Positions for postdoctoral fellows are available in the laboratory of Dr. Gang Han at the Department of Biochemistry and Molecular Pharmacology of The University of Massachusetts- Medical School. Research will focus on developing novel small molecule/ nanoparticle approaches for translational biomedical sciences and molecular imaging. Qualifications: Candidates have a Ph.D degree in (1)Organic Chemistry/polymer synthesis , (2) Molecular cell biology , (3) Biophysics or (4) Biochemistry. A solid training and substantial organic synthesis, animal experiments, spectroscopy and microscopy are desired. Candidates need to have strong work ethic, creativity, and enthusiasm with proven ability to work independently and collaboratively. To apply: Applicants should submit their CV including a full publication list and sources of three reference letters by email to gang.han@umassmed.edu
Rotation projects <p >(1) Specific cell membrane component labeling using bioconjugated nanoparticles <p >(2) To develop tools for targeted and traceable siRNA delivery <p >(3) To synthesize functional nanomaterials for detecting biomarkers in biological fluids
Biochemistry and Molecular Biotechnology
Pietrzak M, Wieczorek Z, Stachelska A, Darzynkiewicz Z
Pietrzak M, Wieczorek Z, Stachelska A, Darzynkiewicz Z. Interactions of chlorophyllin with acridine orange, quinacrine mustard and doxorubicin analyzed by light absorption and fluorescence spectroscopy. Biophys Chem. 2003 May 01; 104(1):305-13.
Interactions of chlorophyllin with acridine orange, quinacrine mustard and doxorubicin analyzed by light absorption and fluorescence spectroscopy.
Korohoda W, Hapek A, Pietrzak M, Ryszawy D, Madeja Z
Korohoda W, Hapek A, Pietrzak M, Ryszawy D, Madeja Z. 9-AAA inhibits growth and induces apoptosis in human melanoma A375 and rat prostate adenocarcinoma AT-2 and Mat-LyLu cell lines but does not affect the growth and viability of normal fibroblasts. Oncol Lett. 2016 Nov; 12(5):4125-4132.
9-AAA inhibits growth and induces apoptosis in human melanoma A375 and rat prostate adenocarcinoma AT-2 and Mat-LyLu cell lines but does not affect the growth and viability of normal fibroblasts.
Skiba E, Michlewska S, Pietrzak M, Wolf WM
Skiba E, Michlewska S, Pietrzak M, Wolf WM. Additive interactions of nanoparticulate ZnO with copper, manganese and iron in Pisum sativum L., a hydroponic study. Sci Rep. 2020 08 11; 10(1):13574.
Additive interactions of nanoparticulate ZnO with copper, manganese and iron in Pisum sativum L., a hydroponic study.
Osowski A, Pietrzak M, Wieczorek Z, Wieczorek J
Journal of toxicology and environmental health. Part A
Osowski A, Pietrzak M, Wieczorek Z, Wieczorek J. Natural compounds in the human diet and their ability to bind mutagens prevents DNA-mutagen intercalation. J Toxicol Environ Health A. 2010; 73(17-18):1141-9.
Natural compounds in the human diet and their ability to bind mutagens prevents DNA-mutagen intercalation.
Wieczorek J, Pietrzak M, Osowski A, Wieczorek Z
Wieczorek J, Pietrzak M, Osowski A, Wieczorek Z. Determination of lead, cadmium, and persistent organic pollutants in wild and orchard-farm-grown fruit in northeastern Poland. J Toxicol Environ Health A. 2010; 73(17-18):1236-43.
Determination of lead, cadmium, and persistent organic pollutants in wild and orchard-farm-grown fruit in northeastern Poland.
Gawrecki A, Zozulinska-Ziolkiewicz D, Michalak MA, Adamska A, Michalak M, Frackowiak U, Flotynska J, Pietrzak M, Czapla S, Gehr B, Araszkiewicz A
Gawrecki A, Zozulinska-Ziolkiewicz D, Michalak MA, Adamska A, Michalak M, Frackowiak U, Flotynska J, Pietrzak M, Czapla S, Gehr B, Araszkiewicz A. Safety and glycemic outcomes of do-it-yourself AndroidAPS hybrid closed-loop system in adults with type 1 diabetes. PLoS One. 2021; 16(4):e0248965.
Safety and glycemic outcomes of do-it-yourself AndroidAPS hybrid closed-loop system in adults with type 1 diabetes.
Giebultowicz J, Wolinowska R, Sztybor A, Pietrzak M, Wroczynski P, Wierzchowski J
Giebultowicz J, Wolinowska R, Sztybor A, Pietrzak M, Wroczynski P, Wierzchowski J. Salivary aldehyde dehydrogenase: activity towards aromatic aldehydes and comparison with recombinant ALDH3A1. Molecules. 2009 Jul 02; 14(7):2363-72.
Salivary aldehyde dehydrogenase: activity towards aromatic aldehydes and comparison with recombinant ALDH3A1.
International journal of molecular sciences
Wolakiewicz G, Pietrzak M, Szabelski M. Silver Nanoparticles Improve Fluorophore Photostability: Application to a Hypericin Study. Int J Mol Sci. 2024 Sep 15; 25(18).
Silver Nanoparticles Improve Fluorophore Photostability: Application to a Hypericin Study.
Uruska A, Zozulinska-Ziolkiewicz D, Niedzwiecki P, Pietrzak M, Wierusz-Wysocka B
Uruska A, Zozulinska-Ziolkiewicz D, Niedzwiecki P, Pietrzak M, Wierusz-Wysocka B. TG/HDL-C ratio and visceral adiposity index may be useful in assessment of insulin resistance in adults with type 1 diabetes in clinical practice. J Clin Lipidol. 2018 May - Jun; 12(3):734-740.
TG/HDL-C ratio and visceral adiposity index may be useful in assessment of insulin resistance in adults with type 1 diabetes in clinical practice.
Wierzchowski J, Pietrzak M, Szelag M, Wroczynski P
Wierzchowski J, Pietrzak M, Szelag M, Wroczynski P. Salivary aldehyde dehydrogenase--reversible oxidation of the enzyme and its inhibition by caffeine, investigated using fluorimetric method. Arch Oral Biol. 2008 May; 53(5):423-8.
Salivary aldehyde dehydrogenase--reversible oxidation of the enzyme and its inhibition by caffeine, investigated using fluorimetric method.
Skiba E, Pietrzak M, Gapinska M, Wolf WM
Skiba E, Pietrzak M, Gapinska M, Wolf WM. Metal Homeostasis and Gas Exchange Dynamics in Pisum sativum L. Exposed to Cerium Oxide Nanoparticles. Int J Mol Sci. 2020 Nov 11; 21(22).
Metal Homeostasis and Gas Exchange Dynamics in Pisum sativum L. Exposed to Cerium Oxide Nanoparticles.
Skiba E, Pietrzak M, Michlewska S, Gruszka J, Malejko J, Godlewska-Zylkiewicz B, Wolf WM
Environmental pollution (Barking, Essex : 1987)
Skiba E, Pietrzak M, Michlewska S, Gruszka J, Malejko J, Godlewska-Zylkiewicz B, Wolf WM. Photosynthesis governed by nanoparticulate titanium dioxide. The Pisum sativum L. case study. Environ Pollut. 2024 Jan 01; 340(Pt 2):122735.
Photosynthesis governed by nanoparticulate titanium dioxide. The Pisum sativum L. case study.
Giebultowicz J, Dziadek M, Wroczynski P, Woznicka K, Wojno B, Pietrzak M, Wierzchowski J
Giebultowicz J, Dziadek M, Wroczynski P, Woznicka K, Wojno B, Pietrzak M, Wierzchowski J. Salivary aldehyde dehydrogenase - temporal and population variability, correlations with drinking and smoking habits and activity towards aldehydes contained in food. Acta Biochim Pol. 2010; 57(3):361-8.
Salivary aldehyde dehydrogenase - temporal and population variability, correlations with drinking and smoking habits and activity towards aldehydes contained in food.
Pietrzak M, Halicka HD, Wieczorek Z, Wieczorek J, Darzynkiewicz Z
Pietrzak M, Halicka HD, Wieczorek Z, Wieczorek J, Darzynkiewicz Z. Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin. Biophys Chem. 2008 Jun; 135(1-3):69-75.
Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin.
Pietrzak M, Skiba E, Wolf WM. Root-Applied Cerium Oxide Nanoparticles and Their Specific Effects on Plants: A Review. Int J Mol Sci. 2024 Apr 04; 25(7).
Root-Applied Cerium Oxide Nanoparticles and Their Specific Effects on Plants: A Review.
Pietrzak M, Wieczorek Z, Wieczorek J, Darzynkiewicz Z
Pietrzak M, Wieczorek Z, Wieczorek J, Darzynkiewicz Z. The "interceptor" properties of chlorophyllin measured within the three-component system: intercalator-DNA-chlorophyllin. Biophys Chem. 2006 Aug 20; 123(1):11-9.
The "interceptor" properties of chlorophyllin measured within the three-component system: intercalator-DNA-chlorophyllin.
Pietrzak M, Szabelski M, Wolakiewicz G, Wieczorek Z
Pietrzak M, Szabelski M, Wolakiewicz G, Wieczorek Z. Spectroscopy studies of interaction hypericin with an anti-cancer therapy drug doxorubicin. Biophys Chem. 2022 09; 288:106858.
Spectroscopy studies of interaction hypericin with an anti-cancer therapy drug doxorubicin.
Bogucka M, Giebultowicz J, Zawada K, Wroczynski P, Wierzchowski J, Pietrzak M, Piekarczyk P, Romanowska K
Bogucka M, Giebultowicz J, Zawada K, Wroczynski P, Wierzchowski J, Pietrzak M, Piekarczyk P, Romanowska K. The oxidation status of ALDH3A1 in human saliva and its correlation with antioxidant capacity measured by ORAC method. Acta Pol Pharm. 2009 Sep-Oct; 66(5):477-82.
The oxidation status of ALDH3A1 in human saliva and its correlation with antioxidant capacity measured by ORAC method.
Wieczorek J, Sienkiewicz S, Pietrzak M, Wieczorek Z
Wieczorek J, Sienkiewicz S, Pietrzak M, Wieczorek Z. Uptake and phytotoxicity of anthracene and benzo[k]fluoranthene applied to the leaves of celery plants (Apium graveolens var. secalinum L.). Ecotoxicol Environ Saf. 2015 May; 115:19-25.
Uptake and phytotoxicity of anthracene and benzo[k]fluoranthene applied to the leaves of celery plants (Apium graveolens var. secalinum L.).
Skiba E, Pietrzak M, Glinska S, Wolf WM. The Combined Effect of ZnO and CeO2 Nanoparticles on Pisum sativum L.: A Photosynthesis and Nutrients Uptake Study. Cells. 2021 Nov 10; 10(11).
The Combined Effect of ZnO and CeO2 Nanoparticles on Pisum sativum L.: A Photosynthesis and Nutrients Uptake Study.
Stachelska A, Wieczorek Z, Ruszczynska K, Stolarski R, Pietrzak M, Lamphear BJ, Rhoads RE, Darzynkiewicz E, Jankowska-Anyszka M
Stachelska A, Wieczorek Z, Ruszczynska K, Stolarski R, Pietrzak M, Lamphear BJ, Rhoads RE, Darzynkiewicz E, Jankowska-Anyszka M. Interaction of three Caenorhabditis elegans isoforms of translation initiation factor eIF4E with mono- and trimethylated mRNA 5' cap analogues. Acta Biochim Pol. 2002; 49(3):671-82.
Interaction of three Caenorhabditis elegans isoforms of translation initiation factor eIF4E with mono- and trimethylated mRNA 5' cap analogues.
Kulecki M, Daroszewski M, Birula P, Bonikowska A, Kreczmer A, Pietrzak M, Adamska A, Michalak M, Sroczynska A, Michalski M, Zozulinska-Zi?lkiewicz D, Gawrecki A
Kulecki M, Daroszewski M, Birula P, Bonikowska A, Kreczmer A, Pietrzak M, Adamska A, Michalak M, Sroczynska A, Michalski M, Zozulinska-Zi?lkiewicz D, Gawrecki A. Management and Medical Care for Individuals with Type 1 Diabetes Running a Marathon. J Clin Med. 2025 Apr 06; 14(7).
Management and Medical Care for Individuals with Type 1 Diabetes Running a Marathon.