Molly McGovern Chair in Biomedical Research
There are a variety of rotation projects that use a variety of imaging and biochemical techniques to assess microglial function in the CNS. The main projects are highlighted below. 1. Dissecting novel molecular mechanisms underlying microglial function at synapses. 2. Exploring new roles for microglia in the spread of neuroinflammation in neurological disease. 3. Identifying novel ways microglia regulate other glial cell populations (astrocytes and oligodendrocytes) in the CNS.
Dr. Eileen L. Berman and Stanley I. Berman Foundation Chair in Biomedical Research
Psychology Department and Center for Neuroendocrin
Department of Psychology; Neuroscience And Behavio
Psychology Department And Center for Neuroendocrin
Health Informatics And Implementation Science
Johnnie Ray Cox Term Chair in Biomedical Research
Clinical research opportunities are available for medical and PhD students, residents and junior faculty upon request. We are currently not hiring paid research staff. We cannot accept basic scientists. Please read up on our research first before applying.
Dr. Muehlschlegel is a neurointensivist devoted to improving the care of patients with catastrophic neurological injuries. Her research interests concentrate on outcome prognostication in neurocritical care, particularly in moderate-severe traumatic brain injury. She is the principal investigator for several research studies at the UMASS Neuro-Intensive care unit (NeuroICU).
Paul J. DiMare Chair in Neurodegenerative Disease
Rotation Projects: See our lab webpage for more information on Research Projects: https://www.umassmed.edu/boscolab
Elucidating the factors involved in sporadic ALS and investigating protein misfunction associated with neurodegenerative disease.
Donna M. and Robert J. Manning Chair in Neurosciences
Dr. Brown’s laboratory has focused on the identification of gene defects that elucidate the molecular pathogenesis of selected neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis.
Governor Paul Cellucci Chair in Neuroscience Research
Project 1: Dervelop RNA-based therapies for frontotemporal dementia (FTD) and related disroders. Project 2: Study pathogenic mechanisms of FTD and related disorders in mouse models.
Our lab uses a combination of molecular, cellular, genetic, and behavioral approaches to further dissect the pathogenic mechanisms of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis with a focus on mutant CHMP2B, progranulin and C9ORF72. We will identify common underlying pathways as potential targets for therapeutic interventions.
Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Kensuke Futai for additional details.
Rotation Projects The Futai laboratory seeks highly motivated graduate students who have interest in the roles of risk genes of neuropsychiatric diseases, such as autism and schizophrenia, on neuronal function.Rotation students will typically work side-by-side with Kenny Futai or Postdoctoral Fellows, and give one laboratory meeting presentation at the conclusion of their rotation project. Rotation projects The roles of the risk genes of neuropsychiatric diseases on neuronal structure and synaptic function The roles of the scaffold molecules in synapse maturation, synaptic transmission and synaptic plasticity Characterization of gultamate receptors which express in interneruon
Dr. Carandang is a neurointensivist and stroke neurologist who provides acute emergent and critical care for patients with ischemic stroke and other devastating neurological diseases like traumatic brain injury, cerebral hemorrhage and subarachnoid hemorrhage. His research interests include cerebral edema, subarachnoid hemorrhage, CNS vasculitis, stroke epidemiology and traumatic brain injury.
A postdoc position is available to study circadian rhythms in Drosophila. Contact Patrick Emery (patrick.emery@umassmed.edu).
Biological clocks play an essential role in the temporal organization of animal physiology and behavior. We combine the powerful genetics of Drosophila with molecular, cell culture and behavioral approaches to obtain a comprehensive view of the mechanisms regulating circadian clocks and one of their critical output: sleep. We also now study the mechanisms enabling marine organisms to anticipate tides. Indeed, we have developed a model organism to study circatidal rhythms: Parhyale hawaiensis. Rotation projects could for example focus on characterizing new candudate post-transcriptional regulators of circadian rhythms, the role of glial genes in the control of sleep, or studying the molecular mechanisms of circatidal clocks.
H. Arthur Smith Chair in Cancer Research
Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
Higgins Family Professor in Neuroscience
Potential Rotation Projects Project #1: Molecular Mechanisms in the Pathogenesis of Neurodegenerative Disease. The student can select projects emphasizing either molecular mechanisms of huntingtin in trafficking in neurons or receptor stimulated effects on gene expression in neurons. Techniques include: Generation of fusion proteins, raising antisera Preparation of organelles Immunocytochemistry, light microscopy and electron microscopy Immunoprecipitation methods PCR Protein separation techniques, gel electrophoresis, immunoblotting Autoradiography
Arthur F. Koskinas Chair in Neuroscience
Many rotation projects are available so please inquire.
Herman G. Berkman Chair in Diabetes Care Innovation
Population and Quantitative Health Sciences
The Yemini Lab investigates how nervous systems change during development and evolution to generate new behaviors. We use cutting-edge tools and a multiscale systems-biology approach to study the genes, circuitry, and neural activity driving behavioral changes. Our findings provide a foundation to understand normal brain development and brain disorders (e.g., autism and intellectual disabilities).
Family Medicine at UMass Chan - Baystate
Healthcare Delivery and Population Sciences at UMass Chan - Baystate
In Living Color: Whole-Nervous-System Cell IDs
Worcester Foundation for Biomedical Research Chair I
Joseph D. Early Chair in Biomedical Research