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Lu, Shan

One or more keywords matched the following properties of Lu, Shan

Property	Value
overview	Academic Background MD, 1982, Nanjing Medical College PhD, 1991, UMass Worcester Immunogenicity of Protein Antigens Our main interest is to understand the immunogenicity of proteinantigens. The human immunodeficiency virus type-1 (HIV-1) envelopeproteins (Env) is used as a model system in our lab. Env, a two-subunitprotein, is generated during the posttranslational cleavage processfrom a single precursor polyprotein. Env heterodimers are furtherorganized into an oligomeric complex. Env conformation is criticalfor the interaction of HIV-1 with a number of viral receptors. Our work is to understand the immunogenicity of various Env subunitsfrom different HIV-1 strains and to find the Env structures thatHIV-1 uses to escape from host immune surveillance. Such informationwill be used to design noval HIV-1 vaccines. Direct DNA immunizationusing eukaryotic expression vectors to make proteins in vivo isa unique approach we have been using to study the immunogenicityof protein antigens. We are also working to further improve thisevolving technology by studying the roles of cytokines and adjuvantsin inducing the desired immune responses by direct DNA immunization.

Property

Value

overview

Academic Background

MD, 1982, Nanjing Medical College
PhD, 1991, UMass Worcester

Immunogenicity of Protein Antigens

Our main interest is to understand the immunogenicity of proteinantigens. The human immunodeficiency virus type-1 (HIV-1) envelopeproteins (Env) is used as a model system in our lab. Env, a two-subunitprotein, is generated during the posttranslational cleavage processfrom a single precursor polyprotein. Env heterodimers are furtherorganized into an oligomeric complex. Env conformation is criticalfor the interaction of HIV-1 with a number of viral receptors. Our work is to understand the immunogenicity of various Env subunitsfrom different HIV-1 strains and to find the Env structures thatHIV-1 uses to escape from host immune surveillance. Such informationwill be used to design noval HIV-1 vaccines. Direct DNA immunizationusing eukaryotic expression vectors to make proteins in vivo isa unique approach we have been using to study the immunogenicityof protein antigens. We are also working to further improve thisevolving technology by studying the roles of cytokines and adjuvantsin inducing the desired immune responses by direct DNA immunization.

One or more keywords matched the following items that are connected to Lu, Shan

Item Type	Name
Academic Article	Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1.
Academic Article	Increased immunogenicity of human immunodeficiency virus gp120 engineered to express Galalpha1-3Galbeta1-4GlcNAc-R epitopes.
Academic Article	Combination DNA plus protein HIV vaccines.
Academic Article	Immunogenicity of DNA vaccines in humans: it takes two to tango.
Academic Article	Improved induction of antibodies against key neutralizing epitopes by human immunodeficiency virus type 1 gp120 DNA prime-protein boost vaccination compared to gp120 protein-only vaccination.
Academic Article	Increased immunogenicity of HIV-1 p24 and gp120 following immunization with gp120/p24 fusion protein vaccine expressing alpha-gal epitopes.
Academic Article	Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity.
Academic Article	A versatile vector for the production of pseudotyped viruses expressing gp120 antigens from different clades of primary HIV-1 isolates.
Academic Article	Polyvalent AIDS vaccines.
Academic Article	Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies.
Academic Article	Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates.
Academic Article	Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates.
Academic Article	A novel rabbit monoclonal antibody platform to dissect the diverse repertoire of antibody epitopes for HIV-1 Env immunogen design.
Academic Article	Independent but not synergistic enhancement to the immunogenicity of DNA vaccine expressing HIV-1 gp120 glycoprotein by codon optimization and C3d fusion in a mouse model.
Academic Article	Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine.
Academic Article	Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and E.
Academic Article	Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
Academic Article	The safety and tolerability of an HIV-1 DNA prime-protein boost vaccine (DP6-001) in healthy adult volunteers.
Academic Article	Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
Academic Article	Heterologous prime-boost vaccination.
Academic Article	Progress on the induction of neutralizing antibodies against HIV type 1 (HIV-1).
Academic Article	Vaccinology: precisely tuned antibodies nab HIV.
Academic Article	Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism.
Concept	HIV Antigens
Concept	Receptors, HIV
Concept	HIV-1
Concept	HIV Envelope Protein gp120
Concept	HIV Infections
Concept	gag Gene Products, Human Immunodeficiency Virus
Concept	HIV Antibodies
Concept	env Gene Products, Human Immunodeficiency Virus
Concept	HIV
Concept	HIV Core Protein p24
Academic Article	Post-translational intracellular trafficking determines the type of immune response elicited by DNA vaccines expressing Gag antigen of Human Immunodeficiency Virus Type 1 (HIV-1).
Academic Article	Reduced MyD88 dependency of ISCOMATRIX? adjuvant in a DNA prime-protein boost HIV vaccine.
Academic Article	Contribution of TLR4 and MyD88 for adjuvant monophosphoryl lipid A (MPLA) activity in a DNA prime-protein boost HIV-1 vaccine.
Academic Article	DNA Immunization for HIV Vaccine Development.
Academic Article	Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001.
Academic Article	HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.
Academic Article	Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines.
Academic Article	Glycan Profiles of gp120 Protein Vaccines from Four Major HIV-1 Subtypes Produced from Different Host Cell Lines under Non-GMP or GMP Conditions.
Academic Article	DNA priming immunization is more effective than recombinant protein vaccine in eliciting antigen-specific B cell responses.
Academic Article	Broadly binding and functional antibodies and persisting memory B cells elicited by HIV vaccine PDPHV.
Academic Article	Human CD4-Binding Site Antibody Elicited by Polyvalent DNA Prime-Protein Boost Vaccine Neutralizes Cross-Clade Tier-2-HIV Strains.
Academic Article	Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains.

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