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Biography

Daryl Bosco received her Ph.D. (bio-organic chemistry) in 2003 from Brandeis University, where she used NMR spectroscopy to study enzyme dynamics. From 2003-2005, Dr. Bosco was a post-doctoral fellow in the lab of Jeffery W. Kelly at the Scripps Research Institute, where she studied the effect of oxidative cholesterol metabolites on the mis-folding of alpha-synuclein, a Parkinson's disease-associated protein. Prior to joining the faculty at UMMS in 2008, Dr. Bosco was an Instructor of Neurology at Harvard Medical School and worked on various aspects of ALS in the Cecile B. Day lab directed by Dr. Robert H. Brown, Jr. at the Massachusetts General Hospital.

Research

Our lab is investigating the pathogenic mechanisms of ALS-associated proteins SOD1, FUS/TLS, profilin-1 and TDP-43.  ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig’s disease, is a fatal neurodegenerative disorder that targets motor neurons.  Motor neuron death culminates in paralysis and eventual death, usually 2-3 years after symptom onset.  To date, there is no cure or effective therapy for ALS.  Our ultimate goal is to translate our basic-research findings into therapies for this devastating disease.   We use a multidisciplinary approach involving biochemistry, cell biology (including iPS cell technology), biophysics and in vivo model systems for our investigations. See our lab webpage for more information on Research Projects: https://www.umassmed.edu/boscolab

Rotation Projects

Rotation Projects:

See our lab webpage for more information on Research Projects: https://www.umassmed.edu/boscolab

Summary Elucidating the factors involved in sporadic ALS and investigating protein misfunction associated with neurodegenerative disease.
One or more keywords matched the following items that are connected to Bosco, Daryl
Item TypeName
Academic Article Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A.
Academic Article Monovalent cation activation in Escherichia coli inosine 5'-monophosphate dehydrogenase.
Academic Article Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization.
Academic Article Paraoxonase gene mutations in amyotrophic lateral sclerosis.
Academic Article Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological HIV-1 capsid substrate by NMR.
Academic Article Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.
Academic Article A yeast model of FUS/TLS-dependent cytotoxicity.
Academic Article Small molecule oxidation products trigger disease-associated protein misfolding.
Academic Article Structure and dynamics of pin1 during catalysis by NMR.
Academic Article Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
Academic Article Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins.
Academic Article Axonal transport defects in neurodegenerative diseases.
Academic Article Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules.
Academic Article Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets.
Academic Article Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis.
Academic Article Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis.
Academic Article Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.
Academic Article FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress.
Academic Article Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase.
Concept Disease Models, Animal
Concept Staphylococcus aureus
Concept Sequence Analysis, DNA
Concept Synaptosomes
Concept RNA, Small Interfering
Concept MAP Kinase Signaling System
Concept Mass Spectrometry
Concept Genetic Association Studies
Concept Magnetic Resonance Spectroscopy
Concept Stereoisomerism
Concept Oxidative Stress
Concept Mutagenesis, Site-Directed
Concept Disease Progression
Concept Amyotrophic Lateral Sclerosis
Concept Cell Survival
Concept Amino Acid Substitution
Concept Neurodegenerative Diseases
Concept Sorbitol
Concept Amino Acid Sequence
Concept Drug Delivery Systems
Concept Stress, Physiological
Concept Saccharomyces cerevisiae
Concept Genetic Predisposition to Disease
Concept Intracellular Signaling Peptides and Proteins
Concept Sodium
Concept Molecular Structure
Concept DNA Repeat Expansion
Concept Signal Transduction
Concept Protein Structure, Secondary
Concept Spinal Cord
Concept Superoxide Dismutase
Concept Protein Structure, Tertiary
Concept Synapses
Concept Catalytic Domain
Concept Alzheimer Disease
Concept Binding Sites
Concept Saccharomyces cerevisiae Proteins
Concept Lewy Body Disease
Concept Induced Pluripotent Stem Cells
Concept Sequence Homology, Amino Acid
Concept Skull
Concept Substrate Specificity
Concept Genome-Wide Association Study
Concept Survival
Concept Superoxides
Concept alpha-Synuclein
Concept Hypertonic Solutions
Concept Base Sequence
Concept Pick Disease of the Brain
Concept Molecular Sequence Data
Academic Article Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage.
Academic Article Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics.
Academic Article An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis.
Academic Article Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.
Academic Article A loss of FUS/TLS function leads to impaired cellular proliferation.
Academic Article Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.
Academic Article Functions of FUS/TLS from DNA repair to stress response: implications for ALS.
Academic Article Autophagy meets fused in sarcoma-positive stress granules.
Academic Article Structural basis for mutation-induced destabilization of profilin 1 in ALS.
Academic Article Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice.
Academic Article ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.
Academic Article Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis.
Academic Article Translation dysregulation in neurodegenerative disorders.
Academic Article Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Academic Article The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.
Academic Article Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction.
Academic Article Is the primate-specific protein pLG72 affecting SOD1 functionality and superoxide formation?
Academic Article ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization.
Academic Article Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway.
Academic Article Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Academic Article Differential association of baseline body weight and body-weight loss with neurological deficits, histology, and death after repetitive closed head traumatic brain injury.
Concept Superoxide Dismutase-1
Concept High-Throughput Nucleotide Sequencing
Concept Exome
Concept Single-Domain Antibodies
Concept Endoplasmic Reticulum Stress
Academic Article Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons.
Academic Article A reference human induced pluripotent stem cell line for large-scale collaborative studies.
Academic Article Human Microglia-like Cells: Differentiation from Induced Pluripotent Stem Cells and In Vitro Live-cell Phagocytosis Assay using Human Synaptosomes.
Academic Article Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons.
Academic Article Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies.
Academic Article Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope.
Academic Article Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.
Academic Article Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice.
Academic Article Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury.
Academic Article Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.
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