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One or more keywords matched the following properties of Gao, Guangping

Academic Background

B.A. West China Univ. of Med. Sciences, Chengdu, China
M.S. Florida International University, Miami, FL
Ph.D. Florida International University, Miami, FL
Postdoctoral training at the University of Pennsylvania - School of Medicine


Research in the Gao Lab primarily involves the discovery, development and use of adeno-associated virus vectors for gene therapy of genetic diseases and the study of miRNA functions in mammals. The lab works on isolation, characterization and vectorology of novel AAV vectors from primate tissues, molecular mechanisms of AAV evolution and diversity, and molecular interactions between endogenous AAV, AAV vector, host genomes and innate RNAi defense pathways. We also develop novel strategies for rAAV gene therapy of an inherited neurodegenerative disease, Canavan Disease, using novel AAVs that can cross the blood-brain-barrier for efficient CNS gene delivery and endogenous miRNA-mediated posttranscriptional de-targeting. Another area of research interest in the lab is to explore AAV vectors for delivery of denovo synthesized biological miRNA antagonists or over expression of microRNAs to elucidate micro RNA functions in adult mammals.

Summary Focus: Adeno-associated virus vector mediated gene transfer for gene therapy, gene therapy of inherited neurodegenerative Canavan Disease
One or more keywords matched the following items that are connected to Gao, Guangping
Item TypeName
Academic Article Adenovirus-adeno-associated virus hybrid for large-scale recombinant adeno-associated virus production.
Academic Article rAAV9--a human-derived adeno-associated virus vector for efficient transgene expression in mouse cingulate cortex.
Academic Article Gene transfer in the lung using recombinant adeno-associated virus.
Academic Article Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus.
Academic Article Recombinant adeno-associated virus integration sites in murine liver after ornithine transcarbamylase gene correction.
Academic Article Vector sequences are not detected in tumor tissue from research subjects with ornithine transcarbamylase deficiency who previously received adenovirus gene transfer.
Academic Article Production and discovery of novel recombinant adeno-associated viral vectors.
Academic Article Gene transfer to the CNS using recombinant adeno-associated virus.
Academic Article Gene transfer in the liver using recombinant adeno-associated virus.
Concept Adenoviridae
Academic Article The potential of adeno-associated viral vectors for gene delivery to muscle tissue.
Academic Article Adeno-associated virus-mediated microRNA delivery and therapeutics.
Academic Article Stability and compatibility of recombinant adeno-associated virus under conditions commonly encountered in human gene therapy trials.
Academic Article Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.
Academic Article Adeno-associated Virus Serotype Vectors Efficiently Transduce Normal Prostate Tissue and Prostate Cancer Cells.
Academic Article Short DNA Hairpins Compromise Recombinant Adeno-Associated Virus Genome Homogeneity.
Academic Article Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras.
Academic Article Slow Infusion of Recombinant Adeno-Associated Viruses into the Mouse Cerebrospinal Fluid Space.
Academic Article Streamlined ex vivo and in vivo genome editing in mouse embryos using recombinant adeno-associated viruses.
Academic Article Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer.
Academic Article Adeno-associated virus vector as a platform for gene therapy delivery.
Academic Article High-Throughput Quantification of In Vivo Adeno-Associated Virus Transduction with Barcoded Non-Coding RNAs.
Academic Article Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno-Associated Virus.
Academic Article Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties.
Academic Article Two-Plasmid Packaging System for Recombinant Adeno-Associated Virus.
Academic Article Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis.
Academic Article Human and Insect Cell-Produced Recombinant Adeno-Associated Viruses Show Differences in Genome Heterogeneity.
Academic Article AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice.
Academic Article Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector.
Search Criteria
  • Adeno
  • Associated Virus