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Ennis, Francis
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overview

Immune response of host to virus infections, emphasizing cellular responses

Overall themes:

  • Human Immune Responses
  • Immunopathology to Virus Infections and
  • Failure to Eliminate Virus in Persistent Infection

A. T cell triggered and cytokine mediated immunopathology.

Photo: Francis A. EnnisWe hypothesize that certain virus infections e.g. Dengue HemorrhagicFever (DHF), or the Hantavirus Pulmonary Syndrome (HPS) may be due to"over"responses of dengue or hantavirus specific T cells incertain high-responders, due to immune responses genes. These T cellresponses are needed for clearance of virus-infected cells but markedinflammatory responses probably mediated by cytokines, cause endothelialcell leakness and shock (DHF) or pulmonary edema (HPS). We are definingCD4+ and CD8+ T cell epitopes, determining the Th1 and Th2 cytokineresponses at the protein and m-RNA levels and by immunocytochemistry. TCRusage is determined, and correlations with disease phenotypes arestudied.

Immunopathogenesis of DHF

Immunopathogenesis of DHF/DSS

B. Failure to Eliminate Virus in HCV Infection

Failure of immune response to eliminate HCV infection is very commonand chronic progression liver disease frequently results. Is this due toa poor CD8+ T cell response in those individuals? We are also developingCD8+ T cell clones from the liver tissues and blood cells of patients withHCV infections. We will determine whether interferon therapy which is theonly known treatment, alters the HCV+ CD8+ CTL responses in the patientswho respond to therapy or those that do not. We are also defining Th1,Th2 cytokine patterns in liver tissues by immunocytochemistry.
One or more keywords matched the following items that are connected to Ennis, Francis
Item TypeName
Academic Article Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers (ISCOMS).
Academic Article Dose-related effects of smallpox vaccine.
Academic Article T cell responses to an HLA-B*07-restricted epitope on the dengue NS3 protein correlate with disease severity.
Academic Article Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren.
Academic Article Quantitation of CD8+ T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) viruses.
Academic Article Definition of two new epitopes on human immunodeficiency virus type 1 gag protein recognized by human CD8+ cytotoxic T lymphocyte clones.
Academic Article Quantitation of antibody-bound and unbound Sin Nombre virus in the plasma of patient with hantavirus pulmonary syndrome.
Academic Article A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity.
Academic Article Quantitation of dengue virus specific CD4+ T cells by intracellular cytokine staining.
Academic Article Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome.
Academic Article Immune responses to Puumala virus infection and the pathogenesis of nephropathia epidemica.
Academic Article Identification and analysis for cross-reactivity among hantaviruses of H-2b-restricted cytotoxic T-lymphocyte epitopes in Sin Nombre virus nucleocapsid protein.
Academic Article Safety and immunogenicity of new cell-cultured smallpox vaccine compared with calf-lymph derived vaccine: a blind, single-centre, randomised controlled trial.
Academic Article Using HLA-transgenic mice to identify immunodominant human CD8+ T cell epitopes--does (genome) size matter?
Academic Article Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis.
Academic Article Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes.
Academic Article Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine.
Academic Article Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans.
Academic Article Comparison of the safety and immunogenicity of ACAM1000, ACAM2000 and Dryvax in healthy vaccinia-naive adults.
Academic Article TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais.
Academic Article Altered effector functions of virus-specific and virus cross-reactive CD8+ T cells in mice immunized with related flaviviruses.
Academic Article Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus.
Academic Article Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections.
Academic Article The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica.
Academic Article Epidemiology of the influenza A virus H5N1 subtype and memory of immunity to the H2N2 subtype.
Academic Article Spatial and temporal circulation of dengue virus serotypes: a prospective study of primary school children in Kamphaeng Phet, Thailand.
Academic Article Long-lived memory T lymphocyte responses after hantavirus infection.
Academic Article High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.
Academic Article Induction of human T cell-mediated immune responses after primary and secondary smallpox vaccination.
Academic Article Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles.
Academic Article Recombinant adenovirus vector vaccine induces stronger cytotoxic T-cell responses than recombinant vaccinia virus vector, plasmid DNA, or a combination of these.
Academic Article Identification of vaccinia CD8+ T-cell epitopes conserved among vaccinia and variola viruses restricted by common MHC class I molecules, HLA-A2 or HLA-B7.
Academic Article Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses.
Academic Article Antibody-dependent cellular cytotoxicity mediated by plasma obtained before secondary dengue virus infections: potential involvement in early control of viral replication.
Academic Article Immunological memory after exposure to variola virus, monkeypox virus, and vaccinia virus.
Academic Article Human cytotoxic CD4+ T cells recognize HLA-DR1-restricted epitopes on vaccinia virus proteins A24R and D1R conserved among poxviruses.
Academic Article Human CD8+ T cell memory generation in Puumala hantavirus infection occurs after the acute phase and is associated with boosting of EBV-specific CD8+ memory T cells.
Academic Article Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers?
Academic Article Clinical and immunologic responses to multiple doses of IMVAMUNE (Modified Vaccinia Ankara) followed by Dryvax challenge.
Academic Article Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
Academic Article Human metapneumovirus reinfection among children in Thailand determined by ELISA using purified soluble fusion protein.
Academic Article Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
Academic Article Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4(+) T-cell responses to internal proteins, hemagglutinins, and neuraminidases.
Academic Article A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes.
Academic Article Sequential immunization with heterologous chimeric flaviviruses induces broad-spectrum cross-reactive CD8+ T cell responses.
Academic Article NIAID workshop on Flavivirus immunity.
Academic Article Long term recall of memory CD8 T cells in mice to first and third generation smallpox vaccines.
Academic Article Development of antigen-specific memory CD8+ T cells following live-attenuated chimeric West Nile virus vaccination.
Academic Article T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndrome.
Academic Article Comparison of complement dependent lytic, hemagglutination inhibition and microneutralization antibody responses in influenza vaccinated individuals.
Academic Article Nuclear export signal and immunodominant CD8+ T cell epitope in influenza A virus matrix protein 1.
Academic Article Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status.
Academic Article CD4+ T cells provide intermolecular help to generate robust antibody responses in vaccinia virus-vaccinated humans.
Concept Enzyme-Linked Immunosorbent Assay
Concept Cytotoxicity Tests, Immunologic
Concept Immunity, Cellular
Concept Dose-Response Relationship, Immunologic
Concept Immunoenzyme Techniques
Concept Adjuvants, Immunologic
Concept Immunoglobulin M
Concept Immunoglobulin G
Concept gag Gene Products, Human Immunodeficiency Virus
Concept Immunodominant Epitopes
Concept Cytotoxicity, Immunologic
Concept Immunization
Concept Hantavirus Pulmonary Syndrome
Concept Immunization, Secondary
Concept Hemorrhagic Fever with Renal Syndrome
Concept Immunohistochemistry
Concept Immune Tolerance
Concept Immunologic Memory
Academic Article Post-translational intracellular trafficking determines the type of immune response elicited by DNA vaccines expressing Gag antigen of Human Immunodeficiency Virus Type 1 (HIV-1).
Academic Article Elucidating the role of T cells in protection against and pathogenesis of dengue virus infections.
Academic Article Relationship of preexisting influenza hemagglutination inhibition, complement-dependent lytic, and antibody-dependent cellular cytotoxicity antibodies to the development of clinical illness in a prospective study of A(H1N1)pdm09 Influenza in children.
Academic Article Non-neutralizing antibody responses following A(H1N1)pdm09 influenza vaccination with or without AS03 adjuvant system.
Concept Enzyme-Linked Immunospot Assay
Search Criteria
  • Immune
  • syndromes