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Papavinasasundaram, Kadambavanasund
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Baehrecke, Eric
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Kelliher, Michelle
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Brown, Robert
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Bailey, Jeffrey
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Swain, Susan
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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
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Shaffer, Scott
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Fitzgerald, Katherine
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Khan, Ashraf
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Murphy, Kenan
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Rotation Projects: Rotation Projects Study the interaction of the ssDNA annealing protein Bet and its cognate exonuclease with dsDNA ends. Compare wild type Bet with one or mutant Bet proteins. Use both genetic and biochemical studies to answer the question of how this annealase binds to ssDNA and promotes recombination. Develop recombineering technologies for M. tuberculosis involving the electroporation of oligos containing clinically relevant single nucleotide polymorphisms (SNPs). Generate a recombineering system for Pseudomonas aeruginosa via the electroporation of PCR substrates into electrocompetent cells containing PA phage Red-like recombination systems.
Summary: Focus: DNA Mismatch repair mechanisms in M. smegmatis; recombineering technology for gene replacement in bacterial pathogens, M. tuberculosis drug discovery.
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Lyons, Michael
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Shultz, Leonard
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Behar, Samuel
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Rotation Projects: LAB ROTATION PROJECTS AVAILABLE -- PLEASE CONTACT SAM BEHAR FOR MORE INFORMATION
Summary: Focus: We seek to understand how the causative agent of tuberculosis, namely the bacterium Mycobacterium tuberculosis evades host immunity, and how different components of the immune response work together to contain infection. Our ultimate goal is to inform vaccine development and the design of host directed therapy.
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Golenbock, Douglas
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Lian, Jane
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Tew, Greg
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Rotello, Vincent
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McClements, David
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Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
webpage: https://profiles.umassmed.edu/profile/28866537
webpage: https://profiles.umassmed.edu/profile/28866541

Baker, Richard
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Person ID: 486
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preferred title: Associate Professor

Daly, Jennifer
first name: Jennifer
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Person ID: 546
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preferred title: Professor

Kornfeld, Hardy
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Person ID: 739
person in primary position: Professor
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Wang, Jennifer
first name: Jennifer
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Person ID: 770
person in primary position: Professor
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Sassetti, Christopher
first name: Christopher
last name: Sassetti
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Person ID: 878
person in primary position: Professor
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Endowed Chair Honorary Title: Elisabeth Chair II
Lab URL: https://www.umassmed.edu/sassettilab/
Rotation Projects: Rotation Projects <p >We have identified a number of bacterial pathways that are required for bacterial viability or virulence. We are particularly interested in: Phosphosignaling systems that regulate cell wall synthesis Metabolic regulatory mechanisms that trigger the “dormancy” response observed during infection. <p >A variety of genetic, biochemical, and informatic methods will be used to define the functions of these genes and the role played by each during infection. <p >
Summary: Focus: Pathogenesis of tuberculosis
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Ostroff, Gary
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last name: Ostroff
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Person ID: 941
person in primary position: Professor
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McManus, David
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Person ID: 994
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
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Szkwarko, Daria
first name: Daria
last name: Szkwarko
full name: Daria Lesia Szkwarko DO
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latitude: 41.87062340000000
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Person ID: 4254
person in primary position: Adjunct Associate Professor
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preferred title: Adjunct Associate Professor

Pediatric Genetics
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Friedmann, Peter
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last name: Friedmann
full name: Peter D Friedmann MD, MPH, DFASAM, FACP
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latitude: 42.10873680000000
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Person ID: 4333
person in primary position: Professor
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Padilla-Benavides, Teresita
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last name: Padilla-Benavides
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latitude: 42.27721220000000
longitude: -71.76106070000000
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Person ID: 4351
person in primary position: Adjunct Assistant Professor
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Post Docs: Claudia A. Vilchis Nestor. Visiting Scholar from CINVESTAV-IPN, MEXICO <img alt="" height="121" src="[binary]" width="93" />
preferred title: Adjunct Assistant Professor

UMass Chan – Baystate Regional Campus
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Theodoropoulos, Nicole
first name: Nicole
last name: Theodoropoulos
full name: Nicole Marie Theodoropoulos MD
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latitude: 42.27767280000000
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Person ID: 4407
person in primary position: Associate Professor
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type: Person
preferred title: Associate Professor

Richmond, Jillian
first name: Jillian
last name: Richmond
full name: Jillian M Richmond PhD
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latitude: 42.27767280000000
longitude: -71.76163720000000
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Person ID: 4448
person in primary position: Adjunct Assistant Professor
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Summary: Interests: Autoimmunity, Immunology, Fibrosis, Translational Research, Lupus
preferred title: Adjunct Assistant Professor

Dermatology
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Baer, Christina
first name: Christina
last name: Baer
full name: Christina E Baer PhD
has faculty rank: Associate Professor
latitude: 42.27767280000000
longitude: -71.76163720000000
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Person ID: 4695
person in primary position: Associate Professor
type: Agent
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Summary: Focus: Director of the Sanderson Center for Optics Experimentation (SCOPE)
preferred title: Associate Professor

Professor
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HR job title: Professor
position in organization: University of Massachusetts Amherst

Professor
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HR job title: Professor
position in organization: University of Massachusetts Amherst

Department Head
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position in division: Chemistry
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HR job title: Department Head
position in organization: University of Massachusetts Amherst

Fergus Clydesdale Endowed Chair
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position in department: College of Natural Sciences
position in division: Department of Food Science
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HR job title: Fergus Clydesdale Endowed Chair
position in organization: University of Massachusetts Amherst

Assistant Professor
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position in department: College of Natural Sciences
position in division: Biochemistry And Molecular Biology
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HR job title: Assistant Professor
position in organization: University of Massachusetts Amherst

Department Head
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position in department: College of Natural Sciences
position in division: Plant, Soil And Insect Sciences
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HR job title: Department Head
position in organization: University of Massachusetts Amherst

https://profiles.umassmed.edu/profile/16241114
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position in department: College of Natural Sciences
position in division: Department of Microbiology
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position in organization: University of Massachusetts Amherst

ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT ASSOCIATE PROFESSOR
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type: Faculty Rank

ADJUNCT PROFESSOR
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type: Faculty Rank

Malonia, Sunil
first name: Sunil
last name: Malonia
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full name: Sunil K Malonia PhD
has faculty rank: Instructor
latitude: 42.27491030000000
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Person ID: 5168
person in primary position: Instructor
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preferred title: Instructor

Seddon, Johanna
first name: Johanna
last name: Seddon
full name: Johanna Margaret Seddon MD, ScM
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 5252
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Strauss, Kevin
first name: Kevin
last name: Strauss
full name: Kevin Strauss MD
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latitude: 39.95747490000000
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Person ID: 5405
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Ophthalmology and Visual Sciences
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type: Organization

Population and Quantitative Health Sciences
type: Department
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Antonelli, Lis
first name: Lis
last name: Antonelli
full name: Lis Antonelli PhD
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latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 5497
person in primary position: Adjunct Assistant Professor
type: Agent
type: Person
preferred title: Adjunct Assistant Professor

Bucci, Vanni
first name: Vanni
last name: Bucci
full name: Vanni Bucci PhD
has faculty rank: Professor
latitude: 42.27834540000000
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Person ID: 5642
person in primary position: Professor
type: Agent
type: Person
Lab URL: https://www.umassmed.edu/buccilab/
Summary: Focus: Host-microbiome interaction, computational biology, synthetic biology
preferred title: Professor

Smulan, Lorissa
first name: Lorissa
last name: Smulan
full name: Lorissa Joy Smulan PhD
has faculty rank: Assistant Professor
latitude: 42.27525000000000
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Person ID: 10246756
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Biochemistry and Molecular Biotechnology
type: Department
type: Organization

Lin, Honghuang
first name: Honghuang
last name: Lin
full name: Honghuang Lin PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
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Person ID: 10247010
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

https://profiles.umassmed.edu/profile/28866427
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label: http://www.umassmed.edu/fitzgeraldlab
link anchor text: Fitzgerald Lab Page

https://profiles.umassmed.edu/profile/28866441
type: URLLink
label: https://www.umassmed.edu/shafferlab/
link anchor text: BMP Faculty Page

https://profiles.umassmed.edu/profile/28866477
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label: https://www.umassmed.edu/mccb/faculty-MCCB/faculty-MCCB/faculty-profile-pages/baehrecke-eric/
link anchor text: Department Faculty Profile

https://profiles.umassmed.edu/profile/28866493
type: URLLink
label: http://www.umassmed.edu/pii
link anchor text: Program in Innate Immunity

https://profiles.umassmed.edu/profile/28866537
type: URLLink
label: https://www.umassmed.edu/rti/
link anchor text: RNA Therapeutics Institute

https://profiles.umassmed.edu/profile/28866541
type: URLLink
label: https://www.umassmed.edu/RNATx/
link anchor text: 2018 RTI Symposia

https://profiles.umassmed.edu/profile/28866549
type: URLLink
label: https://www.umassmed.edu/MSF/
link anchor text: UMMS Mass Spectrometry Facility

https://profiles.umassmed.edu/profile/28866555
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label: https://www.zamorelab.umassmed.edu
link anchor text: Laboratory Website

https://profiles.umassmed.edu/profile/28866617
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label: http://www.baileylab.org
link anchor text: Bailey Lab

Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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type: Organization

Pathology at UMass Chan - Baystate
type: Department
type: Organization

Barbhuiya, Mustafa
first name: Mustafa
last name: Barbhuiya
full name: Mustafa Barbhuiya MSc, PhD
has faculty rank: Assistant Professor
latitude: 42.12294230000000
longitude: -72.60372970000000
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Person ID: 10247040
person in primary position: Assistant Professor
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Summary: Dr. Mustafa Barbhuiya is currently the Medical Director of Clinical Chemistry and Point of Care Testing at the Department of Pathology, Baystate Medical Center, Springfield, MA. His basic and translational research interests include liver and biliary tract cancer biomarkers. He also conducts research on the role of essential diagnostics list in health care delivery and population health.
preferred title: Assistant Professor
webpage: https://profiles.umassmed.edu/profile/34820140

Instructor
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position in department: Molecular, Cell and Cancer Biology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Instructor
position in organization: UMass Chan Medical School

Adjunct Assistant Professor
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position in department: Emergency Medicine
position in division: Toxicology
sort order: 1
type: Position
HR job title: Adjunct Assistant Professor
position in organization: UMass Chan Medical School

Adjunct Assistant Professor
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position in department: Biochemistry and Molecular Biotechnology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Assistant Professor
position in organization: UMass Chan Medical School

Chair and Professor
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position in department: Pathology at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
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HR job title: Chair and Professor
position in organization: UMass Chan – Baystate Regional Campus

Professor
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position in department: Medicine
position in division: Community Internal Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Program in Molecular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in department: Pediatrics
position in division: Community Pediatrics
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in department: Pathology at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan – Baystate Regional Campus

Singhal, Amit
first name: Amit
last name: Singhal
full name: Amit Singhal PhD
has faculty rank: ADJUNCT ASSOCIATE PROFESSOR
latitude: 1.35208300000000
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Person ID: 10247306
person in primary position: Adjunct Associate Professor
type: Agent
type: Person
preferred title: Adjunct Associate Professor

Adjunct Associate Professor
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position in department: Family Medicine and Community Health
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Associate Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/34820140
type: URLLink
label: https://www.faed.in/
link anchor text: FAED

Lai, Rocky
first name: Rocky
last name: Lai
full name: Rocky Shek-Lun Lai PhD
has faculty rank: Instructor
latitude: 42.27834540000000
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Person ID: 10247476
person in primary position: Instructor
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preferred title: Instructor

Restrepo, Angela
first name: Angela
last name: Restrepo
full name: Angela M Restrepo MD
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latitude: 42.48526100000000
longitude: -71.20221980000000
Person ID: 10247654
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Medicine at UMass Chan - Lahey
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type: Organization

Assistant Professor
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position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
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HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Qian, Jing
first name: Jing
last name: Qian
full name: Jing Qian PhD
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latitude: 42.39427560000000
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Person ID: 10247681
person in primary position: Adjunct Associate Professor
type: Agent
type: Person
preferred title: Adjunct Associate Professor

Basic Pathology
type: Division
type: Organization

Endocrinology & Diabetes
type: Division
type: Organization

Health System Science
type: Division
type: Organization

Infectious Diseases
type: Division
type: Organization

Innate Immunity
type: Division
type: Organization

Orthopedics Research
type: Division
type: Organization

Pulmonary Medicine
type: Division
type: Organization

Adjunct Professor
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position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
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position in division: Innate Immunity
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Adjunct Professor
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position in department: Orthopedics and Physical Rehabilitation
position in division: Orthopedics Research
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Medicine
position in division: Pulmonary Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Pathology
position in division: Basic Pathology
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in department: Medicine
position in division: Pulmonary Medicine
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type: Position
HR job title: Assistant Professor
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Associate Professor
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position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Adjunct Assistant Professor
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position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Adjunct Assistant Professor
position in organization: UMass Chan Medical School

Neuromuscular
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type: Organization

Chair and Professor
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position in department: Medicine
position in division: Cardiovascular Medicine
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type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Professor Emeritus
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HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Martinez, Fernando
first name: Fernando
last name: Martinez
full name: Fernando J Martinez MD, MS
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latitude: 42.27525000000000
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Person ID: 10247895
person in primary position: Professor
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Professor
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position in division: Pulmonary Medicine
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HR job title: Professor
position in organization: UMass Chan Medical School

Microbiology
type: Department
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Assistant Professor
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position in department: Microbiology
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sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in department: Microbiology
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HR job title: Assistant Professor
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Associate Professor
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sort order: 1
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HR job title: Associate Professor
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Instructor
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HR job title: Instructor
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Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in organization: UMass Chan Medical School

Professor
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position in division: Infectious Diseases
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in division: Infectious Diseases
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HR job title: Professor
position in organization: UMass Chan Medical School

Maron, Martin
first name: Martin
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full name: Martin S Maron MD, MSPH
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latitude: 42.48526100000000
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Person ID: 10248121
person in primary position: Associate Professor
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preferred title: Associate Professor

Maron, Barry
first name: Barry
last name: Maron
full name: Barry J Maron MD
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latitude: 42.48526100000000
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Person ID: 10248130
person in primary position: Adjunct Professor
type: Agent
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preferred title: Adjunct Professor

Adjunct Professor
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sort order: 1
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HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Rowin, Ethan
first name: Ethan
last name: Rowin
full name: Ethan Rowin MD, MBA
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latitude: 42.48817480000000
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Person ID: 10248175
person in primary position: Associate Professor
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preferred title: Associate Professor

Associate Professor
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HR job title: Associate Professor
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Professor
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position in division: Innate Immunity
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position in organization: UMass Chan Medical School

Associate Professor
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position in department: Microbiology
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sort order: 1
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Instructor
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type: Faculty Rank

Professor
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Professor Emeritus
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Assistant Professor
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type: Faculty Rank

Associate Professor
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type: Faculty Rank

Chair And Professor
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type: Faculty Rank

Professor
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position in division: Endocrinology & Diabetes
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type: Position
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position in organization: UMass Chan Medical School

Psychiatry and Behavioral Sciences
type: Department
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Professor
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sort order: 1
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HR job title: Professor
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Professor
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position in department: Ophthalmology and Visual Sciences
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
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sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Medicine
position in division: Health System Science
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Neurology
position in division: Neuromuscular
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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