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Fitzgerald, Katherine
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Biography

Kate Fitzgerald received her B.Sc. in 1995 from University College Cork, Ireland, and her Ph.D. in 1999 from Trinity College Dublin, Ireland. From 1999 to 2001, she was a post-doctoral fellow in the Department of Biochemistry at Trinity College Dublin in the Laboratory of Professor Luke O'Neill. Dr. Fitzgerald joined the Division of Infectious Disease at the University of Massachusetts Medical School as a recipient of a Welcome Trust International Award in 2001. In 2004 she joined the Faculty as an Assistant Professor and is currently Professor of Medicine and Director of the Program in Innate Immunity (www.umassmed.edu/pii).

Research Information  Katherine Photo

INNATE IMMUNE SIGNALING

Research in the Fitzgerald lab is focused on understanding the molecular basis of host defense and the inflammatory process. Active research areas include: (1) mechanisms and biology of caspase-1 activating inflammasome complexes, (2) nucleic acid sensors, with a particular focus on cytosolic DNA recognition systems and (3) role of long non-coding RNAs (lincRNAs) in the regulation of inflammatory gene expression. Enabling these studies, our research uses immunology, molecular biology, biochemistry and genetics to understand these mechanisms. Our longer term goals are to understand how dysregulation of sensing, signaling and gene regulation in innate immunity underlie the pathogenesis of infectious, inflammatory and autoimmune disease in humans.
One or more keywords matched the following items that are connected to Fitzgerald, Katherine
Item TypeName
Academic Article IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Academic Article DUBbing down innate immunity.
Academic Article TOLLing away in Brazil.
Academic Article The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence.
Academic Article Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
Academic Article The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Academic Article Integr-ating IL-1 alpha in antiviral host defenses.
Academic Article A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
Academic Article Catenin' on to nucleic acid sensing.
Academic Article The interferon inducible gene: Viperin.
Academic Article Pattern recognition receptors and the innate immune response to viral infection.
Academic Article A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans.
Academic Article Cytosolic surveillance and antiviral immunity.
Academic Article Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Academic Article Serine/threonine acetylation of TGF?-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.
Academic Article Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
Academic Article Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?.
Academic Article Molecular basis of DNA recognition in the immune system.
Academic Article A long noncoding RNA mediates both activation and repression of immune response genes.
Academic Article Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.
Academic Article The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Academic Article Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
Academic Article Recognition of herpesviruses by the innate immune system.
Academic Article Innate immune sensing of DNA viruses.
Academic Article Innate immune sensing of DNA.
Academic Article Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Academic Article The PYHIN protein family as mediators of host defenses.
Academic Article Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16.
Academic Article Regulation of inflammasome signaling.
Academic Article Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Academic Article 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential.
Academic Article Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Academic Article Immunology: Lipopolysaccharide sensing on the inside.
Concept Immunity, Innate
Academic Article Long noncoding RNAs in innate and adaptive immunity.
Academic Article STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.
Academic Article Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
Academic Article NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.
Academic Article Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
Academic Article Post-transcriptional regulation of gene expression in innate immunity.
Academic Article TRIL is involved in cytokine production in the brain following Escherichia coli infection.
Academic Article Innate sensing of malaria parasites.
Academic Article STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Academic Article Identification of Aim2 as a sensor for DNA vaccines.
Academic Article Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.
Academic Article Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin.
Academic Article Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.
Academic Article A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines.
Academic Article Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
Academic Article Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression.
Academic Article Control of the innate immune response by the mevalonate pathway.
Academic Article Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity.
Academic Article Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity.
Academic Article A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1? Release in Response to a Pathogenic Fungus.
Academic Article Activation of Stimulator of Interferon Genes (STING) and Sj?gren Syndrome.
Academic Article hnRNPA2B1: Fueling Antiviral Immunity from the Nucleus.
Academic Article A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome.
Academic Article Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection.
Academic Article Toll-like Receptors and the Control of Immunity.
Academic Article Long non-coding RNAs in antiviral immunity.
Academic Article The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans.
Academic Article Overcoming innate immune barriers that impede AAV gene therapy vectors.
Academic Article Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
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  • Innate Immune Responses