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One or more keywords matched the following properties of Fitzgerald, Katherine
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Biography

Kate Fitzgerald received her B.Sc. in 1995 from University College Cork, Ireland, and her Ph.D. in 1999 from Trinity College Dublin, Ireland. From 1999 to 2001, she was a post-doctoral fellow in the Department of Biochemistry at Trinity College Dublin in the Laboratory of Professor Luke O'Neill. Dr. Fitzgerald joined the Division of Infectious Disease at the University of Massachusetts Medical School as a recipient of a Welcome Trust International Award in 2001. In 2004 she joined the Faculty as an Assistant Professor and is currently Professor of Medicine and Director of the Program in Innate Immunity (www.umassmed.edu/pii).

Research Information  Katherine Photo

INNATE IMMUNE SIGNALING

Research in the Fitzgerald lab is focused on understanding the molecular basis of host defense and the inflammatory process. Active research areas include: (1) mechanisms and biology of caspase-1 activating inflammasome complexes, (2) nucleic acid sensors, with a particular focus on cytosolic DNA recognition systems and (3) role of long non-coding RNAs (lincRNAs) in the regulation of inflammatory gene expression. Enabling these studies, our research uses immunology, molecular biology, biochemistry and genetics to understand these mechanisms. Our longer term goals are to understand how dysregulation of sensing, signaling and gene regulation in innate immunity underlie the pathogenesis of infectious, inflammatory and autoimmune disease in humans.

One or more keywords matched the following items that are connected to Fitzgerald, Katherine
Item TypeName
Academic Article IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Academic Article The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
Academic Article TLR-mediated activation of type I IFN during antiviral immune responses: fighting the battle to win the war.
Academic Article A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
Academic Article Integr-ating IL-1 alpha in antiviral host defenses.
Academic Article Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus.
Academic Article Inflammasomes and anti-viral immunity.
Academic Article Pattern recognition receptors and the innate immune response to viral infection.
Academic Article Cytosolic surveillance and antiviral immunity.
Academic Article Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Academic Article Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
Academic Article The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Academic Article IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
Academic Article Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence.
Academic Article Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion.
Academic Article Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection.
Academic Article AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Academic Article Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Academic Article The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Academic Article Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
Academic Article Innate immune sensing of DNA viruses.
Academic Article Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway.
Academic Article RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.
Concept Myxoma virus
Concept Virus Diseases
Concept Viruses
Concept Rift Valley fever virus
Concept Virus Replication
Concept Influenza A Virus, H1N1 Subtype
Concept Adenosine Triphosphate
Concept Virus Internalization
Concept RNA Virus Infections
Concept Dengue Virus
Concept DNA Viruses
Concept RNA Viruses
Concept Vesicular stomatitis Indiana virus
Concept Vaccinia virus
Concept Virus Latency
Concept Lymphocytic choriomeningitis virus
Concept Adenoviridae
Concept Virus Physiological Phenomena
Concept DNA Virus Infections
Concept Encephalomyocarditis virus
Concept Sendai virus
Academic Article Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals.
Academic Article Rift Valley fever virus infection induces activation of the NLRP3 inflammasome.
Academic Article TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
Academic Article Interferon ?-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses.
Academic Article Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease.
Academic Article Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
Academic Article Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.
Academic Article Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
Academic Article A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.
Academic Article Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity.
Academic Article hnRNPA2B1: Fueling Antiviral Immunity from the Nucleus.
Academic Article Long non-coding RNAs in antiviral immunity.
Academic Article Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
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