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Search Results to Ricardo T Gazzinelli DSc, DVM

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One or more keywords matched the following properties of Gazzinelli, Ricardo

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keywords Monocyte-Derived Dendritic Cells
overview

Research:

My research program is developed at the Division of Infectious Diseases and Immunology, Department of Medicine, UMASS Medical School, Worcester, USA and at Oswaldo Cruz Foundation-Minas, in belo Horizonte, Brazil.

Broadly, I am interested in understanding the immunological mechanisms that warrant host resistance to infection and at the same time prevent immune mediated tissue damage and pathology in parasitic diseases. The main areas of scientific research carried in my lab are on: (i) the role innate immunity on host resistance and pathogenesis to infection with protozoan parasites; (ii) the mechanisms of cytotoxic T cells in resistance to infection; and (iii) the development of recombinant vaccines that induce cell-mediated immunity and protect against protozoan infections. When possible, we try to address our questions regarding host-parasite interactions, employing cellular systems, experimental rodent models and well-characterized patients undergoing specific protozoan infection.

Main Projects:

Role of TLRs, inflammasome and inflammatory caspses in malaria pathogenesis

Role of monocyte-derived dendritic cells in malária

The influence of the circadian cycle on inflammation, metabolismo and Plasmodium infection

The role of IRAKs and Myddosomes in infection with T. gondii

Development of the recombinant-A2 vaccine for visceral leishmaniasis

Development of the recombinant-ASP2/TS vaccine for visceral leishmaniasis

My current research is supported by Conselho Nacional de Desenvolvimento Cinetifico e Tecnologico (CNPq), Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) and the National Institutes of Health (NIH).

Post Docs

Fiocruz-Minas

Caroline Junqueira, PhD - Staff Scientist

  • Camila Brabosa, PhD student - Mapping of CD8 T cell-specifc Epitopes from Malaria Blood Stage
  • Gregorio Almeida, DVM, PhD - Immunology of Asymptomatic Malaria
  • Guilherme Maia, PhD - Innate Lymphocytes in Malaria
  • Isabella Hirako, PhD - Monocyte-Derived Dendritic Cells in Malaria
  • Júlia Castro, MSc student - Chagas Disease Vaccine
  • Larissa Pereira, MSc student - Inflammatory Caspases in Malaria
  • Kely Mateucci, PhD - Monocyte-Derived Dendritic Cells Metabolism in Malaria
  • Milton Pereira, PhD - Caspases and inflammasomes in Malaria and Chagas Disease
  • Natalia Satchiko Souza, PhD - CD8+ T cells in malaria

UMASS

  • Danielle Durso, PhD - IRAKs and Myddosomes in host resistance to T. gondii
  • Patricia Assis, PhD - Host Clock genes and Malaria
  • Ogooluwa Ojelabi, PhD - Glucose Metabolism and Malaria

One or more keywords matched the following items that are connected to Gazzinelli, Ricardo

Item TypeName
Academic Article Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi.
Academic Article Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein.
Academic Article Neutrophil paralysis in Plasmodium vivax malaria.
Concept Dendritic Cells
Concept Monocytes
Academic Article Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Academic Article Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Academic Article Oxidized multiwalled carbon nanotubes as antigen delivery system to promote superior CD8(+) T cell response and protection against cancer.
Academic Article The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria.
Academic Article DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14+ CD16+ CD64high CD32low Inflammatory Monocytes from Malaria Patients.
Academic Article Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria.
Academic Article The emergence of pathogenic TNF/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4.
Academic Article Monocyte-derived dendritic cells in malaria.

Search Criteria
  • Monocyte
  • Derived
  • Dendritic Cells