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One or more keywords matched the following properties of Zhu, Lihua

Academic Background

Lihua Julie Zhu obtained her Ph.D. in Nutritional Sciences from the University of Wisconsin-Madison in 1999, and her M.S. in Computer Science from DePaul University in Chicago in 2001. She joined the Bioinformatics Core of the Robert H. Lurie Comprehensive Cancer Center (RHLCCC) of Northwestern University in 2001, where she was the Director of Bioinformatics Consulting Core from 2003 to 2005 and the Director of Clinical Informatics Group from 2005 to 2007. She joined the University of Massachusetts Medical School (UMMS) as the head of Bioinformatics core of Program in Gene Function and Expression (PGFE) in 2007.  Dr. Zhu is currently a professor and the head of Bioinformatics Core in the Department of Molecular, Cell and Cancer Biology (MCCB) of UMMS.

Computational Biology and Bioinformatics

Photo: Julie Zhu, Ph.D.

We are interested in the understanding of gene regulation and cancer etiology, biomarker discovery, and development and application of genome editing technology by mining and integrating various high-throughput datasets such as ChIP-seq, RNA-seq, ATAC-seq, miRNA-seq, Hi-C, shRNA-seq, PAS-seq, NAD-seq and GUIDE-seq. Our expertise is algorithm and computational tool development. My group is an active contributor to the open-source open-development Bioconductor project. We have developed a dozen packages with various utilities, ranging from machine learning, peak calling, motif identification and alignment, quality assessment of ATACseq data, annotation, data integration, visualization, gRNA design and genome-wide offtargets identification in CRISPR genome editing studies.

One or more keywords matched the following items that are connected to Zhu, Lihua
Item TypeName
Academic Article CRISPRseek: a bioconductor package to identify target-specific guide RNAs for CRISPR-Cas9 genome-editing systems.
Academic Article DNA-binding-domain fusions enhance the targeting range and precision of Cas9.
Academic Article Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo.
Academic Article GUIDEseq: a bioconductor package to analyze GUIDE-Seq datasets for CRISPR-Cas nucleases.
Academic Article CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy.
Academic Article Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.
Academic Article Overview of guide RNA design tools for CRISPR-Cas9 genome editing technology
Academic Article Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.
Academic Article C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2.
Academic Article Identification of Epigenetic Regulators of DUX4-fl for Targeted Therapy of Facioscapulohumeral Muscular Dystrophy.
Academic Article Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing.
Academic Article NmeCas9 is an intrinsically high-fidelity genome-editing platform.
Academic Article Enhanced Cas12a editing in mammalian cells and zebrafish.
Academic Article Genome-wide detection and analysis of CRISPR-Cas off-targets.
Concept Clustered Regularly Interspaced Short Palindromic Repeats
Concept CRISPR-Cas Systems
Concept CRISPR-Associated Proteins
Academic Article Genome-wide detection of CRISPR editing in vivo using GUIDE-tag.
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