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Rotation Projects: Clinical research opportunities are available for medical and PhD students, residents and junior faculty upon request. We are currently not hiring paid research staff. We cannot accept basic scientists. Please read up on our research first before applying.
Summary: Dr. Muehlschlegel is a neurointensivist devoted to improving the care of patients with catastrophic neurological injuries. Her research interests concentrate on outcome prognostication in neurocritical care, particularly in moderate-severe traumatic brain injury. She is the principal investigator for several research studies at the UMASS Neuro-Intensive care unit (NeuroICU).
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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
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LaFemina, Jennifer
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Heneka, Michael
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Behar, Samuel
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Woskie, Susan
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Ganz, Aura
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Freedson, Patty
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Zoeller, R.
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Xiao, Hang
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Reeves, Katherine
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Bird, Steven
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Goldberg, Robert
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McManus, David
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Anesthesiology and Perioperative Medicine
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Hinchey, Kevin
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Seymour, Neal
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Friedmann, Peter
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UMass Chan – Baystate Regional Campus
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Singh, Sonal
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Professor
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Associate Professor
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Chair and Professor
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Professor
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https://profiles.umassmed.edu/profile/16237479
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Lindenauer, Peter
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ADJUNCT INSTRUCTOR
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ADJUNCT PROFESSOR
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Seddon, Johanna
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Gurwitz, Jerry
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Endowed Chair Honorary Title: Dr. John Meyers Professor in Primary Care Medicine
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Usmani, Saad
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Ophthalmology and Visual Sciences
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Population and Quantitative Health Sciences
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Bankier, Alexander
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Schlaug, Gottfried
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Musch, Guido
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Quinton, Lee
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Lin, Honghuang
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https://profiles.umassmed.edu/profile/28866543
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https://profiles.umassmed.edu/profile/28866602
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Neurology at UMass Chan - Baystate
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Pediatrics at UMass Chan - Baystate
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Surgery at UMass Chan - Baystate
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Professor
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Professor
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Instructor
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Professor
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Assistant Professor
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Associate Professor
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Korkmaz, Filiz
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Driban, Jeffrey
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Featured Videos: https://profiles.umassmed.edu/profile/40402890
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Professor
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Professor
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Professor
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Associate Professor
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Walkey, Allan
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Person ID: 10247602
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Moffatt-Bruce, Susan
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Stain, Steven
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Medicine at UMass Chan - Lahey
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Surgery at UMass Chan - Lahey
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Professor
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https://profiles.umassmed.edu/profile/40402890
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury
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Radiology at UMass Chan - Lahey
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Professor
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Chair and Professor
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Basic Pathology
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Breast Imaging
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Cardio Thoracic Radiology
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EMS/Disaster
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Health System Science
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Infectious Diseases
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Neurointerventional Radiology
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Pulmonary Medicine
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Professor Emeritus
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Professor
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Professor
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Professor
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Professor
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Professor
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Professor
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Adjunct Professor
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Professor
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Professor
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Professor
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Professor
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Professor
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Adjunct Professor
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Neurocritical Care
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Thoracic Anesthesia
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Stroke and Vascular Neurology
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Chair and Professor
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Dosa, David
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McAlindon, Timothy
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Martinez, Fernando
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Professor
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Wilcox, Susan
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media links: https://profiles.umassmed.edu/profile/66924233
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Summary: Dr. Wilcox trained in EM at the Harvard Affiliated EM Residency, then completed an Anesthesia Critical Care fellowship. In addition to the ED, she has attended in Surgical, Medical, and Cardiac ICUs. She joined Lahey Hospital in 2022 as the Medical Director of the 5C Medical ICU. She is Vice Chair for Academic Affairs and a Professor of Medicine. She is the Associate CMO for Boston MedFlight.
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Professor
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Microbiology
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Professor
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Krings, Timo
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Goldsweig, Andrew
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Associate Professor
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Maron, Martin
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Maron, Barry
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Adjunct Professor
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Professor
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Professor
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Chair and Professor
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Reynolds, Matthew
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Abelson, Jonathan
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