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Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
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Hayman, Laura
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Kamen, Gary
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Helfer, Karen
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Sievert, Lynnette Leidy
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Van Emmerik, Richard
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Kent-Braun, Jane
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McClements, David
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Lacreuse, Agnes
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Spencer, Rebecca
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Reeves, Katherine
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Boyer, Katherine
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Rogaev, Evgeny
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.
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Crawford, Sybil
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Reed, George
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Rosal, Milagros
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Lemon, Stephenie
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Goldberg, Robert
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Shaw, Leslie
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McManus, David
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Research
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Friedmann, Peter
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Clinical Labortory and Nutritional Sciences
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College of Heath Sciences
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Bigornia, Sherman
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UMass Chan – Baystate Regional Campus
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Schaal, Shlomit
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Singh, Sonal
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https://profiles.umassmed.edu/profile/16237473
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Fergus Clydesdale Endowed Chair
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Lindenauer, Peter
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ADJUNCT PROFESSOR
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Seddon, Johanna
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Gurwitz, Jerry
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Usmani, Saad
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Ophthalmology and Visual Sciences
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Population and Quantitative Health Sciences
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Lodato, Michael
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Post Docs: Wet-lab and Bioinformatic postdoctoral fellow positions are available for candidates with recent Ph.D. or M.D./Ph.D. degrees in Molecular Biology, Neuroscience, Genetics, Genomics, Cell Biology, or related fields. They should be highly motivated, have a strong desire to learn, and excellent communication skills. Applicants should send their CV, summary of previous research and the name of three references to Dr. Michael Lodato.
Rotation Projects: Rotations will revolve around studying somatic mutations in the normal brain, in the diseased brain, and outside of the brain using single-cell genomics. Please contact Dr. Lodato for details.
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Schlaug, Gottfried
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Bokhour, Barbara
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Garg, Arvin
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Lin, Honghuang
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https://profiles.umassmed.edu/profile/28866558
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https://profiles.umassmed.edu/profile/28866602
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https://profiles.umassmed.edu/profile/28866604
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https://profiles.umassmed.edu/profile/28867077
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Neurology at UMass Chan - Baystate
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Adjunct Professor
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Professor
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Driban, Jeffrey
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Featured Videos: https://profiles.umassmed.edu/profile/40402890
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Walkey, Allan
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Medicine at UMass Chan - Lahey
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https://profiles.umassmed.edu/profile/40402890
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury
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Radiology at UMass Chan - Lahey
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Basic Pathology
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Health System Science
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Infectious Diseases
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Neurointerventional Radiology
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Pulmonary Medicine
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General Pediatrics
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Stroke and Vascular Neurology
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Tan Chingfen Graduate School of Nursing
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McAlindon, Timothy
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Martinez, Fernando
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Krings, Timo
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Maron, Martin
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Reynolds, Matthew
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