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Fitzgerald, Katherine
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Biography

Dr. Fitzgerald is Professor and Vice Chair of Medicine, Chief of the Division of Innate Immunity, and the Worcester Foundation in Biomedical Sciences Research Chair. Dr. Fitzgerald completed all of her education in Ireland. She received her B.Sc. in Biochemistry in 1995 from University College Cork, Ireland and her PhD in Biochemistry in 1999 from Trinity College Dublin, Ireland. After pursing a post-doctoral fellowship at Trinity College Dublin, she joined UMass Chan as Instructor and is currently a tenured Professor.

Dr. Fitzgerald is an elected fellow of the American Society of Microbiology and an elected member of the Royal Irish Academy, the National Academy of Sciences (USA) and the National Academy of Medicine (USA). She is the recipient of several awards including the  Thermo-Fischer Meritorious Career Award (from the American Association of Immunology), the Saint Patrick’s Day Medal (from the Irish Government and Science Foundation Ireland) and the Milstein Award for Excellence in Interferon and Cytokine research (from the International Cytokine and Interferon Society), amongst others.

She has extensive service both locally at UMass Chan and nationally including service on local and national advisory boards (e.g., Massachusetts Center For Pathogen Readiness, NIAID Board of Scientific Councillors, Burroughs Wellcome Fund Pathogenesis of Infectious Diseases and the Cancer Research Institute). She was also the recent past President of the International Cytokine and Interferon Society.

Research Information  Katherine PhotoHer work is focused on the innate immune system aimed at understanding the molecular basis of the inflammatory response during Infection and in inflammatory diseases. In particular her group studies nucleic acid sensors, inflammasomes as well as long non-coding RNAs in immunity and inflammation. The long-term goal of her work is to determine how innate immune sensing and signaling contribute to infectious, inflammatory, and autoimmune diseases in humans.

 
One or more keywords matched the following items that are connected to Fitzgerald, Katherine
Item TypeName
Academic Article The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence.
Academic Article Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
Academic Article The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Academic Article Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Academic Article Integr-ating IL-1 alpha in antiviral host defenses.
Academic Article IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.
Academic Article TLR4 is a negative regulator in noninfectious lung inflammation.
Academic Article Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome.
Academic Article Activation of autophagy by inflammatory signals limits IL-1? production by targeting ubiquitinated inflammasomes for destruction.
Academic Article Molecular basis of DNA recognition in the immune system.
Academic Article CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Academic Article A long noncoding RNA mediates both activation and repression of immune response genes.
Academic Article The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
Academic Article AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Academic Article Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Academic Article Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
Academic Article NLR-containing inflammasomes: central mediators of host defense and inflammation.
Academic Article NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Academic Article Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
Academic Article Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
Academic Article Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Concept Inflammation Mediators
Concept Inflammation
Academic Article Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Academic Article Post-transcriptional regulation of gene expression in innate immunity.
Academic Article Citrobacter rodentium: infection, inflammation and the microbiota.
Academic Article Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.
Academic Article Transcription of inflammatory genes: long noncoding RNA and beyond.
Academic Article Cutting Edge: A Natural Antisense Transcript, AS-IL1a, Controls Inducible Transcription of the Proinflammatory Cytokine IL-1a.
Academic Article Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation.
Academic Article Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.
Academic Article Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression.
Academic Article Inflammasome Complexes: Emerging Mechanisms and Effector Functions.
Academic Article A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.
Academic Article Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity.
Academic Article Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?
Academic Article IRF3 and type I interferons fuel a fatal response to myocardial infarction.
Academic Article Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.
Academic Article Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
Academic Article Cytokines and Long Noncoding RNAs.
Academic Article DNA sensing by the cGAS-STING pathway in health and disease.
Academic Article Gasdermins and their role in immunity and inflammation.
Academic Article Toll-like Receptors and the Control of Immunity.
Academic Article STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
Academic Article TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge.
Academic Article Caspase-8 mediates inflammation and disease in rodent malaria.
Academic Article Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis.
Academic Article Author Correction: Caspase-8 mediates inflammation and disease in rodent malaria.
Academic Article Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Academic Article Intracellular Sensing of DNA in Autoinflammation and Autoimmunity.
Academic Article Radioresistant cells initiate lymphocyte-dependent lung inflammation and IFN?-dependent mortality in STING gain-of-function mice.
Academic Article Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression.
Academic Article The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2.
Academic Article Type-1 interferon-dependent and -independent mechanisms in cyclic GMP-AMP synthase-stimulator of interferon genes-driven auto-inflammation.
Academic Article ERADication of STING limits inflammation.
Academic Article The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.
Academic Article Lnc-ing RNA to intestinal homeostasis and inflammation.
Academic Article Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease.
Academic Article DNA-sensing pathways in health, autoinflammatory and autoimmune diseases.
Academic Article Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.
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  • Inflammation