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Bailey, Jeffrey

One or more keywords matched the following properties of Bailey, Jeffrey

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overview	Jeffrey Bailey graduated from Saint Olaf College (Northfield Minnesota) in 1989 with a B.A. in Biology Suma Cum Laude. He then pursued volunteer work as a science and math teacher in Liberia and Botswana with the United States Peace Corps. He returned to the United States and entered the Medical Scientist Training Program at Case Western Reserve University. He received his PhD in Genetics characterizing and studying segmental duplications within the human genome in the laboratory of Dr. Evan Eichler. His postdoctoral research has focused on the detection and analysis of copy number variation—particularly in relationship to segmental duplications. After receiving his MD in 2005, he completed a residency in Clinical Pathology at Case Medical Center in Cleveland and the Cleveland City-wide Transfusion Medicine Fellowship. In August of 2009, Dr. Bailey joined the faculty as a tenure-track assistant professor in the Program in Bioinformatics and Integrative Biology. He continues to pursue clinical medicine in the Division of Transfusion Medicine. He is Board certified in Clinical Pathology. Our overall research focus involves understanding the role of segmental duplication and copy number variation in human infectious disease resistance and immunity. Segmental duplications, blocks of transposed genomic DNA within or between chromosomes, have long been recognized as an important substrate for the evolution of novel genes. As a result of the human genome project, they are now generally recognized as a significant source of copy number variation (variation between normal individuals) that can impact human disease. We are optimizing both experimental and computational approaches for the assessment of copy number variation within the context of several specific diseases. Utilizing technologies such as array comparative genomic hybridization and massively-parallel sequencing we hope to gain novel insight into etiologic and pathogenic mechanisms. Major projects in the lab include studies of human variation related to severe malaria, parasite variation in terms of virulence and drug resistance, and endemic Burkitt lymphoma a malaria-related B cell maligancies found at high-prevleance in sub-Saharan Africa.
Rotation Projects	Rotation projects are available related to malaria and Burkitt lymphoma. Our projects range from genetic epidemiology to directed genomics studying human, parasite and tumor.

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overview

Jeffrey Bailey graduated from Saint Olaf College (Northfield Minnesota) in 1989 with a B.A. in Biology Suma Cum Laude. He then pursued volunteer work as a science and math teacher in Liberia and Botswana with the United States Peace Corps. He returned to the United States and entered the Medical Scientist Training Program at Case Western Reserve University. He received his PhD in Genetics characterizing and studying segmental duplications within the human genome in the laboratory of Dr. Evan Eichler. His postdoctoral research has focused on the detection and analysis of copy number variation—particularly in relationship to segmental duplications. After receiving his MD in 2005, he completed a residency in Clinical Pathology at Case Medical Center in Cleveland and the Cleveland City-wide Transfusion Medicine Fellowship. In August of 2009, Dr. Bailey joined the faculty as a tenure-track assistant professor in the Program in Bioinformatics and Integrative Biology. He continues to pursue clinical medicine in the Division of Transfusion Medicine. He is Board certified in Clinical Pathology.

Our overall research focus involves understanding the role of segmental duplication and copy number variation in human infectious disease resistance and immunity. Segmental duplications, blocks of transposed genomic DNA within or between chromosomes, have long been recognized as an important substrate for the evolution of novel genes. As a result of the human genome project, they are now generally recognized as a significant source of copy number variation (variation between normal individuals) that can impact human disease. We are optimizing both experimental and computational approaches for the assessment of copy number variation within the context of several specific diseases. Utilizing technologies such as array comparative genomic hybridization and massively-parallel sequencing we hope to gain novel insight into etiologic and pathogenic mechanisms.

Major projects in the lab include studies of human variation related to severe malaria, parasite variation in terms of virulence and drug resistance, and endemic Burkitt lymphoma a malaria-related B cell maligancies found at high-prevleance in sub-Saharan Africa.

Rotation Projects

Rotation projects are available related to malaria and Burkitt lymphoma. Our projects range from genetic epidemiology to directed genomics studying human, parasite and tumor.

One or more keywords matched the following items that are connected to Bailey, Jeffrey

Item Type	Name
Academic Article	Use of massively parallel pyrosequencing to evaluate the diversity of and selection on Plasmodium falciparum csp T-cell epitopes in Lilongwe, Malawi.
Academic Article	Ahead of the curve: next generation estimators of drug resistance in malaria infections.
Concept	Humans
Concept	Herpesvirus 4, Human
Concept	Chromosomes, Human, Pair 22
Concept	Chromosomes, Human, Pair 14
Concept	Genome, Human
Concept	env Gene Products, Human Immunodeficiency Virus
Concept	Herpesvirus 8, Human
Academic Article	Sickle cell trait is not associated with endemic Burkitt lymphoma: an ethnicity and malaria endemicity-matched case-control study suggests factors controlling EBV may serve as a predictive biomarker for this pediatric cancer.
Academic Article	Inferring the evolutionary history of primate microRNA binding sites: overcoming motif counting biases.
Academic Article	Interleukin-6 and interleukin-10 gene promoter polymorphisms and risk of endemic Burkitt lymphoma.
Academic Article	Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study.
Academic Article	Military trauma system in Afghanistan: lessons for civil systems?
Academic Article	Prospective surveillance of D- recipients of D+ apheresis platelets: alloimmunization against D is not detected.
Academic Article	Automated red blood cell exchange for acute drug removal in a patient with sirolimus toxicity.
Academic Article	Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse.
Academic Article	Prehospital pain medication use by U.S. Forces in Afghanistan.
Academic Article	Human-specific duplication and mosaic transcripts: the recent paralogous structure of chromosome 22.
Academic Article	Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Academic Article	The Effect of a Golden Hour Policy on the Morbidity and Mortality of Combat Casualties.
Academic Article	Evaluation of the Effectiveness of the 2008 Postsplenectomy Vaccination Joint Theater Trauma System Clinical Practice Guideline.
Academic Article	Military trauma training at civilian centers: a decade of advancements.
Academic Article	Review of the Fifth Annual Joint Theater Trauma System Trauma Conference.
Academic Article	Analysis of primate genomic variation reveals a repeat-driven expansion of the human genome.
Academic Article	A review of the first 10 years of critical care aeromedical transport during operation iraqi freedom and operation enduring freedom: the importance of evacuation timing.
Academic Article	Primate segmental duplications: crucibles of evolution, diversity and disease.
Academic Article	Saving Lives on the Battlefield: A Joint Trauma System Review of Pre-Hospital Trauma Care in Combined Joint Operating Area ? Afghanistan (CJOA-A) Executive Summary.
Academic Article	Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study.
Academic Article	Physiological measurements corroborate symptomatic improvement after therapeutic leukapheresis in a pregnant woman with chronic myelogenous leukemia.
Academic Article	Assessment of Groin Application of Junctional Tourniquets in a Manikin Model.
Academic Article	A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse.
Academic Article	Evaluation of role 2 (R2) medical resources in the Afghanistan combat theater: Initial review of the joint trauma system R2 registry.
Academic Article	Malaria - how this parasitic infection aids and abets EBV-associated Burkitt lymphomagenesis.
Academic Article	Longitudinal Pooled Deep Sequencing of the Plasmodium vivax K12 Kelch Gene in Cambodia Reveals a Lack of Selection by Artemisinin.
Academic Article	Therapeutic plasma exchange performed in tandem with hemodialysis without supplemental calcium in the apheresis circuit.
Academic Article	Therapeutic apheresis using a mononuclear cell program to lower the microfilaria burden of a 23-year-old African woman with loiasis.
Academic Article	Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia.
Academic Article	Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma.
Academic Article	Surveillance for sulfadoxine-pyrimethamine resistant malaria parasites in the Lake and Southern Zones, Tanzania, using pooling and next-generation sequencing.
Academic Article	Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences.
Academic Article	A liquid calcium+vitamin D3 supplement is effective prophylaxis against hypocalcemic toxicity during apheresis platelet donation.
Academic Article	Drug-Resistance and Population Structure of Plasmodium falciparum Across the Democratic Republic of Congo Using High-Throughput Molecular Inversion Probes.
Academic Article	Plasmodium falciparum genetic variation of var2csa in the Democratic Republic of the Congo.
Academic Article	A deep sequencing approach to estimate Plasmodium falciparum complexity of infection (COI) and explore apical membrane antigen 1 diversity.
Academic Article	Partner-Drug Resistance and Population Substructuring of Artemisinin-Resistant Plasmodium falciparum in Cambodia.
Academic Article	Matched Placental and Circulating Plasmodium falciparum Parasites are Genetically Homologous at the var2csa ID1-DBL2X Locus by Deep Sequencing.
Academic Article	Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade.
Academic Article	Military use of tranexamic acid in combat trauma: Does it matter?
Academic Article	FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia.
Academic Article	Automated red blood cell exchange in preparation for filgrastim mobilization of autologous peripheral blood hematopoietic progenitor cells in a patient with sickle cell anemia.
Academic Article	Reuse of malaria rapid diagnostic tests for amplicon deep sequencing to estimate Plasmodium falciparum transmission intensity in western Uganda.
Academic Article	Prophylactic infusion of calcium gluconate to prevent a symptomatic fall in plasma ionized calcium during therapeutic plasma exchange: A comparison of two methods.
Academic Article	Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma.
Academic Article	Endotoxin at the Maternal-Fetal Interface in a Resource-Constrained Setting: Risk Factors and Associated Birth Outcomes.
Academic Article	Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes.
Academic Article	The whole-genome landscape of Burkitt lymphoma subtypes.
Academic Article	Sensitive detection of EBV microRNAs across cancer spectrum reveals association with decreased survival in adult acute myelocytic leukemia.
Academic Article	Antimalarial Drug Resistance Profiling of Plasmodium falciparum Infections in Ghana Using Molecular Inversion Probes and Next-Generation Sequencing.
Academic Article	Kaposi Sarcoma-Associated Herpesvirus Infection and Endemic Burkitt Lymphoma.
Academic Article	The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.
Academic Article	A New Hope for CD56negCD16pos NK Cells as Unconventional Cytotoxic Mediators: An Adaptation to Chronic Diseases.
Academic Article	Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma.
Academic Article	The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo.
Academic Article	Falciparum malaria from coastal Tanzania and Zanzibar remains highly connected despite effective control efforts on the archipelago.
Academic Article	Sensitive, Highly Multiplexed Sequencing of Microhaplotypes From the Plasmodium falciparum Heterozygome.
Academic Article	Therapeutic Efficacy of Artemether-Lumefantrine for Uncomplicated Falciparum Malaria in Northern Zambia.
Academic Article	Spatial and epidemiological drivers of Plasmodium falciparum malaria among adults in the Democratic Republic of the Congo.
Academic Article	Selection of Cytochrome b Mutants Is Rare among Plasmodium falciparum Patients Failing Treatment with Atovaquone-Proguanil in Cambodia.
Academic Article	Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda.
Academic Article	Describing the current status of Plasmodium falciparum population structure and drug resistance within mainland Tanzania using molecular inversion probes.
Academic Article	Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children.
Academic Article	Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.
Academic Article	Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates.
Academic Article	Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study.
Academic Article	Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia.
Concept	Serum Albumin, Human
Academic Article	SARS-CoV-2 Serosurveys: How Antigen, Isotype and Threshold Choices Affect the Outcome.
Academic Article	Profiling genome-wide recombination in Epstein Barr virus reveals type-specific patterns and associations with endemic-Burkitt lymphoma.
Academic Article	Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.
Academic Article	Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies.
Academic Article	Distinctive Kaposi Sarcoma-Associated Herpesvirus Serological Profile during Acute Plasmodium falciparum Malaria Episodes.
Academic Article	Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline.
Academic Article	Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors.
Academic Article	Temporal and spatial analysis of Plasmodium falciparum genomics reveals patterns of parasite connectivity in a low-transmission district in Southern Province, Zambia.
Academic Article	coiaf: Directly estimating complexity of infection with allele frequencies.
Academic Article	Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma.
Academic Article	Viral and host factors drive a type 1 Epstein-Barr virus spontaneous lytic phenotype.
Academic Article	Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar.
Academic Article	Ex vivo susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan Plasmodium falciparum isolates.
Academic Article	Population genomics of Plasmodium ovale species in sub-Saharan Africa.
Academic Article	Comparison of nanopore with illumina whole genome assemblies of the Epstein-Barr virus in Burkitt lymphoma.
Academic Article	Incorporation of Epstein-Barr viral variation implicates significance of Latent Membrane Protein 1 in survival prediction and prognostic subgrouping in Burkitt lymphoma.
Academic Article	Transmitted/founder (T/F) HIV-1 derived from sexual contact exhibits greater transmission fitness in human cervical tissue than T/F HIV-1 from blood-to-blood contact: Unique glycan profiles on T/F envelopes associated with transmission phenotypes.

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