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Guertin, DavidPerson Why?
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.Academic Article Why?
Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.Academic Article Why?
Activation of protein kinase C-? in pancreatic ß-cells in vivo improves glucose tolerance and induces ß-cell expansion via mTOR activation.Academic Article Why?
AMPK?3 is dispensable for skeletal muscle hypertrophy induced by functional overload.Academic Article Why?
Dual mTORC1/2 inhibition in a preclinical xenograft tumor model of endometrial cancer.Academic Article Why?
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.Academic Article Why?
Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival.Academic Article Why?
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.Academic Article Why?
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.Academic Article Why?
mTOR-dependent cell survival mechanisms.Academic Article Why?
mTORC1 sustains vision in retinitis pigmentosa.Academic Article Why?
Obesity Notches up fatty liver.Academic Article Why?
Reassessment of the role of TSC, mTORC1 and microRNAs in amino acids-meditated translational control of TOP mRNAs.Academic Article Why?
Sestrin2 is a leucine sensor for the mTORC1 pathway.Academic Article Why?
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