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Lu, Shan

One or more keywords matched the following properties of Lu, Shan

Property	Value
overview	Academic Background MD, 1982, Nanjing Medical College PhD, 1991, UMass Worcester Immunogenicity of Protein Antigens Our main interest is to understand the immunogenicity of proteinantigens. The human immunodeficiency virus type-1 (HIV-1) envelopeproteins (Env) is used as a model system in our lab. Env, a two-subunitprotein, is generated during the posttranslational cleavage processfrom a single precursor polyprotein. Env heterodimers are furtherorganized into an oligomeric complex. Env conformation is criticalfor the interaction of HIV-1 with a number of viral receptors. Our work is to understand the immunogenicity of various Env subunitsfrom different HIV-1 strains and to find the Env structures thatHIV-1 uses to escape from host immune surveillance. Such informationwill be used to design noval HIV-1 vaccines. Direct DNA immunizationusing eukaryotic expression vectors to make proteins in vivo isa unique approach we have been using to study the immunogenicityof protein antigens. We are also working to further improve thisevolving technology by studying the roles of cytokines and adjuvantsin inducing the desired immune responses by direct DNA immunization.

Property

Value

overview

Academic Background

MD, 1982, Nanjing Medical College
PhD, 1991, UMass Worcester

Immunogenicity of Protein Antigens

Our main interest is to understand the immunogenicity of proteinantigens. The human immunodeficiency virus type-1 (HIV-1) envelopeproteins (Env) is used as a model system in our lab. Env, a two-subunitprotein, is generated during the posttranslational cleavage processfrom a single precursor polyprotein. Env heterodimers are furtherorganized into an oligomeric complex. Env conformation is criticalfor the interaction of HIV-1 with a number of viral receptors. Our work is to understand the immunogenicity of various Env subunitsfrom different HIV-1 strains and to find the Env structures thatHIV-1 uses to escape from host immune surveillance. Such informationwill be used to design noval HIV-1 vaccines. Direct DNA immunizationusing eukaryotic expression vectors to make proteins in vivo isa unique approach we have been using to study the immunogenicityof protein antigens. We are also working to further improve thisevolving technology by studying the roles of cytokines and adjuvantsin inducing the desired immune responses by direct DNA immunization.

One or more keywords matched the following items that are connected to Lu, Shan

Item Type	Name
Academic Article	A DNA vaccine producing LcrV antigen in oligomers is effective in protecting mice from lethal mucosal challenge of plague.
Academic Article	Epitope mapping and biological function analysis of antibodies produced by immunization of mice with an inactivated Chinese isolate of severe acute respiratory syndrome-associated coronavirus (SARS-CoV).
Academic Article	Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1.
Academic Article	Increased immunogenicity of human immunodeficiency virus gp120 engineered to express Galalpha1-3Galbeta1-4GlcNAc-R epitopes.
Academic Article	Combination DNA plus protein HIV vaccines.
Academic Article	DNA vaccines expressing glycoprotein complex II antigens gM and gN elicited neutralizing antibodies against multiple human cytomegalovirus (HCMV) isolates.
Academic Article	Current progress of DNA vaccine studies in humans.
Academic Article	Immunogenicity of DNA vaccines in humans: it takes two to tango.
Academic Article	Improved induction of antibodies against key neutralizing epitopes by human immunodeficiency virus type 1 gp120 DNA prime-protein boost vaccination compared to gp120 protein-only vaccination.
Academic Article	Heterologous HA DNA vaccine prime--inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses.
Academic Article	Gene-based adjuvants: a new meaning.
Academic Article	Increased immunogenicity of HIV-1 p24 and gp120 following immunization with gp120/p24 fusion protein vaccine expressing alpha-gal epitopes.
Academic Article	Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity.
Academic Article	Polyvalent AIDS vaccines.
Academic Article	Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies.
Academic Article	Involvement of CD8+ T cell-mediated immune responses in LcrV DNA vaccine induced protection against lethal Yersinia pestis challenge.
Academic Article	Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates.
Academic Article	Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy.
Academic Article	Independent but not synergistic enhancement to the immunogenicity of DNA vaccine expressing HIV-1 gp120 glycoprotein by codon optimization and C3d fusion in a mouse model.
Academic Article	Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus spike glycoprotein produced from the mammalian expression system.
Academic Article	Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine.
Academic Article	Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and E.
Academic Article	Immunogenicity and protection efficacy of monovalent and polyvalent poxvirus vaccines that include the D8 antigen.
Academic Article	Hemagglutinin (HA) proteins from H1 and H3 serotypes of influenza A viruses require different antigen designs for the induction of optimal protective antibody responses as studied by codon-optimized HA DNA vaccines.
Academic Article	Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens.
Academic Article	Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
Academic Article	Relative immunogenicity and protection potential of candidate Yersinia Pestis antigens against lethal mucosal plague challenge in Balb/C mice.
Academic Article	The safety and tolerability of an HIV-1 DNA prime-protein boost vaccine (DP6-001) in healthy adult volunteers.
Academic Article	Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
Academic Article	Heterologous prime-boost vaccination.
Academic Article	Progress on the induction of neutralizing antibodies against HIV type 1 (HIV-1).
Academic Article	Technical transformation of biodefense vaccines.
Academic Article	Antigen engineering can play a critical role in the protective immunity elicited by Yersinia pestis DNA vaccines.
Academic Article	Two is better than one.
Concept	Vaccines, Attenuated
Concept	Vaccines, DNA
Concept	Bacterial Vaccines
Concept	Cancer Vaccines
Concept	Cytomegalovirus Vaccines
Concept	Vaccines, Inactivated
Concept	Hepatitis B Vaccines
Concept	Vaccines
Concept	Viral Vaccines
Concept	Vaccines, Synthetic
Concept	Vaccines, Combined
Concept	Influenza Vaccines
Concept	AIDS Vaccines
Concept	Vaccines, Subunit
Academic Article	Cross reactivity of serum antibody responses elicited by DNA vaccines expressing HA antigens from H1N1 subtype influenza vaccines in the past 30 years.
Academic Article	Post-translational intracellular trafficking determines the type of immune response elicited by DNA vaccines expressing Gag antigen of Human Immunodeficiency Virus Type 1 (HIV-1).
Academic Article	DNA vaccine prime followed by boost with live attenuated virus significantly improves antigen-specific T cell responses against human cytomegalovirus.
Academic Article	DNA immunization.
Academic Article	Editorial overview: vaccines against challenging viral pathogens and new vaccine technology.
Academic Article	Reduced MyD88 dependency of ISCOMATRIX? adjuvant in a DNA prime-protein boost HIV vaccine.
Academic Article	Contribution of TLR4 and MyD88 for adjuvant monophosphoryl lipid A (MPLA) activity in a DNA prime-protein boost HIV-1 vaccine.
Academic Article	Novel vaccine technology and the future of vaccine science.
Academic Article	Identification of Aim2 as a sensor for DNA vaccines.
Academic Article	EV71 vaccines: a milestone in the history of global vaccine development.
Academic Article	Pilot Study on the Use of DNA Priming Immunization to Enhance Y. pestis LcrV-Specific B Cell Responses Elicited by a Recombinant LcrV Protein Vaccine.
Academic Article	DNA Immunization for HIV Vaccine Development.
Academic Article	A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines.
Academic Article	Fc Receptor-Mediated Activities of Env-Specific Human Monoclonal Antibodies Generated from Volunteers Receiving the DNA Prime-Protein Boost HIV Vaccine DP6-001.
Academic Article	Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines.
Academic Article	The dynamics of immunoglobulin V-gene usage and clonotype expansion in mice after prime and boost immunizations as analyzed by NGS.
Academic Article	DNA Vaccination in 2018: An Update.
Academic Article	Glycan Profiles of gp120 Protein Vaccines from Four Major HIV-1 Subtypes Produced from Different Host Cell Lines under Non-GMP or GMP Conditions.
Academic Article	Timely development of vaccines against SARS-CoV-2.
Academic Article	DNA priming immunization is more effective than recombinant protein vaccine in eliciting antigen-specific B cell responses.
Academic Article	Broadly binding and functional antibodies and persisting memory B cells elicited by HIV vaccine PDPHV.
Academic Article	Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains.

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Vaccines