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Rotation Projects: Rotation projects We apply X-ray crystallography and biochemical methods to understand the mechanisms employed by the ribosome. Potential rotation projects are 1) to understand various aspects of translation via mutagenesis/biochemical assays, 2) to crystallize and work on determining the structures of translation factors and functional ribosome complexes, and 3) to improve computational methods used to determine crystal structures of macromolecules. Feel free to contact the lab for a more detailed discussion.
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Rotation Projects: Potential Rotation Projects Rotation projects in my laboratory will involve questions of how cilia are assembled and the function these organelles play in mammals. Projects vary depending on ongoing work in the laboratory and interests of the rotation student. Rotations in my laboratory can give students exposure to a range of techniques from mouse breeding and histological analysis of mouse tissues to mammalian cell culture and other cell biological techniques.
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Rotation Projects: Potential Rotations for Students Characterize the Leydig cell phenotype of different KO and transgenic models of specific genes relevant to reproductive development to determine the role of these genes in Leydig cell development: i.e. GPR54, androgen receptor, etc. Examine the mechanisms underlying the inhibitory effects of dioxin on Leydig cell steroidogenesis and investigate the developmental basis of this. Investigate the role of MIS in the development of Leydig cell tumors. Examine MIS signaling in Leydig cells.
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McManus, David
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Shin, Dong-Soo
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