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McCormick, Beth
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Barton, Bruce
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Latz, Eicke
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Rotation Projects: Rotation Projects Our rotation projects are in the area of diabetes and obesity, and we are interested in basic mechanisms of cell proliferation, differentiation and communication. Diabetes is highly correlated with obesity, but why obesity causes disease in some humans and not others is not understood. Amazingly, we still don’t understand how adipose tissue grows in human adults. A better understanding of this fascinating process can give us insight into basic mechanisms of cell growth, differentiation and communication, as well as mechanisms of disease, not only diabetes but also cancer and developmental defects. During your rotation, you will work on an important piece of a larger project, that has a well-defined outcome. Thus, your successful completion of the rotation project will allow you to be included at the time of publication of the work. Project 1: Adipose tissue is not only formed by adipocytes, but by other cells such as endothelial, mural and immune cells. Also, there are multiple kinds of adipocytes with different functions. We have recently developed conditions to develop adipose tissue from humans in-vitro (adipose tissue “organoids”). From this tissue we have been able to separated single cells, and find that they grow into different kinds of clones. We are now conducting RNAseq on >300 of those clones, to determine how many cell types exist in human adipose tissue, and what their roles are. In this rotation, you will be able to analyze RNAseq data to define what genes characterize these cells, and you will use virus transduction to create immortalized cells for further study. Project 2: Adipose tissue has many functions besides storing and releasing lipids. It also has to coordinate metabolism in the whole body. We have found that human “beige” adipose tissue, which is found in people who are metabolically healthy, expresses genes for secreted factors that communicate with the immune system and the brain. These include IL-33 and enkephalins. In t…
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Guilherme, Adilson
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Shultz, Leonard
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Czech, Michael
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Endowed Chair Honorary Title: Isadore and Fannie Foxman Chair in Medical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Czech for additional details.
Rotation Projects: Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research …
preferred title: Professor Emeritus

Davis, Roger
first name: Roger
last name: Davis
full name: Roger J Davis PhD, FRS
has faculty rank: Chair And Professor
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Person ID: 3130
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: H. Arthur Smith Chair in Cancer Research
Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866429

Zierath, Juleen
first name: Juleen
last name: Zierath
full name: Juleen R Zierath PhD
has faculty rank: ADJUNCT PROFESSOR
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Person ID: 3151
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Lapane, Kate
first name: Kate
last name: Lapane
full name: Kate L Lapane PhD
has faculty rank: Professor
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Person ID: 3252
person in primary position: Professor
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preferred title: Professor

Fitzgibbons, Timothy
first name: Timothy
last name: Fitzgibbons
full name: Timothy P Fitzgibbons MD, PhD
has faculty rank: Associate Professor
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person in primary position: Associate Professor
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preferred title: Associate Professor

Rock, Kenneth
first name: Kenneth
last name: Rock
full name: Kenneth L Rock MD
has faculty rank: Chair And Professor
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Person ID: 332
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: UMass Chan Medical School Chair in Biomedical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rock for additional details.
Rotation Projects: Potential Rotation Projects <p >Rotations are available in Dr. Rock’s laboratory for graduate students in the GSBS program. The rotation projects will explore various aspects of how the immune system carries out surveillance to detect viral infections and cancers. Among the potential areas of research are: (1) The alarm signals that alert the immune system to potential danger; (2) The initial innate immune and inflammatory response to infection or other dangerous situations; (3) The biology of the sentinel cells (e.g. dendritic cells) that sense danger and report it the adaptive immune system; (4) The mechanisms by which sentinel cells (e.g. dendritic cells) acquire and display antigens to T cells; and, (5) The antigen presentation pathways by which virally infected or cancer cells display a sampling of their expressed gene products to the activated T cells. Specific rotation projects are chosen based on the student’s interests and state/availability of the various projects in the laboratory. The goals of rotations are for the student to gain knowledge in immunology, to learn how to approach experimental problems, to learn new techniques and methods, and to actually generate data that moves our knowledge forward. In addition, the rotation provides the student the opportunity to evaluate the laboratory as a possible place to conduct their thesis research in the future.
preferred title: Chair and Professor

Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
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person in primary position: Adjunct Professor
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Golenbock, Douglas
first name: Douglas
last name: Golenbock
full name: Douglas T Golenbock MD
has faculty rank: Professor
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Person ID: 345
person in primary position: Professor
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Endowed Chair Honorary Title: Neil and Margery Blacklow Chair in Infectious Diseases and Immunology
preferred title: Professor

Szabo, Gyongyi
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last name: Szabo
full name: Gyongyi Szabo MD, PhD
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Person ID: 36
person in primary position: Adjunct Professor
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Hayman, Laura
first name: Laura
last name: Hayman
full name: Laura L Hayman PhD
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person in primary position: Adjunct Professor
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Blaustein, Jeffrey
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person in primary position: Professor
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Chasan-Taber, Lisa
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person in primary position: Professor
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Lian, Jane
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full name: Jane B Lian PhD
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person in primary position: Adjunct Professor
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Braun, Barry
first name: Barry
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full name: Barry Braun PhD
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person in primary position: Associate Professor
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preferred title: Associate Professor

Bertone-Johnson, Elizabeth
first name: Elizabeth
last name: Bertone-Johnson
full name: Elizabeth R Bertone-Johnson ScD SM
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person in primary position: Associate Professor
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preferred title: Associate Professor

Freedson, Patty
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person in primary position: Chair and Professor
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preferred title: Chair and Professor

Sievert, Lynnette Leidy
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person in primary position: Professor
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Zoeller, R.
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person in primary position: Professor
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Rotello, Vincent
first name: Vincent
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person in primary position: Department Head
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Kent-Braun, Jane
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person in primary position: Professor
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McClements, David
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Person ID: 3760
person in primary position: Fergus Clydesdale Endowed Chair
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preferred title: Fergus Clydesdale Endowed Chair

Visconti, Pablo
first name: Pablo
last name: Visconti
full name: Pablo Visconti PhD
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person in primary position: Professor
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preferred title: Professor

Park, Yeonhwa
first name: Yeonhwa
last name: Park
full name: Yeonhwa Park BS, MS, PhD
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person in primary position: Associate Professor
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preferred title: Associate Professor

Xiao, Hang
first name: Hang
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full name: Hang Xiao PhD
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person in primary position: Associate Professor
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preferred title: Associate Professor

Crawford, Sybil
first name: Sybil
last name: Crawford
full name: Sybil L Crawford PhD
has faculty rank: Professor
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Person ID: 465
person in primary position: Professor
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preferred title: Professor

Brehm, Michael
first name: Michael
last name: Brehm
full name: Michael A Brehm PhD
has faculty rank: Professor
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Person ID: 474
person in primary position: Professor
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Endowed Chair Honorary Title: Harvey A. Shultz Chair in Diabetes
preferred title: Professor

Richter, Joel
first name: Joel
last name: Richter
Featured Videos: https://profiles.umassmed.edu/profile/28867186
full name: Joel Richter PhD
has faculty rank: Professor
latitude: 42.27913100000000
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Person ID: 554
person in primary position: Professor
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Endowed Chair Honorary Title: Arthur F. Koskinas Chair in Neuroscience
Rotation Projects: Many rotation projects are available so please inquire.
preferred title: Professor

Weaver, David
first name: David
last name: Weaver
full name: David R Weaver PhD
has faculty rank: Professor
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Person ID: 572
person in primary position: Professor
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preferred title: Professor

Rosal, Milagros
first name: Milagros
last name: Rosal
full name: Milagros Rosal PhD
has faculty rank: Professor
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Person ID: 594
person in primary position: Professor
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Endowed Chair Honorary Title: Imoigele P. Aisiku, MD’97 Chair in Health Equity and Diversity
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866430

Greiner, Dale
first name: Dale
last name: Greiner
full name: Dale L Greiner PhD
has faculty rank: Professor
latitude: 42.27913100000000
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Person ID: 612
person in primary position: Professor
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Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
preferred title: Professor

Pazour, Gregory
first name: Gregory
last name: Pazour
full name: Gregory J Pazour PhD
has faculty rank: Professor
latitude: 42.27913100000000
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Person ID: 621
person in primary position: Professor
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Rotation Projects: Potential Rotation Projects Rotation projects in my laboratory will involve questions of how cilia are assembled and the function these organelles play in mammals. Projects vary depending on ongoing work in the laboratory and interests of the rotation student. Rotations in my laboratory can give students exposure to a range of techniques from mouse breeding and histological analysis of mouse tissues to mammalian cell culture and other cell biological techniques.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/41661165

Lemon, Stephenie
first name: Stephenie
last name: Lemon
full name: Stephenie C Lemon PhD
has faculty rank: Professor
latitude: 42.27767280000000
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Person ID: 689
person in primary position: Professor
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Endowed Chair Honorary Title: Barbara Helen Smith Chair in Preventive & Behavioral Medicine
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866492

Bandini, Linda
first name: Linda
last name: Bandini
full name: Linda Bandini PhD
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 690
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

Stern, Lawrence
first name: Lawrence
last name: Stern
full name: Lawrence Stern PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 730
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Potential Rotation Projects Several rotation projects are available in structural biology of immune receptors, antigen presentation pathways, T-cell activation, and development of novel T-cell detection reagents. Please see Prof. Stern for details.
preferred title: Professor

Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
has faculty rank: Professor Emeritus
latitude: 42.27525000000000
longitude: -71.76233800000000
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Person ID: 78
person in primary position: Professor Emeritus
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preferred title: Professor Emeritus

Mercurio, Arthur
first name: Arthur
last name: Mercurio
full name: Arthur M Mercurio PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
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Person ID: 901
person in primary position: Professor
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Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
preferred title: Professor

Guertin, David
first name: David
last name: Guertin
Twitter: https://profiles.umassmed.edu/profile/28867128
full name: David A Guertin PhD
has faculty rank: Professor
latitude: 42.27913100000000
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Person ID: 99
person in primary position: Professor
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr.Guertin for additional details.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866529

McManus, David
first name: David
last name: McManus
full name: David D McManus MD
has faculty rank: Chair And Professor
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Person ID: 994
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
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Friedmann, Peter
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last name: Friedmann
full name: Peter D Friedmann MD, MPH, DFASAM, FACP
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person in primary position: Professor
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Professor
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Population and Quantitative Health Sciences
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Rippe, James
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Lin, Honghuang
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