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Thompson, Paul
One or more keywords matched the following items that are connected to Thompson, Paul
Item TypeName
Concept Enzyme Inhibitors
Academic Article Targeting the arginine phosphatase YwlE with a catalytic redox-based inhibitor.
Academic Article Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis.
Academic Article Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.
Academic Article A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1.
Academic Article Identification of PADI2 as a potential breast cancer biomarker and therapeutic target.
Academic Article Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors.
Academic Article Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.
Academic Article The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.
Academic Article N-a-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.
Academic Article Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors.
Academic Article Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.
Academic Article Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential.
Academic Article Activity-based protein profiling of protein arginine methyltransferase 1.
Academic Article A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation.
Academic Article Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
Academic Article Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.
Academic Article Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Academic Article Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation.
Academic Article A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.
Academic Article Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6).
Academic Article A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation.
Academic Article Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors.
Academic Article Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates.
Academic Article In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1.
Academic Article Protein arginine deiminase 4: a target for an epigenetic cancer therapy.
Academic Article A fluopol-ABPP HTS assay to identify PAD inhibitors.
Academic Article Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Academic Article Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells.
Academic Article Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Academic Article Regulation of p53 target gene expression by peptidylarginine deiminase 4.
Academic Article Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation.
Academic Article Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Academic Article Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Academic Article Photochemical Control of Protein Arginine Deiminase (PAD) Activity.
Academic Article Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination.
Academic Article Halogen Bonding Increases the Potency and Isozyme Selectivity of Protein Arginine Deiminase 1 Inhibitors.
Academic Article Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1.
Academic Article Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.
Academic Article Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock.
Academic Article Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design.
Academic Article Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4.
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  • Enzyme Inhibitors