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Kurt Yilmaz, Nese
One or more keywords matched the following properties of Kurt Yilmaz, Nese
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overview

Academic Background

Ph.D., Chemical Engineering, Bogazici University, Istanbul, Turkey, 2002

Postdoc,  Department of Chemistry, University of Wisconsin-Madison, 2005

 

Research Experience

Associate Professor                                                                                    2017–present

UMASS Medical School, Worcester, MA
Department of Biochemistry and Molecular Pharmacology

 

Research Assistant Professor                                                                    2011–2017

UMASS Medical School, Worcester, MA
Department of Biochemistry and Molecular Pharmacology

·     Drug resistance in viral proteases: Understanding the molecular basis of drug resistance in viral proteases, including HIV-1 and HCV protease.

·     Substrate recognition and product inhibition in HIV-1 protease.

·     Scientific writing and editing.

 

Assistant Scientist                                                                                        2005–2011

University of Wisconsin-Madison, Department of Chemistry

·     Protein folding and effect of chaperone interaction on misfolding polypeptides: Investigated protein folding, unfolding and misfolding under various experimental conditions, and the interaction of chaperones with truncated polypeptide chains by biochemical/biophysical methods incuding fluorescence and NMR techniques.

 

Visiting TUBITAK fellow                                                                              2000 and 2001

UMASS Medical School, Worcester, MA
Department of Biochemistry and Molecular Pharmacology

·     Substrate specificity and simulation of conformational dynamics of HIV-1 protease.

 

Graduate Researcher at the Polymer Research Center                                   1996–2002                 

Bogazici University, Istanbul, Turkey

·     Coarse-grained simulations and analytical methods to study dynamics of globular proteins in native state.

 

 
One or more keywords matched the following items that are connected to Kurt Yilmaz, Nese
Item TypeName
Academic Article Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.
Academic Article Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease.
Academic Article Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
Concept Drug Resistance, Viral
Concept Drug Resistance
Concept Drug Resistance, Multiple, Viral
Concept Drug Resistance, Fungal
Academic Article Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Academic Article HIV-1 protease-substrate coevolution in nelfinavir resistance.
Academic Article Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease.
Academic Article Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
Academic Article Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.
Academic Article Improving Viral Protease Inhibitors to Counter Drug Resistance.
Academic Article Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.
Academic Article Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
Academic Article Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.
Academic Article Elucidating the Interdependence of Drug Resistance from Combinations of Mutations.
Academic Article Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease.
Academic Article Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease.
Academic Article Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance.
Academic Article NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations.
Academic Article Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Academic Article Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Academic Article Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.
Academic Article Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Academic Article Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning.
Academic Article Introduction: Drug Resistance.
Academic Article Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning.
Academic Article Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Academic Article Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.
Academic Article Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Academic Article Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance.
Academic Article Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance.
Academic Article Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease.
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  • Drug Resistance