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Luban, Jeremy
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Please visit the Luban Lab Website

Professor Luban is a physician-scientist who studies the interaction between human cells and deadly pathogens including HIV-1, Ebola virus, and SARS-CoV-2. He has held endowed professorships at Columbia University in New York (where he directed the Columbia-Rockefeller Center for AIDS Research), the University of Geneva in Switzerland, and now the University of Massachusetts Medical School, where he holds the David J. Freelander Chair in AIDS Research. He is an affiliate of the Broad Institute of MIT and Harvard and oversees a program on SARS-CoV-2 as part of the Massachusetts Consortium on Pathogen Readiness. Dr. Luban was elected to the American Society for Clinical Investigation, the Association of American Physicians, and the American Academy of Microbiology. His research program in Virology, Immunology, and Molecular Biology has been continuously funded for the past 30 years by the National Institute of Health and includes Merit and Avant Garde Awards. He has served on editorial boards of four virology journals, on grant review committees and scientific advisory boards for the NIH, the American Cancer Society, the American Foundation for AIDS Research, and has acted as primary mentor for 90 Ph.D. students, post-docs, and undergraduate students.
One or more keywords matched the following items that are connected to Luban, Jeremy
Item TypeName
Academic Article Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization.
Academic Article Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A.
Academic Article Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription.
Academic Article The HIV type 1 replication block in nonhuman primates is not explained by differences in cyclophilin A primary structure.
Academic Article Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses.
Academic Article Translation elongation factor 1-alpha interacts specifically with the human immunodeficiency virus type 1 Gag polyprotein.
Academic Article Basic residues in human immunodeficiency virus type 1 nucleocapsid promote virion assembly via interaction with RNA.
Academic Article Rescue of multiple viral functions by a second-site suppressor of a human immunodeficiency virus type 1 nucleocapsid mutation.
Academic Article Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction.
Academic Article Human immunodeficiency virus type 1 virion density is not determined by nucleocapsid basic residues.
Academic Article Absconding with the chaperone: essential cyclophilin-Gag interaction in HIV-1 virions.
Academic Article The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein.
Academic Article Context-dependent phenotype of a human immunodeficiency virus type 1 nucleocapsid mutation.
Academic Article Genetic assay for multimerization of retroviral gag polyproteins.
Academic Article HIV-1 Vpr: G2 cell cycle arrest, macrophages and nuclear transport.
Academic Article Specific incorporation of heat shock protein 70 family members into primate lentiviral virions.
Academic Article Human immunodeficiency virus type 1 replication is modulated by host cyclophilin A expression levels.
Academic Article As(2)O(3) enhances retroviral reverse transcription and counteracts Ref1 antiviral activity.
Academic Article Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors.
Academic Article HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.
Academic Article Lv1 inhibition of human immunodeficiency virus type 1 is counteracted by factors that stimulate synthesis or nuclear translocation of viral cDNA.
Academic Article Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity.
Academic Article Human immunodeficiency virus type 1 Gag polyprotein multimerization requires the nucleocapsid domain and RNA and is promoted by the capsid-dimer interface and the basic region of matrix protein.
Academic Article Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues.
Academic Article Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein.
Academic Article Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells.
Academic Article HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase.
Academic Article Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.
Academic Article Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components.
Academic Article Human cellular restriction factors that target HIV-1 replication.
Academic Article HIV-1 and Ebola virus: the getaway driver nabbed.
Academic Article Cyclosporine blocks incorporation of HIV-1 envelope glycoprotein into virions.
Academic Article p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.
Academic Article Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection.
Academic Article TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements.
Academic Article TRIM5 is an innate immune sensor for the retrovirus capsid lattice.
Academic Article TRIM5a associates with proteasomal subunits in cells while in complex with HIV-1 virions.
Academic Article Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus.
Academic Article Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection.
Academic Article TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.
Academic Article The carboxyl-terminus of human immunodeficiency virus type 2 circulating recombinant form 01_AB capsid protein affects sensitivity to human TRIM5a.
Academic Article TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm.
Academic Article Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression.
Academic Article Mapping of functionally important residues of a cysteine-histidine box in the human immunodeficiency virus type 1 nucleocapsid protein.
Academic Article Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1.
Academic Article Selection for loss of Ref1 activity in human cells releases human immunodeficiency virus type 1 from cyclophilin A dependence during infection.
Academic Article Covalent modification of human immunodeficiency virus type 1 p6 by SUMO-1.
Academic Article ATPgammaS disrupts human immunodeficiency virus type 1 virion core integrity.
Academic Article Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells.
Academic Article Arsenic counteracts human immunodeficiency virus type 1 restriction by various TRIM5 orthologues in a cell type-dependent manner.
Academic Article Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells.
Academic Article Cyclophilin, TRIM5, and innate immunity to HIV-1.
Academic Article Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection.
Academic Article The role of lysine 186 in HIV-1 integrase multimerization.
Academic Article Lentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells.
Academic Article HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.
Academic Article Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.
Academic Article Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.
Academic Article TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling.
Academic Article TRIM5 and the Regulation of HIV-1 Infectivity.
Academic Article Innate immune sensing of HIV-1 by dendritic cells.
Academic Article Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay.
Academic Article Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.
Academic Article Cyclophilin binding to the human immunodeficiency virus type 1 Gag polyprotein is mimicked by an anti-cyclosporine antibody.
Academic Article Cyclophilin and gag in HIV-1 replication and pathogenesis.
Academic Article Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity.
Academic Article Specific incorporation of cyclophilin A into HIV-1 virions.
Academic Article Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA.
Academic Article Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays.
Academic Article Effect of linker insertion mutations in the human immunodeficiency virus type 1 gag gene on activation of viral protease expressed in bacteria.
Academic Article Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B.
Concept HIV Antigens
Concept rev Gene Products, Human Immunodeficiency Virus
Concept HIV Seropositivity
Concept HIV Long Terminal Repeat
Concept HIV-1
Concept Human Immunodeficiency Virus Proteins
Concept HIV-2
Concept HIV Reverse Transcriptase
Concept vpr Gene Products, Human Immunodeficiency Virus
Concept HIV Envelope Protein gp120
Concept HIV Infections
Concept HIV Protease
Concept Anti-HIV Agents
Concept HIV Integrase
Concept gag Gene Products, Human Immunodeficiency Virus
Concept nef Gene Products, Human Immunodeficiency Virus
Concept HIV Antibodies
Concept env Gene Products, Human Immunodeficiency Virus
Concept vif Gene Products, Human Immunodeficiency Virus
Concept HIV Envelope Protein gp41
Concept HIV
Concept HIV Core Protein p24
Academic Article Overcoming current limitations in humanized mouse research.
Academic Article The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoating.
Academic Article TRIM5a and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment.
Academic Article Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA.
Academic Article Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.
Academic Article Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration.
Academic Article HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.
Academic Article HIV-1 capsid is involved in post-nuclear entry steps.
Academic Article Closing the net on retroviruses.
Academic Article HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.
Academic Article The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5a.
Academic Article Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.
Academic Article Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines.
Academic Article Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
Academic Article Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution.
Academic Article The hidden cost of genetic resistance to HIV-1.
Academic Article Retraction Note: The hidden cost of genetic resistance to HIV-1.
Academic Article Cyclophilin A protects HIV-1 from restriction by human TRIM5a.
Academic Article HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells.
Academic Article TRIM34 restricts HIV-1 and SIV capsids in a TRIM5a-dependent manner.
Academic Article Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity.
Academic Article Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV-1 pathogenesis.
Academic Article The HIV-1 capsid core is an opportunistic nuclear import receptor.
Academic Article Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus.
Academic Article IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.
Academic Article Cyclophilin A Facilitates HIV-1 DNA Integration.
Academic Article IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.
Academic Article Cyclophilin A facilitates HIV-1 integration.
Academic Article Correction for Kajaste-Rudnitski et al., "TRIM22 Inhibits HIV-1 Transcription Independently of Its E3 Ubiquitin Ligase Activity, Tat, and NF-?B-Responsive Long Terminal Repeat Elements".
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