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Gazzinelli, Ricardo
One or more keywords matched the following properties of Gazzinelli, Ricardo
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keywords Vaccines
overview

Research:

My research program is developed at the Division of Infectious Diseases and Immunology, Department of Medicine, UMASS Medical School, Worcester, USA and at Oswaldo Cruz Foundation-Minas, in belo Horizonte, Brazil.

Broadly, I am interested in understanding the immunological mechanisms that warrant host resistance to infection and at the same time prevent immune mediated tissue damage and pathology in parasitic diseases. The main areas of scientific research carried in my lab are on: (i) the role innate immunity on host resistance and pathogenesis to infection with protozoan parasites; (ii) the mechanisms of cytotoxic T cells in resistance to infection; and (iii) the development of recombinant vaccines that induce cell-mediated immunity and protect against protozoan infections. When possible, we try to address our questions regarding host-parasite interactions, employing cellular systems, experimental rodent models and well-characterized patients undergoing specific protozoan infection.

Main Projects:

Role of TLRs, inflammasome and inflammatory caspses in malaria pathogenesis

Role of monocyte-derived dendritic cells in malária

The influence of the circadian cycle on inflammation, metabolismo and Plasmodium infection

The role of IRAKs and Myddosomes in infection with T. gondii

Development of the recombinant-A2 vaccine for visceral leishmaniasis

Development of the recombinant-ASP2/TS vaccine for visceral leishmaniasis

My current research is supported by Conselho Nacional de Desenvolvimento Cinetifico e Tecnologico (CNPq), Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) and the National Institutes of Health (NIH).
One or more keywords matched the following items that are connected to Gazzinelli, Ricardo
Item TypeName
Academic Article Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen: correlation with IFN-gamma and cytolytic activity by CD8+ T cells.
Academic Article Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell-dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination.
Academic Article Prime and boost immunization with influenza and adenovirus encoding the Toxoplasma gondii surface antigen 2 (SAG2) induces strong protective immunity.
Academic Article Trypanosoma cruzi as an effective cancer antigen delivery vector.
Academic Article Vaccination using recombinants influenza and adenoviruses encoding amastigote surface protein-2 are highly effective on protection against Trypanosoma cruzi infection.
Academic Article Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein.
Academic Article Trypanosoma cruzi adjuvants potentiate T cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine.
Academic Article Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine.
Academic Article Making an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives.
Concept Vaccines, DNA
Concept Leishmaniasis Vaccines
Concept Protozoan Vaccines
Concept Malaria Vaccines
Concept Cancer Vaccines
Concept Pneumococcal Vaccines
Concept Vaccines, Inactivated
Concept Viral Vaccines
Concept Vaccines, Synthetic
Concept Vaccines, Combined
Concept Influenza Vaccines
Academic Article Adenovirus vector-induced CD8? T effector memory cell differentiation and recirculation, but not proliferation, are important for protective immunity against experimental Trypanosoma cruzi Infection.
Academic Article Clinical and parasitological protection in a Leishmania infantum-macaque model vaccinated with adenovirus and the recombinant A2 antigen.
Academic Article Oxidized multiwalled carbon nanotubes as antigen delivery system to promote superior CD8(+) T cell response and protection against cancer.
Academic Article Innate sensing of malaria parasites.
Academic Article Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
Academic Article A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine re-programs immune response and reverses chronic cardiomyopathy.
Academic Article The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi.
Academic Article CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge.
Academic Article The immunology of Plasmodium vivax malaria.
Academic Article The global response to the COVID-19 pandemic: how have immunology societies contributed?
Academic Article Rapamycin Improves the Response of Effector and Memory CD8+ T Cells Induced by Immunization With ASP2 of Trypanosoma cruzi.
Academic Article a-Gal immunization positively impacts Trypanosoma cruzi colonization of heart tissue in a mouse model.
Academic Article Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.
Concept Adenovirus Vaccines
Academic Article CoronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Variant.
Academic Article Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine.
Academic Article Why do we still have not a vaccine against Chagas disease?
Academic Article Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein.
Academic Article Differential requirement of neutralizing antibodies and T cells on protective immunity to SARS-CoV-2 variants of concern.
Academic Article ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas' disease.
Academic Article Quality attributes of CTVad1, a nanoemulsified adjuvant for phase I clinical trial of SpiN COVID-19 vaccine.
Academic Article Non-clinical toxicity and immunogenicity evaluation of a Plasmodium vivax malaria vaccine using Poly-ICLC (Hiltonol?) as adjuvant.
Academic Article SpiN-Tec: A T cell-based recombinant vaccine that is safe, immunogenic, and shows high efficacy in experimental models challenged with SARS-CoV-2 variants of concern.
Academic Article Intranasal influenza-vectored vaccine expressing pneumococcal surface protein A protects against Influenza and Streptococcus pneumoniae infections.
Academic Article The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens.
Academic Article Characterization of a novel Leishmania antigen containing a repetitive domain and its potential use as a prophylactic and therapeutic vaccine.
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