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One or more keywords matched the following properties of Gazzinelli, Ricardo
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keywords Innate Immune Responses
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Research:

My research program is developed at the Division of Infectious Diseases and Immunology, Department of Medicine, UMASS Medical School, Worcester, USA and at Oswaldo Cruz Foundation-Minas, in belo Horizonte, Brazil.

Broadly, I am interested in understanding the immunological mechanisms that warrant host resistance to infection and at the same time prevent immune mediated tissue damage and pathology in parasitic diseases. The main areas of scientific research carried in my lab are on: (i) the role innate immunity on host resistance and pathogenesis to infection with protozoan parasites; (ii) the mechanisms of cytotoxic T cells in resistance to infection; and (iii) the development of recombinant vaccines that induce cell-mediated immunity and protect against protozoan infections. When possible, we try to address our questions regarding host-parasite interactions, employing cellular systems, experimental rodent models and well-characterized patients undergoing specific protozoan infection.

Main Projects:

Role of TLRs, inflammasome and inflammatory caspses in malaria pathogenesis

Role of monocyte-derived dendritic cells in malária

The influence of the circadian cycle on inflammation, metabolismo and Plasmodium infection

The role of IRAKs and Myddosomes in infection with T. gondii

Development of the recombinant-A2 vaccine for visceral leishmaniasis

Development of the recombinant-ASP2/TS vaccine for visceral leishmaniasis

My current research is supported by Conselho Nacional de Desenvolvimento Cinetifico e Tecnologico (CNPq), Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) and the National Institutes of Health (NIH).

One or more keywords matched the following items that are connected to Gazzinelli, Ricardo
Item TypeName
Academic Article Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
Academic Article Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.
Academic Article Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii.
Academic Article Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.
Academic Article Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.
Academic Article The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease.
Academic Article Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
Academic Article Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Concept Immunity, Innate
Academic Article Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.
Academic Article Innate sensing of malaria parasites.
Academic Article Leishmania amazonensis Engages CD36 to Drive Parasitophorous Vacuole Maturation.
Academic Article Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity.
Academic Article The immunology of Plasmodium vivax malaria.
Academic Article Toxoplasma gondii-Induced Neutrophil Extracellular Traps Amplify the Innate and Adaptive Response.
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