Lab rotations are currently available in this lab. Please contact Dr. Kim.
My research for almost 30 years has focused on obesity, insulin resistance, and type 2 diabetes and explores the molecular link between inflammation and insulin resistance using transgenic mice with elegant in vivo metabolic experiments and molecular approaches. My research also investigates the role of inflammation and altered metabolism in diabetic heart disease.
Isadore and Fannie Foxman Chair in Medical Research
A postdoctoral position is available to study in this laboratory. Contact Dr. Czech for additional details.
Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research Projects for students following a rotation: Developing CRISPR technology for gene editing in adipocytes: Adipocytes function as master regulators of whole body metabolism and deletions of specific adipocyte genes in knockout mice promote dramatic improvements in glucose tolerance and insulin sensitivity in diabetic models. Thus the ability to direct gene editing in adipocytes in vivo has great potential in developing therapeutic strategies for obesity, type 2 diabetes and cardiovascular complications. Alternatively, an ex vivo approach is also feasible since adipose cells can be genetically altered in vitro prior to implantation into mice with beneficial effects. Such projects are designed to be performed in collaboration with other Czech lab members with the goal of specifically deleting or editing genes in adipose depots that drive increases in fatty acid oxidation, energy expenditure and systemic metabolic activity. Exciting preliminary data at the “proof of principle” stage has been achieved and this project is designed to focus on specific genes of high interest for therapeutics. Signaling by the lipogenesis pathway through Acetyl CoA: A major function of adipocytes is to store calories as triglyceride, in part through the process of fatty acid synthesis (lipogenesis). This metabolic pathway involves a number of metabolites including Acetyl CoA, which is also a substrate for acetylation reactions that modify proteins such as histones. Thus metabolic flux through adipocyte lipogenesis may also function as a signaling pathway to the nucleus to modulate transcription via levels of Acetyl CoA that accumulate during this process. This rotation project is designed to test this idea at the molecular level by monitoring histone acetylations and resultant transcriptional events during changes in Acetyl CoA levels caused by altering physiological conditions such as exercise, obesity and diabetes. If this concept is correct, the project could lead to developing therapeutic strategies for metabolic disease based on targeting lipogenic enzymes.
H. Arthur Smith Chair in Cancer Research
Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
Universidade de Santiago de Compostela, Biology
Universidade de Santiago de Compostela, Neuroscience
Universidade de Santiago de Compostela, Endocrinology
Population and Quantitative Health Sciences
Crespo M, Gonzalez-Teran B, Nikolic I, Mora A, Folgueira C, Rodr?guez E, Leiva-Vega L, Pintor-Chocano A, Fern?ndez-Chac?n M, Ruiz-Garrido I, Cicu?ndez B, Tom?s-Loba A, A-Gonzalez N, Caballero-Molano A, Beiroa D, Hern?ndez-Cosido L, Torres JL, Kennedy NJ, Davis RJ, Benedito R, Marcos M, Nogueiras R, Hidalgo A, Matesanz N, Leiva M, Sabio G
Crespo M, Gonzalez-Teran B, Nikolic I, Mora A, Folgueira C, Rodr?guez E, Leiva-Vega L, Pintor-Chocano A, Fern?ndez-Chac?n M, Ruiz-Garrido I, Cicu?ndez B, Tom?s-Loba A, A-Gonzalez N, Caballero-Molano A, Beiroa D, Hern?ndez-Cosido L, Torres JL, Kennedy NJ, Davis RJ, Benedito R, Marcos M, Nogueiras R, Hidalgo A, Matesanz N, Leiva M, Sabio G. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism. Elife. 2020 12 08; 9.
Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism.
National Mouse Metabolic Phenotyping Center
Tweets by @DrSherryPagoto
Cicu?ndez B, Mora A, L?pez JA, Curtabbi A, P?rez-Garc?a J, Porteiro B, Jimenez-Blasco D, Latorre-Muro P, Vo P, Jerome M, G?mez-Santos B, Romero-Becerra R, Leiva M, Rodr?guez E, Le?n M, Leiva-Vega L, G?mez-Lado N, Torres JL, Hern?ndez-Cosido L, Aguiar P, Marcos M, Jastroch M, Daiber A, Aspichueta P, Bola?os JP, Spinelli JB, Puigserver P, Enriquez JA, V?zquez J, Folgueira C, Sabio G
Cicu?ndez B, Mora A, L?pez JA, Curtabbi A, P?rez-Garc?a J, Porteiro B, Jimenez-Blasco D, Latorre-Muro P, Vo P, Jerome M, G?mez-Santos B, Romero-Becerra R, Leiva M, Rodr?guez E, Le?n M, Leiva-Vega L, G?mez-Lado N, Torres JL, Hern?ndez-Cosido L, Aguiar P, Marcos M, Jastroch M, Daiber A, Aspichueta P, Bola?os JP, Spinelli JB, Puigserver P, Enriquez JA, V?zquez J, Folgueira C, Sabio G. Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis. Nat Commun. 2025 01 13; 16(1):229.
Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis.
Santiago de Compostela (A Coruna), Spain 15706
Folgueira C, Torres-Leal FL, Beiroa D, Pena-Le?n V, Da Silva Lima N, Milbank E, Senra A, Al-Massadi O, L?pez M, Di?guez C, Seoane LM, Nogueiras R
Folgueira C, Torres-Leal FL, Beiroa D, Pena-Le?n V, Da Silva Lima N, Milbank E, Senra A, Al-Massadi O, L?pez M, Di?guez C, Seoane LM, Nogueiras R. Oral Pharmacological Activation of Hypothalamic Guanylate Cyclase 2C Receptor Stimulates Brown Fat Thermogenesis to Reduce Body Weight. Neuroendocrinology. 2020; 110(11-12):1042-1054.
Oral Pharmacological Activation of Hypothalamic Guanylate Cyclase 2C Receptor Stimulates Brown Fat Thermogenesis to Reduce Body Weight.
Romero-Pic? A, Sanchez-Rebordelo E, Imbernon M, Gonz?lez-Touceda D, Folgueira C, Senra A, Fern? J, Blouet C, Cabrera R, van Gestel M, Adan RA, L?pez M, Maldonado R, Nogueiras R, Di?guez C
Romero-Pic? A, Sanchez-Rebordelo E, Imbernon M, Gonz?lez-Touceda D, Folgueira C, Senra A, Fern? J, Blouet C, Cabrera R, van Gestel M, Adan RA, L?pez M, Maldonado R, Nogueiras R, Di?guez C. Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake. Neuropharmacology. 2018 03 01; 130:62-70.
Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake.
Qui?ones M, Folgueira C, S?nchez-Rebordelo E, Al-Massadi O
Qui?ones M, Folgueira C, S?nchez-Rebordelo E, Al-Massadi O. Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents. Mediators Inflamm. 2015; 2015:620919.
Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents.
Qui?ones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-T?volli R, Garc?a-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fern? J, Malagon MM, Contreras R, Pfluger P, Br?ning JC, Yeo G, Tsch?p M, Di?guez C, L?pez M, Claret M, Kloppenburg P, Sabio G, Nogueiras R
Qui?ones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-T?volli R, Garc?a-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fern? J, Malagon MM, Contreras R, Pfluger P, Br?ning JC, Yeo G, Tsch?p M, Di?guez C, L?pez M, Claret M, Kloppenburg P, Sabio G, Nogueiras R. p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nat Commun. 2018 08 24; 9(1):3432.
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Romero-Pic? A, V?zquez MJ, Gonz?lez-Touceda D, Folgueira C, Skibicka KP, Alvarez-Crespo M, Van Gestel MA, Vel?squez DA, Schwarzer C, Herzog H, L?pez M, Adan RA, Dickson SL, Di?guez C, Nogueiras R
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Romero-Pic? A, V?zquez MJ, Gonz?lez-Touceda D, Folgueira C, Skibicka KP, Alvarez-Crespo M, Van Gestel MA, Vel?squez DA, Schwarzer C, Herzog H, L?pez M, Adan RA, Dickson SL, Di?guez C, Nogueiras R. Hypothalamic ?-opioid receptor modulates the orexigenic effect of ghrelin. Neuropsychopharmacology. 2013 Jun; 38(7):1296-307.
Hypothalamic ?-opioid receptor modulates the orexigenic effect of ghrelin.
Ferreira V, Folgueira C, Garc?a-Altares M, Guill?n M, Ru?z-Rosario M, DiNunzio G, Garcia-Martinez I, Alen R, Bookmeyer C, Jones JG, Cigudosa JC, L?pez-Larrubia P, Correig-Blanchar X, Davis RJ, Sabio G, Rada P, Valverde ?M
Ferreira V, Folgueira C, Garc?a-Altares M, Guill?n M, Ru?z-Rosario M, DiNunzio G, Garcia-Martinez I, Alen R, Bookmeyer C, Jones JG, Cigudosa JC, L?pez-Larrubia P, Correig-Blanchar X, Davis RJ, Sabio G, Rada P, Valverde ?M. Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition. Redox Biol. 2023 07; 63:102741.
Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition.
Folgueira C, Herrera-Melle L, L?pez JA, Galvan-Alvarez V, Martin-Rincon M, Cuartero MI, Garc?a-Culebras A, Dumesic PA, Rodr?guez E, Leiva-Vega L, Le?n M, Porteiro B, Iglesias C, Torres JL, Hern?ndez-Cosido L, Bonacasa C, Marcos M, Moro M?, V?zquez J, Calbet JAL, Spiegelman BM, Mora A, Sabio G
Folgueira C, Herrera-Melle L, L?pez JA, Galvan-Alvarez V, Martin-Rincon M, Cuartero MI, Garc?a-Culebras A, Dumesic PA, Rodr?guez E, Leiva-Vega L, Le?n M, Porteiro B, Iglesias C, Torres JL, Hern?ndez-Cosido L, Bonacasa C, Marcos M, Moro M?, V?zquez J, Calbet JAL, Spiegelman BM, Mora A, Sabio G. Remodeling p38 signaling in muscle controls locomotor activity via IL-15. Sci Adv. 2024 08 16; 10(33):eadn5993.
Remodeling p38 signaling in muscle controls locomotor activity via IL-15.
Folgueira C, Beiroa D, Callon A, Al-Massadi O, Barja-Fernandez S, Senra A, Fern? J, L?pez M, Dieguez C, Casanueva FF, Rohner-Jeanrenaud F, Seoane LM, Nogueiras R
Folgueira C, Beiroa D, Callon A, Al-Massadi O, Barja-Fernandez S, Senra A, Fern? J, L?pez M, Dieguez C, Casanueva FF, Rohner-Jeanrenaud F, Seoane LM, Nogueiras R. Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways. Diabetes. 2016 Feb; 65(2):421-32.
Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways.
Folgueira C, Beiroa D, Gonz?lez-Rell?n MJ, Porteiro B, Milbank E, Castelao C, Garc?a-Palacios M, Casanueva FF, L?pez M, Di?guez C, Seoane LM, Nogueiras R
Folgueira C, Beiroa D, Gonz?lez-Rell?n MJ, Porteiro B, Milbank E, Castelao C, Garc?a-Palacios M, Casanueva FF, L?pez M, Di?guez C, Seoane LM, Nogueiras R. Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice. Nutrients. 2019 Mar 30; 11(4).
Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice.
Herrera-Melle L, Cicu?ndez B, L?pez JA, Dumesic PA, Wilensky SE, Rodr?guez E, Leiva-Vega L, Caballero A, Le?n M, V?zquez J, Spiegelman BM, Folgueira C, Mora A, Sabio G
Herrera-Melle L, Cicu?ndez B, L?pez JA, Dumesic PA, Wilensky SE, Rodr?guez E, Leiva-Vega L, Caballero A, Le?n M, V?zquez J, Spiegelman BM, Folgueira C, Mora A, Sabio G. p38a kinase governs muscle strength through PGC1a in mice. Acta Physiol (Oxf). 2024 Nov; 240(11):e14234.
p38a kinase governs muscle strength through PGC1a in mice.
Folgueira C, Beiroa D, Porteiro B, Duquenne M, Puighermanal E, Fondevila MF, Barja-Fern?ndez S, Gallego R, Hern?ndez-Bautista R, Castelao C, Senra A, Seoane P, G?mez N, Aguiar P, Guallar D, Fidalgo M, Romero-Pico A, Adan R, Blouet C, Labandeira-Garc?a JL, Jeanrenaud F, Kallo I, Liposits Z, Salvador J, Prevot V, Dieguez C, Lopez M, Valjent E, Fr?hbeck G, Seoane LM, Nogueiras R
Folgueira C, Beiroa D, Porteiro B, Duquenne M, Puighermanal E, Fondevila MF, Barja-Fern?ndez S, Gallego R, Hern?ndez-Bautista R, Castelao C, Senra A, Seoane P, G?mez N, Aguiar P, Guallar D, Fidalgo M, Romero-Pico A, Adan R, Blouet C, Labandeira-Garc?a JL, Jeanrenaud F, Kallo I, Liposits Z, Salvador J, Prevot V, Dieguez C, Lopez M, Valjent E, Fr?hbeck G, Seoane LM, Nogueiras R. Hypothalamic dopamine signaling regulates brown fat thermogenesis. Nat Metab. 2019 08; 1(8):811-829.
Hypothalamic dopamine signaling regulates brown fat thermogenesis.
Senin LL, Al-Massadi O, Folgueira C, Castelao C, Pardo M, Barja-Fernandez S, Roca-Rivada A, Amil M, Crujeiras AB, Garcia-Caballero T, Gabellieri E, Leis R, Dieguez C, Pagotto U, Casanueva FF, Seoane LM
Senin LL, Al-Massadi O, Folgueira C, Castelao C, Pardo M, Barja-Fernandez S, Roca-Rivada A, Amil M, Crujeiras AB, Garcia-Caballero T, Gabellieri E, Leis R, Dieguez C, Pagotto U, Casanueva FF, Seoane LM. The gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake. PLoS One. 2013; 8(11):e80339.
The gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake.
S?enz de Urturi D, Buqu? X, Porteiro B, Folgueira C, Mora A, Delgado TC, Prieto-Fern?ndez E, Olaizola P, G?mez-Santos B, Apodaka-Biguri M, Gonz?lez-Romero F, Nieva-Zuluaga A, Ruiz de Gauna M, Goikoetxea-Usandizaga N, Garc?a-Rodr?guez JL, Gutierrez de Juan V, Aurrekoetxea I, Montalvo-Romeral V, Novoa EM, Mart?n-Guerrero I, Varela-Rey M, Bhanot S, Lee R, Banales JM, Syn WK, Sabio G, Mart?nez-Chantar ML, Nogueiras R, Aspichueta P
S?enz de Urturi D, Buqu? X, Porteiro B, Folgueira C, Mora A, Delgado TC, Prieto-Fern?ndez E, Olaizola P, G?mez-Santos B, Apodaka-Biguri M, Gonz?lez-Romero F, Nieva-Zuluaga A, Ruiz de Gauna M, Goikoetxea-Usandizaga N, Garc?a-Rodr?guez JL, Gutierrez de Juan V, Aurrekoetxea I, Montalvo-Romeral V, Novoa EM, Mart?n-Guerrero I, Varela-Rey M, Bhanot S, Lee R, Banales JM, Syn WK, Sabio G, Mart?nez-Chantar ML, Nogueiras R, Aspichueta P. Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis. Nat Commun. 2022 03 01; 13(1):1096.
Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis.
Rodriguez-Mu?oz D, S?nchez ?, P?rez-Benavente S, Contreras-Jurado C, Montero-Pedrazuela A, Toledo-Castillo M, Guti?rrez-Hern?ndez M, Rodrigues-D?ez R, Folgueira C, Briones AM, Sabio G, Monedero-Cobeta I, Chaves-Coira I, Castej?n D, Fern?ndez-Valle E, Regadera J, Bautista JM, Aranda A, Alemany S
Rodriguez-Mu?oz D, S?nchez ?, P?rez-Benavente S, Contreras-Jurado C, Montero-Pedrazuela A, Toledo-Castillo M, Guti?rrez-Hern?ndez M, Rodrigues-D?ez R, Folgueira C, Briones AM, Sabio G, Monedero-Cobeta I, Chaves-Coira I, Castej?n D, Fern?ndez-Valle E, Regadera J, Bautista JM, Aranda A, Alemany S. Hypothyroidism confers tolerance to cerebral malaria. Sci Adv. 2022 04 08; 8(14):eabj7110.
Hypothyroidism confers tolerance to cerebral malaria.
Barja-Fern?ndez S, Folgueira C, Seoane LM, Casanueva FF, Dieguez C, Castelao C, Ag?era Z, Ba?os R, Botella C, de la Torre R, Fern?ndez-Garc?a JC, Fern?ndez-Real JM, Fr?hbeck G, G?mez-Ambrosi J, Jim?nez-Murcia S, Tinahones FJ, Estivill X, Fern?ndez-Aranda F, Nogueiras R
The Journal of clinical endocrinology and metabolism
Barja-Fern?ndez S, Folgueira C, Seoane LM, Casanueva FF, Dieguez C, Castelao C, Ag?era Z, Ba?os R, Botella C, de la Torre R, Fern?ndez-Garc?a JC, Fern?ndez-Real JM, Fr?hbeck G, G?mez-Ambrosi J, Jim?nez-Murcia S, Tinahones FJ, Estivill X, Fern?ndez-Aranda F, Nogueiras R. Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women. J Clin Endocrinol Metab. 2015 Sep; 100(9):E1188-96.
Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women.
Duquenne M, Folgueira C, Bourouh C, Millet M, Silva A, Clasadonte J, Imbernon M, Fernandois D, Martinez-Corral I, Kusumakshi S, Caron E, Rasika S, Deliglia E, Jouy N, Oishi A, Mazzone M, Trinquet E, Tavernier J, Kim YB, Ory S, Jockers R, Schwaninger M, Boehm U, Nogueiras R, Annicotte JS, Gasman S, Dam J, Pr?vot V
Duquenne M, Folgueira C, Bourouh C, Millet M, Silva A, Clasadonte J, Imbernon M, Fernandois D, Martinez-Corral I, Kusumakshi S, Caron E, Rasika S, Deliglia E, Jouy N, Oishi A, Mazzone M, Trinquet E, Tavernier J, Kim YB, Ory S, Jockers R, Schwaninger M, Boehm U, Nogueiras R, Annicotte JS, Gasman S, Dam J, Pr?vot V. Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function. Nat Metab. 2021 08; 3(8):1071-1090.
Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.
Imbernon M, Sanchez-Rebordelo E, Romero-Pic? A, Kall? I, Chee MJ, Porteiro B, Al-Massadi O, Contreras C, Fern? J, Senra A, Gallego R, Folgueira C, Seoane LM, van Gestel M, Adan RA, Liposits Z, Dieguez C, L?pez M, Nogueiras R
Imbernon M, Sanchez-Rebordelo E, Romero-Pic? A, Kall? I, Chee MJ, Porteiro B, Al-Massadi O, Contreras C, Fern? J, Senra A, Gallego R, Folgueira C, Seoane LM, van Gestel M, Adan RA, Liposits Z, Dieguez C, L?pez M, Nogueiras R. Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress. Hepatology. 2016 10; 64(4):1086-104.
Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress.
Seoane-Collazo P, Li?ares-Pose L, Rial-Pensado E, Romero-Pic? A, Moreno-Navarrete JM, Mart?nez-S?nchez N, Garrido-Gil P, Iglesias-Rey R, Morgan DA, Tomasini N, Malone SA, Senra A, Folgueira C, Medina-Gomez G, Sobrino T, Labandeira-Garc?a JL, Nogueiras R, Domingos AI, Fern?ndez-Real JM, Rahmouni K, Di?guez C, L?pez M
Seoane-Collazo P, Li?ares-Pose L, Rial-Pensado E, Romero-Pic? A, Moreno-Navarrete JM, Mart?nez-S?nchez N, Garrido-Gil P, Iglesias-Rey R, Morgan DA, Tomasini N, Malone SA, Senra A, Folgueira C, Medina-Gomez G, Sobrino T, Labandeira-Garc?a JL, Nogueiras R, Domingos AI, Fern?ndez-Real JM, Rahmouni K, Di?guez C, L?pez M. Central nicotine induces browning through hypothalamic ? opioid receptor. Nat Commun. 2019 09 06; 10(1):4037.
Central nicotine induces browning through hypothalamic ? opioid receptor.
Carreira MC, Andrade S, Gonzalez-Izquierdo A, Amil M, Folgueira C, Monteiro MP, Sanz E, Crujeiras AB, Casanueva FF
Carreira MC, Andrade S, Gonzalez-Izquierdo A, Amil M, Folgueira C, Monteiro MP, Sanz E, Crujeiras AB, Casanueva FF. Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain. Sci Rep. 2018 11 21; 8(1):17155.
Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain.
Barja-Fern?ndez S, Folgueira C, Castelao C, Pena-Le?n V, Gonz?lez-Saenz P, V?zquez-Cobela R, Aguilera CM, Gil-Campos M, Bueno G, Gil ?, Moreno LA, Ruiz-Pi?on M, Garc?a-Palacios M, Casanueva FF, Di?guez C, Nogueiras R, Leis R, Seoane LM
Barja-Fern?ndez S, Folgueira C, Castelao C, Pena-Le?n V, Gonz?lez-Saenz P, V?zquez-Cobela R, Aguilera CM, Gil-Campos M, Bueno G, Gil ?, Moreno LA, Ruiz-Pi?on M, Garc?a-Palacios M, Casanueva FF, Di?guez C, Nogueiras R, Leis R, Seoane LM. ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents. Nutrients. 2019 Jun 14; 11(6).
ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents.
Cicu?ndez B, P?rez-Garc?a J, Folgueira C
Cicu?ndez B, P?rez-Garc?a J, Folgueira C. A Combination of a Dopamine Receptor 2 Agonist and a Kappa Opioid Receptor Antagonist Synergistically Reduces Weight in Diet-Induced Obese Rodents. Nutrients. 2024 Jan 31; 16(3).
A Combination of a Dopamine Receptor 2 Agonist and a Kappa Opioid Receptor Antagonist Synergistically Reduces Weight in Diet-Induced Obese Rodents.
Barja-Fernandez S, Folgueira C, Castelao C, Leis R, Crujeiras AB, Casanueva FF, Seoane LM
Progress in molecular biology and translational science
Barja-Fernandez S, Folgueira C, Castelao C, Leis R, Crujeiras AB, Casanueva FF, Seoane LM. Regulation of Growth Hormone by the Splanchnic Area. Prog Mol Biol Transl Sci. 2016; 138:41-60.
Regulation of Growth Hormone by the Splanchnic Area.
Senin LL, Al-Massadi O, Barja-Fernandez S, Folgueira C, Castelao C, Tovar SA, Leis R, Lago F, Baltar J, Baamonde I, Dieguez C, Casanueva FF, Seoane LM
Senin LL, Al-Massadi O, Barja-Fernandez S, Folgueira C, Castelao C, Tovar SA, Leis R, Lago F, Baltar J, Baamonde I, Dieguez C, Casanueva FF, Seoane LM. Regulation of NUCB2/nesfatin-1 production in rat's stomach and adipose tissue is dependent on age, testosterone levels and lactating status. Mol Cell Endocrinol. 2015 Aug 15; 411:105-12.
Regulation of NUCB2/nesfatin-1 production in rat's stomach and adipose tissue is dependent on age, testosterone levels and lactating status.
Ferreira V, Folgueira C, Montes-San Lorenzo ?, Rodr?guez-L?pez A, Gonzalez-Iglesias E, Zubiaur P, Abad-Santos F, Sabio G, Rada P, Valverde ?M
Biochimica et biophysica acta. Molecular basis of disease
Ferreira V, Folgueira C, Montes-San Lorenzo ?, Rodr?guez-L?pez A, Gonzalez-Iglesias E, Zubiaur P, Abad-Santos F, Sabio G, Rada P, Valverde ?M. Estrogens prevent the hypothalamus-periphery crosstalk induced by olanzapine intraperitoneal treatment in female mice: Effects on brown/beige adipose tissues and liver. Biochim Biophys Acta Mol Basis Dis. 2024 06; 1870(5):167227.
Estrogens prevent the hypothalamus-periphery crosstalk induced by olanzapine intraperitoneal treatment in female mice: Effects on brown/beige adipose tissues and liver.
Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hern?ndez-Cosido L, Blanco ?, Arab JP, Barrera F, Guallar D, Fidalgo M, L?pez M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R
Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hern?ndez-Cosido L, Blanco ?, Arab JP, Barrera F, Guallar D, Fidalgo M, L?pez M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R. The L-a-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis. Hepatology. 2021 02; 73(2):606-624.
The L-a-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis.
Barja-Fernandez S, Moreno-Navarrete JM, Folgueira C, Xifra G, Sabater M, Castelao C, Fern? J, Leis R, Di?guez C, Casanueva FF, Ricart W, Seoane LM, Fernandez-Real JM, Nogueiras R
Barja-Fernandez S, Moreno-Navarrete JM, Folgueira C, Xifra G, Sabater M, Castelao C, Fern? J, Leis R, Di?guez C, Casanueva FF, Ricart W, Seoane LM, Fernandez-Real JM, Nogueiras R. Plasma ANGPTL-4 is Associated with Obesity and Glucose Tolerance: Cross-Sectional and Longitudinal Findings. Mol Nutr Food Res. 2018 05; 62(10):e1800060.
Plasma ANGPTL-4 is Associated with Obesity and Glucose Tolerance: Cross-Sectional and Longitudinal Findings.
Folgueira C, Barja-Fernandez S, Prado L, Al-Massadi O, Castelao C, Pena-Leon V, Gonzalez-Saenz P, Baltar J, Baamonde I, Leis R, Dieguez C, Pagotto U, Casanueva FF, Tovar SA, Nogueiras R, Seoane LM
Folgueira C, Barja-Fernandez S, Prado L, Al-Massadi O, Castelao C, Pena-Leon V, Gonzalez-Saenz P, Baltar J, Baamonde I, Leis R, Dieguez C, Pagotto U, Casanueva FF, Tovar SA, Nogueiras R, Seoane LM. Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway. World J Gastroenterol. 2017 Sep 21; 23(35):6403-6411.
Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway.
Ferreira V, Folgueira C, Guill?n M, Zubiaur P, Navares M, Sarsenbayeva A, L?pez-Larrubia P, Eriksson JW, Pereira MJ, Abad-Santos F, Sabio G, Rada P, Valverde ?M
Ferreira V, Folgueira C, Guill?n M, Zubiaur P, Navares M, Sarsenbayeva A, L?pez-Larrubia P, Eriksson JW, Pereira MJ, Abad-Santos F, Sabio G, Rada P, Valverde ?M. Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight. Metabolism. 2022 12; 137:155335.
Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight.
Romero-Pic? A, Novelle MG, Folgueira C, L?pez M, Nogueiras R, Di?guez C
Romero-Pic? A, Novelle MG, Folgueira C, L?pez M, Nogueiras R, Di?guez C. Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin. Psychopharmacology (Berl). 2013 Sep; 229(2):275-83.
Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin.
Folgueira C, Barja-Fern?ndez S, Gonzalez-Saenz P, Castelao C, V?zquez-Cobela R, Pena-Leon V, Ruiz-Pi?on M, Casanueva FF, Dieguez C, Leis R, Nogueiras R, Seoane LM
Folgueira C, Barja-Fern?ndez S, Gonzalez-Saenz P, Castelao C, V?zquez-Cobela R, Pena-Leon V, Ruiz-Pi?on M, Casanueva FF, Dieguez C, Leis R, Nogueiras R, Seoane LM. Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty. Sci Rep. 2018 09 28; 8(1):14541.
Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty.
Duquenne M, Deligia E, Folgueira C, Bourouh C, Caron E, Pfrieger F, Schwaninger M, Nogueiras R, Annicotte JS, Imbernon M, Pr?vot V
Duquenne M, Deligia E, Folgueira C, Bourouh C, Caron E, Pfrieger F, Schwaninger M, Nogueiras R, Annicotte JS, Imbernon M, Pr?vot V. Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice. Mol Metab. 2024 Sep; 87:101996.
Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice.
Valdecantos MP, Ruiz L, Folgueira C, Rada P, Gomez-Santos B, Solas M, Hitos AB, Field J, Francisco V, Escalona-Garrido C, Zagmutt S, Calderon-Dominguez M, Mera P, Garcia-Martinez I, Maym?-Masip E, Grajales D, Alen R, Mora A, S?inz N, Vides-Urrestarazu I, Vilarrasa N, Arbones-Mainar JM, Zaragoza C, Moreno-Aliaga MJ, Aspichueta P, Fern?ndez-Veledo S, Vendrell J, Serra D, Herrero L, Schreiber R, Zechner R, Sabio G, Hornigold D, Rondinone CM, Jermutus L, Grimsby J, Valverde ?M
Valdecantos MP, Ruiz L, Folgueira C, Rada P, Gomez-Santos B, Solas M, Hitos AB, Field J, Francisco V, Escalona-Garrido C, Zagmutt S, Calderon-Dominguez M, Mera P, Garcia-Martinez I, Maym?-Masip E, Grajales D, Alen R, Mora A, S?inz N, Vides-Urrestarazu I, Vilarrasa N, Arbones-Mainar JM, Zaragoza C, Moreno-Aliaga MJ, Aspichueta P, Fern?ndez-Veledo S, Vendrell J, Serra D, Herrero L, Schreiber R, Zechner R, Sabio G, Hornigold D, Rondinone CM, Jermutus L, Grimsby J, Valverde ?M. The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk. Nat Commun. 2024 11 28; 15(1):10342.
The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk.
Aboy-Pardal MCM, Guadamillas MC, Guerrero CR, Catal?-Montoro M, Toledano-Donado M, Terr?s-Dom?nguez S, Pav?n DM, Jim?nez-Jim?nez V, Jimenez-Carretero D, Zamai M, Folgueira C, Cerezo A, Lolo FN, Nogueiras R, Sabio G, S?nchez-?lvarez M, Echarri A, Garcia R, Del Pozo MA
Aboy-Pardal MCM, Guadamillas MC, Guerrero CR, Catal?-Montoro M, Toledano-Donado M, Terr?s-Dom?nguez S, Pav?n DM, Jim?nez-Jim?nez V, Jimenez-Carretero D, Zamai M, Folgueira C, Cerezo A, Lolo FN, Nogueiras R, Sabio G, S?nchez-?lvarez M, Echarri A, Garcia R, Del Pozo MA. Plasma membrane remodeling determines adipocyte expansion and mechanical adaptability. Nat Commun. 2024 11 28; 15(1):10102.
Plasma membrane remodeling determines adipocyte expansion and mechanical adaptability.
Al-Massadi O, Qui?ones M, Clasadonte J, Hernandez-Bautista R, Romero-Pic? A, Folgueira C, Morgan DA, Kall? I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, Chee MJ, Imbernon M, Beiroa D, Garc?a-Caballero L, Gallego R, Lam BYH, Yeo G, Lopez M, Liposits Z, Rahmouni K, Prevot V, Dieguez C, Nogueiras R
Al-Massadi O, Qui?ones M, Clasadonte J, Hernandez-Bautista R, Romero-Pic? A, Folgueira C, Morgan DA, Kall? I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, Chee MJ, Imbernon M, Beiroa D, Garc?a-Caballero L, Gallego R, Lam BYH, Yeo G, Lopez M, Liposits Z, Rahmouni K, Prevot V, Dieguez C, Nogueiras R. MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance. Diabetes. 2019 12; 68(12):2210-2222.
MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance.
Senin LL, Roca-Rivada A, Castelao C, Alonso J, Folgueira C, Casanueva FF, Pardo M, Seoane LM
Senin LL, Roca-Rivada A, Castelao C, Alonso J, Folgueira C, Casanueva FF, Pardo M, Seoane LM. Comparative secretome analysis of rat stomach under different nutritional status. Data Brief. 2015 Jun; 3:62-6.
Comparative secretome analysis of rat stomach under different nutritional status.
Manieri E, Folgueira C, Rodr?guez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Rosell A, Sanchez-Cabo F, G?mez MJ, Monte MJ, G Marin JJ, Davis RJ, Mora A, Sabio G
Proceedings of the National Academy of Sciences of the United States of America
Manieri E, Folgueira C, Rodr?guez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Rosell A, Sanchez-Cabo F, G?mez MJ, Monte MJ, G Marin JJ, Davis RJ, Mora A, Sabio G. JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16492-16499.
JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma.
Senin LL, Roca-Rivada A, Castelao C, Alonso J, Folgueira C, Casanueva FF, Pardo M, Seoane LM. Comparative secretome analysis of rat stomach under different nutritional status. J Proteomics. 2015 Feb 26; 116:44-58.
Pena-Leon V, Folgueira C, Barja-Fern?ndez S, P?rez-Lois R, Da Silva Lima N, Martin M, Heras V, Martinez-Martinez S, Valero P, Iglesias C, Duquenne M, Al-Massadi O, Beiroa D, Souto Y, Fidalgo M, Sowmyalakshmi R, Guallar D, Cunarro J, Castelao C, Senra A, Gonz?lez-Saenz P, V?zquez-Cobela R, Leis R, Sabio G, Mueller-Fielitz H, Schwaninger M, L?pez M, Tovar S, Casanueva FF, Valjent E, Di?guez C, Prevot V, Nogueiras R, Seoane LM
Pena-Leon V, Folgueira C, Barja-Fern?ndez S, P?rez-Lois R, Da Silva Lima N, Martin M, Heras V, Martinez-Martinez S, Valero P, Iglesias C, Duquenne M, Al-Massadi O, Beiroa D, Souto Y, Fidalgo M, Sowmyalakshmi R, Guallar D, Cunarro J, Castelao C, Senra A, Gonz?lez-Saenz P, V?zquez-Cobela R, Leis R, Sabio G, Mueller-Fielitz H, Schwaninger M, L?pez M, Tovar S, Casanueva FF, Valjent E, Di?guez C, Prevot V, Nogueiras R, Seoane LM. Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21. Nat Metab. 2022 07; 4(7):901-917.
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21.
Romero-Becerra R, Santamans AM, Folgueira C, Sabio G
International journal of molecular sciences
Romero-Becerra R, Santamans AM, Folgueira C, Sabio G. p38 MAPK Pathway in the Heart: New Insights in Health and Disease. Int J Mol Sci. 2020 Oct 08; 21(19).
p38 MAPK Pathway in the Heart: New Insights in Health and Disease.
Barja-Fern?ndez S, Folgueira C, Castelao C, Leis R, Casanueva FF, Seoane LM
Barja-Fern?ndez S, Folgueira C, Castelao C, Leis R, Casanueva FF, Seoane LM. Peripheral signals mediate the beneficial effects of gastric surgery in obesity. Gastroenterol Res Pract. 2015; 2015:560938.
Peripheral signals mediate the beneficial effects of gastric surgery in obesity.