Orellana E, Stanulla M, Gregory RI, Bauer DE, Wagner FF, Stegmaier K, Gutierrez A
published in: Cancer cell
information resource reference: Hinze L, Pfirrmann M, Karim S, Degar J, McGuckin C, Vinjamur D, Sacher J, Stevenson KE, Neuberg DS, Orellana E, Stanulla M, Gregory RI, Bauer DE, Wagner FF, Stegmaier K, Gutierrez A. Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019 04 15; 35(4):664-676.e7.
journal title abbreviation: Cancer Cell
publication date: 2019-04-15T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of?pluripotency.
PubMed Identifier: 27992407
author list: Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ
published in: Nature cell biology
information resource reference: Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ. LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of?pluripotency. Nat Cell Biol. 2017 Jan; 19(1):60-67.
journal title abbreviation: Nat Cell Biol
publication date: 2016-12-19T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.
PubMed Identifier: 31242253
author list: Floyd JS, Bloch KM, Brody JA, Maroteau C, Siddiqui MK, Gregory R, Carr DF, Molokhia M, Liu X, Bis JC, Ahmed A, Liu X, Hallberg P, Yue QY, Magnusson PKE, Brisson D, Wiggins KL, Morrison AC, Khoury E, McKeigue P, Stricker BH, Lapeyre-Mestre M, Heckbert SR, Gallagher AM, Chinoy H, Gibbs RA, Bondon-Guitton E, Tracy R, Boerwinkle E, Gaudet D, Conforti A, van Staa T, Sitlani CM, Rice KM, Maitland-van der Zee AH, Wadelius M, Morris AP, Pirmohamed M, Palmer CAN, Psaty BM, Alfirevic A
published in: PloS one
information resource reference: Floyd JS, Bloch KM, Brody JA, Maroteau C, Siddiqui MK, Gregory R, Carr DF, Molokhia M, Liu X, Bis JC, Ahmed A, Liu X, Hallberg P, Yue QY, Magnusson PKE, Brisson D, Wiggins KL, Morrison AC, Khoury E, McKeigue P, Stricker BH, Lapeyre-Mestre M, Heckbert SR, Gallagher AM, Chinoy H, Gibbs RA, Bondon-Guitton E, Tracy R, Boerwinkle E, Gaudet D, Conforti A, van Staa T, Sitlani CM, Rice KM, Maitland-van der Zee AH, Wadelius M, Morris AP, Pirmohamed M, Palmer CAN, Psaty BM, Alfirevic A. Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing. PLoS One. 2019; 14(6):e0218115.
journal title abbreviation: PLoS One
publication date: 2019-06-26T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation.
PubMed Identifier: 22735451
author list: Chang HM, Martinez NJ, Thornton JE, Hagan JP, Nguyen KD, Gregory RI
published in: Nature communications
information resource reference: Chang HM, Martinez NJ, Thornton JE, Hagan JP, Nguyen KD, Gregory RI. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012 Jun 26; 3:923.
journal title abbreviation: Nat Commun
publication date: 2012-06-26T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

MicroRNA biogenesis pathways in cancer.
PubMed Identifier: 25998712
author list: Lin S, Gregory RI
published in: Nature reviews. Cancer
information resource reference: Lin S, Gregory RI. MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 2015 Jun; 15(6):321-33.
journal title abbreviation: Nat Rev Cancer
publication date: 2015-06-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).
PubMed Identifier: 22898984
author list: Thornton JE, Chang HM, Piskounova E, Gregory RI
published in: RNA (New York, N.Y.)
information resource reference: Thornton JE, Chang HM, Piskounova E, Gregory RI. Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA. 2012 Oct; 18(10):1875-85.
journal title abbreviation: RNA
publication date: 2012-08-16T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Click chemistry enables preclinical evaluation of targeted epigenetic therapies.
PubMed Identifier: 28619718
author list: Tyler DS, Vappiani J, Ca?eque T, Lam EYN, Ward A, Gilan O, Chan YC, Hienzsch A, Rutkowska A, Werner T, Wagner AJ, Lugo D, Gregory R, Ramirez Molina C, Garton N, Wellaway CR, Jackson S, MacPherson L, Figueiredo M, Stolzenburg S, Bell CC, House C, Dawson SJ, Hawkins ED, Drewes G, Prinjha RK, Rodriguez R, Grandi P, Dawson MA
published in: Science (New York, N.Y.)
information resource reference: Tyler DS, Vappiani J, Ca?eque T, Lam EYN, Ward A, Gilan O, Chan YC, Hienzsch A, Rutkowska A, Werner T, Wagner AJ, Lugo D, Gregory R, Ramirez Molina C, Garton N, Wellaway CR, Jackson S, MacPherson L, Figueiredo M, Stolzenburg S, Bell CC, House C, Dawson SJ, Hawkins ED, Drewes G, Prinjha RK, Rodriguez R, Grandi P, Dawson MA. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 06 30; 356(6345):1397-1401.
journal title abbreviation: Science
publication date: 2017-06-15T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Lin28a regulates germ cell pool size and fertility.
PubMed Identifier: 23378032
author list: Shinoda G, De Soysa TY, Seligson MT, Yabuuchi A, Fujiwara Y, Huang PY, Hagan JP, Gregory RI, Moss EG, Daley GQ
published in: Stem cells (Dayton, Ohio)
information resource reference: Shinoda G, De Soysa TY, Seligson MT, Yabuuchi A, Fujiwara Y, Huang PY, Hagan JP, Gregory RI, Moss EG, Daley GQ. Lin28a regulates germ cell pool size and fertility. Stem Cells. 2013 May; 31(5):1001-9.
journal title abbreviation: Stem Cells
publication date: 2013-05-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.
PubMed Identifier: 31031138
author list: Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR
published in: Cell stem cell
information resource reference: Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR. Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell. 2019 07 03; 25(1):137-148.e6.
journal title abbreviation: Cell Stem Cell
publication date: 2019-04-25T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of small molecule inhibitors of Zcchc11 TUTase activity.
PubMed Identifier: 26114892
author list: Lin S, Gregory RI
published in: RNA biology
information resource reference: Lin S, Gregory RI. Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol. 2015; 12(8):792-800.
journal title abbreviation: RNA Biol
publication date: 2015-01-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.
PubMed Identifier: 33827897
author list: Yan B, Freiwald T, Chauss D, Wang L, West E, Mirabelli C, Zhang CJ, Nichols EM, Malik N, Gregory R, Bantscheff M, Ghidelli-Disse S, Kolev M, Frum T, Spence JR, Sexton JZ, Alysandratos KD, Kotton DN, Pittaluga S, Bibby J, Niyonzima N, Olson MR, Kordasti S, Portilla D, Wobus CE, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M
published in: Science immunology
information resource reference: Yan B, Freiwald T, Chauss D, Wang L, West E, Mirabelli C, Zhang CJ, Nichols EM, Malik N, Gregory R, Bantscheff M, Ghidelli-Disse S, Kolev M, Frum T, Spence JR, Sexton JZ, Alysandratos KD, Kotton DN, Pittaluga S, Bibby J, Niyonzima N, Olson MR, Kordasti S, Portilla D, Wobus CE, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M. SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation. Sci Immunol. 2021 04 07; 6(58).
journal title abbreviation: Sci Immunol
publication date: 2021-04-07T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

The tRNA Editing Complex ADAT2/3 Promotes Cancer Cell Growth and Codon-biased mRNA Translation.
PubMed Identifier: 40907939
author list: Ramirez-Moya J, Antika TR, Liu Q, Xiong X, Ali R, Gutierrez A, Gregory RI
published in: Journal of molecular biology
information resource reference: Ramirez-Moya J, Antika TR, Liu Q, Xiong X, Ali R, Gutierrez A, Gregory RI. The tRNA Editing Complex ADAT2/3 Promotes Cancer Cell Growth and Codon-biased mRNA Translation. J Mol Biol. 2025 Nov 01; 437(21):169414.
journal title abbreviation: J Mol Biol
publication date: 2025-09-02T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Impact of caffeine on metabolic activity and biofilm formation of Candida albicans on acrylic denture resin in the presence of nicotine.
PubMed Identifier: 31703923
author list: Alfaifi AA, Lin WS, Aldhaian BA, Levon JA, Gregory RL
published in: The Journal of prosthetic dentistry
information resource reference: Alfaifi AA, Lin WS, Aldhaian BA, Levon JA, Gregory RL. Impact of caffeine on metabolic activity and biofilm formation of Candida albicans on acrylic denture resin in the presence of nicotine. J Prosthet Dent. 2020 Jun; 123(6):875-879.
journal title abbreviation: J Prosthet Dent
publication date: 2019-11-06T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Antibacterial TAP-mimic electrospun polymer scaffold: effects on P. gingivalis-infected dentin biofilm.
PubMed Identifier: 26319981
author list: Albuquerque MT, Evans JD, Gregory RL, Valera MC, Bottino MC
published in: Clinical oral investigations
information resource reference: Albuquerque MT, Evans JD, Gregory RL, Valera MC, Bottino MC. Antibacterial TAP-mimic electrospun polymer scaffold: effects on P. gingivalis-infected dentin biofilm. Clin Oral Investig. 2016 Mar; 20(2):387-93.
journal title abbreviation: Clin Oral Investig
publication date: 2015-08-29T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Genetic drivers of m6A methylation in human brain, lung, heart and muscle.
PubMed Identifier: 34211177
author list: Xiong X, Hou L, Park YP, Molinie B, Gregory RI, Kellis M
published in: Nature genetics
information resource reference: Xiong X, Hou L, Park YP, Molinie B, Gregory RI, Kellis M. Genetic drivers of m6A methylation in human brain, lung, heart and muscle. Nat Genet. 2021 08; 53(8):1156-1165.
journal title abbreviation: Nat Genet
publication date: 2021-07-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing.
PubMed Identifier: 31913360
author list: Chen H, Gu L, Orellana EA, Wang Y, Guo J, Liu Q, Wang L, Shen Z, Wu H, Gregory RI, Xing Y, Shi Y
published in: Cell research
information resource reference: Chen H, Gu L, Orellana EA, Wang Y, Guo J, Liu Q, Wang L, Shen Z, Wu H, Gregory RI, Xing Y, Shi Y. METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell Res. 2020 06; 30(6):544-547.
journal title abbreviation: Cell Res
publication date: 2020-01-08T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction.
PubMed Identifier: 26080908
author list: Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA
published in: Molecular therapy : the journal of the American Society of Gene Therapy
information resource reference: Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Mol Ther. 2015 Sep; 23(9):1465-74.
journal title abbreviation: Mol Ther
publication date: 2015-06-17T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Argonaute2 expression is post-transcriptionally coupled to microRNA abundance.
PubMed Identifier: 23485552
author list: Martinez NJ, Gregory RI
published in: RNA (New York, N.Y.)
information resource reference: Martinez NJ, Gregory RI. Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA. 2013 May; 19(5):605-12.
journal title abbreviation: RNA
publication date: 2013-03-13T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway.
PubMed Identifier: 23594738
author list: Chang HM, Triboulet R, Thornton JE, Gregory RI
published in: Nature
information resource reference: Chang HM, Triboulet R, Thornton JE, Gregory RI. A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature. 2013 May 09; 497(7448):244-8.
journal title abbreviation: Nature
publication date: 2013-04-17T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Reconstitution of human RNA interference in budding yeast.
PubMed Identifier: 21252293
author list: Suk K, Choi J, Suzuki Y, Ozturk SB, Mellor JC, Wong KH, MacKay JL, Gregory RI, Roth FP
published in: Nucleic acids research
information resource reference: Suk K, Choi J, Suzuki Y, Ozturk SB, Mellor JC, Wong KH, MacKay JL, Gregory RI, Roth FP. Reconstitution of human RNA interference in budding yeast. Nucleic Acids Res. 2011 Apr; 39(7):e43.
journal title abbreviation: Nucleic Acids Res
publication date: 2011-01-19T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.
PubMed Identifier: 21255825
author list: Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW
published in: Cell
information resource reference: Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 04; 144(3):353-63.
journal title abbreviation: Cell
publication date: 2011-01-20T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.
PubMed Identifier: 23666760
author list: Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ
published in: Stem cells (Dayton, Ohio)
information resource reference: Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. 2013 Aug; 31(8):1563-73.
journal title abbreviation: Stem Cells
publication date: 2013-08-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016.
PubMed Identifier: 29328868
author list: Herzog CR, Berzins DW, DenBesten P, Gregory RL, Hargreaves KM, Messer RLW, Mina M, Mooney MP, Paine ML, Phillips C, Presland RB, Quivey RG, Scannapieco FA, Sheridan JF, Svoboda KKH, Trackman PC, Walker MP, Walker SG, Wang CY, Hu JCC
published in: Journal of dental research
information resource reference: Herzog CR, Berzins DW, DenBesten P, Gregory RL, Hargreaves KM, Messer RLW, Mina M, Mooney MP, Paine ML, Phillips C, Presland RB, Quivey RG, Scannapieco FA, Sheridan JF, Svoboda KKH, Trackman PC, Walker MP, Walker SG, Wang CY, Hu JCC. Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016. J Dent Res. 2018 05; 97(5):483-491.
journal title abbreviation: J Dent Res
publication date: 2018-01-12T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Selective blockade of microRNA processing by Lin28.
PubMed Identifier: 18292307
author list: Viswanathan SR, Daley GQ, Gregory RI
published in: Science (New York, N.Y.)
information resource reference: Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of microRNA processing by Lin28. Science. 2008 Apr 04; 320(5872):97-100.
journal title abbreviation: Science
publication date: 2008-02-21T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression.
PubMed Identifier: 26255770
author list: Du P, Wang L, Sliz P, Gregory RI
published in: Cell
information resource reference: Du P, Wang L, Sliz P, Gregory RI. A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression. Cell. 2015 Aug 13; 162(4):885-99.
journal title abbreviation: Cell
publication date: 2015-08-06T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

MicroRNA regulation of stem cell fate.
PubMed Identifier: 18371442
author list: Li Q, Gregory RI
published in: Cell stem cell
information resource reference: Li Q, Gregory RI. MicroRNA regulation of stem cell fate. Cell Stem Cell. 2008 Mar 06; 2(3):195-6.
journal title abbreviation: Cell Stem Cell
publication date: 2008-03-06T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

BET inhibitor resistance emerges from leukaemia stem cells.
PubMed Identifier: 26367796
author list: Fong CY, Gilan O, Lam EY, Rubin AF, Ftouni S, Tyler D, Stanley K, Sinha D, Yeh P, Morison J, Giotopoulos G, Lugo D, Jeffrey P, Lee SC, Carpenter C, Gregory R, Ramsay RG, Lane SW, Abdel-Wahab O, Kouzarides T, Johnstone RW, Dawson SJ, Huntly BJ, Prinjha RK, Papenfuss AT, Dawson MA
published in: Nature
information resource reference: Fong CY, Gilan O, Lam EY, Rubin AF, Ftouni S, Tyler D, Stanley K, Sinha D, Yeh P, Morison J, Giotopoulos G, Lugo D, Jeffrey P, Lee SC, Carpenter C, Gregory R, Ramsay RG, Lane SW, Abdel-Wahab O, Kouzarides T, Johnstone RW, Dawson SJ, Huntly BJ, Prinjha RK, Papenfuss AT, Dawson MA. BET inhibitor resistance emerges from leukaemia stem cells. Nature. 2015 Sep 24; 525(7570):538-42.
journal title abbreviation: Nature
publication date: 2015-09-14T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects.
PubMed Identifier: 24386612
author list: McCarlie VW, Hartsfield JK, Blum JS, Gonz?lez-Cabezas C, Chin JR, Eckert GJ, Morford LA, Pescovitz MD, Rodriguez H, Fontana M, Gregory RL
published in: Open journal of immunology
information resource reference: McCarlie VW, Hartsfield JK, Blum JS, Gonz?lez-Cabezas C, Chin JR, Eckert GJ, Morford LA, Pescovitz MD, Rodriguez H, Fontana M, Gregory RL. Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects. Open J Immunol. 2013 Sep 01; 3(3).
journal title abbreviation: Open J Immunol
publication date: 2013-09-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression.
PubMed Identifier: 26440890
author list: Triboulet R, Pirouz M, Gregory RI
published in: Cell reports
information resource reference: Triboulet R, Pirouz M, Gregory RI. A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression. Cell Rep. 2015 Oct 13; 13(2):260-6.
journal title abbreviation: Cell Rep
publication date: 2015-10-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Methyltransferases modulate RNA stability in embryonic stem cells.
PubMed Identifier: 24481042
author list: Lin S, Gregory RI
published in: Nature cell biology
information resource reference: Lin S, Gregory RI. Methyltransferases modulate RNA stability in embryonic stem cells. Nat Cell Biol. 2014 Feb; 16(2):129-31.
journal title abbreviation: Nat Cell Biol
publication date: 2014-02-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Autoregulatory mechanisms controlling the Microprocessor.
PubMed Identifier: 21627030
author list: Triboulet R, Gregory RI
published in: Advances in experimental medicine and biology
information resource reference: Triboulet R, Gregory RI. Autoregulatory mechanisms controlling the Microprocessor. Adv Exp Med Biol. 2010; 700:56-66.
journal title abbreviation: Adv Exp Med Biol
publication date: 2010-01-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.
PubMed Identifier: 24581491
author list: Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo FD, Gregory RI
published in: Cell
information resource reference: Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo FD, Gregory RI. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell. 2014 Feb 27; 156(5):893-906.
journal title abbreviation: Cell
publication date: 2014-02-27T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

tRNA dysregulation and disease.
PubMed Identifier: 35681060
author list: Orellana EA, Siegal E, Gregory RI
published in: Nature reviews. Genetics
information resource reference: Orellana EA, Siegal E, Gregory RI. tRNA dysregulation and disease. Nat Rev Genet. 2022 11; 23(11):651-664.
journal title abbreviation: Nat Rev Genet
publication date: 2022-06-09T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
PubMed Identifier: 27117702
author list: Lin S, Choe J, Du P, Triboulet R, Gregory RI
published in: Molecular cell
information resource reference: Lin S, Choe J, Du P, Triboulet R, Gregory RI. The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 05 05; 62(3):335-345.
journal title abbreviation: Mol Cell
publication date: 2016-04-21T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource