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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
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Rotation Projects: Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research …
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Professor
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Associate Professor
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Associate Professor
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position in division: Food Science
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Associate Professor
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Chair and Professor
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Lindenauer, Peter
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT PROFESSOR
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Balsam, Leora
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Strauss, Kevin
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person in primary position: Adjunct Professor
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Population and Quantitative Health Sciences
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Jones, Douglas
first name: Douglas
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Binder, Zachary
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Nason, Katie
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Garg, Arvin
first name: Arvin
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Broder-Fingert, Sarabeth
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person in primary position: Associate Professor
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preferred title: Associate Professor

https://profiles.umassmed.edu/profile/28866543
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label: http://umassmed.edu/nccresearch
link anchor text: Muehlschlegel Lab Website

https://profiles.umassmed.edu/profile/28866556
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label: http://mmpc.org
link anchor text: National Mouse Metabolic Phenotyping Center

https://profiles.umassmed.edu/profile/28866602
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label: https://scholar.google.com/citations
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Anesthesiology at UMass Chan - Baystate
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Emergency Medicine at UMass Chan - Baystate
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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type: Organization

Medicine at UMass Chan - Baystate
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Pediatrics at UMass Chan - Baystate
type: Department
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Surgery at UMass Chan - Baystate
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Adjunct Assistant Professor
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position in division: Cardiovascular Medicine
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Adjunct Professor
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Adjunct Professor
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position in division: Preventive And Behavioral Medicine
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Professor
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HR job title: Professor
position in organization: UMass Chan – Baystate Regional Campus

Associate Professor
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sort order: 1
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HR job title: Associate Professor
position in organization: UMass Chan – Baystate Regional Campus

Parker, Margaret
first name: Margaret
last name: Parker
full name: Margaret G.K. Parker MD, MPH
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Person ID: 10247148
person in primary position: Professor
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Professor
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Professor Emeritus
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HR job title: Professor Emeritus
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Sheldrick, Radley
first name: Radley
last name: Sheldrick
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Person ID: 10247437
person in primary position: Professor
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Adjunct Professor
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Professor
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position in division: Cardiovascular Medicine
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Professor
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Associate Professor
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position in division: Cardiovascular Medicine
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Associate Professor
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position in department: Family Medicine and Community Health
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sort order: 1
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HR job title: Associate Professor
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Wilkie, Gianna
first name: Gianna
last name: Wilkie
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latitude: 42.27222560000000
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Person ID: 10247561
person in primary position: Assistant Professor
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Associate Professor
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sort order: 1
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HR job title: Associate Professor
position in organization: UMass Chan – Baystate Regional Campus

Walkey, Allan
first name: Allan
last name: Walkey
full name: Allan Jay Walkey MD, MSc
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latitude: 42.27525000000000
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Person ID: 10247602
person in primary position: Professor
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webpage: https://profiles.umassmed.edu/profile/104051488

Moffatt-Bruce, Susan
first name: Susan
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full name: Susan D Moffatt-Bruce MD, PhD, FRCSC, MBOE, MBA,FACS
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Person ID: 10247633
person in primary position: Professor
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preferred title: Professor

Professor
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position in division: Administrative Leadership
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HR job title: Professor
position in organization: UMass Chan Medical School

Administrative Leadership
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Mosenthal, Anne
first name: Anne
last name: Mosenthal
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Person ID: 10247657
person in primary position: Professor
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Medicine at UMass Chan - Lahey
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Surgery at UMass Chan - Lahey
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Professor
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Professor
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Radiology at UMass Chan - Lahey
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type: Organization

Associate Professor
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position in department: Surgery
position in division: Vascular Surgery
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Professor
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position in department: Population and Quantitative Health Sciences
position in division: Biostatistics And Health Services Research
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HR job title: Professor
position in organization: UMass Chan Medical School

Endocrinology & Diabetes
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type: Organization

Health System Science
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type: Organization

Infectious Diseases
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type: Organization

Neurointerventional Radiology
type: Division
type: Organization

Pulmonary Medicine
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Professor Emeritus
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position in division: Epidemiology
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Professor
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position in division: Infectious Diseases
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type: Position
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Professor
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position in division: Epidemiology
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type: Position
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Professor
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position in division: Neurointerventional Radiology
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Biostatistics And Health Services Research
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in division: Maternal-Fetal Medicine
sort order: 1
type: Position
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Chair and Associate Professor
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position in division: Pediatric Neonatology
sort order: 1
type: Position
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Adjunct Professor
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position in department: Neurology
position in division: Neurocritical Care
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Cardio Thoracic Surgery
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type: Organization

General Pediatrics
type: Division
type: Organization

Neurocritical Care
type: Division
type: Organization

Pediatric Neonatology
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type: Organization

Stroke and Vascular Neurology
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Chair and Professor
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Professor
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Neurology at UMass Chan - Lahey
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Dani, Sourbha
first name: Sourbha
last name: Dani
full name: Sourbha S Dani MD, MSc, GDCE, CCDS, FACC,FACP
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Person ID: 10247888
person in primary position: Associate Professor
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Associate Professor
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Martinez, Fernando
first name: Fernando
last name: Martinez
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Person ID: 10247895
person in primary position: Professor
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
preferred title: Professor

Professor
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position in department: Medicine
position in division: Pulmonary Medicine
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HR job title: Professor
position in organization: UMass Chan Medical School

Wilcox, Susan
first name: Susan
last name: Wilcox
full name: Susan Renee Wilcox MD
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media links: https://profiles.umassmed.edu/profile/66924233
media links: https://profiles.umassmed.edu/profile/66923959
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media links: https://profiles.umassmed.edu/profile/66924015
media links: https://profiles.umassmed.edu/profile/66923911
Person ID: 10247922
person in primary position: Professor
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Summary: Dr. Wilcox trained in EM at the Harvard Affiliated EM Residency, then completed an Anesthesia Critical Care fellowship. In addition to the ED, she has attended in Surgical, Medical, and Cardiac ICUs. She joined Lahey Hospital in 2022 as the Medical Director of the 5C Medical ICU. She is Vice Chair for Academic Affairs and a Professor of Medicine. She is the Associate CMO for Boston MedFlight.
preferred title: Professor

Professor
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Krings, Timo
first name: Timo
last name: Krings
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Person ID: 10247952
person in primary position: Professor
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Goldsweig, Andrew
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Person ID: 10248018
person in primary position: Associate Professor
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Associate Professor
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HR job title: Associate Professor
position in organization: UMass Chan – Baystate Regional Campus

Maron, Martin
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latitude: 42.48526100000000
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Person ID: 10248121
person in primary position: Associate Professor
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preferred title: Associate Professor

Maron, Barry
first name: Barry
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Person ID: 10248130
person in primary position: Adjunct Professor
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Adjunct Professor
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HR job title: Adjunct Professor
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Professor
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Chair and Professor
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Professor Emeritus
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Reynolds, Matthew
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Person ID: 10248173
person in primary position: Professor
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preferred title: Professor

Rowin, Ethan
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last name: Rowin
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Person ID: 10248175
person in primary position: Associate Professor
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Associate Professor
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Professor
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Professor
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Professor Emeritus
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Assistant Professor
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Associate Professor
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Chair And Professor
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Chair And Associate Professor
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Crowley, Conor
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last name: Crowley
full name: Conor Crowley MSN, AG-ACNP
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latitude: 42.48526100000000
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Person ID: 10248259
person in primary position: Assistant Professor
type: Agent
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preferred title: Assistant Professor

Professor
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position in division: Endocrinology & Diabetes
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in division: Endocrinology & Diabetes
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HR job title: Professor
position in organization: UMass Chan Medical School

Assistant Professor
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sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Psychiatry and Behavioral Sciences
type: Department
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Professor
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Neurology
position in division: Stroke and Vascular Neurology
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Psychiatry and Behavioral Sciences
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/66923911
publication date: 2016
type: URLLink
label: https://emcrit.org/emcrit/pulmonary-hypertension-right-ventricular-failure/
link anchor text: EMCrit 181 – Pulmonary Hypertension and Right Ventricular Failure with Susan Wilcox

https://profiles.umassmed.edu/profile/66923959
publication date: 2020
type: URLLink
label: https://www.edx.org/learn/healthcare/harvard-university-mechanical-ventilation-for-covid-19
link anchor text: HarvardX: Mechanical Ventilation for COVID-19

https://profiles.umassmed.edu/profile/66924015
publication date: 2017
type: URLLink
label: https://emergencymedicinecases.com/pulmonary-hypertension/
link anchor text: CritCases 7 Pulmonary Hypertension – A Fine Balance

https://profiles.umassmed.edu/profile/66924043
publication date: 2018
type: URLLink
label: https://www.aliem.com/2018/06/myth-vasopressors-ischemia/
link anchor text: Academic Life in Emergency Medicine: The Myth of Vasopressors and Ischemia

https://profiles.umassmed.edu/profile/66924060
publication date: 2020
type: URLLink
label: https://www.acep.org/corona/covid-19-field-guide/treatment/icu-care-in-the-emergency-department/
link anchor text: ACEP COVID-19 Field Guide: ICU Care in the Emergency Department

https://profiles.umassmed.edu/profile/66924233
publication date: 2021
type: URLLink
label: https://podcasts.apple.com/us/podcast/jem-june-2021-podcast-summary/id1141686910
link anchor text: Podcast summary of articles from the June 2021 edition of the Journal of Emergency Medicine

Adjunct Assistant Professor
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position in department: Radiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Assistant Professor
position in organization: UMass Chan Medical School

Wei, Zhenglun Alan
first name: Zhenglun Alan
last name: Wei
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Person ID: 10248327
person in primary position: Adjunct Assistant Professor
type: Agent
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preferred title: Adjunct Assistant Professor

Adjunct Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Shin, Dong-Soo
first name: Dong-Soo
last name: Shin
full name: Dong-Soo Shin PhD, RN
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Person ID: 10248397
person in primary position: Adjunct Professor
type: Agent
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preferred title: Adjunct Professor

Assistant Professor
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position in department: Neurology at UMass Chan - Lahey
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sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Wilson, Kevin
first name: Kevin
last name: Wilson
full name: Kevin Wilson MD
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Person ID: 10248446
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Associate Professor
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position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Pediatrics
position in division: Pediatric Emergency Medicine
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Adjunct Professor
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position in department: Pediatrics
position in division: Pediatric Genetics
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Pediatrics
position in division: General Pediatrics
sort order: 1
type: Position
HR job title: Professor
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Associate Professor
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