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One or more keywords matched the following properties of Cavacini, Lisa
keywords Immunotherapy, Active
keywords Immunotherapy, Passive
keywords Mucosal Immunity

The major focus of my laboratory research is in the area of immunoregulation of infectious disease, cancer and autoimmune disease. Human monoclonal antibodies are characterized to study the humoral immune response in these disorders. . In addition, the laboratory is interested in developing active and passive forms of immunotherapy for the treatment of these disease areas. Not only do we generate new human monoclonal antibodies for our studies, but also for a large number of laboratories throughout the world for research on infectious diseases, cancer and autoimmune disease. We collaborate with Drs. Greiner, Brehm and Luban here at UMMS and Dr. Leonard Schultz at Jackson Laboratories on humanized mouse models for the generation of human monoclonal antibodies and as models for passive immunotherapy for bacterial or viral infections. The laboratory has also been involved in pharmacokinetic and pharmacodynamic studies of IgG and IgA human monoclonal antibodies, in several bacterial and viral infections. To further develop Dr. Cavacini’s background in mucosal immunology, included in this work is structural modeling of antibody/antigen interactions to improve the design of immunotherapeutic antibodies and development of a platform for production of dimeric and secretory IgA. These leading activities in IgA immunotherapy are currently being translated into clinical development of mucosal IgA molecules for prevention or treatment of two diverse bacterial infections. In addition to Dr. Cavacini’s current work on immunoprophylaxis for mucosal bacterial infections (e.g. Enterotoxigenic Escherichia coli,, Bordetella pertussis, Klebsiella pneumonia), she is also inventor of two human monoclonal antibodies against Staphylococcus aureus and Pseudomonas aeruginosa. Dr. Cavacini also contributes to programs for Lyme Disease and other emerging pathogens. Most recently, this has been to generate reagents and establish assays for screening novel drug candidates for immunoprophylaxis or treatment of COVID-19. Our initial screen of MassBiologics’ existing panel of SARS-CoVspecific antibodies resulted in Mabs with ELISA binding activity to the receptor binding domain of the SARS-CoV-2 Spike protein.  We have moved on to nanobody discovery for broadly neutralizing antibodies against all variants of concern and interest.  The expertise at MassBiologics, particularly in the areas of Discovery and Process Development, has allowed rapid production of SARS CoV-2 proteins (including several spike proteins and N protein) and human antibodies and nanobodies , contributing to the evaluation and development of therapeutics and diagnostics.

One or more keywords matched the following items that are connected to Cavacini, Lisa
Item TypeName
Concept Immunologic Factors
Concept Immunotherapy
Concept Enzyme-Linked Immunosorbent Assay
Concept Immunity, Cellular
Concept Immunoassay
Concept Immunoglobulin Variable Region
Concept Human Immunodeficiency Virus Proteins
Concept Immunoglobulin A, Secretory
Concept Immunoglobulins, Intravenous
Concept Immunophenotyping
Concept Genes, Immunoglobulin
Concept Immunity, Mucosal
Concept Immunoglobulins
Concept Acquired Immunodeficiency Syndrome
Concept Immunoglobulin kappa-Chains
Concept Simian Acquired Immunodeficiency Syndrome
Concept Immunity, Innate
Concept Immune Sera
Concept Immunoglobulin M
Concept Immunoglobulin Fab Fragments
Concept Immunity, Humoral
Concept Immunoglobulin G
Concept Simian Immunodeficiency Virus
Concept Immunologic Deficiency Syndromes
Concept Immunoglobulin A
Concept Immunodominant Epitopes
Concept Cytotoxicity, Immunologic
Concept Immunization, Passive
Concept Immune Evasion
Concept Immunotherapy, Adoptive
Concept Immunoglobulin Heavy Chains
Concept Immunoglobulin Isotypes
Concept Immunoconjugates
Concept Immunoglobulin Light Chains
Concept Immunoglobulin Idiotypes
Concept Immunoglobulin Constant Regions
Concept Immunoglobulin Class Switching
Concept Immunity, Maternally-Acquired
Concept Immunohistochemistry
Academic Article Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Academic Article Interactions of human antibodies, epitope exposure, antibody binding and neutralization of primary isolate HIV-1 virions.
Academic Article Synergistic neutralization of simian-human immunodeficiency virus SHIV-vpu+ by triple and quadruple combinations of human monoclonal antibodies and high-titer anti-human immunodeficiency virus type 1 immunoglobulins.
Academic Article Post-exposure prophylaxis with human monoclonal antibodies prevented SHIV89.6P infection or disease in neonatal macaques.
Academic Article Structure and function of immunoglobulins.
Academic Article Conformational changes in env oligomer induced by an antibody dependent on the V3 loop base.
Academic Article Development of an HIV-1 specific microbicide using Caulobacter crescentus S-layer mediated display of CD4 and MIP1alpha.
Academic Article Structure of the Fab fragment of F105, a broadly reactive anti-human immunodeficiency virus (HIV) antibody that recognizes the CD4 binding site of HIV type 1 gp120.
Academic Article Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization.
Academic Article Human single-chain antibodies inhibit replication of human immunodeficiency virus type 1 (HIV-1).
Academic Article Expression and functional activity of isotype and subclass switched human monoclonal antibody reactive with the base of the V3 loop of HIV-1 gp120.
Academic Article A bispecific antibody composed of a nonneutralizing antibody to the gp41 immunodominant region and an anti-CD89 antibody directs broad human immunodeficiency virus destruction by neutrophils.
Academic Article Binding and neutralization activity of human IgG1 and IgG3 from serum of HIV-infected individuals.
Academic Article Resistance to neutralization by broadly reactive antibodies to the human immunodeficiency virus type 1 gp120 glycoprotein conferred by a gp41 amino acid change.
Academic Article Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425A1g8.
Academic Article Neutralization of HIV by milk expressed antibody.
Academic Article Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies--implications for acquired immunodeficiency syndrome vaccine.
Academic Article Characterization of the opsonic and protective activity against Staphylococcus aureus of fully human monoclonal antibodies specific for the bacterial surface polysaccharide poly-N-acetylglucosamine.
Academic Article Pathogenic human monoclonal antibody against desmoglein 3.
Academic Article Vertical Transmission of HIV-1. Correlation with maternal viral load and plasma levels of CD4 binding site anti-gp120 antibodies.
Academic Article The N-terminal V3 loop glycan modulates the interaction of clade A and B human immunodeficiency virus type 1 envelopes with CD4 and chemokine receptors.
Academic Article Functional activity of an HIV-1 neutralizing IgG human monoclonal antibody: ADCC and complement-mediated lysis.
Academic Article Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody.
Academic Article Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques.
Academic Article Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin.
Academic Article Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody.
Academic Article Human antibody variable region gene usage in HIV-1 infection.
Academic Article Human monoclonal antibodies to Pseudomonas aeruginosa alginate that protect against infection by both mucoid and nonmucoid strains.
Academic Article Evidence of determinant spreading in the antibody responses to prostate cell surface antigens in patients immunized with prostate-specific antigen.
Academic Article The neutralization properties of a HIV-specific antibody are markedly altered by glycosylation events outside the antigen-binding domain.
Academic Article Dichotomy in cross-clade reactivity and neutralization by HIV-1 sera: Implications for active and passive immunotherapy.
Academic Article Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41.
Academic Article Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge.
Academic Article Shared VH1-46 gene usage by pemphigus vulgaris autoantibodies indicates common humoral immune responses among patients.
Academic Article Surface membrane-expressed CD40 is present on tumor cells from squamous cell cancer of the head and neck in vitro and in vivo and regulates cell growth in tumor cell lines.
Academic Article Minimal incidence of serum antibodies reactive with intact primary isolate virions in human immunodeficiency virus type 1-infected individuals.
Academic Article A human anti-HIV autoantibody enhances EBV transformation and HIV infection.
Academic Article Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection.
Academic Article Effect of antibody valency on interaction with cell-surface expressed HIV-1 and viral neutralization.
Academic Article Influence of heavy chain constant regions on antigen binding and HIV-1 neutralization by a human monoclonal antibody.
Academic Article Loss of serum antibodies to a conformational epitope of HIV-1/gp120 identified by a human monoclonal antibody is associated with disease progression.
Academic Article Human immunoglobulin production in immunodeficient mice: enhancement by immunosuppression of host and in vitro activation of human mononuclear cells.
Academic Article Plasma pharmacokinetics and biological activity of a human immunodeficiency virus type 1 neutralizing human monoclonal antibody, F105, in cynomolgus monkeys.
Academic Article V3-specific neutralizing antibodies in sera from HIV-1 gp160-immunized volunteers block virus fusion and act synergistically with human monoclonal antibody to the conformation-dependent CD4 binding site of gp120. NIH-NIAID AIDS Vaccine Clinical Trials Network.
Academic Article Neutralization of HIV-1 by F105, a human monoclonal antibody to the CD4 binding site of gp120.
Academic Article Human monoclonal antibodies to the V3 loop of HIV-1 gp120 mediate variable and distinct effects on binding and viral neutralization by a human monoclonal antibody to the CD4 binding site.
Academic Article Pharmacokinetics of F105, a human monoclonal antibody, in persons infected with human immunodeficiency virus type 1.
Academic Article Potent neutralization of primary human immunodeficiency virus clade C isolates with a synergistic combination of human monoclonal antibodies raised against clade B.
Academic Article Resolution of acute malarial infections by T cell-dependent non-antibody-mediated mechanisms of immunity.
Academic Article Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge.
Academic Article A protective monoclonal antibody recognizes a variant-specific epitope in the precursor of the major merozoite surface antigen of the rodent malarial parasite Plasmodium yoelii.
Academic Article Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission?
Academic Article Protection of neonatal macaques against experimental SHIV infection by human neutralizing monoclonal antibodies.
Academic Article T-cell immunity in murine malaria: adoptive transfer of resistance to Plasmodium chabaudi adami in nude mice with splenic T cells.
Academic Article Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.
Academic Article Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris.
Academic Article Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition.
Academic Article Effect of immunosuppressive therapy on cytolytic activity of immunodeficient mice: implications for xenogeneic transplantation.
Academic Article Cell-mediated immunity to the asexual blood stages of malarial parasites: animal models.
Academic Article Reassessment of the role of splenic leukocyte oxidative activity and macrophage activation in expression of immunity to malaria.
Academic Article Cloned T cells provide help for malaria-specific polyclonal antibody responses.
Academic Article The protective role of T cells in immunity to malaria.
Academic Article Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection.
Academic Article Correction for Giuntini et al., "Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection".
Academic Article Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
Academic Article Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration.
Academic Article Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a nonhuman primate model.
Academic Article IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity.
Academic Article A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.
Academic Article IgA as a potential candidate for enteric monoclonal antibody therapeutics with improved gastrointestinal stability.
Academic Article Highly Specific Mouse Anti-Joining Chain of Human Immunoglobulin A.
Academic Article Investigation of a monoclonal antibody against enterotoxigenic Escherichia coli, expressed as secretory IgA1 and IgA2 in plants.
Academic Article Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design.
Academic Article Human genital antibody-mediated inhibition of Chlamydia trachomatis infection and evidence for ompA genotype-specific neutralization.
Academic Article SARS-CoV-2 Serosurveys: How Antigen, Isotype and Threshold Choices Affect the Outcome.
Academic Article Enteric Polymer-Coated Porous Silicon Nanoparticles for Site-Specific Oral Delivery of IgA Antibody.
Academic Article Agglutination of Borreliella burgdorferi by Transmission-Blocking OspA Monoclonal Antibodies and Monovalent Fab Fragments.
Academic Article Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants.
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