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Thompson, Paul
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Rando, Oliver
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Rotation Projects: Rotation projects are available to study chromatin structure and function. Project 1. Measure histone dynamics in yeast. Histone dynamics play major roles in chromatin metabolism and in the inheritance of chromatin states. To measure histone replacement rates in yeast, we have created yeast strains carrying inducible epitope-tagged histones H3 and H2A. Using microarrays, we will measure histone replacement rates in a variety of mutant yeast to ascertain the role of various chromatin remodeling factors in histone exchange reactions. Project 2. Characterize mechanisms for epigenetic inheritance in yeast. We have identified a variety of genes whose expression state in yeast is epigenetically heritable. We will screen the yeast genome for genes that affect the inheritance of these expression patterns. Project 3. Measure histone dynamics in embryonic stem cells. Embryonic stem cells are pluripotent cells that can give rise to every type of cell in the adult animal. The role of chromatin structure in maintaining this pluripotent state is poorly understood, but it appears that stem cell chromatin is exceptionally labile relative to that in differentiated cells. We will create stem cell lines with inducible tagged histones to measure histone replacement rates across the mouse genome.
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Flotte, Terence
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Baehrecke, Eric
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Kim, Jason
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Summary: My research for almost 30 years has focused on obesity, insulin resistance, and type 2 diabetes and explores the molecular link between inflammation and insulin resistance using transgenic mice with elegant in vivo metabolic experiments and molecular approaches. My research also investigates the role of inflammation and altered metabolism in diabetic heart disease.
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McCormick, Beth
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Brown, Robert
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Gao, Fen-Biao
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Summary: Our lab uses a combination of molecular, cellular, genetic, and behavioral approaches to further dissect the pathogenic mechanisms of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis with a focus on mutant CHMP2B, progranulin and C9ORF72. We will identify common underlying pathways as potential targets for therapeutic interventions.
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Latz, Eicke
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Bergmann, Andreas
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Fitzgerald, Katherine
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Corvera, Silvia
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Endowed Chair Honorary Title: Endowed Chair in Diabetes Research
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Rotation Projects: Rotation Projects Our rotation projects are in the area of diabetes and obesity, and we are interested in basic mechanisms of cell proliferation, differentiation and communication. Diabetes is highly correlated with obesity, but why obesity causes disease in some humans and not others is not understood. Amazingly, we still don’t understand how adipose tissue grows in human adults. A better understanding of this fascinating process can give us insight into basic mechanisms of cell growth, differentiation and communication, as well as mechanisms of disease, not only diabetes but also cancer and developmental defects. During your rotation, you will work on an important piece of a larger project, that has a well-defined outcome. Thus, your successful completion of the rotation project will allow you to be included at the time of publication of the work. Project 1: Adipose tissue is not only formed by adipocytes, but by other cells such as endothelial, mural and immune cells. Also, there are multiple kinds of adipocytes with different functions. We have recently developed conditions to develop adipose tissue from humans in-vitro (adipose tissue “organoids”). From this tissue we have been able to separated single cells, and find that they grow into different kinds of clones. We are now conducting RNAseq on >300 of those clones, to determine how many cell types exist in human adipose tissue, and what their roles are. In this rotation, you will be able to analyze RNAseq data to define what genes characterize these cells, and you will use virus transduction to create immortalized cells for further study. Project 2: Adipose tissue has many functions besides storing and releasing lipids. It also has to coordinate metabolism in the whole body. We have found that human “beige” adipose tissue, which is found in people who are metabolically healthy, expresses genes for secreted factors that communicate with the immune system and the brain. These include IL-33 and enkephalins. In t…
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Shultz, Leonard
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longitude: -68.19692870000000
Person ID: 2863
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Czech, Michael
first name: Michael
last name: Czech
full name: Michael Paul Czech PhD
has faculty rank: Professor Emeritus
latitude: 42.27913450000000
longitude: -71.76550630000000
Person ID: 289
person in primary position: Professor Emeritus
type: Agent
type: Person
Endowed Chair Honorary Title: Isadore and Fannie Foxman Chair in Medical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Czech for additional details.
Rotation Projects: Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research …
preferred title: Professor Emeritus

Walker, Amy
first name: Amy
last name: Walker
full name: Amy K Walker PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 3101
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Determine links between SREBPs, SAMe levels and epigenetic regulation Methylation of histones or DNA affects gene expression at local as well as global levels. The major cellular methyl donor, s-adenosylmethionine (SAMe) is produced by the folate or 1-carbon (1C) cycle. 1CC function may be affected by dietary levels of folate, methionine, choline or betaine, genetic polymorphisms, or alcohol intake, linking potential for epigenetic modification in cancer progression to food intake and metabolism. Physiological limitation of 1CC function has multiple deleterious physiological effects from birth defects to the development of hepatosteatosis and has also been linked to hepatic and colon cancer. While many studies have shown that the availability of methyl donors may dramatically affect human disease, the mechanisms governing SAMe production and epigenetic modification are much less clear. We hypothesize that modulation of SBP-1 function affecting sams-1 expression will also alter methyl group levels and subsequently, histone modification, leading to changes in gene expression relevant to overall nutritional homeostasis. We will determine if modulation of SAMe levels through SBP-1 effects histone methylation at nutritionally important promoters and examine how diet quality and dietary supplementation affect SBP-1 activity by evaluating histone methylation, in addition to employing biological assays for epigenetic changes in gene expression. We will also use unbiased assays such as ChIP-Seq to identify genes whose expression levels are linked to epigenetic changes after sbp-1 RNAi, selecting those with roles in metabolism for further study. These studies will provide a basis for understanding how lipid homeostasis and other dietary influences affect SAMe production and how those are linked to increased lipid accumulation in C. elegans. Future studies will extend these models to mammalian systems to investigate how these changes predispose hepatosteatosis, a component of …
Rotation Projects: Determine mechanisms for differential regulation of SREBP-1 and SREBP-2 by PC-based feedback In recent studies, we have found that inactive precursors for SREBP-1 are cleaved, accumulate in the nucleus and activate lipogenic transcription programs when membrane changes linked to low PC levels alter localization of SREBP-activating proteases (see Research Interests). We also found that SREBP-2 was resistant to this regulation (Figure 1), and note that while mouse models of PC depletion are associated with hepatic steatosis, cholesterol levels are not necessarily affected (Jacobs, et al. 2008, JBC). We will determine the mechanisms of this differential regulation which will be important for understanding how lipid or cholesterol synthesis may be inappropriately stimulated in metabolic disease. Figure 1: Depletion of PC biosynthesis enzymes in HepG2 human hepatoma cells causes nuclear localization of SREBP-1, but not SREBP-2. Yellow line shows cell boundary
Rotation Projects: Identify cellular responses to decreased SAMe production Our studies in C. elegans showed that SREBP transcriptional activators could control expression 1CC genes. These studies are important because they demonstrate that levels of these critical enzymes mRNAa are not controlled as a “housekeeping function” but are instead are coordinated with other cellular processes. We have developed two models for 1CC dysfunction in C. elegans, a genetic model based on loss of function (lof) of sams-1, a SBP-1/SREBP responsive gene encoding the enzyme for producing the methyl donor SAMe and a dietary model in which C. elegans are fed bacteria unable to synthesize folate. In both of these models, transcription of lipogenic genes are highly increased and sams-1(lof) worms accumulate large lipid droplets, mimicking aspects of fatty liver disease in mammals. These models will allow use genetic screens as a tool for identifying 1) other regulatory pathways affecting SAMe production or utilization and 2) cellular responses that limit lipogenesis when methyl donor levels are low.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866527

Davis, Roger
first name: Roger
last name: Davis
full name: Roger J Davis PhD, FRS
has faculty rank: Chair And Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 3130
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: H. Arthur Smith Chair in Cancer Research
Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866429

Zierath, Juleen
first name: Juleen
last name: Zierath
full name: Juleen R Zierath PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 3151
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Rhind, Nicholas
first name: Nicholas
last name: Rhind
full name: Nicholas R Rhind PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
Person ID: 318
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Potential Rotation Projects 1) Coordination of replication and recombination by the S-phase DNA damage checkpoint The replication checkpoint coordinates replication and recombinational repair to allow for the replication of damaged templates, however the mechanism by which the checkpoint regulates recombination is unknown. We have identified a number of potential checkpoint-kinase targets by phosphoproteomics. One possible rotation project would be to create site-directed mutations that would prevent kinase regulation of one or more of the targets. These mutations could be used to validate the role of the target in the checkpoint and to test the importance of checkpoint regulation in S-phase DNA repair. 2) Regulation of replication timing Heterochromatin regulates the timing of replication origin firing, however the mechanism by which it affects origin function is unknown. We have developed a model of how origin timing is regulated in non-heterochromatic chromatin; now we want to test how heterochromatin affects this mechanism. In particular, we want to manipulate the heterochromatic context at specific loci, measure the changes in origin timing and investigate the molecular mechanisms responsible for the change. One possible rotation project would be to establish heterochromatin at a well-characterized origin, measure origin timing, which we presume will be delayed, and then test at which step origin firing is delayed. <p >
preferred title: Professor

Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
has faculty rank: ADJUNCT PROFESSOR
latitude: 50.70274210000000
longitude: 7.10034010000000
Person ID: 3432
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Royer, William
first name: William
last name: Royer
full name: William E Royer PhD
has faculty rank: Professor Emeritus
latitude: 42.27985300000000
longitude: -71.79190270000000
Person ID: 346
person in primary position: Professor Emeritus
type: Agent
type: Person
Rotation Projects: <Long Text /> Potential Rotation Projects Project #1: Probing the structural basis for cooperativity in a dimeric hemoglobin: Scapharca dimeric hemoglobin is an elegantly simple model system for exploring the structural basis for intersubunit communication. Our analysis to date has established a new paradigm for cooperativity in which tightly bound water molecules are used as sensors for ligand state. In this project, the student will first mutate the gene for the native hemoglobin at a residue that is suspected of playing a role in the intersubunit communication. The mutated protein will then be expressed in E. coli and purified and subjected to functional analysis of oxygen binding. Using conditions already established for the native protein, the mutant hemoglobin will then be crystallized and subjected to preliminary x-ray analysis. This project will provide the student with an introduction to two of the most powerful techniques for investigating the structure and function of proteins: site-directed mutagenesis and x-ray crystallography. Additionally, valuable experience in protein purification will be obtained. Project #2: Structural analysis of the polymerization of sickle-cell hemoglobin Sickle cell disease results from the pathological polymerization of deoxygenated hemoglobin S (ß6E->V) within erythrocytes. This polymerization depends upon a complicated interplay of multiple interactions between tetramers. Our high resolution crystal structure of this molecule has elucidated details of some of the important interactions. Several projects are available for rotation students. These include crystallization of sickle-cell hemoglobin in the presence of an inhibitor to identify its binding site, site-directed mutagenesis of hemoglobin S and crystallization of mutants that show altered polymerization characteristics.
preferred title: Professor Emeritus

Yoon, Seongkyu
first name: Seongkyu
last name: Yoon
full name: Seongkyu Yoon PhD
has faculty rank: Assistant Professor
latitude: 42.64602850000000
longitude: -71.36462360000000
Person ID: 3553
person in primary position: https://profiles.umassmed.edu/profile/16237472
type: Agent
type: Person

Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27636250000000
longitude: -71.76564740000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 36
person in primary position: Adjunct Professor
type: Agent
type: Person
Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Lian, Jane
first name: Jane
last name: Lian
full name: Jane B Lian PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27723620000000
longitude: -71.76070940000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 370
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Kamen, Gary
first name: Gary
last name: Kamen
full name: Gary Kamen PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3702
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Wadsworth, Patricia
first name: Patricia
last name: Wadsworth
full name: Patricia Wadsworth PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3707
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Schwartz, Lawrence
first name: Lawrence
last name: Schwartz
full name: Lawrence M Schwartz PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3708
person in primary position: E&R Isenberg Prof Intg Env Sci
type: Agent
type: Person
preferred title: E&R Isenberg Prof Intg Env Sci

Siegelmann, Hava
first name: Hava
last name: Siegelmann
full name: Hava Siegelmann PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3712
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Freedson, Patty
first name: Patty
last name: Freedson
full name: Patty S Freedson BS, MS, PhD
has faculty rank: Chair And Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3733
person in primary position: Chair and Professor
type: Agent
type: Person
preferred title: Chair and Professor

Rotello, Vincent
first name: Vincent
last name: Rotello
full name: Vincent Rotello PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3741
person in primary position: Department Head
type: Agent
type: Person
preferred title: Department Head

Kent-Braun, Jane
first name: Jane
last name: Kent-Braun
full name: Jane Kent-Braun PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3752
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Fissore, Rafael
first name: Rafael
last name: Fissore
full name: Rafael A Fissore DVM-PhD
has faculty rank: Chair And Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3755
person in primary position: Chair and Professor
type: Agent
type: Person
preferred title: Chair and Professor

McClements, David
first name: David
last name: McClements
full name: David J McClements B.S., Ph.D.
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3760
person in primary position: Fergus Clydesdale Endowed Chair
type: Agent
type: Person
preferred title: Fergus Clydesdale Endowed Chair

Henson, Michael
first name: Michael
last name: Henson
full name: Michael Henson PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3761
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Crosby, Alfred
first name: Alfred
last name: Crosby
full name: Alfred J Crosby PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3762
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Forbes, Neil
first name: Neil
last name: Forbes
full name: Neil Forbes PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3764
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Visconti, Pablo
first name: Pablo
last name: Visconti
full name: Pablo Visconti PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3766
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Xiao, Hang
first name: Hang
last name: Xiao
full name: Hang Xiao PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3795
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Debold, Edward
first name: Edward
last name: Debold
full name: Edward P Debold PhD
has faculty rank: Assistant Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3802
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Chien, Peter
first name: Peter
last name: Chien
full name: Peter Chien PhD
has faculty rank: Assistant Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3812
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Zamore, Phillip
first name: Phillip
last name: Zamore
full name: Phillip D Zamore PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 418
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
webpage: https://profiles.umassmed.edu/profile/28866537
webpage: https://profiles.umassmed.edu/profile/28866541

Soller, Babs
first name: Babs
last name: Soller
full name: Babs R Soller PhD
has faculty rank: Professor Emeritus
latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 440
person in primary position: Professor Emeritus
type: Agent
type: Person
preferred title: Professor Emeritus

Imbalzano, Anthony
first name: Anthony
last name: Imbalzano
full name: Anthony N Imbalzano PhD
has faculty rank: Professor
latitude: 42.27767280000000
longitude: -71.76163720000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 507
person in primary position: Professor
type: Agent
type: Person
Post Docs: Please contact Dr. Imbalzano to discuss the possibility of a postdoctoral training.See lab research interests and publications for recent topics of research. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
Rotation Projects: Please contact Dr. Imbalzano to discuss the possibility of a rotation project. Rotation projects are generally based on current work and tailored to the interests of the student. See lab research interests and publications for recent topics. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
preferred title: Professor

Richter, Joel
first name: Joel
last name: Richter
Featured Videos: https://profiles.umassmed.edu/profile/28867186
full name: Joel Richter PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 554
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Arthur F. Koskinas Chair in Neuroscience
Rotation Projects: Many rotation projects are available so please inquire.
preferred title: Professor

Schiffer, Celia
first name: Celia
last name: Schiffer
Featured Videos: https://profiles.umassmed.edu/profile/28867214
full name: Celia A Schiffer PhD
has faculty rank: Chair And Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 558
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Arthur F. and Helen P. Koskinas Professor in Biochemistry and Molecular Biotechnology
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866505

Greiner, Dale
first name: Dale
last name: Greiner
full name: Dale L Greiner PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 612
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
preferred title: Professor

Craig, Roger
first name: Roger
last name: Craig
full name: Roger W Craig PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 73
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Craig for additional details.
Rotation Projects: Potential Rotation Projects Project #1: Lipid-Layer Protein Crystallization for Electron Microscopy.While individual protein molecules can be readily visualized by EM, structural information is greatly enhanced if the molecules can by crystallized into 2-dimensional ordered arrays. Methods for achieving this are well established, making use of lipid monolayers at an air-water interface. Follow literature methods to crystallize "standard" proteins using the lipid-layer method. Observe results by electron microscopy following negative staining. If time permits, carry out preliminary image processing of micrographs and/or crystallization of unknown proteins. Techniques to be learned: lipid layer crystallization methods; grid preparation; use of electron microscope; image processing.
preferred title: Professor

Walhout, Marian
first name: Marian
last name: Walhout
full name: Marian Walhout PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 758
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Maroun Semaan Chair in Biomedical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Please contact Dr. Walhout for additional details.
preferred title: Chair and Professor

Dekker, Job
first name: Job
last name: Dekker
full name: Job Dekker PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 759
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Joseph J. Byrne Chair in Biomedical Research
Rotation Projects: ? Rotation Projects Multiple rotation projects are available in several areas related to long-range gene regulation and higher order chromosome organization. Projects include thorough analyses of the biochemical mechanisms of long-range gene regulation of specific disease-related genes, as well as large-scale analyses of chromosome organization using high-throughput genomics technologies (5C and Hi-C). The lab employs a wide range of experimental approaches, including cell culture, protein biochemistry, microscopy, genomics as well computational approaches such as bioinformatics and modeling. Specific rotation projects are determined dependent on the interest of the student.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866525
webpage: https://profiles.umassmed.edu/profile/28866572

Shaw, Leslie
first name: Leslie
last name: Shaw
full name: Leslie M Shaw PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 900
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866558

Anesthesiology and Perioperative Medicine
type: Department
type: Organization

Pediatric Genetics
type: Division
type: Organization

UMass Chan – Baystate Regional Campus
type: Organization

Haynes, Cole
first name: Cole
last name: Haynes
full name: Cole Michael Haynes PhD
has faculty rank: Professor
latitude: 42.27491030000000
longitude: -71.76424060000000
Person ID: 4422
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866621
webpage: https://profiles.umassmed.edu/profile/28866481

Professor
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E&R Isenberg Prof Intg Env Sci
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Chair and Professor
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Assistant Professor
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https://profiles.umassmed.edu/profile/16237472
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Professor
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Chair and Professor
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Fergus Clydesdale Endowed Chair
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HR job title: Fergus Clydesdale Endowed Chair
position in organization: University of Massachusetts Amherst

Professor
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Professor
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Professor
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ADJUNCT ASSOCIATE PROFESSOR
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ADJUNCT PROFESSOR
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Ralto, Kenneth
first name: Kenneth
last name: Ralto
full name: Kenneth Michael Ralto MD
has faculty rank: Associate Professor
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Martinez, Fernando
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